Sebastian Kreil,for the German Chronic Myelogenous Leukemia (CML) Study Group,Markus Pfirrmann,for the German Chronic Myelogenous Leukemia (CML) Study Group,Claudia Haferlach,for the German Chronic Myelogenous Leukemia (CML) Study Group,Katherine Waghorn,for the German Chronic Myelogenous Leukemia (CML) Study Group,Andrew Chase,for the German Chronic Myelogenous Leukemia (CML) Study Group,Rüdiger Hehlmann,for the German Chronic Myelogenous Leukemia (CML) Study Group,Andreas Reiter,for the German Chronic Myelogenous Leukemia (CML) Study Group,Andreas Hochhaus,for the German Chronic Myelogenous Leukemia (CML) Study Group,Nicholas C. P. Cross,for the German Chronic Myelogenous Leukemia (CML) Study Group

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Supplemental data

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

Lars Bullinger,Frank G. Rücker,Stephan Kurz,Juan Du,Claudia Scholl,Sandrine Sander,Andrea Corbacioglu,Claudio Lottaz,Jürgen Krauter,Stefan Fröhling,Arnold Ganser,Richard F. Schlenk,Konstanze Döhner,Jonathan R. Pollack,Hartmut Döhner

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Supplemental data

Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors

Giulia De Falco,Eleonora Leucci,Dido Lenze,Pier Paolo Piccaluga,Pier Paolo Claudio,Anna Onnis,Giovanna Cerino,Joshua Nyagol,Walter Mwanda,Cristiana Bellan,Michael Hummel,Stefano Pileri,Piero Tosi,Harald Stein,Antonio Giordano,Lorenzo Leoncini

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Supplemental data

Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia

Frank Dicker,Claudia Haferlach,Wolfgang Kern,Torsten Haferlach,Susanne Schnittger

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Reintroduction of C/EBPα in leukemic CD34⁺ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis

Hein Schepers,Albertus T. J. Wierenga,Djoke van Gosliga,Bart J. L. Eggen,Edo Vellenga,Jan Jacob Schuringa

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Galectin-1 mediated suppression of Epstein-Barr virus–specific T-cell immunity in classic Hodgkin lymphoma
Brief Report

Maher K. Gandhi,Guido Moll,Corey Smith,Ujjwal Dua,Eleanore Lambley,Olivier Ramuz,Devinder Gill,Paula Marlton,John F. Seymour,Rajiv Khanna

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Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
Brief Report

Dennis Löffler,Katja Brocke-Heidrich,Gabriele Pfeifer,Claudia Stocsits,Jörg Hackermüller,Antje K. Kretzschmar,Renate Burger,Martin Gramatzki,Conny Blumert,Kay Bauer,Helena Cvijic,A. Kerstin Ullmann,Peter F. Stadler,Friedemann Horn

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Supplemental data

TRANSFUSION MEDICINE

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets
Brief Report

Mimi Kjaersgaard,Rukhsana Aslam,Michael Kim,Edwin R. Speck,John Freedman,Donald I. H. Stewart,Erik J. Wiersma,John W. Semple

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TRANSPLANTATION

Potential risks of bone marrow cell transplantation into infarcted hearts

Martin Breitbach,Toktam Bostani,Wilhelm Roell,Ying Xia,Oliver Dewald,Jens M. Nygren,Jochen W. U. Fries,Klaus Tiemann,Heribert Bohlen,Juergen Hescheler,Armin Welz,Wilhelm Bloch,Sten Eirik W. Jacobsen,Bernd K. Fleischmann

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Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells

Stephanie Smith-Berdan,Daphne Gille,Irving L. Weissman,Julie L. Christensen

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Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders

ChunKang Chang,Barry E. Storer,Bart L. Scott,Eileen M. Bryant,Howard M. Shulman,Mary E. Flowers,Brenda M. Sandmaier,Robert P. Witherspoon,Richard A. Nash,Jean E. Sanders,Antonio Bedalov,John A. Hansen,Bruce E. Clurman,Rainer Storb,Frederick R. Appelbaum,H. Joachim Deeg

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High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study

Richard A. Nash,Peter A. McSweeney,Leslie J. Crofford,Muneer Abidi,Chien-Shing Chen,J. David Godwin,Theodore A. Gooley,Leona Holmberg,Gretchen Henstorf,C. Fred LeMaistre,Maureen D. Mayes,Kevin T. McDonagh,Bernadette McLaughlin,Jerry A. Molitor,J. Lee Nelson,Howard Shulman,Rainer Storb,Federico Viganego,Mark H. Wener,James R. Seibold,Keith M. Sullivan,Daniel E. Furst

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Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia
Brief Report

Hubert Schrezenmeier,Jakob R. Passweg,Judith C. W. Marsh,Andrea Bacigalupo,Christopher N. Bredeson,Eduardo Bullorsky,Bruce M. Camitta,Richard E. Champlin,Robert Peter Gale,Monika Fuhrer,John P. Klein,Anna Locasciulli,Rosi Oneto,Antonius V. M. B. Schattenberg,Gerard Socie,Mary Eapen

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Loss of BAP1 defines a unique subtype of TP53-mutated de novo AML and confers sensitivity to BCL-xL inhibitors

LRRC8 complexes are ATP release channels regulating platelet activation and arterial thrombosis

Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone

Somatic IRF4 Mutations and Thymic Tropism in Primary Mediastinal Large B-cell Lymphoma

Access to AlloTx for AML: the value of the social phenotype

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Issue Archive

Table of Contents

INSIDE BLOOD

Heme/Fe-S intimacies make RBCs blush Free

“Lesser” ALL: treat less or study less? Free Clinical Trials & Observations

The STATus of miR-21 in apoptosis Free

EBV-specific T-cell therapy Free Clinical Trials & Observations

Autologous HSCT: toward scleroderma treatment Free

Inducing Tregs with hepatic gene therapy Free

What for platelet factor 4? Free

EDITORIALS

Notes from the Director, National Heart, Lung, and Blood Institute: NHLBI core values and shaping the 2007 budget Free

PERSPECTIVE

Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel Free

REVIEW IN TRANSLATIONAL HEMATOLOGY

Myeloma bone disease and proteasome inhibition therapies Free

CLINICAL TRIALS AND OBSERVATIONS

Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201 Free Clinical Trials & Observations

Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia Free Clinical Trials & Observations

In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma Free Clinical Trials & Observations

Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial Free Clinical Trials & Observations

GENE THERAPY

Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer Free

HEMATOPOIESIS

Mutations in the SBDS gene in acquired aplastic anemia Free

The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption Free

Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications Free

Multiple prethymic defects underlie age-related loss of T progenitor competence Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Regulation of COX-2–mediated signaling by α3 type IV noncollagenous domain in tumor angiogenesis Free

Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study Free

IMMUNOBIOLOGY

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function Free

Leukocyte PI3Kγ and PI3Kδ have temporally distinct roles for leukocyte recruitment in vivo Free

Role of CD28 in fatal autoimmune disorder in scurfy mice Free

HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts Free

Splenic CD19−CD35+B220+ cells function as an inducer of follicular dendritic cell network formation Free

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression Free

NEOPLASIA

Congestive heart failure is a rare event in patients receiving imatinib therapy Free

VEGFR-1 (FLT-1), β1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome Free

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children Free

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia Free

A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia Free

Concordant but not discordant bone marrow involvement in diffuse large B-cell lymphoma predicts a poor clinical outcome independent of the International Prognostic Index Free

Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia Free

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia Free

Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors Free

Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia Free

Reintroduction of C/EBPα in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis Free

Galectin-1 mediated suppression of Epstein-Barr virus–specific T-cell immunity in classic Hodgkin lymphoma Free Brief Report

Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer Free Brief Report

RED CELLS

Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells Open Access

Developmental- and differentiation-specific patterns of human γ- and β-globin promoter DNA methylation Free

The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload Free

TRANSFUSION MEDICINE

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets Free Brief Report

TRANSPLANTATION

Potential risks of bone marrow cell transplantation into infarcted hearts Free

Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells Free

Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders Free

High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study Free

Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia Free Brief Report

Email alerts

ASH Publications

American Society of Hematology

Heme/Fe-S intimacies make RBCs blush

“Lesser” ALL: treat less or study less?
Clinical Trials & Observations

The STATus of miR-21 in apoptosis

EBV-specific T-cell therapy
Clinical Trials & Observations

Autologous HSCT: toward scleroderma treatment

Inducing T_regs with hepatic gene therapy

What for platelet factor 4?

Notes from the Director, National Heart, Lung, and Blood Institute: NHLBI core values and shaping the 2007 budget

Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel

Myeloma bone disease and proteasome inhibition therapies

Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201
Clinical Trials & Observations

Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia
Clinical Trials & Observations

In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma
Clinical Trials & Observations

Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial
Clinical Trials & Observations

Induction and role of regulatory CD4⁺CD25⁺ T cells in tolerance to the transgene product following hepatic in vivo gene transfer

Mutations in the SBDS gene in acquired aplastic anemia

The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption

Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications

Multiple prethymic defects underlie age-related loss of T progenitor competence

Regulation of COX-2–mediated signaling by α3 type IV noncollagenous domain in tumor angiogenesis

Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Leukocyte PI3Kγ and PI3Kδ have temporally distinct roles for leukocyte recruitment in vivo

Role of CD28 in fatal autoimmune disorder in scurfy mice

HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts

Splenic CD19⁻CD35⁺B220⁺ cells function as an inducer of follicular dendritic cell network formation

Expression of ectonucleotidase CD39 by Foxp3⁺ Treg cells: hydrolysis of extracellular ATP and immune suppression

Congestive heart failure is a rare event in patients receiving imatinib therapy

VEGFR-1 (FLT-1), β₁ integrin, and hERG K⁺ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome

The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia

Concordant but not discordant bone marrow involvement in diffuse large B-cell lymphoma predicts a poor clinical outcome independent of the International Prognostic Index

Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors

Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia

Reintroduction of C/EBPα in leukemic CD34⁺ stem/progenitor cells impairs self-renewal and partially restores myelopoiesis

Galectin-1 mediated suppression of Epstein-Barr virus–specific T-cell immunity in classic Hodgkin lymphoma
Brief Report

Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer
Brief Report

Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells

Developmental- and differentiation-specific patterns of human γ- and β-globin promoter DNA methylation

The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload

Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets
Brief Report

Potential risks of bone marrow cell transplantation into infarcted hearts

Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells

Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders

High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study

Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia
Brief Report