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Issue Archive

Volume 100, Issue 10
November 15 2002
Blood Cover Image for Volume 100, Issue 10

Table of Contents

INSIDE BLOOD

Of mouse, not of man? a surprise at the α-globin locus
John M. Cunningham,Stephen M. Jane
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Phages that display P-selectin antagonism
Paul S. Frenette
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FOCUS ON HEMATOLOGY

Introduction: congenital methemoglobinemia revisited
Quentin Gibson
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Familial idiopathic methemoglobinemia revisited: original cases reveal 2 novel mutations in NADH-cytochrome b5 reductase
Melanie J. Percy,Matthew J. S. Gillespie,Geraldine Savage,Anne E. Hughes,Mary Frances McMullin,Terry R. J. Lappin
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PLENARY PAPERS

Deletion of the mouse α-globin regulatory element (HS −26) has an unexpectedly mild phenotype
Eduardo Anguita,Jacqueline A. Sharpe,Jacqueline A. Sloane-Stanley,Cristina Tufarelli,Douglas R. Higgs,William G. Wood
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REVIEW ARTICLES

Recombinant human thrombopoietin: basic biology and evaluation of clinical studies
Clinical Trials & Observations
David J. Kuter,C. Glenn Begley
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HOW I TREAT

How we manage venous thromboembolism during pregnancy
Clinical Trials & Observations
Shannon M. Bates,Jeffrey S. Ginsberg
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation
Clinical Trials & Observations
Joseph H. Antin,Daniel Weisdorf,Donna Neuberg,Roberta Nicklow,Shawn Clouthier,Stephanie J. Lee,Edwin Alyea,Carol McGarigle,Bruce R. Blazar,Stephen Sonis,Robert J. Soiffer,James L.M. Ferrara
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Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
Clinical Trials & Observations
Paolo Prandoni,Anthonie W. A. Lensing,Andrea Piccioli,Enrico Bernardi,Paolo Simioni,Bruno Girolami,Antonio Marchiori,Paola Sabbion,Martin H. Prins,Franco Noventa,Antonio Girolami
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ERRATA

Erratum for vol. 100, p. 718
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HEMATOPOIESIS

Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children
Hans Verhoef,Clive E. West,Rob Kraaijenhagen,Silas M. Nzyuko,Rose King,Mary M. Mbandi,Susanne van Laatum,Roos Hogervorst,Carla Schep,Frans J. Kok
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Prominent role of TGF-β1 in thrombopoietin-induced myelofibrosis in mice
Hédia Chagraoui,Emiko Komura,Micheline Tulliez,Stéphane Giraudier,William Vainchenker,Françoise Wendling
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B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment
Yoshiko Hashimoto,Encarnacion Montecino-Rodriguez,Hyosuk Leathers,Robert P. Stephan,Kenneth Dorshkind
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GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21WAF1 and p27Kip1 proteins
Sachiko Ezoe,Itaru Matsumura,Soichi Nakata,Karin Gale,Katsuhiko Ishihara,Naoko Minegishi,Takashi Machii,Toshio Kitamura,Masayuki Yamamoto,Tariq Enver,Yuzuru Kanakura
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Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation
Jiang F. Zhong,Yuxia Zhan,W. French Anderson,Yi Zhao
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Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells
Patricia E. Burger,Sandra Coetzee,Wallace L. McKeehan,Mikio Kan,Perry Cook,Yong Fan,Toshio Suda,Robert P. Hebbel,Nicolas Novitzky,William A. Muller,E. Lynette Wilson
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hnRNP-K and Purα act together to repress the transcriptional activity of the CD43 gene promoter
Nicolas Da Silva,Ajit Bharti,Carl S. Shelley
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In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients
P. Artur Plett,Stacy M. Frankovitz,Christie M. Orschell-Traycoff
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Supplemental data
Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow
Wolf-K. Hofmann,Sven de Vos,Martina Komor,Dieter Hoelzer,William Wachsman,H. Phillip Koeffler
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C
Andrew C. Pearce,Jonathan I. Wilde,Gina M. Doody,Denise Best,Osamu Inoue,Elena Vigorito,Victor L. J. Tybulewicz,Martin Turner,Steve P. Watson
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Specific inhibition of P-selectin–mediated cell adhesion by phage display–derived peptide antagonists
Tom J. M. Molenaar,Chantal C. M. Appeldoorn,Sonja A. M. de Haas,Ingrid N. Michon,Arnaud Bonnefoy,Marc F. Hoylaerts,Hans Pannekoek,Theo J. C. van Berkel,Johan Kuiper,Erik A. L. Biessen
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Furin gene (fur) regulation in differentiating human megakaryoblastic Dami cells: involvement of the proximal GATA recognition motif in the P1 promoter and impact on the maturation of furin substrates
Marie-Hélène Laprise,Francine Grondin,Pauline Cayer,Patrick P. McDonald,Claire M. Dubois
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Identification of distal regulatory regions in the human αIIb gene locus necessary for consistent, high-level megakaryocyte expression
Michael A. Thornton,Chunyan Zhang,Maria A. Kowalska,Mortimer Poncz
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Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium
Wen-Hong Su,Hsiun-ing Chen,Chauying J. Jen
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Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow
Hideto Matsui,Mitsuhiko Sugimoto,Tomohiro Mizuno,Shizuko Tsuji,Shigeki Miyata,Michio Matsuda,Akira Yoshioka
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Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction
Andreas E. May,Roland Schmidt,Sandip M. Kanse,Triantafyllos Chavakis,Ross W. Stephens,Albert Schömig,Klaus T. Preissner,Franz-Josef Neumann
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Sialyltransferase specificity in selectin ligand formation
Lesley G. Ellies,Markus Sperandio,Gregory H. Underhill,James Yousif,Michael Smith,John J. Priatel,Geoffrey S. Kansas,Klaus Ley,Jamey D. Marth
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Cloning, expression, and functional characterization of the von Willebrand factor–cleaving protease (ADAMTS13)
Barbara Plaimauer,Klaus Zimmermann,Dirk Völkel,Gerhard Antoine,Randolf Kerschbaumer,Pegah Jenab,Miha Furlan,Helen Gerritsen,Bernhard Lämmle,Hans Peter Schwarz,Friedrich Scheiflinger
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IMMUNOBIOLOGY

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells
Megan A. Cooper,Jennifer E. Bush,Todd A. Fehniger,Jeffrey B. VanDeusen,Ross E. Waite,Yang Liu,Hector L. Aguila,Michael A. Caligiuri
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Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression
James N. Kochenderfer,Sumiko Kobayashi,Eric D. Wieder,Chunliu Su,Jeffrey J. Molldrem
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Long-lived immature dendritic cells mediated by TRANCE-RANK interaction
Isabelle Cremer,Marie-Caroline Dieu-Nosjean,Sylvie Maréchal,Colette Dezutter-Dambuyant,Sarah Goddard,David Adams,Nathalie Winter,Christine Menetrier-Caux,Catherine Sautès-Fridman,Wolf H. Fridman,Chris G. F. Mueller
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Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences ofNf1 deficiency in T-cell development and function
David A. Ingram,Lei Zhang,Jennifer McCarthy,Mary Jo Wenning,Lucy Fisher,Feng-Chun Yang,D. Wade Clapp,Reuben Kapur
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Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31hiLy-6Cneg bone marrow precursors in a mouse model of asthma
Leonie S. van Rijt,Jan-Bas Prins,Pieter J. M. Leenen,Kris Thielemans,Victor C. de Vries,Henk C. Hoogsteden,Bart N. Lambrecht
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Relationships between early B- and NK-lineage lymphocyte precursors in bone marrow
Taku Kouro,Vinay Kumar,Paul W. Kincade
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Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice
Corinna La Rosa,Zhongde Wang,John C. Brewer,Simon F. Lacey,Maria C. Villacres,Rahul Sharan,Radhika Krishnan,Matthew Crooks,Susan Markel,Rebecca Maas,Don J. Diamond
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Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8+ T cells
Evren Özdemir,Lisa S. St. John,Geraldine Gillespie,Sarah Rowland-Jones,Richard E. Champlin,Jeffrey J. Molldrem,Krishna V. Komanduri
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Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)
David Voehringer,Marie Koschella,Hanspeter Pircher
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Interaction of human hematopoietic stem cells with bacterial pathogens
Annette Kolb-Mäurer,Martin Wilhelm,Florian Weissinger,Eva-Bettina Bröcker,Werner Goebel
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NEOPLASIA

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties
Akihiko Yokoyama,Issay Kitabayashi,Paul M. Ayton,Michael L. Cleary,Misao Ohki
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Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells
Claudio Pisano,Peter Kollar,Maurizio Giannı́,Yesim Kalac,Vincenzo Giordano,Fabiana Fosca Ferrara,Richard Tancredi,Antonio Devoto,Alessandra Rinaldi,Alessandro Rambaldi,Sergio Penco,Mauro Marzi,Giampiero Moretti,Loredana Vesci,Ornella Tinti,Paolo Carminati,Mineko Terao,Enrico Garattini
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Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo
Xiaoyan Jiang,Eddy Ng,Calvin Yip,Wolfgang Eisterer,Yves Chalandon,Matthew Stuible,Allen Eaves,Connie J. Eaves
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Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ
Ingo Ringshausen,Folker Schneller,Christian Bogner,Susanne Hipp,Justus Duyster,Christian Peschel,Thomas Decker
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Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-κB/Rel–regulated inhibitors of apoptosis
Gerd Munzert,Dieter Kirchner,Heike Stobbe,Lothar Bergmann,Roland M. Schmid,Hartmut Döhner,Hermann Heimpel
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Increased frequency of mannose-binding lectin insufficiency among children with acute lymphoblastic leukemia
Kjeld Schmiegelow,Peter Garred,Birgitte Lausen,Bente Andreassen,Bodil Laub Petersen,Hans Ole Madsen
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The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia
Claire Seedhouse,Rowena Bainton,Michael Lewis,Alexander Harding,Nigel Russell,Emma Das-Gupta
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BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
Matthias Mayerhofer,Peter Valent,Wolfgang R. Sperr,James D. Griffin,Christian Sillaber
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RED CELLS

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
David A. Weinstein,Cindy N. Roy,Mark D. Fleming,Massimo F. Loda,Joseph I. Wolfsdorf,Nancy C. Andrews
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Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
Silvia Deaglio,Andrea Capobianco,Angelita Calı̀,Francesca Bellora,Federica Alberti,Luisella Righi,Anna Sapino,Clara Camaschella,Fabio Malavasi
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Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin
Neil M. Matsui,Ajit Varki,Stephen H. Embury
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Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma
Mukul S. Goel,Scott L. Diamond
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A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells
Edward Melkun,Mylisa Pilione,Robert F. Paulson
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Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria
Tatsuyuki Kai,Tsutomu Shichishima,Hideyoshi Noji,Tetsuo Yamamoto,Masatoshi Okamoto,Kazuhiko Ikeda,Yukio Maruyama
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BRIEF REPORTS

Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance
Brief Report
Jonathan B. Pollett,Suzanne Trudel,Daniel Stern,Zhixiong H. Li,A. Keith Stewart
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Initial characterization of TREM-like transcript (TLT)–1: a putative inhibitory receptor within the TREM cluster
Brief Report
A. Valance Washington,Laura Quigley,Daniel W. McVicar
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Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants
Brief Report
Stella M. Davies,Loredana Ruggieri,Todd DeFor,John E. Wagner,Daniel J. Weisdorf,Jeffrey S. Miller,Andrea Velardi,Bruce R. Blazar
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Immortalization of yolk sac–derived precursor cells
Brief Report
Wen-Mei Yu,Teresa S. Hawley,Robert G. Hawley,Cheng-Kui Qu
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Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
Brief Report
Caroline Laverdière,Sonia Chiasson,Irina Costea,Albert Moghrabi,Maja Krajinovic
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Two distinct HLA-A0201–presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL
Brief Report
Ilaria Bellantuono,Liquan Gao,Suzanne Parry,Steve Marley,Francesco Dazzi,Jane Apperley,John M. Goldman,Hans J. Stauss
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CORRESPONDENCE

Chromosome 19 abnormalities are commonly seen in AML, M7
Stephen D. Nimer,Donal MacGrogan,Suresh Jhanwar,Sara Alvarez
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Deficiency of ADAMTS13 and thrombotic thrombocytopenic purpura
Han-Mou Tsai
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CMV infection following nonmyeloablative allogeneic stem cell transplantation using Campath
Rowena D. Bainton,Jennifer L. Byrne,Barbara J. Davy,Nigel H. Russell
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All Issues

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