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Johan W. M. Heemskerk
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Journal Articles

Deleting ACC1 in platelets alters phospholipidome and reduces platelet activation and thrombosis in mice

Open Access
Marie Octave, Laurence Pirotton, Emma de Cartier d’Yves, Alice Marino, Jérôme Ambroise, Martin Giera, Bruno Guigas, Audrey Ginion, Valentine Robaux, Marijke Kuijpers, Constance Baaten, Johan W. M. Heemskerk, Zoltan Nagy, Yotis Senis, Davide Brusa, Caroline Bouzin, Luc Bertrand, Christophe Beauloye, Sandrine Horman
Journal: Blood Advances
Blood Adv (2025) 9 (18): 4553–4567.
https://doi.org/10.1182/bloodadvances.2025015796
Published: 2025
Includes: Supplemental data
Journal Articles

Crucial roles of red blood cells and platelets in whole blood thrombin generation

Free
Siyu Sun, Elena Campello, Jinmi Zou, Joke Konings, Dana Huskens, Jun Wan, Delia I. Fernández, Chris P. M. Reutelingsperger, Hugo ten Cate, Serena Toffanin, Cristiana Bulato, Philip G. de Groot, Bas de Laat, Paolo Simioni, Johan W. M. Heemskerk, Mark Roest
Journal: Blood Advances
Blood Adv (2023) 7 (21): 6717–6731.
https://doi.org/10.1182/bloodadvances.2023010027
Published: 2023
Includes: Supplemental data
Journal Articles

High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis

Free
Delia I. Fernandez, Isabella Provenzale, Matthias Canault, Salome Fels, Antonia Lenz, Felicia Andresen, Anne Krümpel, Arnaud Dupuis, Johan W. M. Heemskerk, Doris Boeckelmann, Barbara Zieger
Journal: Blood Advances
Blood Adv (2023) 7 (20): 6163–6177.
https://doi.org/10.1182/bloodadvances.2023009860
Published: 2023
Includes: Supplemental data
Journal Articles

GPVI expression is linked to platelet size, age, and reactivity

Free
Alicia Veninga, Stefan Handtke, Konstanze Aurich, Bibian M. E. Tullemans, Sanne L. N. Brouns, Silas L. Schwarz, Floor C. J. I. Heubel-Moenen, Andreas Greinacher, Johan W. M. Heemskerk, Paola E. J. van der Meijden, Thomas Thiele
Journal: Blood Advances
Blood Adv (2022) 6 (14): 4162–4173.
https://doi.org/10.1182/bloodadvances.2021006904
Published: 2022
Includes: Supplemental data
Journal Articles

High fibrinogen γ′ levels in patient plasma increase clot formation at arterial and venous shear

Free
Fraser L. Macrae, Frauke Swieringa, Johan W. M. Heemskerk, Robert A. S. Ariëns
Journal: Blood Advances
Blood Adv (2021) 5 (17): 3468–3477.
https://doi.org/10.1182/bloodadvances.2020003346
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Flow studies on human GPVI-deficient blood under coagulating and noncoagulating conditions

Free
Magdolna Nagy, Gina Perrella, Amanda Dalby, M. Francisca Becerra, Lourdes Garcia Quintanilla, Jeremy A. Pike, Neil V. Morgan, Elizabeth E. Gardiner, Johan W. M. Heemskerk, Lorena Azócar, Juan Francisco Miquel, Diego Mezzano, Steve P. Watson
Journal: Blood Advances
Blood Adv (2020) 4 (13): 2953–2961.
https://doi.org/10.1182/bloodadvances.2020001761
Published: 2020
Includes: Supplemental data
Journal Articles

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

Free
Constance C. F. M. J. Baaten, Frauke Swieringa, Tomasz Misztal, Tom G. Mastenbroek, Marion A. H. Feijge, Paul E. Bock, Marjo M. P. C. Donners, Peter W. Collins, Renhao Li, Paola E. J. van der Meijden, Johan W. M. Heemskerk
Journal: Blood Advances
Blood Adv (2018) 2 (18): 2320–2331.
https://doi.org/10.1182/bloodadvances.2017011544
Published: 2018
Includes: Supplemental data
Journal Articles

Inhibitory mechanisms of very low–dose rivaroxaban in non–ST-elevation myocardial infarction

Free
Clinical Trials & Observations
Oliver Borst, Patrick Münzer, Nada Alnaggar, Sascha Geue, Roland Tegtmeyer, Dominik Rath, Michal Droppa, Peter Seizer, Stefan Heitmeier, Johan W. M. Heemskerk, Lisa K. Jennings, Robert F. Storey, Dominick J. Angiolillo, Bianca Rocca, Henri Spronk, Hugo Ten Cate, Meinrad Gawaz, Tobias Geisler
Journal: Blood Advances
Blood Adv (2018) 2 (6): 715–730.
https://doi.org/10.1182/bloodadvances.2017013573
Published: 2018
Includes: Supplemental data