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Volume 7, Issue 3

February 14 2023

In this Issue

STIMULUS REPORTS
CLINICAL TRIALS AND OBSERVATIONS
HEALTH SERVICES AND OUTCOMES
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
RESEARCH LETTERS
ERRATA

STIMULUS REPORTS

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance

Dearbhla Doherty,Michelle Lavin,Mary Byrne,Margaret Nolan,Jamie M. O’Sullivan,Kevin Ryan,Niamh M. O’Connell,Sandra L. Haberichter,Pamela A. Christopherson,Jorge Di Paola,Paula D. James,James S. O’Donnell,on behalf of the Zimmerman Program Investigators

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Supplemental data

Absolute neutrophil count by Duffy status among healthy Black and African American adults
Clinical Trials & Observations

Lauren E. Merz,Charlotte M. Story,Miriam A. Osei,Katherine Jolley,Siyang Ren,Hae Soo Park,Revital Yefidoff Freedman,Donna Neuberg,Robin Smeland-Wagman,Richard M. Kaufman,Maureen O. Achebe

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Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

A phase 1 trial utilizing TMI with fludarabine-melphalan in patients with hematologic malignancies undergoing second allo-SCT
Clinical Trials & Observations

Misha C. Tran,Yasmin Hasan,Amy Wang,Kamil Yenice,Julien Partouche,Wendy Stock,Richard A. Larson,Satyajit Kosuri,James L. LaBelle,Justin Kline,Peter A. Riedell,Andrew S. Artz,Ralph Weichselbaum,Michael R. Bishop,Bulent Aydogan,Hongtao Liu

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Supplemental data

A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopenia
Clinical Trials & Observations

John Grainger,James Bussel,Michael Tarantino,Nichola Cooper,Donald Beam,Jenny Despotovic,Alexey Maschan,Kejia Wang,Melissa Eisen,Charles Bowers

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Supplemental data

Safety and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in children with SCD: a V114-023 (PNEU-SICKLE) study
Clinical Trials & Observations

Charles T. Quinn,Richard T. Wiedmann,Daniel Jarovsky,Eduardo Lopez-Medina,Hilze M. Rodriguez,Melanie Papa,Gordana Boggio,Qiong Shou,Ron Dagan,Peter Richmond,Kristen Feemster,Richard McFetridge,Gretchen Tamms,Robert Lupinacci,Luwy Musey,Kara Bickham,on behalf of the V114-023 (PNEU-SICKLE) study group

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Supplemental data

HEALTH SERVICES AND OUTCOMES

Neighborhood disadvantage, health status, and health care utilization after blood or marrow transplant: BMTSS report

Julie A. Wolfson,Smita Bhatia,Lindsey Hageman,E. S. Ross,Nora Balas,Alysia Bosworth,Hok Sreng Te,Liton Francisco,Erin Funk,Jessica Hicks,Wendy Landier,Jessica Wu,Arianna Siler,Shawn Lim,F. Lennie Wong,Saro H. Armenian,Mukta Arora,Monica S. Aswani

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Supplemental data

Lifetime medical costs attributable to sickle cell disease among nonelderly individuals with commercial insurance

Kate M. Johnson,Boshen Jiao,Scott D. Ramsey,M. A. Bender,Beth Devine,Anirban Basu

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Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Interleukin-15 augments NK cell–mediated ADCC of alemtuzumab in patients with CD52⁺ T-cell malignancies
Clinical Trials & Observations

Milos D. Miljkovic,Sigrid P. Dubois,Jürgen R. Müller,Bonita Bryant,Elaine Ma,Kevin C. Conlon,Thomas A. Waldmann

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Supplemental data

LYMPHOID NEOPLASIA

Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment

Nicholas Borcherding,Kevin J. Severson,Nicholas Henderson,Luana S. Ortolan,Allison C. Rosenthal,Andrew M. Bellizzi,Vincent Liu,Brian K. Link,Aaron R. Mangold,Ali Jabbari

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Supplemental data

Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia

Cory Seth Bridges,Taylor J. Chen,Monica Puppi,Karen R. Rabin,H. Daniel Lacorazza

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Supplemental data

Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations

Jingjing Ren,Rihao Qu,Nur-Taz Rahman,Julia M. Lewis,Amber Loren Ong King,Xiaofeng Liao,Fatima N. Mirza,Kacie R. Carlson,Yaqing Huang,Scott Gigante,Benjamin Evans,Barani Kumar Rajendran,Suzanne Xu,Guilin Wang,Francine M. Foss,William Damsky,Yuval Kluger,Smita Krishnaswamy,Michael Girardi

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Supplemental data

MYELOID NEOPLASIA

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice

Andrew Muranyi,Tobias Ammer,Anna Kechter,Vijay P. S. Rawat,Amit Sinha,Irene Gonzalez-Menendez,Leticia Quintanilla-Martinez,Anca Azoitei,Cagatay Günes,Annalisa Mupo,George Vassiliou,Shiva Bamezai,Christian Buske

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Supplemental data

Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation

Marius Bill,Madlen Jentzsch,Lara Bischof,Jessica Kohlschmidt,Juliane Grimm,Laura Katharina Schmalbrock,Donata Backhaus,Dominic Brauer,Karoline Goldmann,Georg-Nikolaus Franke,Vladan Vucinic,Dietger Niederwieser,Alice S. Mims,Uwe Platzbecker,Ann-Kathrin Eisfeld,Sebastian Schwind

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Supplemental data

PLATELETS AND THROMBOPOIESIS

Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation

Aldo A. Acosta-Medina,Ann M. Moyer,Ronald S. Go,Maria Alice V. Willrich,Fernando C. Fervenza,Nelson Leung,Christianne Bourlon,Jeffrey L. Winters,Grant M. Spears,Sandra C. Bryant,Meera Sridharan,on behalf of the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group

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Supplemental data

THROMBOSIS AND HEMOSTASIS

Differences in wild-type– and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies

Jonathan H. Foley,Erald Shehu,Anne Riddell,Elaine Gray,Andrew Goodale,I-Mei Yu,Daniël Verhoef,John Little,Diane Shattock,Steve Kitchen,Pratima Chowdary,Romuald Corbau,Amit C. Nathwani

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Supplemental data

RESEARCH LETTERS

Persistence of chronic inflammation after regular blood transfusion therapy in sickle cell anemia
Clinical Trials & Observations

Abdoul Karim Dembélé,Patricia Hermand,Florence Missud,Emmanuelle Lesprit,Laurent Holvoet,Valentine Brousse,Ghislaine Ithier,Marie-Helene Odievre,Malika Benkerrou,Caroline Le Van Kim,Berengere Koehl

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Supplemental data

A monocentric analysis of the long-term safety and efficacy of crizotinib in relapsed/refractory ALK⁺ lymphomas

Giovanni Rindone,Andrea Aroldi,Elisa Bossi,Luisa Verga,Giovanni Zambrotta,Sara Tarantino,Rocco Piazza,Lara Mussolin,Roberto Chiarle,Carlo Gambacorti-Passerini

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Supplemental data

CAR T-cell therapy for mantle cell lymphoma with central nervous system relapse
Clinical Trials & Observations

Khoan Vu,Matthew J. Frank

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Comparison of bone marrow and peripheral blood aberrant plasma cell assessment by NGF in patients with MM
Clinical Trials & Observations

Katharina Kriegsmann,Calin Manta,Ricarda Schwab,Elias K. Mai,Marc S. Raab,Hans J. Salwender,Roland Fenk,Britta Besemer,Jan Dürig,Roland Schroers,Ivana von Metzler,Mathias Hänel,Christoph Mann,Anne M. Asemissen,Bernhard Heilmeier,Uta Bertsch,Stefanie Huhn,Carsten Müller-Tidow,Hartmut Goldschmidt,Michael Hundemer

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Supplemental data

White blood cell ranges and frequency of neutropenia by Duffy genotype status
Clinical Trials & Observations

Minoo Bagheri,Cecilia P. Chung,Alyson L. Dickson,Sara L. Van Driest,Scott C. Borinstein,Jonathan D. Mosley

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Supplemental data

A novel, effective, and efficient strategy for treating sickle cell vaso-occlusive events in the infusion center setting
Clinical Trials & Observations

Scott A. Peslak,Alexis Brimm Akins,Anessa M. Foxwell,Marie Iannelli,Carolyn Grande,Delisha Breen,J. Eric Russell,Tanya J. Uritsky,Farzana A. Sayani

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Supplemental data

ERRATA

Cheng PTM, Villa D, Tonseth RP, et al. Outcome of limited-stage nodular lymphocyte-predominant Hodgkin lymphoma and the impact of a PET-adapted approach. Blood Adv. 2021;5(18):3647-3655.

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Menghrajani K, Gomez-Arteaga A, Madero-Marroquin R, et al. Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML. Blood Adv. 2022;6(3):828-847.

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Table of Contents

STIMULUS REPORTS

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance

Absolute neutrophil count by Duffy status among healthy Black and African American adults
Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

A phase 1 trial utilizing TMI with fludarabine-melphalan in patients with hematologic malignancies undergoing second allo-SCT
Clinical Trials & Observations

A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopenia
Clinical Trials & Observations

Safety and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in children with SCD: a V114-023 (PNEU-SICKLE) study
Clinical Trials & Observations

HEALTH SERVICES AND OUTCOMES

Neighborhood disadvantage, health status, and health care utilization after blood or marrow transplant: BMTSS report

Lifetime medical costs attributable to sickle cell disease among nonelderly individuals with commercial insurance

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Interleukin-15 augments NK cell–mediated ADCC of alemtuzumab in patients with CD52⁺ T-cell malignancies
Clinical Trials & Observations

LYMPHOID NEOPLASIA

Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment

Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia

Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations

MYELOID NEOPLASIA

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice

Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation

PLATELETS AND THROMBOPOIESIS

Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation

THROMBOSIS AND HEMOSTASIS

Differences in wild-type– and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies

RESEARCH LETTERS

Persistence of chronic inflammation after regular blood transfusion therapy in sickle cell anemia
Clinical Trials & Observations

A monocentric analysis of the long-term safety and efficacy of crizotinib in relapsed/refractory ALK⁺ lymphomas

CAR T-cell therapy for mantle cell lymphoma with central nervous system relapse
Clinical Trials & Observations

Comparison of bone marrow and peripheral blood aberrant plasma cell assessment by NGF in patients with MM
Clinical Trials & Observations

White blood cell ranges and frequency of neutropenia by Duffy genotype status
Clinical Trials & Observations

A novel, effective, and efficient strategy for treating sickle cell vaso-occlusive events in the infusion center setting
Clinical Trials & Observations

ERRATA

Cheng PTM, Villa D, Tonseth RP, et al. Outcome of limited-stage nodular lymphocyte-predominant Hodgkin lymphoma and the impact of a PET-adapted approach. Blood Adv. 2021;5(18):3647-3655.

Menghrajani K, Gomez-Arteaga A, Madero-Marroquin R, et al. Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML. Blood Adv. 2022;6(3):828-847.

Email alerts

ASH Publications

American Society of Hematology

Issue Archive

Table of Contents

STIMULUS REPORTS

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance Free

Absolute neutrophil count by Duffy status among healthy Black and African American adults Free Clinical Trials & Observations

CLINICAL TRIALS AND OBSERVATIONS

A phase 1 trial utilizing TMI with fludarabine-melphalan in patients with hematologic malignancies undergoing second allo-SCT Free Clinical Trials & Observations

A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopenia Free Clinical Trials & Observations

Safety and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in children with SCD: a V114-023 (PNEU-SICKLE) study Free Clinical Trials & Observations

HEALTH SERVICES AND OUTCOMES

Neighborhood disadvantage, health status, and health care utilization after blood or marrow transplant: BMTSS report Free

Lifetime medical costs attributable to sickle cell disease among nonelderly individuals with commercial insurance Free

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Interleukin-15 augments NK cell–mediated ADCC of alemtuzumab in patients with CD52+ T-cell malignancies Free Clinical Trials & Observations

LYMPHOID NEOPLASIA

Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment Free

Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia Free

Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations Free

MYELOID NEOPLASIA

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice Free

Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation Free

PLATELETS AND THROMBOPOIESIS

Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation Free

THROMBOSIS AND HEMOSTASIS

Differences in wild-type– and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies Free

RESEARCH LETTERS

Persistence of chronic inflammation after regular blood transfusion therapy in sickle cell anemia Free Clinical Trials & Observations

A monocentric analysis of the long-term safety and efficacy of crizotinib in relapsed/refractory ALK+ lymphomas Free

CAR T-cell therapy for mantle cell lymphoma with central nervous system relapse Free Clinical Trials & Observations

Comparison of bone marrow and peripheral blood aberrant plasma cell assessment by NGF in patients with MM Free Clinical Trials & Observations

White blood cell ranges and frequency of neutropenia by Duffy genotype status Free Clinical Trials & Observations

A novel, effective, and efficient strategy for treating sickle cell vaso-occlusive events in the infusion center setting Free Clinical Trials & Observations

ERRATA

Cheng PTM, Villa D, Tonseth RP, et al. Outcome of limited-stage nodular lymphocyte-predominant Hodgkin lymphoma and the impact of a PET-adapted approach. Blood Adv. 2021;5(18):3647-3655. Free

Menghrajani K, Gomez-Arteaga A, Madero-Marroquin R, et al. Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML. Blood Adv. 2022;6(3):828-847. Free

Email alerts

ASH Publications

American Society of Hematology

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance

Absolute neutrophil count by Duffy status among healthy Black and African American adults
Clinical Trials & Observations

A phase 1 trial utilizing TMI with fludarabine-melphalan in patients with hematologic malignancies undergoing second allo-SCT
Clinical Trials & Observations

A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopenia
Clinical Trials & Observations

Safety and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in children with SCD: a V114-023 (PNEU-SICKLE) study
Clinical Trials & Observations

Neighborhood disadvantage, health status, and health care utilization after blood or marrow transplant: BMTSS report

Lifetime medical costs attributable to sickle cell disease among nonelderly individuals with commercial insurance

Interleukin-15 augments NK cell–mediated ADCC of alemtuzumab in patients with CD52⁺ T-cell malignancies
Clinical Trials & Observations

Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment

Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia

Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice

Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation

Complement gene variant effect on relapse of complement-mediated thrombotic microangiopathy after eculizumab cessation

Differences in wild-type– and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies

Persistence of chronic inflammation after regular blood transfusion therapy in sickle cell anemia
Clinical Trials & Observations

A monocentric analysis of the long-term safety and efficacy of crizotinib in relapsed/refractory ALK⁺ lymphomas

CAR T-cell therapy for mantle cell lymphoma with central nervous system relapse
Clinical Trials & Observations

Comparison of bone marrow and peripheral blood aberrant plasma cell assessment by NGF in patients with MM
Clinical Trials & Observations

White blood cell ranges and frequency of neutropenia by Duffy genotype status
Clinical Trials & Observations

A novel, effective, and efficient strategy for treating sickle cell vaso-occlusive events in the infusion center setting
Clinical Trials & Observations

Cheng PTM, Villa D, Tonseth RP, et al. Outcome of limited-stage nodular lymphocyte-predominant Hodgkin lymphoma and the impact of a PET-adapted approach. Blood Adv. 2021;5(18):3647-3655.

Menghrajani K, Gomez-Arteaga A, Madero-Marroquin R, et al. Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and KMT2A-rearranged AML. Blood Adv. 2022;6(3):828-847.