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PRMT5 Inhibition Modulates E2F1 Methylation and Gene Regulatory Networks Leading to Therapeutic Efficacy in JAK2VF Mutant MPN

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Friederike Pastore, MD, Neha Bhagwat, PhDBS, Aishwarya Krishnan, Alessandro Pastore, Bing Li, MD, Robert L Bowman, PhD, Wenbin Xiao, MD PhD, Aaron D Viny, MDMS, Abdul Karzai, Anouar Zouak, Young C Park, Keith Cordner, Stephanie Braunstein, Alexander Grego, Jaanvi Mehta, Benjamin H Durham, MD, Richard P. Koche, PhD, Jesper Maag, Peggy Scherle, PhD, Kris Vaddi, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 473.
https://doi.org/10.1182/blood-2019-127122
Published: 2019
Journal Articles

Bone and Joint Health Markers in Persons with Hemophilia A (PwHA) Treated with Emicizumab in HAVEN 3

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Anna Kiialainen, PhD, Markus Niggli, PhD, Christine L. Kempton, MD MSc, Giancarlo Castaman, MD, Tiffany Y. Chang, MD MAS, Ido Paz-Priel, MD, Joanne I Adamkewicz, PhD, Gallia G. Levy, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 626.
https://doi.org/10.1182/blood-2019-123689
Published: 2019
Journal Articles

Double-Blind, Randomized Study of Canakinumab Treatment in Pediatric and Young Adult Patients with Sickle Cell Anemia

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David C Rees, Yurdanur Kilinc, MD, Selma Unal, Carlton Dampier, MD, Betty S. Pace, MD, Banu Kaya, MD, Sara Trompeter, MBChB BSc MRCPCH FRCPath MSc, Isaac Odame, Johnny N Mahlangu, MBBCH, MMed, FCPath, Sule Unal, MD, Julie Brent, MD, Regine Grosse, MD, Beng R. Fuh, MD, Baba PD Inusa, MD, Ariel Koren, MD, Carina Levin, MD PhD, Steven Mortier, Elizabeth McNamara, Yue Li, Stephen John Oliver, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 615.
https://doi.org/10.1182/blood-2019-123355
Published: 2019
Journal Articles

Innate Immune Mechanism of Hemarthrosis in Hemophilia-a Mice

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Tomasz W. Kaminski, PharmD, Egemen Tutuncuoglu, MSc, Margaret V. Ragni, MD MPH, Mark T Gladwin, MD, Prithu Sundd, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1043.
https://doi.org/10.1182/blood-2019-130471
Published: 2019
Journal Articles

Nlrp3 Inflammasome Activation in Bone Marrow-Residing Innate Immunity Cells Governs Circadian Changes in the Number of Circulating Hematopoietic Stem/Progenitor Cells in Peripheral Blood

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Mateusz Adamiak, PhD, Andrzej Ciechanowicz, PhD, Monika Cymer, MS, Marta Skoda, PhD, Mariusz Z Ratajczak, MD PhD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1033.
https://doi.org/10.1182/blood-2019-125853
Published: 2019
Journal Articles

Easix for Prediction of Survival in Myelodysplastic Syndromes

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Almuth Maria Anni Merz, MD, Ulrich Germing, MD, Guido Kobbe, MD, Jennifer Kaivers, MD, Anna Jauch, Aleksandar Radujkovic, MD, Manuela Hummel, Axel Benner, Maximilian Merz, Peter Dreger, Thomas Luft, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1722.
https://doi.org/10.1182/blood-2019-122622
Published: 2019
Journal Articles

Epigenetic Plasticity of Type II Innate Lymphoid Cells in the Lower Gastrointestinal Tract

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Sonia J. Laurie, PhD BSc, Danny W. Bruce, PhD, Hemamalini Bommiasamy, PhD, Melodie P Noel, BS, Joseph P. Foster, III, PhD, Ian J. Davis, MD PhD, Samantha G. Pattenden, PhD, Jonathan S Serody, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1921.
https://doi.org/10.1182/blood-2019-126823
Published: 2019
Journal Articles

Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis

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Yan Zhang, Guoying Zhang, Cui Jian, Congqing Wu, PhD, Nigel Mackman, PhD, Susan Smyth, MD PhD, Yinan Wei, Zhenyu Li, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3644.
https://doi.org/10.1182/blood-2019-130439
Published: 2019
Journal Articles

Abnormal Cytokine Production By Mast Cell Cultures from Sickle Cell Anemia Patients in Response to Inflammatory Stimuli and to Co-Culture with Eosinophils

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Myriam Salazar-Terreros, PhDMSc, Kleber Yotsumoto Fertrin, MD PhD, Nicolas Moreno Reyes, PhD, Fernando Ferreira Costa, MD PhD, Carla F. Franco-Penteado, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3566.
https://doi.org/10.1182/blood-2019-129509
Published: 2019
Journal Articles

Interferon Gamma, a Link between Hemophagocytic Lymphohistiocytosis and Dengue Fever Virus: A Literature Review of a Shared Inflammatory Pathway Resulting in Cytopenias and Potential Future Treatment Directions

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Darla K Liles, MD, Heather Brody, MD MSc, Juan Alvarez Posada, MD, Karim Hebishi, MD, John Thiele, MDcal Student
Journal: Blood
Blood (2019) 134 (Supplement_1): 4869.
https://doi.org/10.1182/blood-2019-126124
Published: 2019
Journal Articles

Microglia-like Cells Derived from Hematopoietic Stem and Progenitor Cells Are a Model System to Investigate Chronic Pain in Sickle Cell Disease

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Yankai Zhang, PhD, Celeste K. Kanne, BA, Jennifer N. Tran, DO, Michael J. Lacagnina, PhD, Peter M. Grace, PhD, Vivien A. Sheehan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3575.
https://doi.org/10.1182/blood-2019-128921
Published: 2019
Journal Articles

Novel Evidence That the Nlrp3 Inflammasome Plays a Role in Bone Marrow As a "Cogwheel" Connecting Purinergic Signaling with Activation of the Complement Cascade to Induce "Sterile Inflammation", Which Is Required for Optimal Mobilization of Hematopoietic Stem/Progenitor Cells

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Mateusz Adamiak, PhD, Anna Lenkiewicz, PhD, Kamila Bujko, MS, Arjun Thapa, PhD, Magdalena Kucia, PhD DSci, Ahmed Abdel-Latif, MD PhD, Janina Ratajczak, MD PhD DSci, Mariusz Z Ratajczak, MD PhD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 4468.
https://doi.org/10.1182/blood-2019-125838
Published: 2019
Journal Articles

Markers of Initial and Long-Term Responses to Idecabtagene Vicleucel (Ide-Cel; bb2121) in the CRB-401 Study in Relapsed/Refractory Multiple Myeloma

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Ethan G. Thompson, PhD, Yue Jiang, PhD, Timothy B. Campbell, MD PhD, Jaymes Fuller, PhD, Shari Kaiser, PhD, Afshin Mashadi-Hossein, MSc, Julie Rytlewski, PhD, Nathan Martin, PhD, Olivia Finney, PhD, Katja Kleinsteuber, PhD, Eric Alonzo, PhD, Chetanya Pandya, PhD, Amit Agarwal, MD PhD, Kristen Hege, Noopur S. Raje, MD, Nikhil C. Munshi, MD, Ronald J. Hause, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4328.
https://doi.org/10.1182/blood-2019-124998
Published: 2019
Journal Articles

CAR T Cells Derived from Healthy Mice Lead to Cytokine Release Syndrome (CRS) in the TCL1 Chronic Lymphocytic Leukemia Model; Mice with CLL Treated with Acalabrutinib or Ibrutinib Have Improved CAR T Cell Function without Increasing the Cytokines of CRS

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Robin Sanderson, MRCP,FRCPath, Arantxa Romero-Toledo, MSc, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 249.
https://doi.org/10.1182/blood-2019-125647
Published: 2019
Journal Articles

Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include up-Regulated Innate Immune Modulators

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Ahmad Faisal Karim, PhD, Anthony R. Soltis, PhD, Nadia P Ewing, MD, Clifton L. Dalgard, PhD, Matthew D. Wilkerson, PhD, Kathleen P. Pratt, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 160.
https://doi.org/10.1182/blood-2019-124855
Published: 2019
Journal Articles

A New Cytokine-Based Stratification Is Highly Predictive of Survivals in AML Patients

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Pierre Peterlin, Joelle Gaschet, PhD, Thierry Guillaume, MD PhD, Alice Garnier, MD, Marion Eveillard, Amandine Le Bourgeois, MD, Michel Cherel, MD PhD, Juliette Brouazin, Camille Debord, PharmD, Yannick Le Bris, PharmD, Olivier Theisen, MD, Beatrice Mahe, MD, Viviane Dubruille, MD, Soraya Wuilleme, PharmD, PhD, Catherine Godon, Cyrille Touzeau, MD, Thomas Gastinne, MD, Nicolas Blin, MD, Anne Lok, Benoit Tessoulin, MD PhD, Steven Le Gouill, Philippe Moreau, MD, Marie-Christine Béné, PharmSciD, PhD, Patrice Chevallier, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1412.
https://doi.org/10.1182/blood-2019-125774
Published: 2019
Journal Articles

Acute Myeloid Leukemia Export Mitochondria in Extracellular Vesicles Which Induces Pro-Tumoral Changes in Bone Marrow Macrophages

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Jamie A Moore, BSc, MSc, Jayna J Mistry, BSc, Rebecca H Horton, Charlotte Hellmich, MBBChir, Adam Pattinson, MSc, BSc, Adam Morfakis, BSc, Yu Sun, BSc, MSc, PhD, Matthew Lawes, MD, Christopher J Morris, PhD, Anna Haestier, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1427.
https://doi.org/10.1182/blood-2019-128447
Published: 2019
Journal Articles

Interleukin 1 Beta As a Promising Therapeutic Target in ABL Tyrosine Kinase Inhibitor Resistant Chronic Myeloid Leukemia Cells

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Seiichi Okabe, MD PhD, Tetsuzo Tauchi, MD PhD, Yuko Tanaka, Kazuma Ohyashiki, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4249.
https://doi.org/10.1182/blood-2018-99-114030
Published: 2018
Journal Articles

Prediction of CAR T-Related Toxicities in R/R DLBCL Patients Treated with Axicabtagene Ciloleucel Using Point of Care Cytokine Measurements

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Rawan Faramand, MD, Hiroshi Kotani, MD PhD, Dylan Morrissey, Bin Yu, Frederick L. Locke, MD, Michael D. Jain, MDPhD, Julio C. Chavez, MD, Xuefeng Wang, PhD, Asmita Mishra, MD, Christina A Bachmeier, PharmD, Renier J. Brentjens, MD PhD, Sarah Yoo, Jae H. Park, MD, Marco L. Davila, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 95.
https://doi.org/10.1182/blood-2018-99-116539
Published: 2018
Journal Articles

Loss of Abelson Interactor-1 Is Linked to Inflammatory Hematopoiesis and Accelerated Aging of Hematopoietic System

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Anna Dorota Chorzalska, PhD, John Morgan, PhD, Max Petersen, Diana O Treaba, MD, Adam J Olszewski, MD, John L. Reagan, MD, Patrycja Dubielecka, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1285.
https://doi.org/10.1182/blood-2018-99-118393
Published: 2018