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Journal Articles

Loss of a 7q gene, CUX1 , disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms

Free
Molly K. Imgruet, Julian Lutze, Ningfei An, Bonnie Hu, Saira Khan, Jeffrey Kurkewich, Tanner C. Martinez, Donald Wolfgeher, Sandeep K. Gurbuxani, Stephen J. Kron, Megan E. McNerney
Journal: Blood
Blood (2021) 138 (9): 790–805.
https://doi.org/10.1182/blood.2020009195
Published: 2021
Includes: Supplemental data
Journal Articles

Single-cell transcriptomics dissects hematopoietic cell destruction and T-cell engagement in aplastic anemia

Free
Caiying Zhu, Yu Lian, Chenchen Wang, Peng Wu, Xuan Li, Yan Gao, Sibin Fan, Lanlan Ai, Liwei Fang, Hong Pan, Tao Cheng, Jun Shi, Ping Zhu
Journal: Blood
Blood (2021) 138 (1): 23–33.
https://doi.org/10.1182/blood.2020008966
Published: 2021
Includes: Supplemental data
Journal Articles

Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage

Free
Linping Hu, Xiuxiu Yin, Yawen Zhang, Aiming Pang, Xiaowei Xie, Shangda Yang, Caiying Zhu, Yapu Li, Biao Zhang, Yaojin Huang, Yunhong Tian, Mei Wang, Wenbin Cao, Shulian Chen, Yawei Zheng, Shihui Ma, Fang Dong, Sha Hao, Sizhou Feng, Yongxin Ru, Hui Cheng, Erlie Jiang, Tao Cheng
Journal: Blood
Blood (2021) 137 (24): 3339–3350.
https://doi.org/10.1182/blood.2020007362
Published: 2021
Includes: Supplemental data
Journal Articles

Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia

Free
Jenny Klintman, Niamh Appleby, Basile Stamatopoulos, Katie Ridout, Toby A. Eyre, Pauline Robbe, Laura Lopez Pascua, Samantha J. L. Knight, Helene Dreau, Maite Cabes, Niko Popitsch, Mats Ehinger, Jose I. Martín-Subero, Elías Campo, Robert Månsson, Davide Rossi, Jenny C. Taylor, Dimitrios V. Vavoulis, Anna Schuh
Journal: Blood
Blood (2021) 137 (20): 2800–2816.
https://doi.org/10.1182/blood.2020005650
Published: 2021
Includes: Supplemental data
Journal Articles

Venetoclax and dexamethasone synergize with inotuzumab ozogamicin–induced DNA damage signaling in B-lineage ALL

Free
Brief Report
Hanna Kirchhoff, Uemran Karsli, Caroline Schoenherr, Karin Battmer, Sergej Erschow, Steven R. Talbot, Doris Steinemann, Michael Heuser, Olaf Heidenreich, Denise Hilfiker-Kleiner, Arnold Ganser, Matthias Eder, Michaela Scherr
Journal: Blood
Blood (2021) 137 (19): 2657–2661.
https://doi.org/10.1182/blood.2020008544
Published: 2021
Includes: Supplemental data
Journal Articles

Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia–like IBMFS ADH5/ALDH2 deficiency

Free
Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Kazuko Inoue, Keita Kondo, Masato T. Kanemaki, Tomonari Matsuda, Etsuro Ito, Seiji Kojima, Tatsutoshi Nakahata, Seishi Ogawa, Keigo Tanaka, Keitaro Matsuo, Megumu K. Saito, Minoru Takata
Journal: Blood
Blood (2021) 137 (15): 2021–2032.
https://doi.org/10.1182/blood.2020009111
Published: 2021
Includes: Supplemental data
Journal Articles

LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells

Free
Tomoyasu Jo, Momoko Nishikori, Yasunori Kogure, Hiroshi Arima, Katsuhiro Sasaki, Yoshiteru Sasaki, Tomoko Nakagawa, Fumie Iwai, Shuji Momose, Aki Shiraishi, Hiroshi Kiyonari, Noritaka Kagaya, Tetsuo Onuki, Kazuo Shin-ya, Minoru Yoshida, Keisuke Kataoka, Seishi Ogawa, Kazuhiro Iwai, Akifumi Takaori-Kondo
Journal: Blood
Blood (2020) 136 (6): 684–697.
https://doi.org/10.1182/blood.2019002654
Published: 2020
Includes: Supplemental data
Journal Articles

Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

Free
Tiancheng Fang, Yurun Zhang, Vivian Y. Chang, Martina Roos, Christina M. Termini, Lia Signaevskaia, Mamle Quarmyne, Paulina K. Lin, Amara Pang, Jenny Kan, Xiao Yan, Anna Javier, Katherine Pohl, Liman Zhao, Peter Scott, Heather A. Himburg, John P. Chute
Journal: Blood
Blood (2020) 136 (4): 441–454.
https://doi.org/10.1182/blood.2020005895
Published: 2020
Includes: Supplemental data
Journal Articles

Ripk3 Signaling Regulates Hematopoietic Stem Cell Number and Function during Stress

Free
Lei Zhang, PhD, Huacheng Luo, PhD, Jing Li, Hong-Min Ni, Mark Sellin, Feng Zhang, Jun Zhang, Peter Breslin, PhD, Wei Wei, William Small, Jr., Wen-Xin Ding, Suming Huang, PhD, Jiwang Zhang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3714.
https://doi.org/10.1182/blood-2019-131332
Published: 2019
Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Free
Sakshi Jasra, MD, Orsi Giricz, PhD, Rachel Zeig-Owens, M.P.H, David Goldfarb, M.P.H, Angelica Barreto-Galvez, Kith Pradhan, PhD, Jiahao Chen, PhD, Gaurav S Choudhary, PhD, Srinivas Aluri, Tushar D Bhagat, PhD, Aditi Shastri, MD, Victor Thiruthuvanathan, M.S, Hiroki Goto, MD PhD, Jeannine Gerhardt, PhD, Shanisha Gordon, Arul Veerappan, PhD, Syed Hissam Haider, MD, Matthias Bartenstein, MD, George Nwankwo, Ola Landgren, MD PhD, Michael Weiden, MD, Frederick Fletcher, Lee Greenberger, PhD, Benjamin L. Ebert, MD PhD, Ulrich G. Steidl, MD PhD, Britta Will, PhD, Anna Nolan, MD MS, David Prezant, MD, Advaitha Madireddy, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3720.
https://doi.org/10.1182/blood-2019-129276
Published: 2019
Journal Articles

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)

Free
Liana E Gynn, BSc, Elizabeth Anderson, PhD, Gareth M Robinson, PhD, Sarah Anne Wexler, MBBS, MRCP, FRCPath, Gillian Upstill-Goddard, Christine Cox, Rhys Gareth Morgan, PhD, Jennifer E May, PhD BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 2492.
https://doi.org/10.1182/blood-2019-122891
Published: 2019
Journal Articles

CYT-0853, a Novel RAD51 Inhibitor, Modulates Immunoregulatory B-Lymphocytes

Free
Tamar Aprahamian, PhD, ED Keniston, Jane Branca, Muneer G Hasham, PhD, Melinda Day, PhD, Kevin Mills, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2330.
https://doi.org/10.1182/blood-2019-131311
Published: 2019
Journal Articles

Accumulation of DNA Damage and Alteration of the DNA Damage Response in Chronic Myeloid Leukemia

Free
Henning D. Popp, Vanessa Kohl, MSc, Johanna Flach, PhD, Susanne Brendel, MTA, Helga Kleiner, MTA, Wolfgang Seifarth, PhD, Christel Weiss, PhD, Susanne Saussele, MD, Wolf-Karsten Hofmann, MD PhD, Alice Fabarius, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5364.
https://doi.org/10.1182/blood-2019-122698
Published: 2019
Journal Articles

Dysregulation of Splicing Patterns in MDS Induced By the S100A9/Fto Axis

Free
Erika Adriana Eksioglu, MS PhD, Ling Cen, PhD, Xianghong Chen, PhD, Pingyan Cheng, MD, Kenneth Wright, PhD, Thu Le Trinh, PhD, Danielle Gilvary, BS, Wendy Kandell, BS, Jinhong Liu, MD, Yin-Kai Chen, MD, Amy F McLemore, M.S., Alexandra Calescibetta, John Cleveland, PhD, Alan F. List, MD, Sheng Wei, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4215.
https://doi.org/10.1182/blood-2019-128434
Published: 2019
Journal Articles

RUNX1 Mutation Accompanied with Dysregulated Cellular Senescence in Lower-Risk Myelodysplastic Syndrome Patients Is Associated with Disease Progression

Free
Monika Hruba, Jitka Vesela, Hana Votavova, PhD, Michaela Dostalova Merkerova, PhD MSc, David Kundrat, Katarina Szikszai, PhD, Marie Lauermanova, MD, Zuzana Zemanova, PhD, Anna Jonasova, MD PhD, Jaroslav Cermak, MD PhD, Monika Belickova, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4230.
https://doi.org/10.1182/blood-2019-131150
Published: 2019
Journal Articles

Significance of Abnormalities of PPM1D in Myeloproliferative Neoplasms

Free
Bridget Marcellino, MD PhD, Joseph Tripodi, Michal Bar-Natan, MD, Harry Fruchtman, Noushin Farnoud, PhD, Min Lu, PhD, Heidi E. Kosiorek, MS, Amylou C. Dueck, PhD, Raajit K. Rampal, MD PhD, John Mascarenhas, MD, Vesna Najfeld, PhD, Ronald Hoffman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4207.
https://doi.org/10.1182/blood-2019-129565
Published: 2019
Journal Articles

R-Loops-Induced ATR Signaling As a Potential Therapeutic Target in Myelodysplastic Syndrome

Free
Johann-Christoph Jann, Johanna Flach, PhD, Antje Knaflic, Eva Altrock, PhD, Nanni Schmitt, MSc, Alexander Streuer, Justine Danner, Franziska Hofmann, Verena Nowak, Nina Draeger, Julia Obländer, Iris Palme, Patrick Wuchter, MD, Ahmed Jawhar, MD, Georgia Metzgeroth, MD, Florian Nolte, MD, Wolf-Karsten Hofmann, MD PhD, Daniel Nowak, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4218.
https://doi.org/10.1182/blood-2019-126431
Published: 2019
Journal Articles

The SF3B1 K700E Mutation Induces R-Loop Accumulation and Associated DNA Damage

Free
Shalini Singh, Doaa Ahmed, Hamid Dolatshad, Dharamveer Tatwavedi, Ulrike Schulze, Andrea Sanchi, Sarah Ryley, Ashish Dhir, Lee Carpenter, Suzanne M. Watt, Amal M. Abdel-Aal, Sohair K. Sayed, Somia A. Mohamed, Anna Schuh, PhD, Nicholas J. Proudfoot, Andriana G. Kotini, Eirini P. Papapetrou, Daniel Wiseman, FRCPath, Andrea Pellagatti, Jacqueline Boultwood
Journal: Blood
Blood (2019) 134 (Supplement_1): 4219.
https://doi.org/10.1182/blood-2019-126981
Published: 2019
Journal Articles

Fanconi Anemia: A Paradigm for Understanding DNA Repair During Replication.

Free
Agata Smogorzewska, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-32.
https://doi.org/10.1182/blood-2019-121229
Published: 2019
Journal Articles

UAF1 DNA Binding Activity Is Critical for RAD51-Mediated Homologous DNA Pairing

Free
Fengshan Liang, PhD, Adam S Miller, PhD, Carolilne Tang, Patrick Sung, PhD, Gary M. Kupfer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2497.
https://doi.org/10.1182/blood-2019-130435
Published: 2019