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Journal Articles

Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Yu Qian, PhD, Henry W.B. Johnson, PhD, Christopher J. Kirk, PhD, Eric Lowe, BS, Dustin McMinn, PhD, Beatriz Millare, BS, Tony Muchamuel, MS, Jinhai Wang, PhD

Blood (2019) 134 (Supplement_1): 2076.

https://doi.org/10.1182/blood-2019-125988

Published: 2019

Journal Articles

Evaluation of in Vitro Macrophage Characterization in Gaucher Type 1 (GD1) Patients

Paola Delbini, PhD, Viola Ghiandai, Maria Domenica Cappellini, MD, Lorena Duca, Isabella Nava, Elena Cassinerio, MD, Irene Motta, MD

Blood (2019) 134 (Supplement_1): 3592.

https://doi.org/10.1182/blood-2019-130032

Published: 2019

Journal Articles

Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia

Yun Chen, Liguang Chen, Jian Yu, Emanuela M. Ghia, Michael Y. Choi, Ling Zhang, Suping Zhang, Elsa Sanchez-Lopez, George F. Widhopf, II, Karen Messer, Laura Z. Rassenti, Catriona Jamieson, Thomas J. Kipps

Blood (2019) 134 (13): 1084–1094.

https://doi.org/10.1182/blood.2019001366

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma

Linda von Hoff, Eva Kärgel, Vedran Franke, Erik McShane, Kathrin W. Schulz-Beiss, Giannino Patone, Nikolai Schleussner, Marina Kolesnichenko, Norbert Hübner, Oliver Daumke, Matthias Selbach, Altuna Akalin, Stephan Mathas, Claus Scheidereit

Blood (2019) 133 (13): 1489–1494.

https://doi.org/10.1182/blood-2018-08-871293

Published: 2019

Includes: Supplemental data

Journal Articles

Monitoring ESAM Expression Levels Reveals Autonomous Fluctuation of Leukemia Stem Cells By Autocrine/Paracrine Cytokine Signaling

Yasuhiro Shingai, MD, Takafumi Yokota, MD PhD, Takayuki Ozawa, MD, Tomoaki Ueda, Yukiko Doi, Tomohiko Ishibashi, Akira Tanimura, Michiko Ichii, MD PhD, Hirohiko Shibayama, MD PhD, Yuzuru Kanakura, MD PhD

Blood (2018) 132 (Supplement 1): 3950.

https://doi.org/10.1182/blood-2018-99-111085

Published: 2018

Journal Articles

Immature CML cells implement a BMP autocrine loop to escape TKI treatment

Elodie Grockowiak, Bastien Laperrousaz, Sandrine Jeanpierre, Thibault Voeltzel, Boris Guyot, Stéphanie Gobert, Franck E. Nicolini, Véronique Maguer-Satta

Blood (2017) 130 (26): 2860–2871.

https://doi.org/10.1182/blood-2017-08-801019

Published: 2017

Includes: Supplemental data

Journal Articles

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2017) 130 (Supplement 1): 3919.

https://doi.org/10.1182/blood.V130.Suppl_1.3919.3919

Published: 2017

Journal Articles

Leukemia-Derived Exosomes Induce Paracrine and Autocrine Cell Proliferation in Pediatric ALL

Shabirul Haque, PhD, Sarah Rivkah Vaiselbuh, MD

Blood (2016) 128 (22): 4080.

https://doi.org/10.1182/blood.V128.22.4080.4080

Published: 2016

Journal Articles

Autocrine and Paracrine Interactions Between Multiple Myeloma Cells and Bone Marrow Stromal Cells By Growth Arrest-Specific Gene 6 Crosstalk with Interleukin-6

Miki Furukawa, MD, Ohkawara Hiroshi, MD PhD, Kazuei Ogawa, MD PhD, Kazuhiko Ikeda, MD PhD, Ueda Koki, MD PhD, Akiko Shichishima-Nakamura, MD PhD, Emi Ito, PhD, Jun-ichi Imai, PhD, Yuka Yanagisawa, PhD, Reiko Honma, PhD, Shinya Watanabe, MD PhD, Satoshi Waguri, MD PhD, Takayuki Ikezoe, MD PhD, Yasuchika Takeishi, MD PhD

Blood (2016) 128 (22): 5606.

https://doi.org/10.1182/blood.V128.22.5606.5606

Published: 2016

Journal Articles

Lymphocyte Activation Gene 3-a Novel Therapeutic Target in Chronic Lymphocytic Leukemia

Mika Shapiro, PhD, Ben-Zion Katz, PhD, Chava Perry, MD PhD, Clare Sun, MD, Nili Dezorella, M.Sc, Sigi Kay, PhD, Irit Avivi, MD, Adrian Wiestner, MD PhD, Herishanu Yair, MD

Blood (2016) 128 (22): 2018.

https://doi.org/10.1182/blood.V128.22.2018.2018

Published: 2016

Journal Articles

Transforming Growth Factor- β1 Signaling in Vascular Endothelial Cells Inhibits Hematopoietic Stem Cell Regeneration

Derek Zachman, MS, Devorah C Goldman, PhD, Chandan Guha, MD PhD, Beth Wilmot, William H. Fleming, MD PhD

Blood (2016) 128 (22): 1493.

https://doi.org/10.1182/blood.V128.22.1493.1493

Published: 2016

Journal Articles

Periostin Supports Hematopoietic Stem/Progenitor Cells and Niche-Dependent Myeloblastoma Cells In Vitro

Akio Maekawa, Natsumi Hasegawa, Satowa Tanaka, Leo Matsubara, Azusa Imanishi, Masaya Yano, Robert Roeder, PhD, Shigetaka Asano, MD DMSci, Mitsuhiro Ito, MD PhD

Blood (2016) 128 (22): 1494.

https://doi.org/10.1182/blood.V128.22.1494.1494

Published: 2016

Journal Articles

IMiDs Cause Thrombocytopenia By the Inhibition of Proplatelet Formation, through Blocking Estradiol Autocrine Loop in Human Megakaryocytes

Taro Tochigi, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2016) 128 (22): 894.

https://doi.org/10.1182/blood.V128.22.894.894

Published: 2016

Journal Articles

Autocrine and Paracrine Regulatory Mechanisms of Growth Arrest-Specific Gene 6 Contribute to Disease Progression of Multiple Myeloma

Miki Furukawa, MD, Hiroshi Ohkawara, MD PhD, Kazuhiko Ikeda, MD PhD, Emi Ito, PhD, Jun-ichi Imai, PhD, Yuka Yanagisawa, PhD, Reiko Honma, PhD, Shinya Watanabe, MD PhD, Satoshi Waguri, MD PhD, Kazuei Ogawa, MD PhD, Yasuchika Takeishi, MD PhD

Blood (2015) 126 (23): 4179.

https://doi.org/10.1182/blood.V126.23.4179.4179

Published: 2015

Journal Articles

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

Vincenzo Giambra, PhD, Sonya H Lam, Miriam Belmonte, Sam Gusscott, Sohrab Salehi, Fong Chun Chan, Robert Kridel, MD MPH, Alireza Lorzadeh, Catherine Hoofd, PhD, Christian Steidl, MD, Connie J. Eaves, PhD, Martin Hirst, PhD, Andrew P. Weng, MD PhD

Blood (2015) 126 (23): 3637.

https://doi.org/10.1182/blood.V126.23.3637.3637

Published: 2015

Journal Articles

TIM-3 and Its Ligand, Galectin-9 Constitute a Pan-Myeloid Autocrine Loop to Develop and Maintain Malignant Stem Cells in Most Human Myeloid Leukemia

Yoshikane Kikushige, MD PhD, Junichiro Yuda, MD, Takahiro Shima, MD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2014) 124 (21): 835.

https://doi.org/10.1182/blood.V124.21.835.835

Published: 2014

Journal Articles

Differential Effects of Wnt Signaling on Proliferation and Hematopoietic Support of Adult and Fetal Bone Marrow-Derived MSCs

Maja Maria Paciejewska, MSc, Marijke Maijenburg, Christian Gilissen, Kim Vermeul, Marion Kleijer, Kees Weijer, Marieke von Lindern, PhD, Ellen van der Schoot, Carlijn Voermans, PhD

Blood (2014) 124 (21): 5137.

https://doi.org/10.1182/blood.V124.21.5137.5137

Published: 2014

Journal Articles

Cell Engineering with Glycogen Synthase Kinase-3 Beta Inhibitor-Loaded Synthetic Nanoparticles Enhances Hematopoietic Engraftment of Bone Marrow Mononuclear Cells Following in Utero Transplantation

Stavros P Loukogeorgakis, MDBSc PhDMRCS(Eng.), Haiying Li, Li Tang, PhD, Aimee G Kim, MD, Jesse D Vrecenak, MD, Ilana Nissim, Michael A Conner, MSc, Izhtak Nissim, PhD, Paolo De Coppi, MDPhD, William Peranteau, MD, Darrell J Irvine, PhD, Alan W Flake, MD

Blood (2014) 124 (21): 2414.

https://doi.org/10.1182/blood.V124.21.2414.2414

Published: 2014

Journal Articles

Inhibition of CML Stem Cell Growth By Targeting WNT Signaling Using a Porcupine Inhibitor

Puneet Agarwal, MS, Bin Zhang, PhD, YinWei Ho, Amy Cook, PhD, Ling Li, PhD, Youzhen Wang, Margaret McLaughlin, PhD, Ravi Bhatia, MD

Blood (2014) 124 (21): 3130.

https://doi.org/10.1182/blood.V124.21.3130.3130

Published: 2014

Journal Articles

The Effects of Lipocalin (LCN2) on Hematopoiesis in Primary Myelofibrosis

Min Lu, PhD MD, Lijuan Xia, Yen-Chun Liu, Tsivia Hochman, Rona Singer Weinberg, PhD, Judith D Goldberg, Ronald Hoffman

Blood (2014) 124 (21): 1878.

https://doi.org/10.1182/blood.V124.21.1878.1878

Published: 2014

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Proteomic Profiling and Mechanistic Investigating of a Novel Anti-Cancer Small Molecule Inhibitor of Sec61

Evaluation of in Vitro Macrophage Characterization in Gaucher Type 1 (GD1) Patients

Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma

Monitoring ESAM Expression Levels Reveals Autonomous Fluctuation of Leukemia Stem Cells By Autocrine/Paracrine Cytokine Signaling

Immature CML cells implement a BMP autocrine loop to escape TKI treatment

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

Leukemia-Derived Exosomes Induce Paracrine and Autocrine Cell Proliferation in Pediatric ALL

Autocrine and Paracrine Interactions Between Multiple Myeloma Cells and Bone Marrow Stromal Cells By Growth Arrest-Specific Gene 6 Crosstalk with Interleukin-6

Lymphocyte Activation Gene 3-a Novel Therapeutic Target in Chronic Lymphocytic Leukemia

Transforming Growth Factor- β1 Signaling in Vascular Endothelial Cells Inhibits Hematopoietic Stem Cell Regeneration

Periostin Supports Hematopoietic Stem/Progenitor Cells and Niche-Dependent Myeloblastoma Cells In Vitro

IMiDs Cause Thrombocytopenia By the Inhibition of Proplatelet Formation, through Blocking Estradiol Autocrine Loop in Human Megakaryocytes

Autocrine and Paracrine Regulatory Mechanisms of Growth Arrest-Specific Gene 6 Contribute to Disease Progression of Multiple Myeloma

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

TIM-3 and Its Ligand, Galectin-9 Constitute a Pan-Myeloid Autocrine Loop to Develop and Maintain Malignant Stem Cells in Most Human Myeloid Leukemia

Differential Effects of Wnt Signaling on Proliferation and Hematopoietic Support of Adult and Fetal Bone Marrow-Derived MSCs

Cell Engineering with Glycogen Synthase Kinase-3 Beta Inhibitor-Loaded Synthetic Nanoparticles Enhances Hematopoietic Engraftment of Bone Marrow Mononuclear Cells Following in Utero Transplantation

Inhibition of CML Stem Cell Growth By Targeting WNT Signaling Using a Porcupine Inhibitor

The Effects of Lipocalin (LCN2) on Hematopoiesis in Primary Myelofibrosis

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