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Zhenyuan Dong
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Journal Articles

Humanized PDX models reveal Lymphoma–Host interactions and enhanced T-cell therapies via epigenetic modulation

Free
Giovanni Medico, Giorgia Zanetti, Giorgio Bertolazzi, Francesco Vallania, Paul Zumbo, Maider Amiama, Doron Betel, Maria Cacciapuoti, Abigail Taylor, Clarisse Kayembe, Sanjay Patel, Jennifer Ziello, Arvin Ruiz, Jason Weirather, Gulpreet Kaur, Luca Cappelli, Luca Paruzzo, Marco Ruella, Zhenyuan Dong, Larry Kwak, Nicolás Di Siervi, María Revuelta, Claudio Tripodo, Leandro Cerchietti, Giorgio Inghirami
Journal: Blood
Blood (2025) 146 (Supplement 1): 350.
https://doi.org/10.1182/blood-2025-350
Published: 2025
Journal Articles

BAFFR-CAR T cells (PMB-CT01) demonstrate durable responses and manageable toxicities in relapsed/refractory B-cell lymphomas with prior CD19-directed therapy failure or CD19-negative disease

Free
Elizabeth Budde, Marissa Del Real, John Baird, Lu Chen, Joo Song, Xiuli Wang, Swetha Thiruvengadam, Marie Hu, Alan Macias, Emanuela Marcucci, Soungchul Cha, Zhenyuan Dong, Teresa Kim, Baishakhi Barva, Sandrine Puverel, Qing Liu-Michael, Hazel (Ting-Ying) Cheng, Stephen Forman, Larry Kwak
Journal: Blood
Blood (2025) 146 (Supplement 1): 268.
https://doi.org/10.1182/blood-2025-268
Published: 2025
Journal Articles

Favorable Safety Profile and Durable Responses to Pmb-CT01 (BAFFR-CAR T Cell) Therapy in Patients with B-Cell Lymphomas Ineligible for or Who Failed CD19-Targeted Therapy, Including CD19-Negative Disease

Free
Marissa Morales Del Real, John H. Baird, Lu Chen, Joo Y. Song, Xiuli Wang, Swetha Kambhampati, Alan Macias, Emanuela C Marcucci, Soungchul Cha, Zhenyuan Dong, Teresa Kim, Baishakhi Barva, Sandrine Puverel, Qing Liu-Michael, Hazel Ting-Ying Cheng, Stephen J. Forman, Larry W. Kwak, Lihua E. Budde
Journal: Blood
Blood (2024) 144 (Supplement 1): 3127.
https://doi.org/10.1182/blood-2024-198416
Published: 2024
Journal Articles

Early Intervention and Favorable Biologic Effects of Personalized Neoantigen Vaccines on the Tumor Immune Microenvironment in Smoldering Waldenstrom Macroglobulinemia

Free
Szymon Szymura, Soungchul Cha, Lin Wang, Tiantian Zhang, Zhenyuan Dong, Aaron Anderson, Elizabeth Oh, Zhe Wang, Vincent Lee, Sapna Parshottham, Sheetal Rao, Jasper B Olsem, Brandon N Crumpton, Hans C. Lee, Elisabet E. Manasanch, Sattva S. Neelapu, Sheeba K. Thomas, Larry W. Kwak
Journal: Blood
Blood (2023) 142 (Supplement 1): 212.
https://doi.org/10.1182/blood-2023-182448
Published: 2023
Journal Articles

Development of a Novel Platform for in-Vitro Immune-Monitoring of Antigen-Specific T Cells and Discovery of Novel Antigen-Specific TCRs Using Immortalized B Cells Transfected with mRNA of Antigen Fused to Mitd (IBMAM)

Free
Tiantian Zhang, Zhe Wang, Soung-chul Cha, Aaron Anderson, Jingwei Liu, Zhenyuan Dong, Szymon Szymura, Benjamin Kuang, Elizabeth Oh, Sattva S. Neelapu, Larry W. Kwak
Journal: Blood
Blood (2022) 140 (Supplement 1): 4699–4700.
https://doi.org/10.1182/blood-2022-157599
Published: 2022
Journal Articles

CD19/BAFF-R Dual-Targeted CAR T Cells for the Treatment of Mixed Antigen-Negative Variants of Acute Lymphoblastic Leukemia

Free
Xiuli Wang, Zhenyuan Dong, Wen-Chung Chang, Wesley Cheng, Vibhuti Vyas, Dennis Awuah, Soung-chul Cha, Aaron Anderson, Mary C. Clark, Stephen J Forman, Larry W. Kwak, Hong Qin
Journal: Blood
Blood (2021) 138 (Supplement 1): 2783.
https://doi.org/10.1182/blood-2021-151293
Published: 2021
Journal Articles

Overcoming CD19 Antigen Loss in B-Cell Malignancies with CAR T Cells Targeting BAFF-R

Free
Hong Qin, MD PhD, Zhenyuan Dong, PhD, Xiuli Wang, PhD, Wesley Cheng, BS, Diane Lynne Smith, PhD, Joo Y Song, MD, Ibrahim Aldoss, MD, Stephen J Forman, MD, Larry W Kwak, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3871.
https://doi.org/10.1182/blood-2019-129228
Published: 2019
Journal Articles

Novel BAFF-R CAR T-Cell Therapy for CD19 Antigen-Loss Relapsed B Cell Tumors

Free
Hong Qin, MD PhD, Zhenyuan Dong, PhD, Xiuli Wang, PhD, Wesley Cheng, BS, Diane Lynne Smith, PhD, Joo Y Song, MD, Ibrahim Aldoss, MD, Markus Muschen, MD, Stephen J Forman, Larry W Kwak, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1411.
https://doi.org/10.1182/blood-2018-99-117513
Published: 2018
Journal Articles

CAR-T Cells Targeting BAFF-Receptor for B-Cell Malignancies: A Potential Alternative to CD19

Free
Hong Qin, MD PhD, Zhenyuan Dong, PhD, Fen Wen, MD, Wesley Cheng, BS, Han Sun, PhD, Guowei Wei, PhD, Diane Lynne Smith, PhD, Sattva S. Neelapu, MD, Xiuli Wang, PhD, Stephen J. Forman, MD FACP, Larry W Kwak, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3180.
https://doi.org/10.1182/blood.V130.Suppl_1.3180.3180
Published: 2017
Journal Articles

Novel BAFF-Receptor Antibody to Natively Folded and Glycosylated Recombinant Protein Eliminates Drug Resistant B Cell Malignancies In Vivo

Free
Hong Qin, MD PhD, Guowei Wei, PhD, Ippei Sakamaki, MD PhD, Zhenyuan Dong, PhD, Diane Lynne Smith, PhD, Feng Wen, MS, Han Sun, PhD, Wesley A Cheng, BS, Larry W Kwak, MD PhD
Journal: Blood
Blood (2016) 128 (22): 468.
https://doi.org/10.1182/blood.V128.22.468.468
Published: 2016