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Yusuke Isshiki
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Journal Articles

A phase 1b trial of the EZH2 inhibitor tazemetostat combined with CAR T cell therapy in B cell lymphomas

Free
Samuel Yamshon, Caitlin Gribbin, Yusuke Isshiki, Ioannis Karagiannidis, Sunjae Lee, Jizhi Yan, Gwynne Ozkan, Anna Alperovich, Barbara Ma, Christopher Hackett, Mateo Mejia-Saldarriaga, Daniel Choi, Selina Chen-Kiang, John Leonard, Ari Melnick, Juliet Barker, Giorgio Inghirami, Wendy Béguelin, Peter Martin
Journal: Blood
Blood (2025) 146 (Supplement 1): 1011.
https://doi.org/10.1182/blood-2025-1011
Published: 2025
Journal Articles

Sasp-driven immune evasion defines a novel African ancestry-associated DLBCL subtype with distinctive molecular and immune vulnerabilities

Free
Sanket Shah, Meng Li, Michelle Lee, Matthew Teater, Kumudha Balakrishnan, Vishal Sahu, Vignesh Shanmugam, Sunjae Lee, Isabella Kong, Ioannis Karagiannidis, Tania Sainz, Wilfred Leung, Andrea Orlando, Jongkuen Lee, Benedikt Pelzer, Dejauwne Young, Sravya Tumuluru, David Jaye, Mohamed Moustafa, Deniz Peker, Yusuke Isshiki, Daniela Magliulo, Hao Shen, Piali Mukherjee, Anthony Santella, Maneeza Bilal, Pengyan Fa, Lisa Roth, Giorgio Inghirami, Victoria Alagiozian-Angelova, Leandro Cerchietti, Simone Sidoli, Paul Rubinstein, Roberta Zappasodi, Wendy Béguelin, Yuri Fedoriw, Francisco Vega, Jean Koff, Christopher Flowers, Ari Melnick
Journal: Blood
Blood (2025) 146 (Supplement 1): 3.
https://doi.org/10.1182/blood-2025-3
Published: 2025
Journal Articles

Qpctl Inhibition, By Targeting the Inflammatory Tumor Microenvironment, Constitutes a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma

Free
Nicolas Di Siervi, Jasper Mullender, María Victoria Revuelta, Nahuel Zamponi, Eloisi Caldas-Lopes, Yusuke Isshiki, Wendy Béguelin, Marcel Scheepstra, Bastiaan Evers, Jens Wuerthner, Leandro Cerchietti
Journal: Blood
Blood (2023) 142 (Supplement 1): 49.
https://doi.org/10.1182/blood-2023-181264
Published: 2023
Journal Articles

Inhibition of EZH2 Improves CART19 Immunotherapy By Reprogramming Lymphoma Tumor Cells and Enhancing T-Cell Functionality

Free
Patrizia Porazzi, Yusuke Isshiki, Guido Ghilardi, Siena Nason, Ziqi Yang, Alberto Carturan, Linhui Chen, Yunlin Zhang, Ruchi P. Patel, Puneeth Guruprasad, Ositadimma Ugwuanyi, Ivan J Cohen, Stephen J Schuster, Ari M Melnick, Wendy Béguelin, Marco Ruella
Journal: Blood
Blood (2023) 142 (Supplement 1): 1018.
https://doi.org/10.1182/blood-2023-182440
Published: 2023
Journal Articles

Development of Syngeneic Murine Cell Lines of Germinal Center-Derived B-Cell Lymphomas

Free
Henna S. Nam, Yusuke Isshiki, Min Xia, Sanket Shah, Meng Li, Ioannis Karagiannidis, Matthew Teater, Ari M Melnick, Wendy Béguelin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4365.
https://doi.org/10.1182/blood-2023-186686
Published: 2023
Journal Articles

EZH2 Inhibitors Enhance CART Cell Quality, Efficacy, In Vivo Homing, Tumor Cell Binding and Killing of Fully Syngeneic Primary B Cell Lymphomas, As Well As Reprogramming Lymphoma Cells to a Highly Immunogenic and T Cell Adherent Phenotype

Free
Yusuke Isshiki, Patrizia Porazzi, Xi Chen, Matthew Teater, Ioannis Karagiannidis, Henna S. Nam, Ari M Melnick, Marco Ruella, Wendy Béguelin
Journal: Blood
Blood (2023) 142 (Supplement 1): 432.
https://doi.org/10.1182/blood-2023-190610
Published: 2023
Journal Articles

Exhausted T Cells Characterized By Upregulation of Specific Transcription Factors Are Increased in a Mouse Model of De Novo Mature B Cell Neoplasms

Free
Asuka Shibamiya, Naoya Mimura, Yurie Miyamoto-Nagai, Shuhei Koide, Motohiko Oshima, Ola Rizq, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Kensuke Kayamori, Yusuke Isshiki, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Yusuke Takeda, Ryo Koyama-Nasu, Tetsuhiro Chiba, Hiroaki Honda, Koutaro Yokote, Atsushi Iwama, Emiko Sakaida
Journal: Blood
Blood (2022) 140 (Supplement 1): 4240–4241.
https://doi.org/10.1182/blood-2022-158111
Published: 2022
Journal Articles

Evolution of the Tumor Microenvironment throughout Progression and Transformation of EZH2 Mutant Follicular Lymphoma

Free
Yusuke Isshiki, Dylan McNally, Ari M. Melnick, Wendy Béguelin
Journal: Blood
Blood (2021) 138 (Supplement 1): 446.
https://doi.org/10.1182/blood-2021-148996
Published: 2021
Journal Articles

Akt Inhibition Differently Controls PRC2 Components and Synergizes with Dual EZH2/1 Inhibitor in the Treatment of Multiple Myeloma

Free
Mohamed Rizk, BSc, MSc, Ola Rizq, MD PhD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Shuhei Koide, PhD, Atsunori Saraya, Yusuke Isshiki, MD PhD, Tetsuhiro Chiba, MD PhD, Satoshi Yamazaki, PhD, Anqi Ma, PhD, Jian Jin, PhD, Atsushi Iwama, MD PhD, Naoya Mimura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4400.
https://doi.org/10.1182/blood-2019-122157
Published: 2019
Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Free
Yurie Nagai, MD, Naoya Mimura, MD PhD, Ola Rizq, MD PhD, Yusuke Isshiki, MD PhD, Motohiko Oshima, PhD, Mohamed Rizk, BSc, MSc, Atsunori Saraya, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Makiko Miyota, Nagisa Oshima-Hasegawa, MD PhD, Shokichi Tsukamoto, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Chikako Ohwada, MD PhD, Masahiro Takeuchi, MD PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD PhD, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4414.
https://doi.org/10.1182/blood-2019-122350
Published: 2019
Journal Articles

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

Free
Shiro Tara, Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Tomoyuki Tanaka, Daisuke Shinoda, Shuhei Koide, Atsunori Saraya, Satoru Miyagi, Ichiro Manabe, Hirotaka Matsui, Haruhiko Koseki, Vivian J. Bardwell, Atsushi Iwama
Journal: Blood
Blood (2018) 132 (23): 2470–2483.
https://doi.org/10.1182/blood-2018-01-827964
Published: 2018
Includes: Supplemental data
Journal Articles

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Free
Yusuke Isshiki, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Kazumasa Aoyama, PhD, Atsunori Saraya, Emiko Sakaida, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2018-99-117831
Published: 2018
Journal Articles

Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells

Free
Koji Takaishi, MD, Masahiro Takeuchi, MD PhD, Shokichi Tsukamoto, MD PhD, Naoya Takayama, MD PhD, Motohiko Oshima, PhD, Yusuke Isshiki, MD, Kensuke Kayamori, MD, Kenji Kimura, MD, Yutaro Hino, MD, Nagisa Oshima-Hasegawa, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Naoya Mimura, MD PhD, Chikako Ohwada, MD PhD, Tohru Iseki, MD PhD, Sou Nakamura, PhD, Koji Eto, MD PhD, Atsushi Iwama, MD PhD, Koutaro Yokote, MD PhD, Chiaki Nakaseko, MDPhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1789.
https://doi.org/10.1182/blood-2018-99-111683
Published: 2018