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Journal Articles

Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

Blood (2017) 130 (Supplement 1): 794.

https://doi.org/10.1182/blood.V130.Suppl_1.794.794

Published: 2017

Journal Articles

Oncogenic Mutations in XPO1 Promote Lymphoid Transformation By Altering Nuclear/Cytoplasmic Localization of NFκB Signaling Intermediates

Justin Taylor, MD, Xiao Jing Zhang, Stella V Paffenholz, Alexander V Penson, PhD, Matthew Chang, Christina Marcelus, Lillian E Bitner, Young Rock Chung, MS, Akihide Yoshimi, MD, Stanley Chun-Wei Lee, PhD, Myriam Boukhali, MS, Rajesh K Soni, PhD, Ronald C Hendrickson, PhD, Barry S Taylor, PhD, Jose A Rodríguez, PhD, Wilhelm Haas, PhD, Omar Abdel-Wahab, MD

Blood (2017) 130 (Supplement 1): 879.

https://doi.org/10.1182/blood.V130.Suppl_1.879.879

Published: 2017

Journal Articles

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Blood (2017) 130 (Supplement 1): 473.

https://doi.org/10.1182/blood.V130.Suppl_1.473.473

Published: 2017

Journal Articles

Genomic Analysis of Hairy Cell Leukemia Identifies Novel Recurrent Genetic Alterations

Blood (2017) 130 (Supplement 1): 2994.

https://doi.org/10.1182/blood.V130.Suppl_1.2994.2994

Published: 2017

Journal Articles

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

Blood (2017) 130 (14): 1644–1648.

https://doi.org/10.1182/blood-2017-01-765107

Published: 2017

Includes: Supplemental data

Journal Articles

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

Blood (2017) 130 (4): 397–407.

https://doi.org/10.1182/blood-2017-01-763219

Published: 2017

Includes: Supplemental data

Journal Articles

Serine/Arginine-Rich Splicing Factor 1 (SRSF1) Is Required for Adult and Embryonic Hematopoiesis and Has Non-Overlapping Roles with SRSF2 in Hematopoiesis

Young Rock Chung, MS, Hana Cho, Young Joon Kim, Eunhee Kim, PhD, Stanley Chun-Wei Lee, PhD, Omar Abdel-Wahab, MD

Blood (2016) 128 (22): 1478.

https://doi.org/10.1182/blood.V128.22.1478.1478

Published: 2016

Journal Articles

Frequent Clinical Overlap of Histiocytic Neoplasms and WHO-Classified Myeloid Malignancies Leads to Functional Insights into the Cell-of-Origin of Histiocytoses

Benjamin Heath Durham, MD BS, Akihide Yoshimi, MD PhD, Matthias Papo, Young Rock Chung, MS, Neval Ozkaya, MD, Chezi Ganzel, Ahmet Dogan, David M. Hyman, Christopher Y. Park, MD PhD, Raajit K. Rampal, MD, PhD, Damien Roos Weil, Francois Michel Lemoine, MD PhD, Zahir Amoura, Olivier A. Bernard, PhD, Eli L. Diamond, MD, Jean-François Emile, MD PhD, Julien Haroche, MD PhD, Omar Abdel-Wahab, MD

Blood (2016) 128 (22): 951.

https://doi.org/10.1182/blood.V128.22.951.951

Published: 2016

Journal Articles

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

Stanley Chun-Wei Lee, PhD, Khrystyna Dilai, Esther A. Obeng, MDPhD, Eunhee Kim, PhD, Jean-Baptiste Micol, MD PhD, Akihide Yoshimi, MD PhD, Christophe Willekens, MD, Daichi Inoue, Véronique Saada, PharmD, Hana Cho, Young Rock Chung, MS, James Palacino, PhD, Michael Seiler, PhD, Silvia Buonamici, PhD, Peter Smith, Benjamin L. Ebert, MD PhD, Robert Bradley, PhD, Omar Abdel-Wahab, MD

Blood (2016) 128 (22): 961.

https://doi.org/10.1182/blood.V128.22.961.961

Published: 2016

Journal Articles

Diverse Mechanisms of Vemurafenib Resistance in BRAF-Mutant Hairy Cell Leukemia

Jae H Park, MD, Stephen S. Chung, MD, Benjamin Durham, MD PhD, Young Rock Chung, MS, Sasinya Scott, MPH, Bartlomiej Getta, MBBS,, Eunhee Kim, PhD, Alan Saven, MD, Richard M. Stone, MD, Kanti R Rai, MD, Michael R. Grever, MD, Jessica K. Altman, MD, Neal Rosen, MD PhD, Ross L. Levine, MD, Michael Berger, PhD, Martin S Tallman, MD, Omar Abdel-Wahab

Blood (2015) 126 (23): 449.

https://doi.org/10.1182/blood.V126.23.449.449

Published: 2015

Journal Articles

Therapeutic Targeting of Spliceosomal Mutant Myeloid Leukemias through Modulation of Splicing Catalysis

Stanley Chun-Wei Lee, PhD, Heidi Dvinge, Eunhee Kim, PhD, Hana Cho, Young Rock Chung, MS, Jean-Baptiste Micol, MD, Benjamin Durham, MD PhD, Young Joon Kim, Michael Thomas, Camille Lobry, PhD, Silvia Buonamici, PhD, Peter Smith, Robert K. Bradley, PhD, Omar Abdel-Wahab

Blood (2015) 126 (23): 4.

https://doi.org/10.1182/blood.V126.23.4.4

Published: 2015

Journal Articles

ASXL2 Is a Novel Mediator of RUNX1-ETO Transcriptional Function and Collaborates with RUNX1-ETO to Promote Leukemogenesis

Jean-Baptiste Micol, MD, Nicolas Duployez, Alessandro Pastore, MD, Robert Williams, Eunhee Kim, PhD, Stanley Lee, Benjamin Durham, MD PhD, Young Rock Chung, MS, Hana Cho, Claude Preudhomme, Omar Abdel-Wahab

Blood (2015) 126 (23): 302.

https://doi.org/10.1182/blood.V126.23.302.302

Published: 2015

Journal Articles

Prospective Blinded Study of BRAF V600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders

David M. Hyman, MD, Eli Diamond, Cecile Rose Vibat, Latifa Hassaine, Jason Poole, Minal Patel, Veronica Holley, Goran Cabrilo, Timothy T. Lu, Maria Arcila, MD, Young Rock Chung, MS, Raajit K. Rampal, MD PhD, Funda Meric-Bernstam, MD, Jose Baselga, MD PhD, Razelle Kurzrock, MD, Mark Erlander, Filip Janku, MD PhD, Omar Abdel-Wahab, MD

Blood (2014) 124 (21): 1833.

https://doi.org/10.1182/blood.V124.21.1833.1833

Published: 2014

Journal Articles

Unraveling the Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms through Whole Exome Sequencing

Benjamin Durham, MD, Jing Ma, PhD, Eunhee Kim, PhD, John K. Choi, MD, Patrick Campbell, MD PhD, Juvianee Estrada-Veras, MD, Michael P Walsh, PhD, Mario E Lacouture, MD, Young Rock Chung, MS, Joy Nakitandwe, PhD, Eli Diamond, David M. Hyman, MD, Raajit K. Rampal, MD PhD, Minal Patel, Christopher Y. Park, MD PhD, Tanja A. Gruber, MD PhD, Omar Abdel-Wahab, MD

Blood (2014) 124 (21): 1887.

https://doi.org/10.1182/blood.V124.21.1887.1887

Published: 2014

Journal Articles

SRSF2 Mutations Impair Hematopoietic Differentiation By Altering Exonic Splicing Enhancer Preference

Eunhee Kim, PhD, Janine O. Ilagan, PhD, Stanley Lee, PhD, Aravind Ramakrishnan, MD, Young Rock Chung, MS, Jean-Baptiste Micol, MD, Michele E. Murphy, Min-Kyung Kim, BS, Ahmad S. Zebari, Jacob Feala, Silvia Buonamici, PhD, Peter G Smith, PhD, H. Joachim Deeg, MD, Camille Lobry, PhD, Iannis Aifantis, PhD MSC, Robert K. Bradley, PhD, Omar Abdel-Wahab, MD

Blood (2014) 124 (21): 824.

https://doi.org/10.1182/blood.V124.21.824.824

Published: 2014

Journal Articles

Vemurafenib Has Potent Antitumor Activity in Patients with Relapsed/Refractory BRAF Mutant Hairy Cell Leukemia

Jae H Park, MD, Stephen S. Chung, MD, Young Rock Chung, MS, Helen Won, MS, Eunhee Kim, PhD, Alan Saven, MD, Martha Wadleigh, MD, Richard M. Stone, MD, Jacqueline C. Barrientos, MD, Kanti R. Rai, MD, Michael R. Grever, MD, Jessica K. Altman, MD, Mario E Lacouture, MD, Neal Rosen, MD PhD, Michael Berger, PhD, Ross L Levine, MD, Omar Abdel-Wahab, MD, Martin S. Tallman, MD

Blood (2014) 124 (21): 24.

https://doi.org/10.1182/blood.V124.21.24.24

Published: 2014

Journal Articles

Identification Of Markers Of Thrombotic Risk and Response To Cytoreductive Intervention In Philadelphia-Chromosome Negative Myeloproliferative Neoplams

Gabriela Soriano Hobbs, MD, Minal Patel, Young Rock Chung, MSc, Omar Abdel-Wahab, MD, Gerald A. Soff, MD, Raajit K. Rampal, M.D., Ph.D.

Blood (2013) 122 (21): 3627.

https://doi.org/10.1182/blood.V122.21.3627.3627

Published: 2013

Journal Articles

BRAF V600E Mutations Occur In The Hematopoietic Stem Cell Compartment In Hairy Cell Leukemia

Stephen S. Chung, MD, Jae H. Park, MD, Eunhee Kim, PhD, Young Rock Chung, MSc, Wenhuo Hu, PhD, Piro Lito, MD, PhD, Julie Teruya Feldstein, MD, Raajit K. Rampal, M.D., Ph.D., Leon Telis, Minal Patel, Neal Rosen, Christopher Y. Park, M.D., Ph.D., Martin S. Tallman, MD, Omar Abdel-Wahab, MD

Blood (2013) 122 (21): 816.

https://doi.org/10.1182/blood.V122.21.816.816

Published: 2013

Journal Articles

EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains

Wendy Béguelin, PhD, Matt R. Teater, MS, Katerina Hatzi, PhD, Relja Popovich, PhD, Yanwen Jiang, PhD, Karen L. Bunting, PhD, Monica Rosen, Hao Shen, MD, Shao Ning Yang, Young Rock Chung, MSc, Rita Shaknovich, MD/PhD, Caretha Creasy, Randy D. Gascoyne, MD, Leandro Cerchietti, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Jonathan D. Licht, MD, Olivier Elemento, PhD, Ari M. Melnick, MD

Blood (2013) 122 (21): 1.

https://doi.org/10.1182/blood.V122.21.1.1

Published: 2013

Journal Articles

Phase II Trial Of The BRAF Inhibitor, Vemurafenib, In Patients With BRAF Mutant Relapsed Or Refractory Hairy Cell Leukemia

Jae H Park, MD, Stephen S. Chung, MD, Young Rock Chung, MSc, Helen Won, MS, Julie Teruya-Feldstein, MD, Michael Berger, PhD, Talal T Khawaja, BS, Mario E Lacouture, MD, Ross L. Levine, MD, Omar Abdel-Wahab, MD, Martin S Tallman, MD

Blood (2013) 122 (21): 2876.

https://doi.org/10.1182/blood.V122.21.2876.2876

Published: 2013

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Characterization of Ntrk fusions and Therapeutic Response to Ntrk Inhibition in Hematologic Malignancies

Oncogenic Mutations in XPO1 Promote Lymphoid Transformation By Altering Nuclear/Cytoplasmic Localization of NFκB Signaling Intermediates

Spliceosomal Dysfunction Is a Critical Mediator of IDH2 Mutant Leukemogenesis

Genomic Analysis of Hairy Cell Leukemia Identifies Novel Recurrent Genetic Alterations

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

Serine/Arginine-Rich Splicing Factor 1 (SRSF1) Is Required for Adult and Embryonic Hematopoiesis and Has Non-Overlapping Roles with SRSF2 in Hematopoiesis

Frequent Clinical Overlap of Histiocytic Neoplasms and WHO-Classified Myeloid Malignancies Leads to Functional Insights into the Cell-of-Origin of Histiocytoses

Synthetic Lethal Interactions of MDS-Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual Exclusivity

Diverse Mechanisms of Vemurafenib Resistance in BRAF-Mutant Hairy Cell Leukemia

Therapeutic Targeting of Spliceosomal Mutant Myeloid Leukemias through Modulation of Splicing Catalysis

ASXL2 Is a Novel Mediator of RUNX1-ETO Transcriptional Function and Collaborates with RUNX1-ETO to Promote Leukemogenesis

Prospective Blinded Study of BRAF V600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders

Unraveling the Molecular Basis of Langerhans and Non-Langerhans Cell Histiocytic Neoplasms through Whole Exome Sequencing

SRSF2 Mutations Impair Hematopoietic Differentiation By Altering Exonic Splicing Enhancer Preference

Vemurafenib Has Potent Antitumor Activity in Patients with Relapsed/Refractory BRAF Mutant Hairy Cell Leukemia

Identification Of Markers Of Thrombotic Risk and Response To Cytoreductive Intervention In Philadelphia-Chromosome Negative Myeloproliferative Neoplams

BRAF V600E Mutations Occur In The Hematopoietic Stem Cell Compartment In Hairy Cell Leukemia

EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains

Phase II Trial Of The BRAF Inhibitor, Vemurafenib, In Patients With BRAF Mutant Relapsed Or Refractory Hairy Cell Leukemia

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