1-8 of 8
Tomi K. Sawyer
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Stapled Peptides: Leveraging the BH3 α-Helix to Create a New Class of Drugs to Treat Hematological Malignancies

Free
Rosana Kapeller, Jiawen Han, Kaiming Sun, Pranoti Gangurde, Nori Kawahata, Matt Iadanza, Vincent Guerlevais, Jim Horstick, Justin Noehre, Allen Annis, Larry Licklider, Huw M. Nash, Andrew Kung, Tomi K. Sawyer
Journal: Blood
Blood (2008) 112 (11): 2929.
https://doi.org/10.1182/blood.V112.11.2929.2929
Published: 2008
Journal Articles

Orally Active Inhibitors of the Imatinib Resistant Bcr-Abl Mutant T315I.

Free
William C. Shakespeare, PhD, Frank Wang, Ph.D., Qihong Xu, Ph.D., Xiaotian Zhu, Ph.D., Narayana Narasimham, Ph.D., Chester A. Metcalf, Ph.D., Yihan Wang, Ph.D., Raji Sundaramoorthi, Ph.D., Wei-Sheng Huang, Ph.D., Dong Zou, Ph.D., Mathew Thomas, Ph.D., Jan Romero, Ph.D., David Wen, M.S., Ingrid Chen, B.S., Lisi Cai, M.S., Shuangying Liu, M.S., Scott Wardwell, B.S., Yaoyu Ning, M.S., Jeff Keats, B.S., Joseph Snodgrass, Ph.D., Karin Russian, M.S., Marc Broudy, B.S., Thomas O’Hare, Ph.D., Caitlyn Smith, B.S., Amie Corbin, Ph.D., Brian Druker, M.D., John Iuliucci, Ph.D., David Dalgarno, Ph.D., Tomi K. Sawyer, Ph.D., Tim Clackson, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 2180.
https://doi.org/10.1182/blood.V108.11.2180.2180
Published: 2006
Journal Articles

Imatinib-Resistant BCR-ABL Mutant Cellular Screening Paradigm To Characterize Promising Small-Molecule Inhibitors: T315I-BCR-ABL Targeted Drug Discovery.

Free
Mohammad Azam, PhD, William C. Shakespeare, PhD, Chester Metcalf, PhD, Yihan Wang, PhD, Raji Sunderamoorthi, PhD, Xiaotan Zhu, PhD, Wei-Sheng Huang, PhD, Dong Zou, PhD, Mathew Thomas, PhD, Jan Romero, PhD, Jeff Keats, PhD, Qihang Xu, PhD, David Dalgarno, PhD, Tim Clackson, PhD, Tomi K. Sawyer, PhD, George Q. Daley, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 2181.
https://doi.org/10.1182/blood.V108.11.2181.2181
Published: 2006
Journal Articles

BCR-ABL Kinase Dynamics and Drug Resistance.

Free
Mohammad Azam, PhD, Valentina Nardi, MD, William C. Shakespear, PhD, Robert R. Latek, PhD, Darren Veach, PhD, Bernard Clarckson, PhD, Regine Bohacheck, PhD, Tomi K. Sawyer, PhD, George Q. Daley, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 1996.
https://doi.org/10.1182/blood.V106.11.1996.1996
Published: 2005
Journal Articles

In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit

Free
Amie S. Corbin, Shadmehr Demehri, Ian J. Griswold, Yihan Wang, Chester A. Metcalf, III, Raji Sundaramoorthi, William C. Shakespeare, Joseph Snodgrass, Scott Wardwell, David Dalgarno, John Iuliucci, Tomi K. Sawyer, Michael C. Heinrich, Brian J. Druker, Michael W. N. Deininger
Journal: Blood
Blood (2005) 106 (1): 227–234.
https://doi.org/10.1182/blood-2004-12-4771
Published: 2005
Includes: Supplemental data
Journal Articles

A Potent Src/Abl Kinase Inhibitor (Ap23464) Potently Inhibits the Growth of Myeloid Leukemic Cells Characterized by Flt3-Itd Expression, GM-CSF Dependency, or G-CSF Responsiveness Via an Abl-Independent Mechanism.

Free
Jukka Kanerva, MD, PhD, Ogonna Nwawka, BS, Kevin Hwang, William C. Shakespeare, PhD, Chester A. Metcalf, III, PhD, Tomi K. Sawyer, PhD, Camille L. Bedrosian, MD, Seth J. Corey, MD
Journal: Blood
Blood (2004) 104 (11): 4479.
https://doi.org/10.1182/blood.V104.11.4479.4479
Published: 2004
Journal Articles

In Vitro and In Vivo Activity of the Src/Abl Kinase Inhibitor AP23464 and Analogs Against Activation Loop Mutants of KIT.

Free
Amie S. Corbin, Shadmehr Demehri, Ian J. Griswold, Chester A. Metcalf, III, William C. Shakespeare, Joseph Snodgrass, Scott Wardwell, David C. Dalgarno, John Iuliucci, Tomi K. Sawyer, Brian J. Druker, Michael W. Deininger
Journal: Blood
Blood (2004) 104 (11): 793.
https://doi.org/10.1182/blood.V104.11.793.793
Published: 2004
Journal Articles

Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML

Free
Thomas O'Hare, Roy Pollock, Eric P. Stoffregen, Jeffrey A. Keats, Omar M. Abdullah, Erika M. Moseson, Victor M. Rivera, Hao Tang, Chester A. Metcalf, III, Regine S. Bohacek, Yihan Wang, Raji Sundaramoorthi, William C. Shakespeare, David Dalgarno, Tim Clackson, Tomi K. Sawyer, Michael W. Deininger, Brian J. Druker
Journal: Blood
Blood (2004) 104 (8): 2532–2539.
https://doi.org/10.1182/blood-2004-05-1851
Published: 2004