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Tobias Maetzig
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Journal Articles

Targeting the WT1 mut -M ir-193a Transcriptional Axis with INT-1B3, a Novel Lipid Nanoparticle-Formulated Mir -193a-3p Mimic in Acute Myeloid Leukemia

Xining Yang, Kathrin Krowiorz, Raj Bhayadia, Jessica Kohlschmidt, Deedra Nicolet, Tobias Maetzig, Caroline Pabst, Jeremy Hui, Arshia Shad, Sharon Gao, Maria Stephenson, Si Wei Wu, Marion van den Bosch, Daelynn Buelow, Sharyn Baker, Leo Escano, Frances E Lock, Afsaneh Panahi, Liam MacPhee, Irina Maksakova, Amanda Amoah, Konstanze Döhner, Linda Fogelstrand, Ann-Kathrin Eisfeld, Sanaz Yahyanejad, Michel Janicot, Christopher C. Oakes, Jan-Henning Klusmann, Arefeh Rouhi, Florian Kuchenbauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 6224–6225.
https://doi.org/10.1182/blood-2022-157833
Published: 2022
Journal Articles

Bcl11b -Edited Lymphoid Progenitors for the Generation of CAR-Engineered Natural Killer-like Cells with Potent Anti-Leukemic Activity

Franziska Baatz, Jessica Herbst, Johann Meyer, Axel Schambach, Tobias Maetzig, Michael Hust, Martin G. Sauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 2862–2863.
https://doi.org/10.1182/blood-2022-157663
Published: 2022
Journal Articles

The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML

Hanyang Lin, Katharina Rothe, Min Chen, Andrew Wu, Artem Babaian, Ryan Yen, Jonathan Zeng, Jens Ruschmann, Oleh I. Petriv, Kieran O'Neill, Tobias Maetzig, David J. H. F. Knapp, Naoto Nakamichi, Ryan Brinkman, Inanc Birol, Donna L. Forrest, Carl Hansen, R. Keith Humphries, Connie J. Eaves, Xiaoyan Jiang
Journal: Blood
Blood (2020) 136 (5): 596–609.
https://doi.org/10.1182/blood.2019003636
Published: 2020
Includes: Supplemental data
Journal Articles

Members of the microRNA-106a-363 Cluster Associate with Unfavorable Outcome in Adult Acute Myeloid Leukemia Patients and Promote Leukemogenesis in vivo through Increased Metabolic Activity

Nadine Sperb, MSc, Kathrin Krowiorz, Sarah Grasedieck, MSc, Christoph Rueß, MSc, Nicole Pochert, MSc, Edith Schneider, PhD, Pegah Johansson, PhD, Erik Delsing Malmberg, MD, Laleh Arabanian, PhD, Tobias Maetzig, PhD, Linda Fogelstrand, MD PhD, Hartmut Döhner, MD, Lars Palmqvist, Professor, Reinhild Rösler, PhD, Sebastian Wiese, PhD, Enrico Calzia, Prof. Dr., Arefeh Rouhi, PhD, Florian Kuchenbauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3924.
https://doi.org/10.1182/blood-2018-99-116035
Published: 2018
Journal Articles

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

Andrew Wu, BSc, Lin Hanyang, PhD, Katharina Rothe, PhD, Min Chen, MD PhD, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, MD, David Knapp, PhD, Naoto Nakamichi, MD PhD, Ryan Brinkman, PhD, Inanc Birol, PhD, Donna L Forrest, MD, Carl Hansen, PhD, R. Keith Humphries, MD PhD, Connie J. Eaves, PhD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 931.
https://doi.org/10.1182/blood-2018-99-113559
Published: 2018
Journal Articles

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Kathrin Krowiorz, Raj Bhayadia, Razan Jammal, Caroline Pabst, Nicole Pochert, MSc, Christoph Rueß, MSc, Christina Miller, Konstanze Döhner, MD, Tobias Maetzig, PhD, Hartmut Döhner, MD, Lars Bullinger, MD, Stephan Emmrich, PhD MSc, Dirk Heckl, PhD, Vera Martins, Reinhild Rösler, PhD, Sebastian Wiese, PhD, R. Keith Humphries, MD PhD, Arefeh Rouhi, PhD, Jan-Henning Klusmann, Florian Kuchenbauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2627.
https://doi.org/10.1182/blood-2018-99-116256
Published: 2018
Journal Articles

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Razan Jammal, Kathrin Krowiorz, Nadine Haetscher, PhD, Stephan Emmrich, PhD MSc, Arefeh Rouhi, PhD, Michael Heuser, MD, Sabrina Bothur, Lars Bullinger, MD, Konstanze Döhner, Courteney Lai, Tobias Maetzig, Askar Obulkasim, Vera Martins, PhD, Medhanie A. Mulaw, Jun.-Prof. Dr., Jan Stary, MD D.Sc., Andre Baruchel, MD, Valerie De Haas, MD PhD, Dirk Reinhardt, MD PhD, Hartmut Döhner, MD, Jens Ruschmann, Michel Zwaan, Marry van den Heuvel-Eibrink, Dirk Heckl, PhD, Maarten Fornerod, PhD, R. Keith Humphries, MD PhD, Michael A Rieger, PhD, Florian Kuchenbauer, Jan-Henning Klusmann, MD
Journal: Blood
Blood (2016) 128 (22): 1534.
https://doi.org/10.1182/blood.V128.22.1534.1534
Published: 2016
Journal Articles

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Kathrin Krowiorz, Razan Jammal, Stephan Emmrich, PhD MSc, Arefeh Rouhi, PhD, Michael Heuser, MD, Lars Bullinger, Konstanze Döhner, MD, Lai Courteney, Tobias Maetzig, PhD, Vera Martins, Medhanie Assmelash Mulaw, BSc,MSc,PhD, Dirk Heckl, PhD, Christian M. Zwaan, MD PhD, Jan Stary, Andre Baruchel, MD, Valerie De Haas, MD PhD, Dirk Reinhardt, MD, Maarten Fornerod, Hartmut Döhner, MD, Jens Ruschmann, Marry M van den Heuvel-Eibrink, MD PhD, R. Keith Humphries, MD PhD, Florian Kuchenbauer, MD PhD, Jan-Henning Klusmann, MD
Journal: Blood
Blood (2015) 126 (23): 1244.
https://doi.org/10.1182/blood.V126.23.1244.1244
Published: 2015
Journal Articles

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

Hanyang Lin, BSc, MSc, Jonathan Zeng, Katharina Rothe, BSc, MSc, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, PhD, David Knapp, BSc, Ryan R. Brinkman, PhD, Inanc Birol, PhD, Donna L. Forrest, MD, Carl Hansen, PhD, Connie J. Eaves, PhD, R. Keith Humphries, MD PhD, Xiaoyan Jiang, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1567.
https://doi.org/10.1182/blood.V126.23.1567.1567
Published: 2015
Journal Articles

Polyclonal fluctuation of lentiviral vector–transduced and expanded murine hematopoietic stem cells

Tobias Maetzig, Martijn H. Brugman, Stefan Bartels, Niels Heinz, Olga S. Kustikova, Ute Modlich, Zhixiong Li, Melanie Galla, Bernhard Schiedlmeier, Axel Schambach, Christopher Baum
Journal: Blood
Blood (2011) 117 (11): 3053–3064.
https://doi.org/10.1182/blood-2010-08-303222
Published: 2011
Includes: Supplemental data