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Journal Articles

HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Yoshitaka Zaimoku, Kazuyoshi Hosomichi, Noriaki Tsuji, Mikoto Tanabe, Noriharu Nakagawa, Takeshi Yoroidaka, Hiroki Mizumaki, Tatsuya Imi, Hiroyuki Maruyama, Kohei Hosokawa, Hiroyuki Takamatsu, Hirohito Yamazaki, Kazuya Sakai, Ishikazu Mizuno, Toshihiro Miyamoto, Shinji Nakao

Blood (2024) 144 (Supplement 1): 1307.

https://doi.org/10.1182/blood-2024-208660

Published: 2024

Journal Articles

Prevalence and Outcome of Vexas Syndrome in Unrelated Hematopoietic Stem Cell Transplantation

Blood (2023) 142 (Supplement 1): 1354.

https://doi.org/10.1182/blood-2023-190791

Published: 2023

Journal Articles

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Takeshi Yoroidaka, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Kohei Hosokawa, Takamasa Katagiri, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Toshihiro Miyamoto, Shinji Nakao

Blood (2022) 140 (Supplement 1): 710–711.

https://doi.org/10.1182/blood-2022-165962

Published: 2022

Journal Articles

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

Yoshitaka Zaimoku, Hiroki Mizumaki, Tatsuya Imi, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Takeshi Yoroidaka, Noriharu Nakagawa, Mikoto Tanabe, Noriaki Tsuji, Ryota Urushihara, Hiroyuki Takamatsu, Hirohito Yamazaki, Ken Ishiyama, Shinji Nakao

Blood (2021) 138 (Supplement 1): 604.

https://doi.org/10.1182/blood-2021-148240

Published: 2021

Journal Articles

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Blood (2021) 137 (25): 3576–3580.

https://doi.org/10.1182/blood.2020010586

Published: 2021

Includes: Supplemental data

Journal Articles

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Hiroki Mizumaki, MD, Takeshi Yoroidaka, MD, Hiroyuki Maruyama, MDPhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Ryota Urushihara, MD, Mikoto Tanabe, MD, Yoshitaka Zaimoku, MDPhD, Mai Anh Thi Nguyen, MD, Dung Cao Tran, MD, Ken Ishiyama, MD PhD, Hirohito Yamazaki, MD PhD, Takamasa Katagiri, PhD, Kazuyoshi Hosomichi, PhD, Atsushi Tajima, PhD, Fumihiro Azuma, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-138636

Published: 2020

Journal Articles

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tatsuya Imi, MD PhD, Noriaki Tsuji, MD, Tanabe Mikoto, MD, Dung Cao Tran, MD, Kohei Thi Hosokawa, MD PhD, Yoshitaka Zaimoku, MD PhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Fumihiro Azuma, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 1215.

https://doi.org/10.1182/blood-2019-123266

Published: 2019

Journal Articles

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Kohei Thi Hosokawa, MD PhD, Kohei Hosokawa, MD PhD, Tanabe Mikoto, MD, Md Mohiuddin, Takeshi Yoroidaka, MD, Hiroki Mizumaki, MD, Tatsuya Imi, MD PhD, Masaya Ueno, PhD, Atsushi Hirao, MD PhD, Shinji Nakao, MD PhD

Blood (2019) 134 (Supplement_1): 5000.

https://doi.org/10.1182/blood-2019-127767

Published: 2019

Journal Articles

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Hiroki Mizumaki, MD, Kazuyoshi Hosomichi, PhD, Tanabe Mikoto, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MDPhD, Kohei Hosokawa, MD PhD, Takamasa Katagiri, PhD, Hiroyuki Takamatsu, MD PhD, Tatsuhiko Ozawa, PhD, Fumihiro Azuma, Hiroyuki Kishi, PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 2584.

https://doi.org/10.1182/blood-2018-99-118541

Published: 2018

Journal Articles

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Kohei Hosokawa, MD PhD, Mahmoud Ibrahim Elbadry, MD, Hiroki Mizumaki, MD, Luis Espinoza, MD PhD, Noriharu Nakagawa, MD, Kazuhisa Chonabayashi, MD PhD, Yoshinori Yoshida, MD PhD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD PhD, Tatsuya Imi, MD, Nguyen Thi Mai Anh, MD, Yoichi Fujii, MD, Seishi Ogawa, MD PhD, Katsuto Takenaka, MD PhD, Koichi Akashi, MD PhD, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 3855.

https://doi.org/10.1182/blood-2018-99-113756

Published: 2018

Journal Articles

Bystander Proliferation of Piga-M utated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes

Takeshi Yoroidaka, MD, Kohei Hosokawa, MD PhD, Tatsuya Imi, MD, Takamasa Katagiri, PhD, Fumihiro Azuma, Shinji Nakao, MD PhD

Blood (2018) 132 (Supplement 1): 1308.

https://doi.org/10.1182/blood-2018-99-115623

Published: 2018

Journal Articles

Frequent STAT3 Mutations in CD8 + T Cells from Patients with Pure Red Cell Aplasia

Toru Kawakami, MD, Nodoka Sekiguchi, MD PhD, Jun Kobayashi, Tatsuya Imi, MD, Kazuyuki Matsuda, PhD, Taku Yamane, Sayaka Nishina, MD, Yasushi Senoo, MD, Hitoshi Sakai, MD PhD, Toshiro Ito, MD PhD, Tomonobu Koizumi, MD PhD, Makoto Hirokawa, MD PhD, Shinji Nakao, MD PhD, Hideyuki Nakazawa, PhD MD, Fumihiro Ishida, MD FACP

Blood (2018) 132 (Supplement 1): 536.

https://doi.org/10.1182/blood-2018-99-112132

Published: 2018

Journal Articles

PNH-Phenotype Cells and HLA Class I Allele-Lacking Leukocytes Shared By Family Members Who Developed Acquire Aplastic Anemia: Studies on Six Pairs of Patients in Different Families

Hiroki Mizumaki, MD, Hirohito Yamazaki, MD PhD, Kazuyoshi Hosomichi, PhD, Noriharu Nakagawa, MD, Takeshi Yoroidaka, MD, Tatsuya Imi, MD, Hiromi Iwasaki, MD PhD, Mika Kuroiwa, Ryosuke Ogawa, MDPhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 1176.

https://doi.org/10.1182/blood.V130.Suppl_1.1176.1176

Published: 2017

Journal Articles

Recurrent STAT3 Mutations in the Lymphocytes of Pure Red Cell Aplasia without T-Cell Large Granular Lymphocytic Leukemia

Toru Kawakami, MD, Nodoka Sekiguchi, MD, Toshiya Otsuka, Tatsuya Imi, MD, Sayaka Nishina, MD, Noriko Senoo, MD, Yasushi Senoo, MD, Hitoshi Sakai, MD, Toshiro Ito, MD PhD, Tomonobu Koizumi, MD PhD, Shinji Nakao, MD PhD, Hideyuki Nakazawa, MD PhD, Fumihiro Ishida, MD PhD

Blood (2017) 130 (Supplement 1): 1181.

https://doi.org/10.1182/blood.V130.Suppl_1.1181.1181

Published: 2017

Journal Articles

A Moderate Increase in the WT1 mRNA Copy Number in Peripheral Blood of Patients with Long-Standing Acquired Aplastic Anemia without Apparent Signs of Myelodysplastic Syndrome

Ken Ishiyama, MD PhD, Takeshi Yoroidaka, MD, Noriharu Nakagawa, MD, Hiroki Mizumaki, MD, Tatsuya Imi, MD, Kohei Hosokawa, Hirohito Yamazaki, MD PhD, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2462.

https://doi.org/10.1182/blood.V130.Suppl_1.2462.2462

Published: 2017

Journal Articles

Identification of T Cell Receptors Specific to Antigens Presented By HLA-B5401 on IPS Cell-Derived Hematopoietic Stem Cells in a Patient with Acquired Aplastic Anemia Carrying B5401-Lacking Leukocytes

Noriharu Nakagawa, MD, Mahmoud Ibrahim Elbadry, MD, Yoshiki Akatsuka, MD, Hiroshi Hamana, Kiyomi Shitaoka, Yoshinori Yoshida, MD PhD, Kazuhisa Chonabayashi, MD PhD, Tatsuya Imi, MD, Yoshitaka Zaimoku, MD, Katsuto Takenaka, Hiroshi Fujiwara, MD PhD, Hiroyuki Kishi, PhD, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2458.

https://doi.org/10.1182/blood.V130.Suppl_1.2458.2458

Published: 2017

Journal Articles

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia

Yoshitaka Zaimoku, Hiroyuki Takamatsu, Kazuyoshi Hosomichi, Tatsuhiko Ozawa, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Takamasa Katagiri, Hiroyuki Kishi, Atsushi Tajima, Atsushi Muraguchi, Koichi Kashiwase, Shinji Nakao

Blood (2017) 129 (21): 2908–2916.

https://doi.org/10.1182/blood-2016-11-752378

Published: 2017

Includes: Supplemental data

Journal Articles

HLA Class I Allele-Lacking Hematopoietic Stem/Progenitor Cells Support Long-Term Clonal Hematopoiesis without Oncogenic Driver Mutations in Acquired Aplastic Anemia

Tatsuya Imi, MD, Takamasa Katagiri, Kazuyoshi Hosomichi, PhD, Noriharu Nakagawa, Yoshitaka Zaimoku, MD, Ken Ishiyama, MD PhD, Atsushi Tajima, PhD, Shinji Nakao, MD PhD

Blood (2016) 128 (22): 3894.

https://doi.org/10.1182/blood.V128.22.3894.3894

Published: 2016

Journal Articles

Identification of an HLA Class I Allele Closely Involved in the Pathogenesis of Acquired Aplastic Anemia

Yoshitaka Zaimoku, MD, Hiroyuki Takamatsu, MD PhD, Kazuyoshi Hosomichi, PhD, Tatsuhiko Ozawa, PhD, Noriharu Nakagawa, Tatsuya Imi, MD, Hiroyuki Kishi, PhD, Koichi Kashiwase, MD PhD, Shinji Nakao, MD PhD

Blood (2016) 128 (22): 729.

https://doi.org/10.1182/blood.V128.22.729.729

Published: 2016

Journal Articles

Evidence That T Cells Specific for Non-Hematopoietic Cells Trigger the Development of Acquired Aplastic Anemia

Tatsuya Imi, Hiroyuki Maruyama, MD, Takamasa Katagiri, PhD, Yoshitaka Zaimoku, MD, Kana Maruyama, MD, Noriharu Nakagawa, MD, Kohei Hosokawa, MDPhD, Ken Ishiyama, Hirohito Yamazaki, MD PhD, Koichi Kashiwase, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 1168.

https://doi.org/10.1182/blood.V126.23.1168.1168

Published: 2015

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HLA Class I Allele-Deficient Clones Regenerate in Immune Aplastic Anemia without Anti-Thymocyte Globulin

Prevalence and Outcome of Vexas Syndrome in Unrelated Hematopoietic Stem Cell Transplantation

HLA Class I Allele-Specific Pathology Defines Clinical Manifestations of Immune Aplastic Anemia

The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia

HLA class I allele–lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Clonal Hematopoiesis By HLA Class I Allele-Lacking Hematopoietic Stem Cells and Concomitant Aberrant Stem Cells Is Rarely Associated with Clonal Evolution to Secondary Myelodysplastic Syndrome and Acute Myeloid Leukemia in Patients with Acquired Aplastic Anemia

A Common HLA Allelic Mutation of exon1 in Leukocytes Defines Class I Alleles Responsible for Autoantigen Presentation of Acquired Aplastic Anemia

Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure

Loss-of-Function Mutations in HLA-Class I Alleles in Acquire Aplastic Anemia: Evidence for the Involvement of Limited Class I Alleles in the Auto-Antigen Presentation of Aplastic Anemia

Escape Hematopoiesis By HLA-B5401-Lacking Hematopoietic Stem Progenitor Cells in Male Patients with Acquired Aplastic Anemia

Bystander Proliferation of Piga-M utated Hematopoietic Progenitor Cells in Acquired Aplastic Anemia Patients Possessing HLA Class I Allele-Lacking Leukocytes

Frequent STAT3 Mutations in CD8 + T Cells from Patients with Pure Red Cell Aplasia

PNH-Phenotype Cells and HLA Class I Allele-Lacking Leukocytes Shared By Family Members Who Developed Acquire Aplastic Anemia: Studies on Six Pairs of Patients in Different Families

Recurrent STAT3 Mutations in the Lymphocytes of Pure Red Cell Aplasia without T-Cell Large Granular Lymphocytic Leukemia

A Moderate Increase in the WT1 mRNA Copy Number in Peripheral Blood of Patients with Long-Standing Acquired Aplastic Anemia without Apparent Signs of Myelodysplastic Syndrome

Identification of T Cell Receptors Specific to Antigens Presented By HLA-B5401 on IPS Cell-Derived Hematopoietic Stem Cells in a Patient with Acquired Aplastic Anemia Carrying B5401-Lacking Leukocytes

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia

HLA Class I Allele-Lacking Hematopoietic Stem/Progenitor Cells Support Long-Term Clonal Hematopoiesis without Oncogenic Driver Mutations in Acquired Aplastic Anemia

Identification of an HLA Class I Allele Closely Involved in the Pathogenesis of Acquired Aplastic Anemia

Evidence That T Cells Specific for Non-Hematopoietic Cells Trigger the Development of Acquired Aplastic Anemia

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