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Silvia Thoene
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Journal Articles

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

Tobias Berg, Silvia Thoene, Damian Yap, Tracee Wee, Nathalie Schoeler, Patty Rosten, Emilia Lim, Misha Bilenky, Andrew J. Mungall, Thomas Oellerich, Sherry Lee, Courteney K. Lai, Patricia Umlandt, Anisa Salmi, Harry Chang, Lisa Yue, David Lai, S.-W. Grace Cheng, Ryan D. Morin, Martin Hirst, Hubert Serve, Marco A. Marra, Gregg B. Morin, Randy D. Gascoyne, Samuel A. Aparicio, R. Keith Humphries
Journal: Blood
Blood (2014) 123 (25): 3914–3924.
https://doi.org/10.1182/blood-2012-12-473439
Published: 2014
Includes: Supplemental data
Journal Articles

Characterization Of The Effects Of Mutated EZH2 On Expression and Epigenome In a Mouse Lymphoma Model

Tobias Berg, MD, Silvia Thoene, PhD, Damian Yap, PhD, Tracee Wee, Nathalie Schoeler, Patty Rosten, Emilia Lim, Misha Bilenky, Andrew J Mungall, Ph.D., Thomas Oellerich, Patricia Umlandt, Anisa Salmi, Harry Chang, Lisa Yue, David Lai, Grace Cheng, PhD, Hubert Serve, MD, Ryan D Morin, Martin Hirst, Marco A. Marra, PhD, Gregg B. Morin, PhD, Randy D. Gascoyne, MD, Samuel A. Aparicio, PhD, R. Keith Humphries, PhD
Journal: Blood
Blood (2013) 122 (21): 346.
https://doi.org/10.1182/blood.V122.21.346.346
Published: 2013
Journal Articles

Mutated EZH2 Collaborates with Myc in Inducing Lymphoma in a Mouse Model

Tobias Berg, MD, Damian Yap, PhD, Silvia Thoene, PhD, Tracee Wee, Nathalie Schoeler, Patricia Umlandt, Harry Chang, Lisa Yue, David Lai, Grace Cheng, PhD, Ryan D Morin, M.Sc., Martin Hirst, Marco A. Marra, PhD, Gregg B. Morin, PhD, Randy D. Gascoyne, MD, Samuel A. Aparicio, PhD, R. Keith Humphries, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 227.
https://doi.org/10.1182/blood.V118.21.227.227
Published: 2011
Journal Articles

The Vent-Like Homeobox Gene VENTX Promotes Human Myeloid Development and Is Highly Expressed In Acute Myeloid Leukemia

Vijay P. S. Rawat, Ph.D, Natalia Arseni, Farid Ahmed, Medhanie A. Mulaw, Silvia Thoene, Bernhard Heilmeier, M.D., Tim Sadlon, J. D.' Andrea, Wolfgang Hiddemann, MD, S. K Bohlander, MD, Christian Buske, MD, Michaela Feuring-Buskea, MD
Journal: Blood
Blood (2010) 116 (21): 739.
https://doi.org/10.1182/blood.V116.21.739.739
Published: 2010
Journal Articles

Sorafenib and Nilotinib Are Candidates to Overcome Imatinib Resistance in Myeloproliferation with FIP1L1-PDGFRA.

Nikolas von Bubnoff, MD, Sivahari P Gorantla, MSc, Richard A. Engh, PhD, Taiana de Oliveira, PhD, Silvia Thoene, MSc, Espen Åberg, PhD, Christian Peschel, MD, Justus Duyster, MD
Journal: Blood
Blood (2009) 114 (22): 2912.
https://doi.org/10.1182/blood.V114.22.2912.2912
Published: 2009
Journal Articles

Cdx4 Differs from Cdx2 in Its Oncogenic Potential and Its Regulation of Hox Gene Expression in the Murine Bone Marrow Transplantation Model.

Silvia Thoene, MSc, Vijay P.S. Rawat, PhD, Vegi M. Naidu, MSc, Wolfgang Hiddemann, MD, Michaela Feuring-Buske, MD, Christian Buske, MD
Journal: Blood
Blood (2008) 112 (11): 1187.
https://doi.org/10.1182/blood.V112.11.1187.1187
Published: 2008
Journal Articles

The Leukemogenic Potential of Cdx2 Is Dependent on Its N-Terminal Serine Sites and Can Be Counteracted by MAPK Inhibitors

Vijay P.S. Rawat, PhD, Vegi M. Naidu, MSc, Deepak Bararia, PhD, Silvia Thoene, MSc, Farid Ahmed, PhD, Leticia Quintanilla-Martinez, MD, Wolfgang Hiddemann, Stefan Bohlander, Michaela Feuring-Buske, MD, Christian Buske, MD
Journal: Blood
Blood (2008) 112 (11): 3784.
https://doi.org/10.1182/blood.V112.11.3784.3784
Published: 2008
Journal Articles

Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia

Vijay P. S. Rawat, Silvia Thoene, Vegi M. Naidu, Natalia Arseni, Bernhard Heilmeier, Klaus Metzeler, Konstantin Petropoulos, Aniruddha Deshpande, Leticia Quintanilla-Martinez, Stefan K. Bohlander, Karsten Spiekermann, Wolfgang Hiddemann, Michaela Feuring-Buske, Christian Buske
Journal: Blood
Blood (2008) 111 (1): 309–319.
https://doi.org/10.1182/blood-2007-04-085407
Published: 2008
Includes: Supplemental data
Journal Articles

Ectopic Expression of CDX2 Perturbs HOX Gene Expression in Murine Progenitors Depending on Its N-Terminal Transactivation Domain and Is Closely Correlated with Deregulated HOX Gene Expression in Human Acute Myeloid Leukemia.

Vijay P.S. Rawat, PhD, Silvia Thoene, M.Sc, Vegi M. Naidu, M.Sc, Natalia Arseni, Ph.D., Bernhard Heilmeier, M.D., Klaus Metzeler, M.D., Konstantin Petropoulos, M.Sc, Aniruddha Deshpande, Ph.D., Leticia Quintanilla-Martinez, M.D., Stefan Bohlander, M.D., Karsten Spiekermann, M.D., Wolfgang Hiddemann, M.D., Michaela Feuring-Buske, M.D., Christian Buske, M.D.
Journal: Blood
Blood (2007) 110 (11): 2125.
https://doi.org/10.1182/blood.V110.11.2125.2125
Published: 2007
Journal Articles

Generation of Specific Resistance Profiles in FLT3-ITD and FIP1L1-PDGFRalpha towards Specifically Acting Tyrosine Kinase Inhibitors.

Nikolas von Bubnoff, MD, Silvia Thoene, Sivahari P. Gorantla, Jana Saenger, Christian Peschel, MD, Justus Duyster, MD
Journal: Blood
Blood (2006) 108 (11): 1376.
https://doi.org/10.1182/blood.V108.11.1376.1376
Published: 2006