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Journal Articles

Improved outcomes following allogeneic hematopoietic stem cell transplantation in patients with DDX41-mutated myeloid neoplasms: A prospective analysis of survival, GVHD, and transplant-related mortality

Shreyas Hanmantgad, Alan Mitchell, Kayleigh Mccloskey, James Aries, Francesco Versino, Roochi Trikha, Shreyans Gandhi, Madson Correia De Farias, Maria Cuadrado, Mili Shah, Varun Mehra, Pramila Krishnamurthy, Michelle Kenyon, Victoria Potter, Austin Kulasekararaj

Blood (2025) 146 (Supplement 1): 6083.

https://doi.org/10.1182/blood-2025-6083

Published: 2025

Journal Articles

17p loss in TP53-non-mutated myeloid neoplasms confers survival comparable to TP53-mutated disease

Blood (2025) 146 (Supplement 1): 3858.

https://doi.org/10.1182/blood-2025-3858

Published: 2025

Journal Articles

6pLOH as a marker of immune-mediated bone marrow failure: Insights from a large single center experience

Francesco Versino, Roochi Trikha, Joanna Large, Henry Wood, Azim Mohamedali, Kar Lok Kong, Shreyans Gandhi, Austin Kulasekararaj

Blood (2025) 146 (Supplement 1): 3194.

https://doi.org/10.1182/blood-2025-3194

Published: 2025

Journal Articles

Real-world use of oral iptacopan monotherapy in paroxysmal nocturnal hemoglobinuria

Blood (2025) 146 (Supplement 1): 1427.

https://doi.org/10.1182/blood-2025-1427

Published: 2025

Journal Articles

Molecular gene panel analysis in aplastic anaemia: Diagnostic utility and clinical implications

Francesco Versino, Roochi Trikha, Joanna Large, Guy Hannah, Steve Best, Shreyans Gandhi, Luke Ficinski, Paul Inocencio, Ana Olivera, Jianne Miran, Kar Lok Kong, Austin Kulasekararaj

Blood (2025) 146 (Supplement 1): 1711.

https://doi.org/10.1182/blood-2025-1711

Published: 2025

Journal Articles

Switching between complement inhibitors in patients with PNH: A real-world analysis of strategy, efficacy, and safety.

Morag Griffin, Bruno Fattizzo, Jong Wook Lee, Richard Kelly, Roochi Trikha, Yasutaka Ueda, Jun-ichi Nishimura, Christopher Patriquin, Alexander Röth, Petra Muus, Jens Panse, Miguel Gómez Álvarez, Alexandra Pike, Talha Munir, Shreyans Gandhi, Austin Kulasekararaj

Blood (2025) 146 (Supplement 1): 1114.

https://doi.org/10.1182/blood-2025-1114

Published: 2025

Journal Articles

DDX41-related myeloid neoplasms: Insights and treatment landscape in 250 patients managed at a large tertiary centre

Francesco Versino, Shreyas Hanmantgad, Pramila Krishnamurthy, Victoria Potter, Roochi Trikha, Mili Shah, Varun Mehra, Lynn Quek, Guy Hannah, Henry Wood, Shreyans Gandhi, Joanna Large, Clair Engelbrecht, Katie Snape, Guilherme Sapinho, Steve Best, Kar Lok Kong, Austin Kulasekararaj

Blood (2025) 146 (Supplement 1): 5262.

https://doi.org/10.1182/blood-2025-5262

Published: 2025

Journal Articles

Paroxysmal nocturnal hemoglobinuria in pediatric patients: A UK experience

Morag Griffin, Malinthi Adikarama, Shreyans Gandhi, Petra Muus, Alexandra Pike, Talha Munir, Matthew Holt, Louise Arnold, Franceso Versino, Joanna Large, Richard Kelly, Austin Kulasekararaj, Roochi Trikha

Blood (2025) 146 (Supplement 1): 4662.

https://doi.org/10.1182/blood-2025-4662

Published: 2025

Journal Articles

Real-world analysis of ravulizumab safety and effectiveness in advanced age patients with paroxysmal nocturnal hemoglobinuria: Insights from the international PNH registry

Shreyans Gandhi, Ami Patel, Alix Augustin-Wright, Hubert Schrezenmeier, Philippe Gustovic, Jesse Metzger, Yasutaka Ueda, Richard Kelly

Blood (2025) 146 (Supplement 1): 6238.

https://doi.org/10.1182/blood-2025-6238

Published: 2025

Journal Articles

Aplastic Anemia in the Elderly: Treatment Patterns and Outcomes from an International Observational Study

Bruno Fattizzo, Carmelo Gurnari, Sabrina Giammarco, Antony Ricchiuti, Hussein Awada, Marta Bortolotti, Giacinto Luca Pedone, Francesco Versino, Dario Consonni, Roochi Trikha, Shreyans Gandhi, Simona Sica, Jaroslaw Maciejewski, Austin G. Kulasekararaj, Wilma Barcellini

Blood (2024) 144 (Supplement 1): 4076.

https://doi.org/10.1182/blood-2024-198321

Published: 2024

Journal Articles

Treatment of Idiopathic Aplastic Anemia (AA) with Expanded Autologous Regulatory T Cells: The Tiara Phase One Trial

Nazia Matto, Shreyans Gandhi, Marta Rzepkowska, Sila Gerlevik, Mohammad M Karimi, Austin G. Kulasekararaj, Abdel Douiri, Angela Miller, Lynne Duran, Haili Cui, Jen Lewis, Shahram Kordasti, Giovanna Lombardi, Giorgio Napolitani, Ghulam Jeelani Mufti

Blood (2024) 144 (Supplement 1): 301.

https://doi.org/10.1182/blood-2024-207101

Published: 2024

Journal Articles

Incremental Effectiveness of Iptacopan Compared with C5 Inhibitors in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria: Results from a Modelling Analysis

Shreyans Gandhi, Regis Peffault De Latour, Katharina Pannagl, Maria-Magdalena Balp, Anggie Wiyani, Cheryl Druchok, Paul Lebeau, Richard J. Kelly

Blood (2024) 144 (Supplement 1): 5012.

https://doi.org/10.1182/blood-2024-201424

Published: 2024

Journal Articles

Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria

Richard J. Kelly, Matthew Holt, Jennifer Vidler, Louise M. Arnold, Joanna Large, Briony Forrest, Catherine Barnfield, Alexandra Pike, Morag Griffin, Talha Munir, Petra Muus, Sateesh K. Nagumantry, Abraham Varghese, John R. Davies, Roochi Trikha, Austin G. Kulasekararaj, Lindsay Mitchell, Shreyans Gandhi

Blood (2024) 143 (12): 1157–1166.

https://doi.org/10.1182/blood.2023021762

Published: 2024

Journal Articles

Impact of Somatic Second Hit and Comutations in Myeloid Neoplasms with Germline DDX41 Mutations

Guilherme Mendes Sapinho, Pramila Krishnamurthy, Guy Hannah, Shreyans Gandhi, Victoria Potter, Mili Shah, Nicholas Lea, Clair Engelbrecht, Heidre Bezuidenhout, Katie Snape, Steve Best, Austin Kulasekararaj

Blood (2023) 142 (Supplement 1): 6446.

https://doi.org/10.1182/blood-2023-189451

Published: 2023

Journal Articles

Factor B Inhibition with Oral Iptacopan Monotherapy Demonstrates Sustained Long-Term Efficacy and Safety in Anti-C5-Treated Patients (pts) with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Persistent Anemia: Final 48-Week Results from the Multicenter, Phase III APPLY-PNH Trial

Blood (2023) 142 (Supplement 1): 571.

https://doi.org/10.1182/blood-2023-180780

Published: 2023

Journal Articles

Deciphering the Differential Diagnosis of Inherited Versus Acquired Bone Marrow Failure Syndromes: A Large Cohort Study

Marta Bortolotti, Roochi Trikha, Sarah Salter, Joanna Large, Shreyans Gandhi, Bruno Fattizzo, Wilma Barcellini, Austin Kulasekararaj

Blood (2023) 142 (Supplement 1): 1360.

https://doi.org/10.1182/blood-2023-186516

Published: 2023

Journal Articles

Deciphering Treatment Patterns in Non-Severe Aplastic Anemia: An International Observational Study

Bruno Fattizzo, Carmelo Gurnari, Giulio Cassanello, Marta Bortolotti, Hussein Awada, Sabrina Giammarco, Dario Consonni, Simona Sica, Shreyans Gandhi, Roochi Trikha, Jaroslaw P. Maciejewski, Austin Kulasekararaj, Wilma Barcellini

Blood (2022) 140 (Supplement 1): 8638–8640.

https://doi.org/10.1182/blood-2022-166347

Published: 2022

Journal Articles

Terminal Complement Inhibition and Control of Hemolysis in Paroxysmal Nocturnal Hemoglobinuria Following Switching from High-Dose Eculizumab to Ravulizumab: An Interim Analysis

Morag Griffin, Shreyans Gandhi, Eden Hicks, Deepak Jain, Richard Kelly, Talha Munir, Petra Muus, Masayo Ogawa, Roochi Trikha, Ji Yu, Austin Kulasekararaj

Blood (2022) 140 (Supplement 1): 2928–2930.

https://doi.org/10.1182/blood-2022-159498

Published: 2022

Journal Articles

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Shok Ping Lim, Benedetta Costantini, Syed A. Mian, Pilar Perez Abellan, Shreyans Gandhi, Marc Martinez Llordella, Juan Jose Lozano, Rita Antunes dos Reis, Giovanni A. M. Povoleri, Thanos P. Mourikis, Ander Abarrategi, Linda Ariza-McNaughton, Susanne Heck, Jonathan M. Irish, Giovanna Lombardi, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Ghulam J. Mufti

Blood (2020) 136 (7): 885–897.

https://doi.org/10.1182/blood.2019001347

Published: 2020

Includes: Supplemental data

Journal Articles

Telomeric Length to Characterize and Prognosticate Bone Marrow Failure, Risk of Clonal Evolution and Multi-System Complications in Aplastic Anemia and Other Hypocellular Cytopenic Disorders, Independent of Telomere Gene Complex Mutations

Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath,MPhil, Jie Jiang, PhD, Simon Slade, BSc, Austin Kulasekararaj, MD MRCP, FRCPath, Victoria Potter, BSc, MBBS, FRCPA, Varun Mehra, MBBS,MRCP,FRCPath, Petra Muus, MD PhD, Andrea Da Silva, MBBS, Sudarshan Gurung, MBBS, MRCP, Alice Mason, B.Pharm, Aytug Kizilors, PhD, Nicholas Lea, PhD, Sahar Mansour, MD, Robin M. Ireland, MBBS, FRCP, FRCPath, Ghulam J. Mufti, MBBS, FRCP, FRCPath, DM, Judith Marsh, MD FRCPath

Blood (2019) 134 (Supplement_1): 3749.

https://doi.org/10.1182/blood-2019-130754

Published: 2019

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Improved outcomes following allogeneic hematopoietic stem cell transplantation in patients with DDX41-mutated myeloid neoplasms: A prospective analysis of survival, GVHD, and transplant-related mortality

17p loss in TP53-non-mutated myeloid neoplasms confers survival comparable to TP53-mutated disease

6pLOH as a marker of immune-mediated bone marrow failure: Insights from a large single center experience

Real-world use of oral iptacopan monotherapy in paroxysmal nocturnal hemoglobinuria

Molecular gene panel analysis in aplastic anaemia: Diagnostic utility and clinical implications

Switching between complement inhibitors in patients with PNH: A real-world analysis of strategy, efficacy, and safety.

DDX41-related myeloid neoplasms: Insights and treatment landscape in 250 patients managed at a large tertiary centre

Paroxysmal nocturnal hemoglobinuria in pediatric patients: A UK experience

Real-world analysis of ravulizumab safety and effectiveness in advanced age patients with paroxysmal nocturnal hemoglobinuria: Insights from the international PNH registry

Aplastic Anemia in the Elderly: Treatment Patterns and Outcomes from an International Observational Study

Treatment of Idiopathic Aplastic Anemia (AA) with Expanded Autologous Regulatory T Cells: The Tiara Phase One Trial

Incremental Effectiveness of Iptacopan Compared with C5 Inhibitors in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria: Results from a Modelling Analysis

Treatment outcomes of complement protein C5 inhibition in 509 UK patients with paroxysmal nocturnal hemoglobinuria

Impact of Somatic Second Hit and Comutations in Myeloid Neoplasms with Germline DDX41 Mutations

Factor B Inhibition with Oral Iptacopan Monotherapy Demonstrates Sustained Long-Term Efficacy and Safety in Anti-C5-Treated Patients (pts) with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Persistent Anemia: Final 48-Week Results from the Multicenter, Phase III APPLY-PNH Trial

Deciphering the Differential Diagnosis of Inherited Versus Acquired Bone Marrow Failure Syndromes: A Large Cohort Study

Deciphering Treatment Patterns in Non-Severe Aplastic Anemia: An International Observational Study

Terminal Complement Inhibition and Control of Hemolysis in Paroxysmal Nocturnal Hemoglobinuria Following Switching from High-Dose Eculizumab to Ravulizumab: An Interim Analysis

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Telomeric Length to Characterize and Prognosticate Bone Marrow Failure, Risk of Clonal Evolution and Multi-System Complications in Aplastic Anemia and Other Hypocellular Cytopenic Disorders, Independent of Telomere Gene Complex Mutations

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