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Samit Ghosh, PhD
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Journal Articles

The T117S Variant of Cytochrome b5 Reductase 3 Increases the Risk for Ischemic Stroke with Enhanced Anemia in Mice with Sickle Cell Disease

Free
Katherine C Wood, PhD, Heidi M Schmidt, Scott Hahn, MS, Subramaniam Sanker, PhD, Samit Ghosh, PhD, Solomon Fiifi Ofori-Acquah, PhD, Seyed Mehdi Nouraie, MD PhD, Mark T Gladwin, MD, Adam C Straub, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142076
Published: 2020
Journal Articles

Nonhematopoietic Nrf2 Deficiency Worsens Chronic Intravascular Hemolysis but Not Cardiomyopathy in Transgenic Sickle Cell Mice

Free
Maureen Mburu, Samit Ghosh, PhD, Xucai Chen, PhD, Solomon Fiifi Ofori-Acquah, PhD, Flordeliza S Villanueva, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18.
https://doi.org/10.1182/blood-2020-142783
Published: 2020
Journal Articles

Heterogeneity in Multi-Organ Expression of HO-1 and PlGF in Sickle Mice Mimic Exposure of Non-Sickle Mice to Extracellular Heme Via Nrf2-Dependent Pathways

Free
Oluwabukola Gbotosho, BSc, MSc, PhD, Maria G Kapetanaki, PhD, Samit Ghosh, PhD, Yu Lin, Frances Weidert, MSc, Solomon Fiifi Ofori-Acquah, PhD, Gregory J. Kato, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2392.
https://doi.org/10.1182/blood-2018-99-113451
Published: 2018
Journal Articles

Enhanced Renal Clearance of Heme Triggers Acute Kidney Injury in Sickle Cell Disease

Free
Samit Ghosh, PhD, Vivian Paintsil, MD, Rimi Hazra, PhD, Oluowaseun O. Orikogbo, Bethany Flage, Ezekiel Bonwin Ackah, Ellis Owusu-Dabo, PhD, Solomon Fiifi Ofori-Acquah, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 441.
https://doi.org/10.1182/blood.V130.Suppl_1.441.441
Published: 2017
Journal Articles

Cardiomyopathy Associated with Worsening Intravascular Hemolysis in Transgenic Knock-in Mouse Model of Sickle Cell Disease

Free
Maureen Mburu, MD, Rafey Feroze, BS, Daniel Whitehurst, BS, Xucai Chen, PhD, Samit Ghosh, PhD, Solomon Fiifi Ofori-Acquah, PhD, Flordeliza S Villanueva, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3512.
https://doi.org/10.1182/blood.V130.Suppl_1.3512.3512
Published: 2017
Journal Articles

A Novel Role for P-Selectin in the Pathogenesis of Acute Chest Syndrome

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Samit Ghosh, PhD, Frances Weidert, MS, Bethany Flage, BS, Prithu Sundd, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2016) 128 (22): 157.
https://doi.org/10.1182/blood.V128.22.157.157
Published: 2016
Journal Articles

Nrf2 Activation Attenuates Hemolysis but Promotes Pulmonary Vascular Dysfunction in Sickle Mice

Free
Chibueze A. Ihunnah, PhD, Samit Ghosh, PhD, Scott A. Hahn, MS, Adam C Straub, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2016) 128 (22): 1296.
https://doi.org/10.1182/blood.V128.22.1296.1296
Published: 2016
Journal Articles

Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice

Free
Samit Ghosh, PhD, Chibueze A. Ihunnah, PhD, Rimi Hazra, PhD, Amma T. Owusu-Ansah, MD, Jason M Hansen, PhD, David R. Archer, PhD, Solomon Fiifi Ofori-Acquah, PhD
Journal: Blood
Blood (2015) 126 (23): 3394.
https://doi.org/10.1182/blood.V126.23.3394.3394
Published: 2015
Journal Articles

Targeted Disruption of Nrf2 in Non-Hematopoietic Tissues Exacerbates Hemolysis and Accelerates Chronic Lung Disease in Transgenic Sickle Cell Anemia Mice

Free
Samit Ghosh, PhD, Jason Hansen, PhD, Rimi Hazra, PhD, David R. Archer, PhD, Solomon F. Ofori-Acquah, PhD
Journal: Blood
Blood (2014) 124 (21): 456.
https://doi.org/10.1182/blood.V124.21.456.456
Published: 2014
Journal Articles

Extracellular Hemin Auto-Amplification Intensifies Tissue Injury In Sickle Cell Disease

Free
Samit Ghosh, PhD, Solomon F. Ofori-Acquah, PhD
Journal: Blood
Blood (2013) 122 (21): 972.
https://doi.org/10.1182/blood.V122.21.972.972
Published: 2013
Journal Articles

Targeted Treatment Of Acute Chest Syndrome In Transgenic Sickle Mice

Free
Samit Ghosh, PhD, Olufolake Adisa, MD, Prasanthi Chappa, Fang Tan, PhD, Kesmic A Jackson, PhD, David R. Archer, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2013) 122 (21): 727.
https://doi.org/10.1182/blood.V122.21.727.727
Published: 2013
Journal Articles

Determinants Of Heme-Oxygenase-1 Upregulation In Patients With Sickle Cell Disease

Free
Olufolake Adisa, MD, Benjamin Yaw Owusu, B.S., Yijuan Hu, PhD, Samit Ghosh, PhD, Fang Tan, PhD, Frederika Sey, MD, Ivy Ekem, MD, Isaac Quaye, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2013) 122 (21): 2235.
https://doi.org/10.1182/blood.V122.21.2235.2235
Published: 2013
Journal Articles

Heme Induced Organ Failure in Sickle Cell Disease Is Spatiotemporally Determined by the Amount of Heme Released Into the Bloodstream

Free
Samit Ghosh, PhD, Olufolake Adisa, MD, Doreen Aryee, MD, Fang Tan, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2011) 118 (21): 2135.
https://doi.org/10.1182/blood.V118.21.2135.2135
Published: 2011
Journal Articles

Toll-Like Receptor 4 Mediates Heme Induced Acute Lung Injury: Preclinical Study of Resatorvid in Sickle Cell Disease

Free
Samit Ghosh, PhD, Olufolake Adisa, MD, Yu Yang, Fang Tan, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2011) 118 (21): 2113.
https://doi.org/10.1182/blood.V118.21.2113.2113
Published: 2011
Journal Articles

Bone-Marrow Derived Cells Can Reconstitute GCLM Function in the Sickle Lung

Free
Olufolake Adisa, MD, Samit Ghosh, PhD, Fang Tan, PhD, Prasanthi Chappa, David R. Archer, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2011) 118 (21): 4836.
https://doi.org/10.1182/blood.V118.21.4836.4836
Published: 2011
Journal Articles

Acute Chest Syndrome In Transgenic Mouse Models of Sickle Cell Disease Triggered by Free Heme

Free
Samit Ghosh, PhD, Solomon F Ofori-Acquah, PhD
Journal: Blood
Blood (2010) 116 (21): 944.
https://doi.org/10.1182/blood.V116.21.944.944
Published: 2010
Journal Articles

Bio-Distribution of Recombinant Factor VIIa: A Possible Explanation for the Hemostatic Effect of rFVIIa in Prophylaxis.

Free
Ramakrishnan Gopalakrishnan, PhD, Ulla Hedner, MD, PhD, Samit Ghosh, PhD, Ramesh Nayak, PhD, Usha Pendurthi, PhD, L. Vijaya Mohan Rao, PhD
Journal: Blood
Blood (2009) 114 (22): 3480.
https://doi.org/10.1182/blood.V114.22.3480.3480
Published: 2009
Journal Articles

Activity and Regulation of Long-Acting Factor VIIa Analogs.

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Samit Ghosh, PhD, Prosenjit Sen, Ph.D, Mirella Ezban, Ph.D., Usha R. Pendurthi, Ph.D., L. Vijaya Mohan Rao
Journal: Blood
Blood (2007) 110 (11): 3141.
https://doi.org/10.1182/blood.V110.11.3141.3141
Published: 2007
Journal Articles

Activity and Regulation of Factor VIIa Analogs with Increased Potency at the Endothelial Cell Surface.

Free
Samit Ghosh, PhD, Mirella Ezban, Ph.D., Egon Persson, Ph.D., Ulla Hedner, M.D., Usha Pendurthi, Ph.D., L. Vijaya Mohan Rao, Ph.D
Journal: Blood
Blood (2006) 108 (11): 1751.
https://doi.org/10.1182/blood.V108.11.1751.1751
Published: 2006