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Journal Articles

High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

Karina Barbosa, BSc, Anagha Deshpande, PhD, Ping Xiang, PhD, Bo-Rui Chen, PhD, Adam Brown, MSc, Neil Robertson, Younguk Sun, PhD, John Doench, PhD, Peter D Adams, PhD, R. Keith Humphries, MD PhD, Prashant Mali, PhD, Aniruddha J. Deshpande, PhD

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-141412

Published: 2020

Journal Articles

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Ivan Sloma, PharmD, PhD, Philip Beer, PhD FRCPath, MRCP, Christophe Desterke, PhD, Elizabeth Bulaeva, Misha Bilenky, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G Turhan, MD PhD, Orianne Wagner-Ballon, MD PhD, Philippe Gaulard, MD PhD, R. Keith Humphries, MD PhD, Martin Hirst, PhD BS, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 4139.

https://doi.org/10.1182/blood-2019-127839

Published: 2019

Journal Articles

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Blood (2018) 132 (Supplement 1): 1322.

https://doi.org/10.1182/blood-2018-99-120120

Published: 2018

Journal Articles

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

Andrew Wu, BSc, Lin Hanyang, PhD, Katharina Rothe, PhD, Min Chen, MD PhD, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, MD, David Knapp, PhD, Naoto Nakamichi, MD PhD, Ryan Brinkman, PhD, Inanc Birol, PhD, Donna L Forrest, MD, Carl Hansen, PhD, R. Keith Humphries, MD PhD, Connie J. Eaves, PhD, Xiaoyan Jiang, MD PhD

Blood (2018) 132 (Supplement 1): 931.

https://doi.org/10.1182/blood-2018-99-113559

Published: 2018

Journal Articles

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 2627.

https://doi.org/10.1182/blood-2018-99-116256

Published: 2018

Journal Articles

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling By Suppression of Mir-146a in Acute Myeloid Leukemia

Blood (2016) 128 (22): 1533.

https://doi.org/10.1182/blood.V128.22.1533.1533

Published: 2016

Journal Articles

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Blood (2016) 128 (22): 1534.

https://doi.org/10.1182/blood.V128.22.1534.1534

Published: 2016

Journal Articles

Modeling of Pediatric Acute Megakaryoblastic Leukemia Using Cord Blood Stem/Progenitor Cells

Sophie Cardin, PhD, Louise Laramee, Tara MacRae, M.Sc., Jalila Chagraoui, PhD, Guy Sauvageau, MD PhD, R. Keith Humphries, MD PhD, Josée Hébert, MD, Brian T. Wilhelm, PhD, Sonia Cellot, MD PhD

Blood (2016) 128 (22): 1535.

https://doi.org/10.1182/blood.V128.22.1535.1535

Published: 2016

Journal Articles

A Tumor Suppressor microRNA Defines the Leukemic Hierarchy in Acute Myeloid Leukemia

Edith Schneider, MSc, Anna Staffas, PhD, Linda Roehner, MSc, Christian Buske, Lars Bullinger, MD, Michael Heuser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD, R. Keith Humphries, MD PhD, Arefeh Rouhi, PhD, Lars Palmqvist, MD PhD, Florian Kuchenbauer, MD PhD

Blood (2015) 126 (23): 3653.

https://doi.org/10.1182/blood.V126.23.3653.3653

Published: 2015

Journal Articles

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Blood (2015) 126 (23): 1244.

https://doi.org/10.1182/blood.V126.23.1244.1244

Published: 2015

Journal Articles

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

Hanyang Lin, BSc, MSc, Jonathan Zeng, Katharina Rothe, BSc, MSc, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, PhD, David Knapp, BSc, Ryan R. Brinkman, PhD, Inanc Birol, PhD, Donna L. Forrest, MD, Carl Hansen, PhD, Connie J. Eaves, PhD, R. Keith Humphries, MD PhD, Xiaoyan Jiang, MDPhD

Blood (2015) 126 (23): 1567.

https://doi.org/10.1182/blood.V126.23.1567.1567

Published: 2015

Journal Articles

High-Throughput Drug Screening Identifies Pyrimethamine As a Potent and Selective Inhibitor of Acute Myeloid Leukemia

Amit Sharma, PhD, Nidhi Jyotsana, Courteney K. Lai, BSc, Anuhar Chaturvedi, PhD, Kerstin Görlich, Cecilia Murphy, Jan E. Blanchard, Arnold Ganser, Eric Brown, John A. Hassell, R. Keith Humphries, MD PhD, Michael A Morgan, PhD, Michael Heuser, MD

Blood (2014) 124 (21): 2304.

https://doi.org/10.1182/blood.V124.21.2304.2304

Published: 2014

Journal Articles

Aldehyde Dehydrogenases Play a Role in Acute Myeloid Leukemia and Have Prognostic and Therapeutic Significance

Maura Gasparetto, MD, Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Daniel A. Pollyea, MD MS, Vasilis Vasiliou, PhD, R. Keith Humphries, MD PhD, Craig T. Jordan, PhD, Clayton A. Smith, MD FRCPC

Blood (2014) 124 (21): 2238.

https://doi.org/10.1182/blood.V124.21.2238.2238

Published: 2014

Journal Articles

Hoxa9/Meis1 Mediate Leukemic Programming through Microrna-155

Edith Schneider, M.Sc., Anna Staffas, PhD, Milijana Mirkovic-Hoesle, PhD, Bernhard Gentner, MD, Jens Ruschmann, Christian Buske, MD, Michael Heuser, MD, Konstanze Döhner, MD, Hartmut Döhner, MD, R. Keith Humphries, MD PhD, Arefeh Rouhi, PhD, Florian Kuchenbauer, MD PhD, Lars Palmqvist, MD PhD

Blood (2014) 124 (21): 884.

https://doi.org/10.1182/blood.V124.21.884.884

Published: 2014

Journal Articles

Identification of New microRNA Biomarkers and Candidate Target Genes in Primitive CML Cells Using Global Comparative RNA analyses

Hanyang Lin, Katharina Rothe, Jens Ruschmann, Oleh Petriv, Kieran O'Neill, David J.H.F. Knapp, Ryan R. Brinkman, Inanc Birol, Donna L. Forrest, MD, Carl Hansen, Connie J Eaves, R. Keith Humphries, MD PhD, Xiaoyan Jiang

Blood (2014) 124 (21): 3133.

https://doi.org/10.1182/blood.V124.21.3133.3133

Published: 2014

Journal Articles

ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML

Maura Gasparetto, MD, Craig T. Jordan, PhD, Mohammad Minhajuddin, Daniel A Pollyea, MD, MS, Vasilis Vasilou, Philip Reigan, PhD, R. Keith Humphries, MD, PhD, Clayton A. Smith, MD, FRCPC

Blood (2013) 122 (21): 2893.

https://doi.org/10.1182/blood.V122.21.2893.2893

Published: 2013

Journal Articles

Short Term Signalling Responses of the Most Primitive Subsets of Human Hematopoietic Cells Stimulated in Vitro Correlate with Their Subsequent Self-Renewal Behaviour.

David J.H.F. Knapp, Sean C. Bendall, PhD, Paul H. Miller, Alice M.S. Cheung, PhD, Suzan Imren, MD, R. Keith Humphries, MD, PhD, Ryan R. Brinkman, Robert A.J. Oostendorp, BSc, MSc, PhD, Garry P. Nolan, PhD, Connie J. Eaves, PhD

Blood (2012) 120 (21): 2341.

https://doi.org/10.1182/blood.V120.21.2341.2341

Published: 2012

Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Blood (2011) 118 (21): 233.

https://doi.org/10.1182/blood.V118.21.233.233

Published: 2011

Journal Articles

Mutated EZH2 Collaborates with Myc in Inducing Lymphoma in a Mouse Model

Tobias Berg, MD, Damian Yap, PhD, Silvia Thoene, PhD, Tracee Wee, Nathalie Schoeler, Patricia Umlandt, Harry Chang, Lisa Yue, David Lai, Grace Cheng, PhD, Ryan D Morin, M.Sc., Martin Hirst, Marco A. Marra, PhD, Gregg B. Morin, PhD, Randy D. Gascoyne, MD, Samuel A. Aparicio, PhD, R. Keith Humphries, MD, PhD

Blood (2011) 118 (21): 227.

https://doi.org/10.1182/blood.V118.21.227.227

Published: 2011

Journal Articles

Distinct Human Cell Populations Produce Rapidly Detectable Levels of Neutrophils and Platelets in NOD/SCID-IL-2Receptor Gamma Chain Null Mice Transgenically Engineered to Produce Human Myeloid Growth Factors

Paul H. Miller, Alice M.S. Cheung, PhD, Suzan Imren, MD, Philip A Beer, BM, MRCP, MRCPath, Shabnam Rostamirad, Kiran Dhillon, R. Keith Humphries, MD, PhD, Connie J. Eaves, PhD

Blood (2011) 118 (21): 1892.

https://doi.org/10.1182/blood.V118.21.1892.1892

Published: 2011

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High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

MiR-193a Is a Negative Regulator of Hematopoietic Stem Cells and Promotes Anti-Leukemic Effects in Acute Myeloid Leukemia

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling By Suppression of Mir-146a in Acute Myeloid Leukemia

The miRNA-193 Family Is a Potent Tumor-Suppressor and a Biomarker for Poor Prognosis in Acute Myeloid Leukemia

Modeling of Pediatric Acute Megakaryoblastic Leukemia Using Cord Blood Stem/Progenitor Cells

A Tumor Suppressor microRNA Defines the Leukemic Hierarchy in Acute Myeloid Leukemia

The Mir-193 Family Antagonizes Stem Cell Pathways and Is a Potent Tumor Suppressor in Childhood and Adult Acute Myeloid Leukemia

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

High-Throughput Drug Screening Identifies Pyrimethamine As a Potent and Selective Inhibitor of Acute Myeloid Leukemia

Aldehyde Dehydrogenases Play a Role in Acute Myeloid Leukemia and Have Prognostic and Therapeutic Significance

Hoxa9/Meis1 Mediate Leukemic Programming through Microrna-155

Identification of New microRNA Biomarkers and Candidate Target Genes in Primitive CML Cells Using Global Comparative RNA analyses

ALDH Genes and Reactive Aldehydes Play Important Roles in HSCs and Leukemia and May Be Exploited to Treat AML

Short Term Signalling Responses of the Most Primitive Subsets of Human Hematopoietic Cells Stimulated in Vitro Correlate with Their Subsequent Self-Renewal Behaviour.

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Mutated EZH2 Collaborates with Myc in Inducing Lymphoma in a Mouse Model

Distinct Human Cell Populations Produce Rapidly Detectable Levels of Neutrophils and Platelets in NOD/SCID-IL-2Receptor Gamma Chain Null Mice Transgenically Engineered to Produce Human Myeloid Growth Factors

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