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Journal Articles

Loss of Microtubule Protein Stathmin-1 Impairs Autophagy in Hematopoietic Stem Cells

Free
Luana Chiquetto Paracatu, Qian Dong, Mia G Warmka, Liana Valin, Patrick Hunt, Ashley Jones, Meg Schuetz, Mousumi Chakraborty, Zev Greenberg, Christine RC Zhang, Grant A Challen, Cliff Luke, Robert Signer, Wandy Beatty, David Kast, Stephen Sykes, Laura G. Schuettpelz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4041.
https://doi.org/10.1182/blood-2024-208205
Published: 2024
Journal Articles

Transmembrane Adaptor Protein Scimp Promotes TLR Signaling to Regulate Hematopoietic Stem Cell Function

Free
Mousumi Chakraborty, Luana Chiquetto Paracatu, Zev Greenberg, Qian Dong, Ashley Jones, Laura G. Schuettpelz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4040.
https://doi.org/10.1182/blood-2024-208139
Published: 2024
Journal Articles

The Tetraspanin CD53 Promotes the Clonal Advantage of Dnmt3a-Deficient Hematopoietic Stem Cells

Free
Mia G Warmka, Luana Chiquetto Paracatu, Mousumi Chakraborty, Qian Dong, Nate Roundy, Grant A Challen, Laura G. Schuettpelz
Journal: Blood
Blood (2023) 142 (Supplement 1): 5602.
https://doi.org/10.1182/blood-2023-180980
Published: 2023
Journal Articles

Stathmin-1 Regulates Hematopoietic Stem Cell Mitochondrial and Cellular Function

Free
Luana Chiquetto Paracatu, Qian Dong, Mia G Warmka, Liana Valin, Mousumi Chakraborty, Zev Greenberg, Nate Roundy, Christine RC Zhang, Grant A Challen, Cliff Luke, Wandy Beatty, Stephen M Sykes, Laura G. Schuettpelz
Journal: Blood
Blood (2023) 142 (Supplement 1): 4045.
https://doi.org/10.1182/blood-2023-189443
Published: 2023
Journal Articles

The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex–mediated quiescence

Free
Zev J. Greenberg, Luana Chiquetto Paracatu, Darlene A. Monlish, Qian Dong, Michael Rettig, Nate Roundy, Rofaida Gaballa, Weikai Li, Wei Yang, Cliff J. Luke, Laura G. Schuettpelz
Journal: Blood
Blood (2023) 141 (10): 1180–1193.
https://doi.org/10.1182/blood.2022016929
Published: 2023
Includes: Supplemental data
Journal Articles

The Tetraspanin CD53 Promotes CXCR4 Signaling to Facilitate B Cell Migration

Free
Mousumi Chakraborty, Zev J. Greenberg, Eric J. Duncavage, Nate Roundy, Qian Dong, Laura G. Schuettpelz
Journal: Blood
Blood (2022) 140 (Supplement 1): 8345–8346.
https://doi.org/10.1182/blood-2022-166906
Published: 2022
Journal Articles

Genetic and Epigenetic Cis -Regulatory Disruptions Impacting the Canonical Wnt Signaling Repressor TLE1 Gene Promote Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia

Free
Brennan P. Bergeron, Jonathan D. Diedrich, Yang Zhang, Kelly R. Barnett, Qian Dong, Daniel Ferguson, Robert J Autry, Wenjian Yang, Baranda S Hansen, Colton A Smith, Kristine R. Crews, Yiping Fan, Ching-Hon Pui, Shondra Miller, Mary V. Relling, Jun J. Yang, Chunliang Li, William E. Evans, Daniel Savic
Journal: Blood
Blood (2022) 140 (Supplement 1): 8838–8839.
https://doi.org/10.1182/blood-2022-166973
Published: 2022
Journal Articles

The Role of Stathmin-1 in the Regulation of Hematopoietic Stem Cells

Free
Luana Chiquetto Paracatu, Qian Dong, Zev J. Greenberg, Liana Valin, Nate Roundy, Christine R Zhang, Grant A Challen, Cliff Luke, Stephen M. Sykes, Laura G. Schuettpelz
Journal: Blood
Blood (2022) 140 (Supplement 1): 5734–5735.
https://doi.org/10.1182/blood-2022-166665
Published: 2022
Journal Articles

Epigenetic Age Acceleration and Neurocognitive Function Among Long-Term Survivors of Pediatric Hodgkin Lymphoma: A Report from the St. Jude Lifetime Cohort

Free
AnnaLynn M Williams, Qian Dong, Nicholas S. Phillips, Matt J. Ehrhardt, Deokumar Srivastava, Sedigheh Mirzaei Salehabadi, Yutaka Yasui, Kirsten K. Ness, Melissa M. Hudson, Leslie L. Robison, Kevin R. Krull, Zhaoming Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 2181–2182.
https://doi.org/10.1182/blood-2022-159026
Published: 2022
Journal Articles

Amino Acid Stress Response Genes Promote L-Asparaginase Resistance in Pediatric Acute Lymphoblastic Leukemia

Free
Daniel Ferguson, J. Robert McCorkle, Qian Dong, Erik Bonten, Wenjian Yang, Brennan P. Bergeron, Robert J Autry, Jonathan Diedrich, Yoshihiro Gocho, Richa Bajpai, Kristine R. Crews, Shondra M. Pruett-Miller, Kathryn G Roberts, Wendy Stock, Charles G. Mullighan, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Jun J. Yang, Mary V. Relling, William E. Evans, Daniel Savic
Journal: Blood
Blood (2021) 138 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2021-152940
Published: 2021
Journal Articles

Mapping the Glucocorticoid Gene Regulatory Network and Alterations That Contribute to Steroid Resistance in Childhood Acute Lymphoblastic Leukemia

Free
Brennan P. Bergeron, Jonathan Diedrich, Yang Zhang, Qian Dong, Daniel Ferguson, Robert J Autry, Wenjian Yang, Baranda S Hansen, Kristine R. Crews, Ching-Hon Pui, Yiping Fan, Shondra M. Pruett-Miller, Mary V. Relling, Jun J. Yang, Chunliang Li, William E. Evans, Daniel Savic
Journal: Blood
Blood (2021) 138 (Supplement 1): 674.
https://doi.org/10.1182/blood-2021-153002
Published: 2021
Journal Articles

The Tetraspanin CD53 Protects Hematopoietic Stem Cells Following Cellular Stress through Induction of DREAM Complex-Mediated Quiescence

Free
Zev J. Greenberg, Darlene A. Monlish, Qian Dong, Luana Chiquetto Paracatu, Michael P. Rettig, Wei Yang, Weikai Li, Laura G. Schuettpelz
Journal: Blood
Blood (2021) 138 (Supplement 1): 295.
https://doi.org/10.1182/blood-2021-151010
Published: 2021
Journal Articles

CC-486 Reduces Hospitalization and Associated Estimated Costs in Patients with Acute Myeloid Leukemia (AML) in First Remission after Intensive Chemotherapy: Results from the QUAZAR AML-001 Maintenance Trial

Free
Esther Natalie Oliva, MD, Suman Kambhampati, MD, Albert Oriol, Ignazia La Torre, Barry Skikne, MD, C.L. Beach, PharmD, Keshava Kumar, PhD, Qian Dong, DrPH, Clara Chen, Sandip Ranjan, MTech, Zephirin Kiendrebeogo, Msc, PMP, Thorsten Braun, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-137562
Published: 2020
Journal Articles

CC-486 Prolongs Survival for Patients with Acute Myeloid Leukemia (AML) in Remission after Intensive Chemotherapy (IC) Independent of the Presence of Measurable Residual Disease (MRD) at Study Entry: Results from the QUAZAR AML-001 Maintenance Trial

Free
Gail J. Roboz, MD, Farhad Ravandi, MBBS, Andrew H Wei, MBBS, PhD, Hervé Dombret, MD, Hartmut Döhner, Felicitas Thol, Maria Teresa Voso, MD, Andre C. Schuh, Kimmo Porkka, Ignazia La Torre, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, C.L. Beach, PharmD, Alberto Risueño, Daniel Lopes de Menezes, PhD, Gert Ossenkoppele, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-140837
Published: 2020
Journal Articles

CC-486 Improves Overall Survival (OS) and Relapse-Free Survival (RFS) for Patients with Acute Myeloid Leukemia (AML) in First Remission after Intensive Chemotherapy (IC), Regardless of Amount of Consolidation Received: Results from the Phase III QUAZAR AML-001 Maintenance Trial

Free
Andrew Wei, MBBS,PhD, Gail J. Roboz, MD, Hervé Dombret, MD, Hartmut Döhner, Andre C. Schuh, Pau Montesinos, MD PhD, Christopher Pocock, MBBS, Dominik Selleslag, MD, Sergey N. Bondarenko, Ignazia La Torre, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, C.L. Beach, PharmD, Farhad Ravandi, MBBS
Journal: Blood
Blood (2020) 136 (Supplement 1): 38–40.
https://doi.org/10.1182/blood-2020-138498
Published: 2020
Journal Articles

Gastrointestinal Events and Management Strategies for Patients with Acute Myeloid Leukemia (AML) in First Remission Receiving CC-486 in the Randomized, Placebo-Controlled, Phase III QUAZAR AML-001 Maintenance Trial

Free
Farhad Ravandi, MBBS, Christopher Pocock, MBBS, Dominik Selleslag, MD, Pau Montesinos, MD PhD, Hamid Sayar, MD MSc, Maurizio Musso, MD, Angela Figuera Alvarez, Hana Safah, MD, William Tse, MD FACP, Sang Kyun Sohn, MDPhD, Devendra K Hiwase, MBBS, MD FRACP, FRCPA, PhD, Timothy Chevassut, Francesca Pierdomenico, Ignazia La Torre, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, C.L. Beach, PharmD, Hervé Dombret, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-137669
Published: 2020
Journal Articles

The QUAZAR AML-001 Maintenance Trial: Results of a Phase III International, Randomized, Double-Blind, Placebo-Controlled Study of CC-486 (Oral Formulation of Azacitidine) in Patients with Acute Myeloid Leukemia (AML) in First Remission

Free
Andrew H. Wei, MBBS, FRACP, FRCPA, PhD, Hartmut Döhner, MD, Christopher Pocock, MBBS, Pau Montesinos, MD PhD, Boris Afanasyev, MD DSci, Hervé Dombret, MD, Farhad Ravandi, MD, Hamid Sayar, MD MSc, Jun Ho Jang, MD PhD, Kimmo Porkka, MD, Dominik Selleslag, MD, Irwindeep Sandhu, MD, Mehmet Turgut, MD, Valentina Giai, MD, Yishai Ofran, MD, Merih Kizil Cakar, MD, Aida Botelho de Sousa, MD, Justyna Rybka, MD PhD, Chiara Frairia, MD, Lorenza Borin, MD, Germana Beltrami, MD, Jaroslav Cermak, MD PhD, Gert J. Ossenkoppele, MD PhD, Ignazia La Torre, MD, Barry Skikne, MD, Keshava Kumar, PhD, Qian Dong, DrPH, CL Beach, PharmD, Gail J. Roboz, MD
Journal: Blood
Blood (2019) 134 (Supplement_2): LBA-3.
https://doi.org/10.1182/blood-2019-132405
Published: 2019
Journal Articles

CC-486 (Oral Azacitidine) in Patients with Hematological Malignancies Who Had Received Prior Treatment with Injectable Hypomethylating Agents (HMAs): Results from Phase 1/2 CC-486 Studies

Free
Guillermo Garcia-Manero, MD, Michael R. Savona, MD, Steven D. Gore, MD, Bart L. Scott, MD, Christopher R. Cogle, MD, Thomas Boyd, MD, Paul Conkling, Joel Hetzer, PhD, Qian Dong, MS, Keshava Kumar, PhD, Stacey M. Ukrainskyj, BSN, Barry S. Skikne, MD
Journal: Blood
Blood (2016) 128 (22): 905.
https://doi.org/10.1182/blood.V128.22.905.905
Published: 2016
Journal Articles

CC-486 (Oral Azacitidine) Monotherapy in Patients with Acute Myeloid Leukemia (AML)

Free
Michael R. Savona, MD, Steven D. Gore, MD, Kathryn S. Kolibaba, Stacey M. Ukrainskyj, BSN, Keshava Kumar, PhD, Qian Dong, MS, Joel Hetzer, PhD, Barry Skikne, MD, Guillermo Garcia-Manero, MD
Journal: Blood
Blood (2015) 126 (23): 452.
https://doi.org/10.1182/blood.V126.23.452.452
Published: 2015
Journal Articles

CC-486 in Patients with Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML), or Chronic Myelomonocytic Leukemia (CMML): Safety, Tolerability, and Response

Free
Michael R. Savona, MD, Kathryn Kolibaba, MD, Paul Conkling, MD, Edwin C. Kingsley, MD, Carlos Becerra, MD, John Morris, MD, Robert M. Rifkin, MD, Eric Laille, MS, Amy Kellerman, BA, Stacey M. Ukrainskyj, BSN,RN, Qian Dong, MS, Barry S. Skikne, MD
Journal: Blood
Blood (2014) 124 (21): 4638.
https://doi.org/10.1182/blood.V124.21.4638.4638
Published: 2014