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Pranita Kaphle
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Journal Articles

CD44-mediated metabolic rewiring is a targetable dependency of IDH-mutant leukemia

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Junhua Lyu, Yuxuan Liu, Ningning Liu, Hieu S. Vu, Feng Cai, Hui Cao, Pranita Kaphle, Zheng Wu, Giovanni A. Botten, Yuannyu Zhang, Jin Wang, Sarada Achyutuni, Xiaofei Gao, Ilaria Iacobucci, Charles G. Mullighan, Stephen S. Chung, Min Ni, Ralph J. DeBerardinis, Jian Xu
Journal: Blood
Blood (2025) 145 (14): 1553–1567.
https://doi.org/10.1182/blood.2024027207
Published: 2025
Includes: Supplemental data
Journal Articles

Structural variation cooperates with permissive chromatin to control enhancer hijacking–mediated oncogenic transcription

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Giovanni A. Botten, Yuannyu Zhang, Kseniia Dudnyk, Yoon Jung Kim, Xin Liu, Jacob T. Sanders, Aygun Imanci, Nathalie Droin, Hui Cao, Pranita Kaphle, Kathryn E. Dickerson, Kirthi R. Kumar, Mingyi Chen, Weina Chen, Eric Solary, Peter Ly, Jian Zhou, Jian Xu
Journal: Blood
Blood (2023) 142 (4): 336–351.
https://doi.org/10.1182/blood.2022017555
Published: 2023
Includes: Supplemental data
Journal Articles

Targeting Cell Adhesion Molecules in IDH Mutant Myeloid Malignances

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Junhua Lyu, Yuxuan Liu, Yuannyu Zhang, Feng Cai, Giovanni A. Botten, Hui Cao, Pranita Kaphle, Ralph J Deberardinis, Jian Xu
Journal: Blood
Blood (2022) 140 (Supplement 1): 8704–8705.
https://doi.org/10.1182/blood-2022-168313
Published: 2022
Journal Articles

Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription

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Giovanni A. Botten, Yuannyu Zhang, Kseniia Dudnyk, Xin Liu, Jacob T. Sanders, Aygun Imanci, Nathalie Droin, Hui Cao, Pranita Kaphle, Kathryn E. Dickerson, Mingyi Chen, Weina Chen, Eric Solary, Peter Ly, Jian Zhou, Jian Xu
Journal: Blood
Blood (2022) 140 (Supplement 1): 1007–1008.
https://doi.org/10.1182/blood-2022-169565
Published: 2022
Journal Articles

Elucidating Mechanisms of Acquired Resistance to IDH Inhibition By Saturation Variant Screening of Base-Edited Leukemia Cells

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Junhua Lyu, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yazan F. Madanat, MD, Yuannyu Zhang, PhD, Zhimin Gu, PhD, Pranita Kaphle, MS, Kathryn E. Dickerson, MD, Paul Yenerall, PhD, Rahul Kollipara, PhD, Ralf Kittler, PhD, John Minna, MD, Weina Chen, MD PhD, Stephen Chung, MD, Robert H. Collins, MD, Xin Liu, PhD, Jian Xu, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-141433
Published: 2020