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Journal Articles

The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation

Chuanbin Shen, Ming Liu, Runjia Xu, Gan Wang, June Li, Pingguo Chen, Wenjing Ma, James Mwangi, Qiumin Lu, Zilei Duan, Zhiye Zhang, Fatima Zohra Dahmani, Daniel Thomas Mackeigan, Heyu Ni, Ren Lai

Blood (2020) 136 (8): 974–988.

https://doi.org/10.1182/blood.2019002314

Published: 2020

Includes: Supplemental data

Journal Articles

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Tyler W. Stratton, MSc, Guangheng Zhu, MD, Yiming Wang, MD PhD, Pingguo Chen, PhD, Miguel A. D. Neves, PhD MSc, Reid C. Gallant, MSc, Peter A. A. Norris, BSc, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2018) 132 (Supplement 1): 1246.

https://doi.org/10.1182/blood-2018-99-119964

Published: 2018

Journal Articles

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

Jade Sullivan, BSc, Brigitta Elaine Oswald, B.Sc, Brian Vadasz, BSc, June Li, MSc, Pingguo Chen, PhD, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD MSc, PhD

Blood (2017) 130 (Supplement 1): 233.

https://doi.org/10.1182/blood.V130.Suppl_1.233.233

Published: 2017

Journal Articles

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

Blood (2017) 129 (13): 1840–1854.

https://doi.org/10.1182/blood-2016-07-729400

Published: 2017

Includes: Supplemental data

Journal Articles

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Miao Xu, MSc, MD, Li Ma, PhD, Naadiya Carrim, PhD, Issaka Yougbare, PhD, June Li, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 12.

https://doi.org/10.1182/blood.V126.23.12.12

Published: 2015

Journal Articles

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

Issaka Yougbare, PhD, Tai Wei-she, Bsc, Darko Zdravic, MSc, Pingguo Chen, MD PhD, Guangheng Zhu, MD, Howard Leong-Poi, MD, Qu Dawei, PhD, X. Lisa Yu, MD, S. Adamson Lee, PhD, John Sled, PhD, Freedman John, MD, Heyu Ni, MD PhD

Blood (2015) 126 (23): 2254.

https://doi.org/10.1182/blood.V126.23.2254.2254

Published: 2015

Journal Articles

CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Li Ma, Elisa Simpson, June Li, Min Xuan, Miao Xu, Laura Baker, Yan Shi, Issaka Yougbaré, Xiaozhong Wang, Guangheng Zhu, Pingguo Chen, Gerald J. Prud’homme, Alan H. Lazarus, John Freedman, Heyu Ni

Blood (2015) 126 (2): 247–256.

https://doi.org/10.1182/blood-2015-03-635417

Published: 2015

Includes: Supplemental data

Journal Articles

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Blood (2014) 124 (21): 92.

https://doi.org/10.1182/blood.V124.21.92.92

Published: 2014

Journal Articles

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Li Ma, PhD, Elisa K. Simpson, MSc., June Li, MSc, Min Xuan, PhD, Miao Xu, MSc, MD, Laura Baker, BSc., Yan Shi, MD, Guangheng Zhu, MD, Pingguo Chen, MD PhD, Alan H Lazarus, PhD, John J. Freedman, MD, Heyu Ni, MD PhD

Blood (2014) 124 (21): 576.

https://doi.org/10.1182/blood.V124.21.576.576

Published: 2014

Journal Articles

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

Blood (2014) 124 (21): 2772.

https://doi.org/10.1182/blood.V124.21.2772.2772

Published: 2014

Journal Articles

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Li Ma, Elisa K. Simpson, H.B.Sc., June Li, BSc, Guangheng Zhu, MD, Pingguo Chen, PhD, John W. Semple, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 1076.

https://doi.org/10.1182/blood.V122.21.1076.1076

Published: 2013

Journal Articles

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Brian Vadasz, BSc, Pingguo Chen, PhD, Yougbare Issaka, PhD, Guangheng Zhu, MD, Frampton Jonathan, Ph.D, Mortimer Poncz, MD, John J. Freedman, MD, Heyu Ni, MD, PhD

Blood (2013) 122 (21): 2314.

https://doi.org/10.1182/blood.V122.21.2314.2314

Published: 2013

Journal Articles

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Guangheng Zhu, MD, Pingguo Chen, PhD, Adili Reheman, MD, June Li, BSc, Heyu Ni, MD, PhD

Blood (2012) 120 (21): 382.

https://doi.org/10.1182/blood.V120.21.382.382

Published: 2012

Journal Articles

Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy

Pingguo Chen, Conglei Li, Sean Lang, Guangheng Zhu, Adili Reheman, Christopher M. Spring, John Freedman, Heyu Ni

Blood (2010) 116 (18): 3660–3668.

https://doi.org/10.1182/blood-2010-05-284919

Published: 2010

Journal Articles

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8 + T cell–mediated responses that are differentially sensitive to therapy

Leola Chow, Rukhsana Aslam, Edwin R. Speck, Michael Kim, Norman Cridland, Michelle Lee Webster, Pingguo Chen, Kim Sahib, Heyu Ni, Alan H. Lazarus, M. Bernadette Garvey, John Freedman, John W. Semple

Blood (2010) 115 (6): 1247–1253.

https://doi.org/10.1182/blood-2009-09-244772

Published: 2010

Includes: Supplemental data

Journal Articles

Administration of Anti-Platelet Antibodies Prevents the Anti-Platelet Immune Response and Bleeding Complications of Neonatal Immune Thrombocytopenia in a Murine Model.

Heidi Tiller, Pingguo Chen, Bjorn Skogen, Mette Kjaer Killie, Anne Husebekk, Maryana Matviyenko, Jens Kjeldsen-Kragh, Heyu Ni

Blood (2009) 114 (22): 223.

https://doi.org/10.1182/blood.V114.22.223.223

Published: 2009

Journal Articles

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

Hong Yang, Sean Lang, Zhimin Zhai, Ling Li, Walter H. A. Kahr, Pingguo Chen, Jelena Brkić, Christopher M. Spring, Matthew J. Flick, Jay L. Degen, John Freedman, Heyu Ni

Blood (2009) 114 (2): 425–436.

https://doi.org/10.1182/blood-2008-03-145821

Published: 2009

Journal Articles

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

Leola Chow, PhD, Michael Kim, BSc, Edwin R. Speck, BRT, Rukhsana Aslam, PhD, Michelle Lee Webster, MSc, Pingguo Chen, PhD, Heyu Ni, MD, PhD, John Freedman, MD, John W. Semple, PhD

Blood (2008) 112 (11): 399.

https://doi.org/10.1182/blood.V112.11.399.399

Published: 2008

Journal Articles

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Hong Yang, MD, Sean Lang, BSc, Zhimin Zhai, MD, Christopher M. Spring, MSc, Adili Reheman, MD, Pingguo Chen, PhD, Matthew J. Flick, PhD, Jay L. Degen, PhD, Ling Li, MSc, Walter H.A. Kahr, MD, PhD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2008) 112 (11): 2868.

https://doi.org/10.1182/blood.V112.11.2868.2868

Published: 2008

Journal Articles

Maternal Immune Response to Fetal Platelet GPIbα Causes More Frequent Miscarriage in An Animal Model: A Potential Explanation for Low Reported Incidence of Fetal and Neonatal Immune Thrombocytopenia Mediated by Anti-GPIbα Antibodies.

Conglei Li, MD, Siavash Piran, MSc., Pingguo Chen, PhD, Sean Lang, BSc., Jerry Ware, PhD, Zaverio M. Ruggeri, MD, John Freedman, MD, Heyu Ni, MD, PhD

Blood (2008) 112 (11): 3426.

https://doi.org/10.1182/blood.V112.11.3426.3426

Published: 2008

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The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation

Targeting β3 Integrin Psi Domain Inhibits Both Platelet Aggregation and Blood Coagulation: Two Birds with One Stone

Maternal Anti-αIIb Antibodies Target Fetal Hematopoietic Stem Cells and May Lead to Pancytopenia and Miscarriage in Fnait

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy

Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation

Natural Killer Cells Contribute to Pathophysiology of Placenta Leading to Miscarriage in Fetal and Neonatal Alloimmune Thrombocytopenia

CD8 + T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia

Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe

Unveiling the Regulatory Role of CD8+ T-Cells in the Pathogenesis and Effective Steroid Treatment in ITP

Maternal Anti-Platelet β3 Integrin Antibodies Impair Angiogenesis and Cause Intracranial Hemorrhage in Fetal and Neonatal Alloimmune Thrombocytopenia

CD8+ T Cells Are Predominantly Protective In a Murine Model Of ITP and Is Required For Effective Steroid Therapy

Novel Murine Models Of Fetal and Neonatal Alloimmune Thrombocytopenia Established In αIIb Deficient and Human αIIb Transgenic Mice

Psi Domain of b3 Integrin Has Endogenous Thiol Isomerase Function and Is a Potential New Target for Anti-Thrombotic Therapy

Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8 + T cell–mediated responses that are differentially sensitive to therapy

Administration of Anti-Platelet Antibodies Prevents the Anti-Platelet Immune Response and Bleeding Complications of Neonatal Immune Thrombocytopenia in a Murine Model.

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

Antibody- and Cell-Mediated Immune Thrombocytopenia Are Differentially Sensitive to Intravenous Gammaglobulin Therapy

Engagement of Fibrinogen and β3 Integrin Is Required for Maintenance of Platelet Intracellular and Cell Surface P-Selectin Expression

Maternal Immune Response to Fetal Platelet GPIbα Causes More Frequent Miscarriage in An Animal Model: A Potential Explanation for Low Reported Incidence of Fetal and Neonatal Immune Thrombocytopenia Mediated by Anti-GPIbα Antibodies.

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