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Journal Articles

Extra-Splenic Role of B Cell Activating Factor Blockade in Prevention of Factor VIII Inhibitors

Bhavya S Doshi, Mostafa A Shaheen, Juliana C Small, Paris Margaritis, Valder R Arruda

Blood (2021) 138 (Supplement 1): 1025.

https://doi.org/10.1182/blood-2021-149259

Published: 2021

Journal Articles

The Endothelial Protein C Receptor (EPCR) Regulates Endogenous Factor VII Levels in Mice

Juliana Small, PhD, Shannon Zintner, PhD, Lynn E Dankner, Paris Margaritis, DPhil

Blood (2019) 134 (Supplement_1): 3629.

https://doi.org/10.1182/blood-2019-130596

Published: 2019

Journal Articles

Characterization of the Interaction of Activated FVII with the Endothelial Protein C Receptor (EPCR) in the Rat

Juliana Small, PhD, Shannon Zintner, PhD, Lynn E Dankner, Paris Margaritis, DPhil

Blood (2018) 132 (Supplement 1): 2455.

https://doi.org/10.1182/blood-2018-99-116892

Published: 2018

Journal Articles

Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII

Oscar A. Marcos-Contreras, Shannon M. Smith, Dwight A. Bellinger, Robin A. Raymer, Elizabeth Merricks, Armida Faella, Giulia Pavani, Shangzhen Zhou, Timothy C. Nichols, Katherine A. High, Paris Margaritis

Blood (2016) 127 (5): 565–571.

https://doi.org/10.1182/blood-2015-09-671420

Published: 2016

Includes: Supplemental data

Journal Articles

A Single Amino Acid in the Gla Domain Mouse FVIIa Allows Its Binding to the Endothelial Protein C Receptor and Enhances Its Coagulant Activity In Vivo

Giulia Pavani, PhD, Lacramioara Ivanciu, PhD, Katherine A. Stafford, Paris Margaritis, DPhil

Blood (2015) 126 (23): 3489.

https://doi.org/10.1182/blood.V126.23.3489.3489

Published: 2015

Journal Articles

VKORc1 Is Under-Expressed in Skeletal Muscle of Humans, Dogs and Mice: Potential Implications for Ectopic Coagulation Factor Expression in Pre-Clinical and Therapeutic Applications

Courtney T Connolly, Armida Faella, Timothy C. Nichols, MD, Katherine A. High, MD, Valder R. Arruda, MD, PhD, Paris Margaritis, DPhil

Blood (2014) 124 (21): 1477.

https://doi.org/10.1182/blood.V124.21.1477.1477

Published: 2014

Journal Articles

Sequence Determinants of Mouse Protein C Interaction with Mouse Endothelial Protein C Receptor

Giulia Pavani, PhD, Katherine A. Stafford, Paris Margaritis, DPhil

Blood (2014) 124 (21): 4227.

https://doi.org/10.1182/blood.V124.21.4227.4227

Published: 2014

Journal Articles

Improved Factor VIII Expression with the Introduction of a PACE-Furin Variant into Codon-Optimized Human Factor VIII

Liron Elkouby, PhD, Robert J. Davidson, Paris Margaritis, DPhil, Katherine A. High, MD, Denise E. Sabatino, PhD

Blood (2014) 124 (21): 3498.

https://doi.org/10.1182/blood.V124.21.3498.3498

Published: 2014

Journal Articles

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo

Giulia Pavani, Lacramioara Ivanciu, Armida Faella, Oscar A. Marcos-Contreras, Paris Margaritis

Blood (2014) 124 (7): 1157–1165.

https://doi.org/10.1182/blood-2014-04-567297

Published: 2014

Includes: Supplemental data

Journal Articles

Does rFVIIa work solo in hemophilia?

Paris Margaritis

Blood (2014) 123 (11): 1631–1633.

https://doi.org/10.1182/blood-2014-01-551275

Published: 2014

Journal Articles

Insights Into the Mechanism of Zymogen Protein C Protection Against Cancer Progression

Julie M Crudele, BA, Geerte L. Van Sluis, MD, Paris Margaritis, DPhil, Joshua I Siner, Michael Sliozberg, Jenna Maurer, Armida Faella, Shangzhen Zhou, MD, Katherine A. High, MD, Charles T Esmon, PhD, C. Arnold Spek, PhD, Valder R Arruda, MD, PhD

Blood (2012) 120 (21): 3350.

https://doi.org/10.1182/blood.V120.21.3350.3350

Published: 2012

Journal Articles

Delivery of a Modified U1 Small Nuclear RNA Alleviates Splicing-Defective Coagulation Factor VII Expression in Mouse Models

Dario Balestra, PhD, Armida Faella, Nicola Cavallari, PhD, Paris Margaritis, PhD, Franco Pagani, MD, Francesco Bernardi, PhD, Valder R Arruda, MD, PhD, Mirko Pinotti, PhD

Blood (2012) 120 (21): 754.

https://doi.org/10.1182/blood.V120.21.754.754

Published: 2012

Journal Articles

FVIIa Binding to the Endothelial Protein C Receptor Reduces Protein Recovery in Vivo

Giulia Pavani, MS, Lacramioara Ivanciu, PhD, Paris Margaritis, DPhil

Blood (2012) 120 (21): 18.

https://doi.org/10.1182/blood.V120.21.18.18

Published: 2012

Journal Articles

Novel Solution and Membrane-Based Assays Reveal Lack of Interaction Between Murine FVIIa and Murine EPCR

Giulia Pavani, MS, Paris Margaritis, DPhil

Blood (2011) 118 (21): 531.

https://doi.org/10.1182/blood.V118.21.531.531

Published: 2011

Journal Articles

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo

Paris Margaritis, Elise Roy, Armida Faella, Harre D. Downey, Lacramioara Ivanciu, Giulia Pavani, Shangzhen Zhou, Ralph M. Bunte, Katherine A. High

Blood (2011) 117 (15): 3974–3982.

https://doi.org/10.1182/blood-2010-09-309732

Published: 2011

Includes: Supplemental data

Journal Articles

Zymogen Protein C as a Novel Modulator of Cancer Progression In Murine Models

Geerte L. Van Sluis, Paris Margaritis, DPhil, Michael Sliozberg, Jenna Mauer, Armida Faella, Shangzhen Zhou, Katherine A. High, MD, Arnold Spek, Valder R. Arruda, MD, PhD

Blood (2010) 116 (21): 718.

https://doi.org/10.1182/blood.V116.21.718.718

Published: 2010

Journal Articles

Efficacy and Safety of Continuous Expression of An Improved Variant of FVIIa On Murine Hemostasis with or without Inhibitors to Human Factor IX.

Elise Roy, Armida Faella, Harre Downey, Lacramioara Ivanciu, Ph.D., Shangzhen Zhou, Katherine A. High, MD, Paris Margaritis, D.Phil

Blood (2009) 114 (22): 2466.

https://doi.org/10.1182/blood.V114.22.2466.2466

Published: 2009

Journal Articles

Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Paris Margaritis, Elise Roy, Majed N. Aljamali, Harre D. Downey, Urs Giger, Shangzhen Zhou, Elizabeth Merricks, Aaron Dillow, Mirella Ezban, Timothy C. Nichols, Katherine A. High

Blood (2009) 113 (16): 3682–3689.

https://doi.org/10.1182/blood-2008-07-168377

Published: 2009

Journal Articles

Nonsense Suppression Approaches in Treating Hemophilia

Yi-Lin Liu, Paris Margaritis, Fayaz Khazi, Harre Downey, Stephan Kadauke, Nicole Hasbrouck, Josephine Sheedy, Ellen Welch, Marla Weetall, Katherine A. High, MD

Blood (2008) 112 (11): 512.

https://doi.org/10.1182/blood.V112.11.512.512

Published: 2008

Journal Articles

Successful and Safe Treatment of Canine Hemophilia by Continuous Expression of Canine FVIIa: a Model for FVIII/FIX Gene-Based Bypassing Agents

Paris Margaritis, Elise Roy, Majed N Aljamali, Harre Downey, Shangzhen Zhou, Elizabeth Merricks, Aaron Dillow, Timothy C Nichols, Katherine A. High, MD

Blood (2008) 112 (11): lba-4.

https://doi.org/10.1182/blood.V112.11.lba-4.lba-4

Published: 2008

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Extra-Splenic Role of B Cell Activating Factor Blockade in Prevention of Factor VIII Inhibitors

The Endothelial Protein C Receptor (EPCR) Regulates Endogenous Factor VII Levels in Mice

Characterization of the Interaction of Activated FVII with the Endothelial Protein C Receptor (EPCR) in the Rat

Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII

A Single Amino Acid in the Gla Domain Mouse FVIIa Allows Its Binding to the Endothelial Protein C Receptor and Enhances Its Coagulant Activity In Vivo

VKORc1 Is Under-Expressed in Skeletal Muscle of Humans, Dogs and Mice: Potential Implications for Ectopic Coagulation Factor Expression in Pre-Clinical and Therapeutic Applications

Sequence Determinants of Mouse Protein C Interaction with Mouse Endothelial Protein C Receptor

Improved Factor VIII Expression with the Introduction of a PACE-Furin Variant into Codon-Optimized Human Factor VIII

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo

Does rFVIIa work solo in hemophilia?

Insights Into the Mechanism of Zymogen Protein C Protection Against Cancer Progression

Delivery of a Modified U1 Small Nuclear RNA Alleviates Splicing-Defective Coagulation Factor VII Expression in Mouse Models

FVIIa Binding to the Endothelial Protein C Receptor Reduces Protein Recovery in Vivo

Novel Solution and Membrane-Based Assays Reveal Lack of Interaction Between Murine FVIIa and Murine EPCR

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo

Zymogen Protein C as a Novel Modulator of Cancer Progression In Murine Models

Efficacy and Safety of Continuous Expression of An Improved Variant of FVIIa On Murine Hemostasis with or without Inhibitors to Human Factor IX.

Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Nonsense Suppression Approaches in Treating Hemophilia

Successful and Safe Treatment of Canine Hemophilia by Continuous Expression of Canine FVIIa: a Model for FVIII/FIX Gene-Based Bypassing Agents

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