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Journal Articles

Identification of NAE1-dependent β-catenin neddylation as selective vulnerability in B-cell malignancies

Kadriye Nehir Cosgun, Takeshi Ito, Mark Robinson, Esma Fera, Salim Oulghazi, Yanzhi Feng, Jodi Forward, Tianhao Yin, Gang Xin, Sidi Chen, Matthew S Davids, Markus Müschen

Blood (2025) 146 (Supplement 1): 5042.

https://doi.org/10.1182/blood-2025-5042

Published: 2025

Journal Articles

Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia

Zhangliang Cheng, Kohei Kume, Ruoyi Shi, Mark Robinson, Kadriye Nehir Cosgun, Yujin Bao, Siyi Chen, Pranav Mishra, Joerg Bewersdorf, Mina Xu, Markus Müschen

Blood (2025) 146 (Supplement 1): 1485.

https://doi.org/10.1182/blood-2025-1485

Published: 2025

Journal Articles

Harnessing repressive LEF1/β-catenin complexes to overcome drug resistance in chronic lymphocytic leukemia

Kadriye Nehir Cosgun, Takeshi Ito, Mark Robinson, Esma Fera, Pranav Mishra, Jodi Forward, Prajish Iyer, Lili Wang, Tiziana Vaisitti, Silvia Deaglio, Maike Buchner, Hai-Hui Xue, Matthew S Davids, Markus Müschen

Blood (2025) 146 (Supplement 1): 5659.

https://doi.org/10.1182/blood-2025-5659

Published: 2025

Journal Articles

Targeting immunoproteasome-dependent β-catenin degradation as a therapeutic strategy in Relapsed/Refractory acute lymphoblastic leukemia

Jodi Forward, Kadriye Nehir Cosgun, Tianhao Yin, Esma Fera, Deepa Bhojwani, David Teachey, Markus Müschen

Blood (2025) 146 (Supplement 1): 5092.

https://doi.org/10.1182/blood-2025-5092

Published: 2025

Journal Articles

Apoptotic rewiring via PI3K hyperactivation as a therapeutic strategy in B-cell malignancies

Stephen Martindale, Etienne Leveille, Jing Wang, Takeshi Ito, Kadriye Nehir Cosgun, Matthew S Davids, Markus Müschen

Blood (2025) 146 (Supplement 1): 437.

https://doi.org/10.1182/blood-2025-437

Published: 2025

Journal Articles

Targeted hyperactivation of oncogenic STAT5-signaling in acute lymphoblastic leukemia

Kohei Kume, Zhangliang Cheng, Jian Xin Lin, Liang Xu, Gang Xiao, Mark Robinson, Etienne Leveille, Eden Bramson, Kadriye Nehir Cosgun, Huimin Geng, Merja Heinäniemi, Thomas Graeber, Janis Abkowitz, Hongbo Chi, Warren Alexander, Roberto Chiarle, Warren Leonard, Markus Müschen

Blood (2025) 146 (Supplement 1): 433.

https://doi.org/10.1182/blood-2025-433

Published: 2025

Journal Articles

Targeting β-catenin nuclear export and protein degradation in high-risk acute lymphoblastic leukemia

Jodi Forward, Kadriye Nehir Cosgun, Esma Fera, Deepa Bhojwani, David Teachey, Markus Müschen

Blood (2025) 146 (Supplement 1): 3371.

https://doi.org/10.1182/blood-2025-3371

Published: 2025

Journal Articles

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Zhangliang Cheng, Salim Oulghazi, Philipp Berning, David Fonseca-Arce, Kohei Kume, Jake Fontaine, Lai N Chan, Jaewoong Lee, Fang Yu, Zhijian Qian, Joo Y. Song, Wing Chung Chan, Jianjun Chen, Mark M Taketo, Hilde Schjerven, Markus Müschen

Blood (2024) 144 (Supplement 1): 4125.

https://doi.org/10.1182/blood-2024-208125

Published: 2024

Journal Articles

Mechanism of Negative Feedback Regulation of Oncogenic BCR-Signaling in Mature B-Cell Lymphoma

Ruifeng Sun, Jaewoong Lee, Mark E Robinson, Kohei Kume, Chuanzong Zhan, Zhangliang Cheng, Kadriye Nehir Cosgun, Lai N Chan, Etienne Leveille, Shalin Kothari, Samuel G. Katz, Ning Ma, Vivasvan S Vykunta, Brian Shy, Daniel J Hodson, Alexander Marson, Nagarajan Vaidehi, Markus Müschen

Blood (2024) 144 (Supplement 1): 3003.

https://doi.org/10.1182/blood-2024-211693

Published: 2024

Journal Articles

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

Ruifeng Sun, Jaewoong Lee, Dewan Artadji, Mark E Robinson, Kohei Kume, Zhangliang Cheng, Kadriye Nehir Cosgun, Lai N Chan, Etienne Leveille, Ning Ma, Huimin Geng, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2024) 144 (Supplement 1): 632.

https://doi.org/10.1182/blood-2024-211038

Published: 2024

Journal Articles

Targeting β-Catenin Protein Degradation in Refractory B-Cell Malignancies

Kadriye Nehir Cosgun, Mark E Robinson, Nikol Agadzhanian, Philipp Berning, David Fonseca-Arce, Etienne Leveille, Shalin Kothari, Matthew S. Davids, Julia Jellusova, Markus Müschen

Blood (2024) 144 (Supplement 1): 1412.

https://doi.org/10.1182/blood-2024-208598

Published: 2024

Journal Articles

Identification of Nuclear NAD+ Salvage As a Therapeutic Vulnerability in B-Lymphoid Malignancies

Mark E Robinson, Qin Li, Chang Zhang, Chuanzong Zhan, Zhangliang Cheng, Kohei Kume, Kadriye Nehir Cosgun, Shalin Kothari, Nikol Agadzhanian, Daisuke Nakada, Markus Müschen

Blood (2024) 144 (Supplement 1): 4164.

https://doi.org/10.1182/blood-2024-205729

Published: 2024

Journal Articles

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Ruifeng Sun, Jaewoong Lee, Mark E Robinson, Kohei Kume, Ning Ma, Kadriye Nehir Cosgun, Lai N Chan, Irina Antoshkina, Dhruv Khanduja, Etienne Leveille, Samuel G. Katz, Jianjun Chen, Elisabeth Paietta, Nagarajan Vaidehi, Markus Müschen

Blood (2023) 142 (Supplement 1): 719.

https://doi.org/10.1182/blood-2023-189742

Published: 2023

Journal Articles

Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies

Franz Ketzer, Lars Klemm, Mark E Robinson, Christian Loucks, David Fonseca Arce, Kadriye Nehir Cosgun, Shalin Kothari, Markus Müschen

Blood (2023) 142 (Supplement 1): 1396.

https://doi.org/10.1182/blood-2023-189221

Published: 2023

Journal Articles

The Transcriptional Landscape of Ph+B-ALL Is Orchestrated By Long-Range Enhancer-Promoter Interactions and the Coordinated Action of Phosphorylation-Dependent and Phosphorylation-Independent Transcription Factors

Han Leng Ng, Mark E Robinson, Valeria Malysheva, Ozgen Deniz, Nicholas Crump, Kadriye Nehir Cosgun, Kaiyue Helian, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn

Blood (2023) 142 (Supplement 1): 2779.

https://doi.org/10.1182/blood-2023-173435

Published: 2023

Journal Articles

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Blood (2023) 142 (Supplement 1): 2818.

https://doi.org/10.1182/blood-2023-190522

Published: 2023

Journal Articles

Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies

Kohei Kume, Jaewoong Lee, Zhangliang Cheng, Mark E Robinson, Etienne Leveille, Kadriye Nehir Cosgun, Lai N Chan, Yanzhi Feng, David Fonseca Arce, Dhruv Khanduja, Derek Toomre, Markus Müschen

Blood (2023) 142 (Supplement 1): 4138.

https://doi.org/10.1182/blood-2023-190926

Published: 2023

Journal Articles

STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia

Kohei Kume, Zhengshan Chen, Mark E Robinson, Lai N Chan, Etienne Leveille, Kadriye Nehir Cosgun, Zhangliang Cheng, David Fonseca Arce, Dhruv Khanduja, Thomas Graeber, Markus Müschen

Blood (2023) 142 (Supplement 1): 2977.

https://doi.org/10.1182/blood-2023-191006

Published: 2023

Journal Articles

Computational Discovery and Validation of NAD+ Biosynthesis As Unique Vulnerability in B-Lymphoid Malignancies

Qin Li, Mark E Robinson, Etienne Leveille, Chang Zhang, Ruifeng Sun, Zhangliang Cheng, Kohei Kume, Kadriye Nehir Cosgun, Shalin Kothari, Dhruv Khanduja, Daisuke Nakada, Markus Müschen

Blood (2023) 142 (Supplement 1): 418.

https://doi.org/10.1182/blood-2023-190269

Published: 2023

Journal Articles

Immunoglobulin Light Chains Control Permissiveness to Malignant B-Cell Transformation By RAS-Pathway Lesions

Lai N Chan, Kohei Kume, Christian Hurtz, Mark E Robinson, Kadriye Nehir Cosgun, Markus Müschen

Blood (2023) 142 (Supplement 1): 2974.

https://doi.org/10.1182/blood-2023-190163

Published: 2023

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Identification of NAE1-dependent β-catenin neddylation as selective vulnerability in B-cell malignancies

Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia

Harnessing repressive LEF1/β-catenin complexes to overcome drug resistance in chronic lymphocytic leukemia

Targeting immunoproteasome-dependent β-catenin degradation as a therapeutic strategy in Relapsed/Refractory acute lymphoblastic leukemia

Apoptotic rewiring via PI3K hyperactivation as a therapeutic strategy in B-cell malignancies

Targeted hyperactivation of oncogenic STAT5-signaling in acute lymphoblastic leukemia

Targeting β-catenin nuclear export and protein degradation in high-risk acute lymphoblastic leukemia

Identification of High-Efficiency β-Catenin Protein Degradation As Critical Vulnerability in B-Cell Malignancies

Mechanism of Negative Feedback Regulation of Oncogenic BCR-Signaling in Mature B-Cell Lymphoma

PKCδ-Mediated Phosphorylation of CD25 Initiates Feedback Control of Oncogenic Tyrosine Kinases in Acute Lymphoblastic Leukemia

Targeting β-Catenin Protein Degradation in Refractory B-Cell Malignancies

Identification of Nuclear NAD+ Salvage As a Therapeutic Vulnerability in B-Lymphoid Malignancies

Dynamic Recruitment of Inhibitory Complexes Controls Oncogenic Signaling in B-Cell Malignancies

Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies

The Transcriptional Landscape of Ph+B-ALL Is Orchestrated By Long-Range Enhancer-Promoter Interactions and the Coordinated Action of Phosphorylation-Dependent and Phosphorylation-Independent Transcription Factors

Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies

Optogenetic Control of Oncogenic Signaling in B-Cell Malignancies

STAT5-Feedback Controls Distinct Metabolic States for Dynamic Transitions between Cellular Activation and Quiescence in Acute Lymphoblastic Leukemia

Computational Discovery and Validation of NAD+ Biosynthesis As Unique Vulnerability in B-Lymphoid Malignancies

Immunoglobulin Light Chains Control Permissiveness to Malignant B-Cell Transformation By RAS-Pathway Lesions

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American Society of Hematology

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