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Journal Articles

Phase III Randomized COMMODORE 2 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Naive to Complement Inhibition

Alexander Röth, Guangsheng He, Andres Brodsky, Chatree Chai-Adisaksopha, Narcisa Sonia Comia, Anna Gaya, Martin Höglund, Richard J. Kelly, Ahlam Naila Kori, Je-Hwan Lee, Naoshi Obara, Antonio M Risitano, Anita Appius, Leigh Beveridge, Brittany Gentile, Zilu Zhang, Bing Han, Sasha Sreckovic

Blood (2024) 144 (Supplement 1): 2687.

https://doi.org/10.1182/blood-2024-208072

Published: 2024

Journal Articles

Long-Term Follow-up of Patients with Aplastic Anemia Enrolled in Phase 2/3 Trials of Immunosuppressive Therapy Plus Romiplostim As a First-Line Treatment: Two-Year Interim Analysis

Blood (2024) 144 (Supplement 1): 1310.

https://doi.org/10.1182/blood-2024-193925

Published: 2024

Journal Articles

Dynamics of Red Blood Cell Hematopoiesis Following ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation

Yusuke Kiyoki, Yumiko Maruyama, Yuzuki Maruyama, Yusuke Arai, Takuya Oda, Takumi Kaieda, Toshihiro Miyakoshi, Yutaro Tarui, Fumiaki Matsumura, Yasuhito Suehara, Keiichiro Hattori, Tatsuhiro Sakamoto, Takayasu Kato, Naoki Kurita, Yasuhisa Yokoyama, Naoshi Obara, Hidekazu Nishikii, Shigeru Chiba, Mamiko Sakata-Yanagimoto

Blood (2024) 144 (Supplement 1): 7102.

https://doi.org/10.1182/blood-2024-201915

Published: 2024

Journal Articles

Tumor Necrosis Factor from Leukemic Microenvironment Provides Non-Leukemic Hematopoietic Stem Cells with Megakaryocyte Lineage Bias

Hidekazu Nishikii, Mizuki Saito, Takaharu Kimura, Yusuke Kiyoki, Takayasu Kato, Tatsuhiro Sakamoto, Mamiko Sakata-Yanagimoto, Naoshi Obara, Satoshi Yamazaki, Shigeru Chiba

Blood (2022) 140 (Supplement 1): 5774–5775.

https://doi.org/10.1182/blood-2022-162978

Published: 2022

Journal Articles

Real-World Treatment Patterns, Outcomes and Disease Burden of Japanese Patients with High-Risk Myelodysplastic Syndrome: A Claims Database Study

Naoshi Obara, Hirotomo Shioi, Shi Hong Ooi, Hao Zhe Tay, Tze Fang Wong

Blood (2022) 140 (Supplement 1): 12327–12328.

https://doi.org/10.1182/blood-2022-162196

Published: 2022

Journal Articles

Elongation of Long-Chain Fatty Acids Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation

Takayasu Kato, Yusuke Kiyoki, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, Shigeru Chiba

Blood (2022) 140 (Supplement 1): 728–729.

https://doi.org/10.1182/blood-2022-165818

Published: 2022

Journal Articles

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

Yasutaka Ueda, Kohei Hosokawa, Ken Ishiyama, Hiroyuki Takamori, Yuji Yonemura, Naoshi Obara, Hideyoshi Noji, Kiyoshi Ando, Tsutomu Shichishima, Takayuki Ikezoe, Shigeru Chiba, Haruhiko Ninomiya, Tatsuya Kawaguchi, Jun-ichi Nishimura, Yuzuru Kanakura, Shinji Nakao

Blood (2021) 138 (Supplement 1): 1122.

https://doi.org/10.1182/blood-2021-146353

Published: 2021

Journal Articles

Distinct Bone Marrow Microenvironment Abnormalities in MDS and MPN with Fibrosis

Cao Sy Luan, MS, Yoshiaki Takahoko, MS, Hidekazu Nishikii, MD PhD, Naoshi Obara, MD PhD, Tatsuhiro Sakamoto, MD PhD, Takayasu Kato, MD PhD, Keiichiro Hattori, MD PhD, Ryota Matsuoka, MD PhD, Shingo Sakashita, MD PhD, Yasuhito Nannya, MD PhD, Hideki Makishima, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Seishi Ogawa, MD PhD, Shigeru Chiba, MD PhD

Blood (2019) 134 (Supplement_1): 2976.

https://doi.org/10.1182/blood-2019-129423

Published: 2019

Journal Articles

Liquid Biopsy for the Identification of Intravascular Large B-Cell Lymphoma

Blood (2017) 130 (Supplement 1): 378.

https://doi.org/10.1182/blood.V130.Suppl_1.378.378

Published: 2017

Journal Articles

Baseline Assessment of Patients with Newly-Diagnosed Acquired Bone Marrow Failure Enrolled in a Prospective Observational Study, "Search for Unidentified Links between PNH Clone Size and the Related Clinical Manifestations By High Precision Flow Cytometry (SUPREMACY)"

Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Ken Ishiyama, MD PhD, Chiharu Sugimori, MD PhD, Kohei Hosokawa, Naoshi Obara, MD PhD, Hideyoshi Noji, MD PhD, Yukari Shirasugi, MD PhD, Yasutaka Ueda, MD PhD, Hiroyuki Takamori, MD PhD, Tsutomu Shichishima, MD PhD, Shigeru Chiba, MD PhD, Haruhiko Ninomiya, MD PhD, Kiyoshi Ando, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Masanori Takahashi, Shinji Nakao, MD PhD

Blood (2017) 130 (Supplement 1): 2466.

https://doi.org/10.1182/blood.V130.Suppl_1.2466.2466

Published: 2017

Journal Articles

Effects of Eculizumab Treatment on the Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated in Japan

Yasutaka Ueda, MD PhD, Naoshi Obara, MD PhD, Yuji Yonemura, MD PhD, Hideyoshi Noji, MD PhD, Takahisa Matsuda, Hirozumi Akiyama, Takayuki Ikezoe, MD, PhD, Shigeru Chiba, MD PhD, Yoshinobu Kanda, MD PhD, Tatsuya Kawaguchi, MD PhD, Tsutomu Shichishima, MD PhD, Hideki Nakakuma, MD PhD, Shinichiro Okamoto, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Haruhiko Ninomiya, MD PhD

Blood (2017) 130 (Supplement 1): 4749.

https://doi.org/10.1182/blood.V130.Suppl_1.4749.4749

Published: 2017

Journal Articles

Notch Signaling in Bone Marrow Nestin-Expressing Cells Controls Balance of Erythropoiesis at the Bone Marrow and Spleen

Tatsuhiro Sakamoto, MD, Naoshi Obara, MDPhD, Takayasu Kato, MD PhD, Luan Cao Sy, Hidekazu Nishikii, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Satoru Takahashi, MDPhD, Shigeru Chiba, MD, PhD

Blood (2016) 128 (22): 432.

https://doi.org/10.1182/blood.V128.22.432.432

Published: 2016

Journal Articles

The First Follow-up Data Analysis of Patients with Acquired Bone Marrow Failure Harboring a Small Population of PNH-Type Cells in the Japanese, Multicenter, Prospective Study Optima

Yasutaka Ueda, MD PhD, Jun-Ichi Nishimura, MD PhD, Chiharu Sugimori, MD PhD, Kohei Hosokawa, MDPhD, Yuji Yonemura, MD PhD, Naoshi Obara, MDPhD, Hideyoshi Noji, MD PhD, Yoshihiko Nakamura, PhD, Yukari Shirasugi, MD PhD, Kiyoshi Ando, Tsutomu Shichishima, MD PhD, Haruhiko Ninomiya, MD PhD, Shigeru Chiba, MD, PhD, Tatsuya Kawaguchi, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2016) 128 (22): 3896.

https://doi.org/10.1182/blood.V128.22.3896.3896

Published: 2016

Journal Articles

Abnormal Increase in a Distinct Subset of Nestin-Expressing Cells in the Bone Marrow of Myelodysplastic Syndromes

Luan Cao-Sy, MS, Naoshi Obara, MD PhD, Tatsuhiro Sakamoto, MD, Takayasu Kato, MD PhD, Hidekazu Nishikii, MD, PhD, Mamiko Sakata-Yanagimoto, MD PhD, Shigeru Chiba, MD, PhD

Blood (2016) 128 (22): 3887.

https://doi.org/10.1182/blood.V128.22.3887.3887

Published: 2016

Journal Articles

Genetic Predispositions to Myeloid Neoplasms Caused By Germline DDX41 Mutations

June Takeda, MD, Kenichi Yoshida, MD PhD, Hideki Makishima, MD PhD, Tetsuichi Yoshizato, MD, Yusuke Shiozawa, MD, Yuichi Shiraishi, MD PhD, Yusuke Okuno, MD PhD, Ayana Kon, MD PhD, Yasunobu Nagata, MDPhD, Keisuke Kataoka, MD PhD, Kenichi Chiba, BA, Hiroko Tanaka, BA, Masashi Sanada, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Naoshi Obara, MD PhD, Tsuyoshi Nakamaki, MD, Ken Ishiyama, MD PhD, Akira Haigaishi, MDPhD, Shigeru Chiba, MD, PhD, Hiraku Mori, MDPhD, Norio Asou, MD PhD, Hitoshi Kiyoi, MD, Chikara Hirase, MDPhD, Kiyotoshi Imai, MD PhD, Nobuaki Dobashi, MD, Toru Kiguchi, MDPhD, Yasushi Miyazaki, MD PhD, Tomoki Naoe, MD PhD, Satoru Miyano, MD PhD, Kensuke Usuki, MDPhD, Shuichi Miyawaki, MDPhD, Yoichiro Kamatani, MDPhD, Yukihide Momozawa, MD PhD, Michiaki Kubo, MD PhD, Chantana Polprasert, MD, Jaroslaw P. Maciejewski, MD PhD, Seishi Ogawa, MD PhD

Blood (2015) 126 (23): 2843.

https://doi.org/10.1182/blood.V126.23.2843.2843

Published: 2015

Journal Articles

An Interim 4-Year Analysis of Prospective Multicenter Observational Study of PNH-Type Cells in Japanese Patients with Bone Marrow Failure Syndrome (OPTIMA study)

Yukari Shirasugi, MD PhD, Hideyoshi Noji, MD PhD, Tsutomu Shichishima, MD PhD, Chiharu Sugimori, MD PhD, Naoshi Obara, MDPhD, Shigeru Chiba, MD, PhD, Haruhiko Ninomiya, MD PhD, Yoshihiko Nakamura, PhD, Kiyoshi Ando, MD PhD, Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Kohei Hosokawa, MDPhD, Yasutaka Ueda, MDPhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2015) 126 (23): 4781.

https://doi.org/10.1182/blood.V126.23.4781.4781

Published: 2015

Journal Articles

Analysis of 3 Year Post Marketing Surveillance of Eculizumab in Japan

Blood (2014) 124 (21): 4870.

https://doi.org/10.1182/blood.V124.21.4870.4870

Published: 2014

Journal Articles

The Interim Analysis of the Optima (observation of GPI-anchored protein-deficient [PNH-type]) Cells in Japanese Patients with Bone Marrow Failure Syndrome and in Those Suspected of Having PNH) Study

Hideyoshi Noji, MD PhD, Tsutomu Shichishima, MD PhD, Chiharu Sugimori, MD PhD, Naoshi Obara, MD PhD, Kohei Hosokawa, MDPhD, Shigeru Chiba, MD PhD, Yoshihiko Nakamura, MD PhD, Kiyoshi Ando, MD PhD, Satoru Hayashi, MD PhD, Yuji Yonemura, MD PhD, Tatsuya Kawaguchi, MD PhD, Haruhiko Ninomiya, MD PhD, Jun-ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD, Shinji Nakao, MD PhD

Blood (2014) 124 (21): 1595.

https://doi.org/10.1182/blood.V124.21.1595.1595

Published: 2014

Journal Articles

A Novel Diagnostic Method For AITL By Detecting RHOA G17V Hotspot Mutation Using Allele-Specific Real-Time PCR

Blood (2013) 122 (21): 3000.

https://doi.org/10.1182/blood.V122.21.3000.3000

Published: 2013

Journal Articles

Peripherally Inserted Central Catheters Are a Good Option For Venous Access In The Patients With Hematologic Diseases

Naoko Takaiwa, MD, Masanori Seki, MD, PhD, Naoki Kurita, MD, PhD, Yasuhisa Yokoyama, MD, PhD, Mamiko Sakata-Yanagimoto, MD, PhD, Naoshi Obara, MD, PhD, Kazumi Suzukawa, MD, PhD, Yuichi Hasegawa, MD, PhD, Shigeru Chiba, MD, PhD

Blood (2013) 122 (21): 2956.

https://doi.org/10.1182/blood.V122.21.2956.2956

Published: 2013

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Phase III Randomized COMMODORE 2 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Naive to Complement Inhibition

Long-Term Follow-up of Patients with Aplastic Anemia Enrolled in Phase 2/3 Trials of Immunosuppressive Therapy Plus Romiplostim As a First-Line Treatment: Two-Year Interim Analysis

Dynamics of Red Blood Cell Hematopoiesis Following ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation

Tumor Necrosis Factor from Leukemic Microenvironment Provides Non-Leukemic Hematopoietic Stem Cells with Megakaryocyte Lineage Bias

Real-World Treatment Patterns, Outcomes and Disease Burden of Japanese Patients with High-Risk Myelodysplastic Syndrome: A Claims Database Study

Elongation of Long-Chain Fatty Acids Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation

Clinical Significance of Small PNH-Type Cell Populations in Bone Marrow Failure Syndromes - an Interim Analysis of Japanese Multicentrer Prospective Study -

Distinct Bone Marrow Microenvironment Abnormalities in MDS and MPN with Fibrosis

Liquid Biopsy for the Identification of Intravascular Large B-Cell Lymphoma

Baseline Assessment of Patients with Newly-Diagnosed Acquired Bone Marrow Failure Enrolled in a Prospective Observational Study, "Search for Unidentified Links between PNH Clone Size and the Related Clinical Manifestations By High Precision Flow Cytometry (SUPREMACY)"

Effects of Eculizumab Treatment on the Quality of Life in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated in Japan

Notch Signaling in Bone Marrow Nestin-Expressing Cells Controls Balance of Erythropoiesis at the Bone Marrow and Spleen

The First Follow-up Data Analysis of Patients with Acquired Bone Marrow Failure Harboring a Small Population of PNH-Type Cells in the Japanese, Multicenter, Prospective Study Optima

Abnormal Increase in a Distinct Subset of Nestin-Expressing Cells in the Bone Marrow of Myelodysplastic Syndromes

Genetic Predispositions to Myeloid Neoplasms Caused By Germline DDX41 Mutations

An Interim 4-Year Analysis of Prospective Multicenter Observational Study of PNH-Type Cells in Japanese Patients with Bone Marrow Failure Syndrome (OPTIMA study)

Analysis of 3 Year Post Marketing Surveillance of Eculizumab in Japan

The Interim Analysis of the Optima (observation of GPI-anchored protein-deficient [PNH-type]) Cells in Japanese Patients with Bone Marrow Failure Syndrome and in Those Suspected of Having PNH) Study

A Novel Diagnostic Method For AITL By Detecting RHOA G17V Hotspot Mutation Using Allele-Specific Real-Time PCR

Peripherally Inserted Central Catheters Are a Good Option For Venous Access In The Patients With Hematologic Diseases

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