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Journal Articles

NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLLr B-ALL by regulating NR3C1 expression

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Belén Lopez-Millan, Alba Rubio-Gayarre, Meritxell Vinyoles, Juan L. Trincado, Mario F. Fraga, Narcís Fernandez-Fuentes, Mercedes Guerrero-Murillo, Alba Martinez, Talia Velasco-Hernandez, Aïda Falgàs, Carla Panisello, Gemma Valcarcel, José Luis Sardina, Paula López-Martí, Biola M. Javierre, Beatriz Del Valle-Pérez, Antonio García de Herreros, Franco Locatelli, Rob Pieters, Michela Bardini, Giovanni Cazzaniga, Juan Carlos Rodríguez-Manzaneque, Thomas Hanewald, Rolf Marschalek, Thomas A. Milne, Ronald W. Stam, Juan Ramón Tejedor, Pablo Menendez, Clara Bueno
Journal: Blood
Blood (2024) 144 (19): 2002–2017.
https://doi.org/10.1182/blood.2023022050
Published: 2024
Includes: Supplemental data
Journal Articles

Targeting Hyperactivated Lck in PAX5 Rearranged Pediatric B-Cell Precursors Acute Lymphoblastic Leukemia

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Grazia Fazio, Manuel Quadri, Silvia Bresolin, Chiara Palmi, Michela Bardini, Athanasios Oikonomou, Jia-Wey Tu, Katerina Scharov, Alberto Peloso, Titus Watrin, Sanil Bhatia, Arndt Borkhardt, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 3107–3108.
https://doi.org/10.1182/blood-2022-169023
Published: 2022
Journal Articles

Ph-like and IKZF1plus Features in Children with Down Syndrome and B Cell Precursor Acute Lymphoblastic Leukemia

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Chiara Palmi, Silvia Bresolin, Stefanie V. Junk, Grazia Fazio, Daniela Silvestri, Marketa Zaliova, Athanasios Oikonomou, Katerina Scharov, Martin Stanulla, Anja Moericke, Martin Zimmermann, Martin Schrappe, Barbara Buldini, Claudia Saitta, Marta Galbiati, Michela Bardini, Sanil Bhatia, Arndt Borkhardt, Luca Lo Nigro, Valentino Conter, Maria Grazia Valsecchi, Andrea Biondi, Geertruij Te Kronnie, Gunnar Cario, Giovanni Cazzaniga
Journal: Blood
Blood (2022) 140 (Supplement 1): 6367–6368.
https://doi.org/10.1182/blood-2022-169131
Published: 2022
Journal Articles

BCR::ABL1-Positive Acute Lymphoblastic Leukemia: Different Clinical Behavior and Relevance of Prognostic Features in Typical ALL and in CML-like Disease

Free
Jan Zuna, Lenka Hovorkova, Justina Krotka, Amelie Koehrmann, Michela Bardini, Lucie Winkowska, Eva Fronkova, Julia Alten, Rolf Koehler, Cornelia Eckert, Lisa Brizzolara, Jan Stuchly, Martin Zimmermann, Paola De Lorenzo, Maria Grazia Valsecchi, Valentino Conter, Jan Stary, Martin Schrappe, Andrea Biondi, Jan Trka, Marketa Zaliova, Giovanni Cazzaniga, Gunnar Cario
Journal: Blood
Blood (2022) 140 (Supplement 1): 9179–9180.
https://doi.org/10.1182/blood-2022-158926
Published: 2022
Journal Articles

The RNA Binding Protein Musashi-2 (MSI2) Sustains the Growth and the Leukemogenic Potential of MLL-Rearranged Acute Lymphoblastic Leukemia, and It Is Involved in Glucocorticoid Resistance

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Luigia Valsecchi, Simone Naso, Simona Procopio, Mario Mauri, Rocco Piazza, Titus Watrin, Sanil Bhatia, Valentina Pasquale, Elena Sacco, Chiara Palmi, Grazia Fazio, Luca Trentin, Silvia Bresolin, Andrea Biondi, Giovanni Cazzaniga, Michela Bardini
Journal: Blood
Blood (2022) 140 (Supplement 1): 8827–8828.
https://doi.org/10.1182/blood-2022-166313
Published: 2022
Journal Articles

Implication of ICOSLG on Relapse in Infant T(4;11) Acute Lymphoblastic Leukemia

Free
Marius Külp, Anna Lena Siemund, Claus Meyer, Patrizia Larghero, Alissa Dietz, Julia Alten, Gunnar Cario, Aurélie Caye-Eude, Hélène Cavé, Michela Bardini, Paola De Lorenzo, Giovanni Cazzaniga, Laura Diehl, Halvard Bonig, Rolf Marschalek
Journal: Blood
Blood (2021) 138 (Supplement 1): 3481.
https://doi.org/10.1182/blood-2021-146181
Published: 2021
Journal Articles

Recurrent genetic fusions redefine MLL germ line acute lymphoblastic leukemia in infants

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Grazia Fazio, Michela Bardini, Paola De Lorenzo, Andrea Grioni, Manuel Quadri, Lucia Pedace, Lilia Corral Abascal, Sonia Palamini, Chiara Palmi, Barbara Buldini, Luciana Vinti, Rosanna Parasole, Elena Barisone, Marco Zecca, Claudio Favre, Franco Locatelli, Valentino Conter, Carmelo Rizzari, Maria Grazia Valsecchi, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood
Blood (2021) 137 (14): 1980–1984.
https://doi.org/10.1182/blood.2020009032
Published: 2021
Includes: Supplemental data
Journal Articles

Pre-Clinical Efficacy of the Novel Kinase Inhibitor Nintedanib on PAX5 Fusion Genes in Pediatric Ph-like B-Cell Precursor Acute Lymphoblastic Leukemia

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Grazia Fazio, Silvia Bresolin, Claudia Saitta, Daniela Silvestri, Elena Vendramini, Chiara Palmi, Silvia Rigamonti, Marta Galbiati, Manuel Quadri, Stefano Mecca, Angela Maria Savino, Michela Bardini, Andrea Grioni, Maria Grazia Valsecchi, PhD, Geertruy te Kronnie, Andrea Biondi, MD, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 745.
https://doi.org/10.1182/blood-2019-128509
Published: 2019
Journal Articles

Sleeping Beauty Modified CAR+ Lymphocytes Engraft and Exhibit Anti-Tumor Activity in Patient-Derived Xenograft Models of Acute Lymphoblastic Leukemia

Free
Chiara F. Magnani, PhD, Claudia Mezzanotte, Claudia Cappuzzello, PhD, Fabrizio Benedicenti, Michela Bardini, PhD, Sarah Tettamanti, PhD, Grazia Fazio, PhD, Gianni Cazzaniga, PhD, Laurence J.N. Cooper, MD PhD, Eugenio Montini, PhD, Andrea Biondi, MD, Ettore Biagi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4022.
https://doi.org/10.1182/blood.V128.22.4022.4022
Published: 2016
Journal Articles

Role of the Histone Deacetylase Inhibitor Givinostat (ITF2357) in Treatment of CRLF2 Rearranged Acute Lymphoblastic Leukemia

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Angela Maria Savino, Jolanda Sarno, Luca Trentin, Margherita Vieri, Grazia Fazio, PhD, Michela Bardini, Cristina Bugarin, Gianluca Fossati, Kara L. Davis, DO, Giuseppe Gaipa, PhD, Lueder Hinrich Meyer, MD, Garry P. Nolan, Prof, PhD, Andrea Biondi, Prof, MD, Geertruy Te Kronnie, PhD, Chiara Palmi, PhD, Giovanni Cazzaniga
Journal: Blood
Blood (2015) 126 (23): 2534.
https://doi.org/10.1182/blood.V126.23.2534.2534
Published: 2015
Journal Articles

In Infant ALL with t(4;11)/ MLL-AF4 Multiple and Phenotypically Distinct CD19+ BM Subsets Initiate Leukemia in NOD/SCID Mice..

Free
Michela Bardini, Lilian Wittmann, Lilia Corral, Luca Lo Nigro, Zhi Ma, Rakesh Singh, Giuseppe Basso, Giulio De Rossi, Mel Greaves, Andrea Biondi, Giovanni Cazzaniga, Sten Eirik Jacobsen
Journal: Blood
Blood (2009) 114 (22): 1432.
https://doi.org/10.1182/blood.V114.22.1432.1432
Published: 2009
Journal Articles

Infant ALL Patients Carrying t(4;11) Have a Different Genotypic Profile Than Older ALL Children.

Free
Michela Bardini, PhD,Fellow, Lilia Corral, Eleonora Mangano, PhD, fellow, Roberta Spinelli, Grazia Fazio, Ingrid Cifola, PhD, Andrea Biondi, MD, Cristina Battaglia, Giovanni Cazzaniga, PhD
Journal: Blood
Blood (2007) 110 (11): 1436.
https://doi.org/10.1182/blood.V110.11.1436.1436
Published: 2007
Journal Articles

Inducible activation of CEBPB , a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells

Free
Clara Guerzoni, Michela Bardini, Samanta A. Mariani, Giovanna Ferrari-Amorotti, Paolo Neviani, Maria Luisa Panno, Ying Zhang, Robert Martinez, Danilo Perrotti, Bruno Calabretta
Journal: Blood
Blood (2006) 107 (10): 4080–4089.
https://doi.org/10.1182/blood-2005-08-3181
Published: 2006