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Journal Articles

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

Ilenia Simeoni, Jonathan C. Stephens, Fengyuan Hu, Sri V. V. Deevi, Karyn Megy, Tadbir K. Bariana, Claire Lentaigne, Sol Schulman, Suthesh Sivapalaratnam, Minka J. A. Vries, Sarah K. Westbury, Daniel Greene, Sofia Papadia, Marie-Christine Alessi, Antony P. Attwood, Matthias Ballmaier, Gareth Baynam, Emilse Bermejo, Marta Bertoli, Paul F. Bray, Loredana Bury, Marco Cattaneo, Peter Collins, Louise C. Daugherty, Rémi Favier, Deborah L. French, Bruce Furie, Michael Gattens, Manuela Germeshausen, Cedric Ghevaert, Anne C. Goodeve, Jose A. Guerrero, Daniel J. Hampshire, Daniel P. Hart, Johan W. M. Heemskerk, Yvonne M. C. Henskens, Marian Hill, Nancy Hogg, Jennifer D. Jolley, Walter H. Kahr, Anne M. Kelly, Ron Kerr, Myrto Kostadima, Shinji Kunishima, Michele P. Lambert, Ri Liesner, José A. López, Rutendo P. Mapeta, Mary Mathias, Carolyn M. Millar, Amit Nathwani, Marguerite Neerman-Arbez, Alan T. Nurden, Paquita Nurden, Maha Othman, Kathelijne Peerlinck, David J. Perry, Pawan Poudel, Pieter Reitsma, Matthew T. Rondina, Peter A. Smethurst, William Stevenson, Artur Szkotak, Salih Tuna, Christel van Geet, Deborah Whitehorn, David A. Wilcox, Bin Zhang, Shoshana Revel-Vilk, Paolo Gresele, Daniel B. Bellissimo, Christopher J. Penkett, Michael A. Laffan, Andrew D. Mumford, Augusto Rendon, Keith Gomez, Kathleen Freson, Willem H. Ouwehand, Ernest Turro

Blood (2016) 127 (23): 2791–2803.

https://doi.org/10.1182/blood-2015-12-688267

Published: 2016

Includes: Supplemental data

Journal Articles

Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease

Maha Othman, Yvette Chirinian, Christine Brown, Colleen Notley, Nicholas Hickson, Daniel Hampshire, Suzanne Buckley, Simon Waddington, Alan L. Parker, Andrew Baker, Paula James, David Lillicrap

Blood (2010) 116 (18): 3645–3652.

https://doi.org/10.1182/blood-2009-12-261131

Published: 2010

Journal Articles

Results of a World Wide Survey On the Diagnostic Dilemma Between Type 2B Von Willeband Disease and the PT-VWD.

Maha Othman, MD, MSc, PhD, Alexander Hamilton, David Lillicrap, MD

Blood (2009) 114 (22): 4436.

https://doi.org/10.1182/blood.V114.22.4436.4436

Published: 2009

Journal Articles

Thromboelastogrpahy Reveals Kinetics of LPS- Induced Coagulopathy and Correlates to Fetal Outcome in a Rat Model of Pregnancy Complications.

Maha Othman, MD, MSc, PhD, Stephen Renaud, PhD, Jill Quirt, Shannyn MacDonald-Goodfellow, Charles Graham, PhD

Blood (2009) 114 (22): 4200.

https://doi.org/10.1182/blood.V114.22.4200.4200

Published: 2009

Journal Articles

Functional Characterization of Three VWF- A1 Domain Mutations Causing Type 2 Von Willebrand Disease.

Maha Othman, MD, MSc, PhD, Rouzbeh Chegeni, BSc, MSc, PhD, Linda M Vickars, MD, Emmanuel J Favaloro, PhD, M.A.I.M.S, David Lillicrap

Blood (2009) 114 (22): 1305.

https://doi.org/10.1182/blood.V114.22.1305.1305

Published: 2009

Journal Articles

Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice

Mohammad Qadura, Braden Waters, Erin Burnett, Rouzbeh Chegeni, Scott Bradshaw, Christine Hough, Maha Othman, David Lillicrap

Blood (2009) 114 (4): 871–880.

https://doi.org/10.1182/blood-2008-09-174649

Published: 2009

Includes: Supplemental data

Journal Articles

Investigating the Mechanisms Underlying FVIII Antibody Production in Hemophilic Mice Following Recombinant and Plasma-Derived FVIII Infusion

Mohammad Qadura, BSc, Braden Waters, BSc, Erin Burnett, BSc, Rouzbeh Chegeni, BSc, MSc, PhD, Maha Othman, PhD, MD, David Lillicrap, MD

Blood (2008) 112 (11): 237.

https://doi.org/10.1182/blood.V112.11.237.237

Published: 2008

Journal Articles

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance

Maha Othman, Andrea Labelle, Ian Mazzetti, Hisham S. Elbatarny, David Lillicrap

Blood (2006) 109 (7): 2832–2839.

https://doi.org/10.1182/blood-2006-06-032524

Published: 2006

Journal Articles

Reduction in Factor VIII Inhibitors Mediated through Tolerogenic Antigen Presentation by immature Dendritic Cells.

Mohammad Qadura, BSc, Andrea Labelle, Kirsten Walker, Kathleen Pratt, PhD, Maha Othman, MD, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2006) 108 (11): 762.

https://doi.org/10.1182/blood.V108.11.762.762

Published: 2006

Journal Articles

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

Paula D. James, Colleen Notley, Carol Hegadorn, Jayne Leggo, Angie Tuttle, Shawn Tinlin, Christine Brown, Chandler Andrews, Andrea Labelle, Yvette Chirinian, Lee O'Brien, Maha Othman, Georges Rivard, Dilys Rapson, Christine Hough, David Lillicrap, for the Association of Hemophilia Clinic Directors of Canada

Blood (2006) 109 (1): 145–154.

https://doi.org/10.1182/blood-2006-05-021105

Published: 2006

Journal Articles

Dexamethasone Promotes Transgene Expression and Supresses the Early Immune /Inflammatory Response in Adenovirus- Mediated Gene Delivery to Hemophilic Mice.

Maha Othman, MD, PhD, Ian Mazzetti, Andrea Labelle, David Lillicrap, MD FRCPC

Blood (2005) 106 (11): 5534.

https://doi.org/10.1182/blood.V106.11.5534.5534

Published: 2005

Journal Articles

Adenovirus Induced Thrombocytopenia: The Role of P-Selectin and von Willebrand Factor in Virus- Mediated Platelet Clearance.

Maha Othman, MD, PhD, Andrea Labelle, Ian Mazzetti, David Lillicrap, MD FRCP

Blood (2005) 106 (11): 222.

https://doi.org/10.1182/blood.V106.11.222.222

Published: 2005

Journal Articles

Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease

Maha Othman, Colleen Notley, Frances Louise Lavender, Helen White, Christopher D. Byrne, David Lillicrap, Denise Frances O'Shaughnessy

Blood (2005) 105 (11): 4330–4336.

https://doi.org/10.1182/blood-2002-09-2942

Published: 2005

Journal Articles

Identification and Functional Characterization of a Novel 27bp Deletion in the Macroglycopeptide-Coding Region of the GPIbα Gene Resulting in Platelet-Type Von Willebrand Disease.

Maha Othman, MD, PhD, Hisham S. Elbatarny, MD, MSc, Colleen Notley, Louise F. Lavender, PhD, Helen White, PhD, Christopher D. Byrne, FRCP, FRCPath, PhD, Denise F. O’Shaughnessy, FRCP, FRCPath, PhD, MBA, David P. Lillicrap, MD, FRCPC, PhD

Blood (2004) 104 (11): 1023.

https://doi.org/10.1182/blood.V104.11.1023.1023

Published: 2004

Journal Articles

Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease

Lee A. O'Brien, Paula D. James, Maha Othman, Ergul Berber, Cherie Cameron, Colleen R. P. Notley, Carol A. Hegadorn, Jeffrey J. Sutherland, Christine Hough, Georges E. Rivard, Denise O'Shaunessey, David Lillicrap, the Association of Hemophilia Clinic Directors of Canada

Blood (2003) 102 (2): 549–557.

https://doi.org/10.1182/blood-2002-12-3693

Published: 2003

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A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease

Results of a World Wide Survey On the Diagnostic Dilemma Between Type 2B Von Willeband Disease and the PT-VWD.

Thromboelastogrpahy Reveals Kinetics of LPS- Induced Coagulopathy and Correlates to Fetal Outcome in a Rat Model of Pregnancy Complications.

Functional Characterization of Three VWF- A1 Domain Mutations Causing Type 2 Von Willebrand Disease.

Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice

Investigating the Mechanisms Underlying FVIII Antibody Production in Hemophilic Mice Following Recombinant and Plasma-Derived FVIII Infusion

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance

Reduction in Factor VIII Inhibitors Mediated through Tolerogenic Antigen Presentation by immature Dendritic Cells.

The mutational spectrum of type 1 von Willebrand disease: results from a Canadian cohort study

Dexamethasone Promotes Transgene Expression and Supresses the Early Immune /Inflammatory Response in Adenovirus- Mediated Gene Delivery to Hemophilic Mice.

Adenovirus Induced Thrombocytopenia: The Role of P-Selectin and von Willebrand Factor in Virus- Mediated Platelet Clearance.

Identification and functional characterization of a novel 27-bp deletion in the macroglycopeptide-coding region of the GPIBA gene resulting in platelet-type von Willebrand disease

Identification and Functional Characterization of a Novel 27bp Deletion in the Macroglycopeptide-Coding Region of the GPIbα Gene Resulting in Platelet-Type Von Willebrand Disease.

Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease

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