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Journal Articles

Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model

Yu Wang, Lei Yu, Kaiwen Deng, Mathivanan Packiarajan, Angelo Aguilar, Sojin An, Greggory Myers, Hoon Oh, Sharon A. Singh, Uhn-soo Cho, Shaomeng Wang, Yuanfang Guan, Andrew White, Rami Khoriaty, James Douglas Engel

Blood blood.2024028006.

https://doi.org/10.1182/blood.2024028006

Published: 2025

Includes: Supplemental data

Journal Articles

TR4 and BCL11A repress γ-globin transcription via independent mechanisms

Yu Wang, Greggory Myers, Lei Yu, Kaiwen Deng, Ginette Balbin-Cuesta, Sharon A. Singh, Yuanfang Guan, Rami Khoriaty, James Douglas Engel

Blood (2024) 144 (26): 2762–2772.

https://doi.org/10.1182/blood.2024024599

Published: 2024

Includes: Supplemental data

Journal Articles

The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II

Lei Yu, Yu Wang, Richard King, Greggory Myers, Beth McGee, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Xiaofang Liu, Claire Kerpet, Kaiwen Deng, Aaron Robida, James Engel, Rami Khoriaty

Blood (2024) 144 (Supplement 1): 938.

https://doi.org/10.1182/blood-2024-201649

Published: 2024

Journal Articles

Sequential Infusion of Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor T-Cells: A Promising Treatment Strategy for Refractory Immune-Mediated Platelet Transfusion Refractoriness

Yunju Ma, Qingya Cui, Chunxiu Yang, Wei Cui, Mengyun Li, Zheng Li, Haiping Dai, Liqing Kang, Lei Yu, Zaixiang Tang, Jianxin Fu, Min Jiang, Depei Wu, Xiaowen Tang

Blood (2024) 144 (Supplement 1): 683.

https://doi.org/10.1182/blood-2024-209249

Published: 2024

Journal Articles

SF3B1 Mutation Drives Loss of Y Chromosome in Chronic Lymphocytic Leukemia

Mike Fernandez, Lei Yu, Qiong Jia, Xuesong Wang, Kevyn Hart, Zhenyu Jia, Ren-Jang Lin, Lili Wang

Blood (2024) 144 (Supplement 1): 46.

https://doi.org/10.1182/blood-2024-208209

Published: 2024

Journal Articles

Long-Term Remission and Survival in Patients with Rituximab-Refractory/Relapsed B-Cell Non-Hodgkin Lymphoma after Treatment with U16 (CD20 CAR-T cells)

Qian Cheng, JingWen Tan, Rui Liu, Liqing Kang, Hongjia Zhu, Yi Zhang, Erhua Wang, Ying Li, Jian Zhang, Han Xiao, Rong He, Xiaoyan Lou, Nan Xu, Wei Wang, Zhou Yu, Minghao Li, Hongfei Gu, Lei Yu, Xin Li

Blood (2024) 144 (Supplement 1): 3447.

https://doi.org/10.1182/blood-2024-200516

Published: 2024

Journal Articles

5-Year Follow-up of Combined Infusion of Anti-CD19 and Anti-BCMA CAR-T after ASCT for High-Risk Newly Diagnosed Multiple Myeloma

Xiaolan Shi, Chengcheng Fu, Lingzhi Yan, Yingying Zhai, Zhi Yan, Jingjing Shang, Song Jin, Xingyue Wu, Hongying You, Shuang Yan, Weiqin Yao, Liqing Kang, Lei Yu, Depei Wu

Blood (2024) 144 (Supplement 1): 4766.

https://doi.org/10.1182/blood-2024-207687

Published: 2024

Journal Articles

Bird Regimen Followed By Anti-BCMA CAR T-Cell Immunotherapy As First-Line Therapy for Newly Diagnosed Multiple Myeloma: A Prospective, Single-Arm, Phase 3 Trial

Yue Zhou, Juan Chen, Qingya Cui, Haiping Dai, Zheng Li, Jia Yin, Wei Cui, Mengyun Li, Xuekai Li, Xin Zhang, Feiran Gong, Xiaming Zhu, Liqing Kang, Lei Yu, Depei Wu, Xiaowen Tang

Blood (2024) 144 (Supplement 1): 3384.

https://doi.org/10.1182/blood-2024-199119

Published: 2024

Journal Articles

Safety and Efficacy of CD22/ CD19 CAR-T and Auto-HSCT “Sandwich”Strategy As Consolidation Therapy for Ph Negative B Cell Acute Lymphoblastic Leukemia

Zihao Wang, Chong-Sheng Qian, Yan Qiu, Hai-xia Zhou, Mingzhu Xu, Li-Qing Kang, Ai-Ning Sun, Depei Wu, Lei Yu, Sheng-Li Xue

Blood (2024) 144 (Supplement 1): 4840.

https://doi.org/10.1182/blood-2024-204636

Published: 2024

Journal Articles

Unleashing the Power of CD19 CAR-T in Relapsed AML: Findings from a Prospective Single-Center Clinical Trial

Jia Yin, Qingya Cui, Haiping Dai, Zheng Li, Liqing Kang, Wei Cui, Xiaopeng Tian, Xiaming Zhu, Lei Yu, Depei Wu, Xiaowen Tang

Blood (2024) 144 (Supplement 1): 4836.

https://doi.org/10.1182/blood-2024-207197

Published: 2024

Journal Articles

Target Antigen-Expressing T Cells Facilitate CAR-T Cell Eradication of Residual CD19+ B Malignant Cells

Blood (2024) 144 (Supplement 1): 4794.

https://doi.org/10.1182/blood-2024-206406

Published: 2024

Journal Articles

Chemotherapy-Free Induction with Venetoclax and Azacitidine, Followed By Tandem CD19/CD22 CAR-T Cell Therapy As First-Line Treatment in Newly Diagnosed High-Risk Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Prospective, Single-Center, Single-Arm, Phase 2 Trial

Mengyun Li, Qingya Cui, Xuekai Li, Wei Cui, Xiaoqian Chen, Yan Yu, Juan Chen, Xin Zhang, Liqing Kang, Lei Yu, Depei Wu, Xiaowen Tang

Blood (2024) 144 (Supplement 1): 4197.

https://doi.org/10.1182/blood-2024-207017

Published: 2024

Journal Articles

Efficacy and Safety of the Second CAR-T Therapy in Patients with Refractory/Relapsed Acute B-Cell Lymphoblastic Leukemia

Sining Liu, Qingya Cui, Zheng Li, Wei Cui, Mengyun Li, Huiying Qiu, Shengli Xue, Suning Chen, Zhengming Jin, Miao Miao, Yue Han, Ying Wang, Xiaming Zhu, Lei Yu, Depei Wu, Xiaowen Tang

Blood (2023) 142 (Supplement 1): 3491.

https://doi.org/10.1182/blood-2023-186718

Published: 2023

Journal Articles

Identification of CNOT4 As a Positive Regulator of Erythroid Cell Growth Using a Genome Wide CRISPR Knock-out Screen

Claire Drysdale, Greggory Myers, Lei Yu, Ann Friedman, Claire Kerpet, Ginette Balbin-Cuesta, Zesen Lin, Ayse Bilge Ozel, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 2447.

https://doi.org/10.1182/blood-2023-182187

Published: 2023

Journal Articles

Efficacy and Safety of Interleukin-6-Knockdown CD19-Targeted CAR T Cells(ssCART-19) for Relapsed/Refractory B-ALL

Blood (2023) 142 (Supplement 1): 889.

https://doi.org/10.1182/blood-2023-172615

Published: 2023

Journal Articles

Phase I Open-Label Single-Arm Study of Sscart-19 in Adult Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia in China

Liqing Kang, Shengli Xue, Xiaowen Tang, Xiaoyan Lou, Chongsheng Qian, Wenjie Gong, Mingzhu Xu, Haixia Zhou, Zhen Yao, Wei Wang, Minghao Li, Nan Xu, Zhou Yu, Suning Chen, Huiying Qiu, Haiping Dai, Yang Xu, Depei Wu, Lei Yu

Blood (2023) 142 (Supplement 1): 3477.

https://doi.org/10.1182/blood-2023-181552

Published: 2023

Journal Articles

Safety and Efficacy of CD22/ CD19 CAR-T and Auto-HSCT “Sandwich” Strategy As Consolidation Therapy for Ph Negative B Cell Acute Lymphoblastic Leukemia

Yan Qiu, Chong-Sheng Qian, Hai-Xia Zhou, Ming-Zhu Xu, Li-Qing Kang, Ai-Ning Sun, De-Pei Wu, Lei Yu, Sheng-Li Xue

Blood (2023) 142 (Supplement 1): 3481.

https://doi.org/10.1182/blood-2023-182728

Published: 2023

Journal Articles

Proteogenomic Features Define Novel Subtypes of Mantle Cell Lymphoma

Yuting Yan, Xinzhou Ge, Jian Sun, Lei Yu, Qunling Zhang, Ying Yu, Zhenyu Jia, Dehui Zou, Jessica Li, Lugui Qiu, Lili Wang, Shuhua Yi

Blood (2023) 142 (Supplement 1): 4368.

https://doi.org/10.1182/blood-2023-190838

Published: 2023

Journal Articles

Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II

Lei Yu, Greggory Myers, Beth McGee, Xiaofang Liu, Gallagher Patrick, Richard King, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale, Claire Kerpet, Singh Sharon, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 12.

https://doi.org/10.1182/blood-2023-182246

Published: 2023

Journal Articles

A Genome Scale CRISPR Screen Identifies Novel Genes That Regulate Erythropoietin Production

Zesen Lin, Ginette Balbin-Cuesta, Greggory Myers, Lei Yu, Claire Drysdale, Vi Tang, Ayse Bilge Ozel, Ann Friedman, Beth McGee, Masaki Ito, Rilie Saba, Claire Kerpet, Richard King, Gallagher Patrick, James Engel, Rami Khoriaty

Blood (2023) 142 (Supplement 1): 3820.

https://doi.org/10.1182/blood-2023-182427

Published: 2023

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Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model

TR4 and BCL11A repress γ-globin transcription via independent mechanisms

The LSD1 Inhibitor RN1 Rescues Congenital Dyserythropoietic Anemia Type II

Sequential Infusion of Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor T-Cells: A Promising Treatment Strategy for Refractory Immune-Mediated Platelet Transfusion Refractoriness

SF3B1 Mutation Drives Loss of Y Chromosome in Chronic Lymphocytic Leukemia

Long-Term Remission and Survival in Patients with Rituximab-Refractory/Relapsed B-Cell Non-Hodgkin Lymphoma after Treatment with U16 (CD20 CAR-T cells)

5-Year Follow-up of Combined Infusion of Anti-CD19 and Anti-BCMA CAR-T after ASCT for High-Risk Newly Diagnosed Multiple Myeloma

Bird Regimen Followed By Anti-BCMA CAR T-Cell Immunotherapy As First-Line Therapy for Newly Diagnosed Multiple Myeloma: A Prospective, Single-Arm, Phase 3 Trial

Safety and Efficacy of CD22/ CD19 CAR-T and Auto-HSCT “Sandwich”Strategy As Consolidation Therapy for Ph Negative B Cell Acute Lymphoblastic Leukemia

Unleashing the Power of CD19 CAR-T in Relapsed AML: Findings from a Prospective Single-Center Clinical Trial

Target Antigen-Expressing T Cells Facilitate CAR-T Cell Eradication of Residual CD19+ B Malignant Cells

Chemotherapy-Free Induction with Venetoclax and Azacitidine, Followed By Tandem CD19/CD22 CAR-T Cell Therapy As First-Line Treatment in Newly Diagnosed High-Risk Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Prospective, Single-Center, Single-Arm, Phase 2 Trial

Efficacy and Safety of the Second CAR-T Therapy in Patients with Refractory/Relapsed Acute B-Cell Lymphoblastic Leukemia

Identification of CNOT4 As a Positive Regulator of Erythroid Cell Growth Using a Genome Wide CRISPR Knock-out Screen

Efficacy and Safety of Interleukin-6-Knockdown CD19-Targeted CAR T Cells(ssCART-19) for Relapsed/Refractory B-ALL

Phase I Open-Label Single-Arm Study of Sscart-19 in Adult Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia in China

Safety and Efficacy of CD22/ CD19 CAR-T and Auto-HSCT “Sandwich” Strategy As Consolidation Therapy for Ph Negative B Cell Acute Lymphoblastic Leukemia

Proteogenomic Features Define Novel Subtypes of Mantle Cell Lymphoma

Whole-Genome CRISPR-Cas9 Screen Identifies ZBTB7A As a Potential Therapeutic Target for Cda-II

A Genome Scale CRISPR Screen Identifies Novel Genes That Regulate Erythropoietin Production

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