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Laurence J. N. Cooper
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Journal Articles

Rapid Personalized Manufacture (RPM) of Sleeping Beauty System-Generated NY-ESO-1-Specific TCR-T Cells Co-Expressing Membrane-Bound IL-15 Yields Anti-Tumor Responses

Free
Lenka V Hurton, PhD, Tiejuan Mi, Kirsten C Switzer, PhD, Ling Zhang, Cuiping Dai, Misun Kim, Karishma R Bavisi, Matthew J Figliola, Vazquez M Lydia, Sourindra N Maiti, Shihuang Su, Drew C Deniger, PhD, Simon Olivares, Laurence J N Cooper, MD PhD, Harjeet Singh, MSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3218.
https://doi.org/10.1182/blood-2019-131419
Published: 2019
Journal Articles

Adoptive T-Cell Therapy with TCL1-Specific TCR for B-Cell Lymphomas

Free
Jinsheng Weng, MD PhD, Kelsey Moriarty, BD, Yong Pan, Man Chun John MA, PhD, Rohit Mathur, PhD, Zheng Zhang, Hiroki Torikai, MD, Sourindra N Maiti, Fuliang Chu, PhD, Xiaoyun Cheng, Swathi Karri, Deepshika Medapalli, Laurence J N Cooper, MD PhD, R. Eric Davis, MD, Sattva S. Neelapu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3488.
https://doi.org/10.1182/blood-2018-99-115424
Published: 2018
Journal Articles

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Free
Partow Kebriaei, MD, Helen Huls, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Elenanor De Groot, Amy Smith, Yijun Yang, PhD, Gabriela Rondon, MD, Muzaffar H. Qazilbash, MD, Stefan O. Ciurea, Amin M. Alousi, Yago Nieto, MD PhD, David Costa Marin, MD, Uday Popat, MD, Chitra Hosing, MD, Hagop M. Kantarjian, MD, Katayoun Rezvani, MD PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Laurence J N Cooper, MDPhD, Harjeet Singh, MSc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2059.
https://doi.org/10.1182/blood.V130.Suppl_1.2059.2059
Published: 2017
Journal Articles

CD19-Specific Chimeric Antigen Receptor-Modified T Cells with Safety Switch Produced Under "Point-of-Care" Using the Sleeping Beauty System for the Very Rapid Manufacture and Treatment of B-Cell Malignancies

Free
Tim Chan, PhD, John Gallagher, Nai-Lin Cheng, PhD, Fernando Carvajal-Borda, DVM, Jacques Plummer, Adeline Govekung, John A Barrett, PhD, Pranay D. Khare, PhD, Laurence J N Cooper, MDPhD, Rutul R Shah
Journal: Blood
Blood (2017) 130 (Supplement 1): 1324.
https://doi.org/10.1182/blood.V130.Suppl_1.1324.1324
Published: 2017
Journal Articles

Autologous T Cells Modified to Co-Express CD33-Specific Chimeric Antigen Receptor and a Kill Switch for Treatment of CD33 + Acute Myeloid Leukemia

Free
Degang Song, PhD, Michael H Swartz, Linhua Tian, Fernando Carvajal-Borda, DVM, Jacques Plummer, Rutul R Shah, William G Wierda, MD PhD, Laurence J N Cooper, MDPhD, Tim Chan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1376.
https://doi.org/10.1182/blood.V130.Suppl_1.1376.1376
Published: 2017
Journal Articles

Genetically Engineered Regulatory T Cells for Treatment of Graft-Versus-Host-Disease

Free
Eric Tu, PhD, Jennifer Fox, PhD, Christina Ly, BS, Christine Steinhart, PhD, Mike Laporte, MS, James Brennan, PhD, Cheryl Bolinger, PhD, Laurence J N Cooper, MDPhD, Hanspeter Waldner, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3176.
https://doi.org/10.1182/blood.V130.Suppl_1.3176.3176
Published: 2017
Journal Articles

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Free
Partow Kebriaei, MD, Helen Huls, Susan Lynn Neel, RN, OCN, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Amy Smith, Elenanor De Groot, Hagop M. Kantarjian, MD, Maro Ohanian, DO, Katy Rezvani, MD PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Laurence J N Cooper, MDPhD, Harjeet Singh, MSc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2060.
https://doi.org/10.1182/blood.V130.Suppl_1.2060.2060
Published: 2017
Journal Articles

Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Free
Clinical Trials & Observations
Xiuli Wang, Leslie L. Popplewell, Jamie R. Wagner, Araceli Naranjo, M. Suzette Blanchard, Michelle R. Mott, Adam P. Norris, ChingLam W. Wong, Ryan Z. Urak, Wen-Chung Chang, Samer K. Khaled, Tanya Siddiqi, Lihua E. Budde, Jingying Xu, Brenda Chang, Nikita Gidwaney, Sandra H. Thomas, Laurence J. N. Cooper, Stanley R. Riddell, Christine E. Brown, Michael C. Jensen, Stephen J. Forman
Journal: Blood
Blood (2016) 127 (24): 2980–2990.
https://doi.org/10.1182/blood-2015-12-686725
Published: 2016
Includes: Supplemental data
Journal Articles

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

Free
Uday Popat, Rohtesh S. Mehta, Katayoun Rezvani, Patricia Fox, Kayo Kondo, David Marin, Ian McNiece, Betul Oran, Chitra Hosing, Amanda Olson, Simrit Parmar, Nina Shah, Michael Andreeff, Partow Kebriaei, Indreshpal Kaur, Eric Yvon, Marcos de Lima, Laurence J. N. Cooper, Priti Tewari, Richard E. Champlin, Yago Nieto, Borje S. Andersson, Amin Alousi, Roy B. Jones, Muzaffar H. Qazilbash, Qaiser Bashir, Stefan Ciurea, Sairah Ahmed, Paolo Anderlini, Doyle Bosque, Catherine Bollard, Jeffrey J. Molldrem, Julianne Chen, Gabriela Rondon, Michael Thomas, Leonard Miller, Steve Wolpe, Paul Simmons, Simon Robinson, Patrick A. Zweidler-McKay, Elizabeth J. Shpall
Journal: Blood
Blood (2015) 125 (19): 2885–2892.
https://doi.org/10.1182/blood-2015-01-607366
Published: 2015
Journal Articles

Immune Reconstitution With Activated T Cells In Companion Canines With Lymphoma

Free
Colleen M. O'Connor, PhD, Sonny Ang, PhD, Sourindra Maiti, PHD, George McNamara, PHD, Sabina Sheppard, MS, Tasha Miller, BS, Helen Huls, BS, Richard E Champlin, MD, Heather Wilson, DVM, Laurence J N Cooper, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 5153.
https://doi.org/10.1182/blood.V122.21.5153.5153
Published: 2013
Journal Articles

Targeting An Ancient Retrovirus In Tumor Using Engineered T Cells

Free
Janani Krishnamurthy, Brian Rabinovich, Simon Olivares, BS, Mi Teijuan, Kirsten Switzer, Joshua Plummer, Sourindra Maiti, PHD, Harjeet Singh, PhD, Helen Huls, BS, Feng-wang Johanning, Laurence J N Cooper, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4206.
https://doi.org/10.1182/blood.V122.21.4206.4206
Published: 2013
Journal Articles

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

Free
Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R Kumar, BS, Bipulendu Jena, PhD, Rineka N Jackson, BBA, Tingting Liu, BS, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4208.
https://doi.org/10.1182/blood.V122.21.4208.4208
Published: 2013
Journal Articles

Stable Expression Of Chimeric Antigen Receptors (CARs) By Sleeping Beauty-Mediated Gene Transfer and Efficient Expansion Of Leukemia-Specific Cytokine-Induced Killer (CIK) Cells

Free
Chiara Francesca Magnani, PhD, Nice Turazzi, Fabrizio Benedicenti, Greta Maria Paola Giordano Attianese, PhD, Sarah Tettamanti, PhD, Eugenio Montini, PhD, Laurence J N Cooper, MD, PhD, Alessandro Aiuti, MD, PhD, Andrea Biondi, MD, Ettore Biagi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1663.
https://doi.org/10.1182/blood.V122.21.1663.1663
Published: 2013
Journal Articles

ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor

Free
Hiroki Torikai, Tiejuan Mi, Sonny O Ang, PhD, Loren Gragert, Martin Maiers, Sourindra Maiti, PHD, Kirsten Switzer, Helen Huls, BS, Andreas Reik, Michael C. Holmes, PhD, Philip D Gregory, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1655.
https://doi.org/10.1182/blood.V122.21.1655.1655
Published: 2013
Journal Articles

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Free
Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R. Kumar, BS, Bipulendu Jena, PhD, Marie Andree Forget, Sonny Ang, PhD, Rineka N. Jackson, BBA, Tingting Liu, BS, Doyle Bosque, ADN, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Chitra M. Hosing, MD, Elizabeth J. Shpall, MD, Richard E. Champlin, MD, Laurence J N. Cooper, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 166.
https://doi.org/10.1182/blood.V122.21.166.166
Published: 2013
Journal Articles

Ex Vivo Fucosylation Of Cord Blood Accelerates Neutrophil and Platelet Engraftment

Free
Uday R Popat, MD, Betul Oran, MD, Chitra M. Hosing, MD, Partow Kebriaei, MD, Katy Rezvani, MD, PhD, Simrit Parmar, MD, Nina Shah, MD, Catherine M. Bollard, MBChB, MD, Jeffrey J. Molldrem, MD, Yago Nieto, MD, PhD, Borje S. Andersson, MD, PhD, Amin Alousi, MD, Roy B. Jones, MD, PhD, Laurence J N Cooper, MD, PhD, Muzaffar H. Qazilbash, MD, Qaiser Bashir, MD, Sairah Ahmed, MD, Doyle Bosque, ADN, Julianne Chen, Jessica McCarty, Gabriela Rondon, MD, Mark Munsell, Ian K. McNiece, PhD, Indreshpal Kaur, PhD, Eric Yvon, PhD, Katherine Annandale, Sarah Olchesky, Marcos J de Lima, MD, Richard E Champlin, MD, Leonard Miller, PhD, Linda Paradiso, DVM.MBA, Lynnet Koh, MS, MBA, Patrick A Zweidler-McKay, MD, PhD, Elizabeth J Shpall, MD
Journal: Blood
Blood (2013) 122 (21): 691.
https://doi.org/10.1182/blood.V122.21.691.691
Published: 2013
Journal Articles

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Free
Hiroki Torikai, Andreas Reik, Frank Soldner, Edus H. Warren, Carrie Yuen, Yuanyue Zhou, Denise L. Crossland, Helen Huls, Nicholas Littman, Ziying Zhang, Scott S. Tykodi, Partow Kebriaei, Dean A. Lee, Jeffrey C. Miller, Edward J. Rebar, Michael C. Holmes, Rudolf Jaenisch, Richard E. Champlin, Philip D. Gregory, Laurence J. N. Cooper
Journal: Blood
Blood (2013) 122 (8): 1341–1349.
https://doi.org/10.1182/blood-2013-03-478255
Published: 2013
Includes: Supplemental data
Journal Articles

Sustained Functional T Cell Persistence and B Cell Aplasia Following CD19-Targeting Adoptive T Cell Immunotherapy for Relapsed, Refractory CD19+ Malignacy

Free
Michael Kalos, PhD, Bruce L. Levine, PhD, Timothy L Macatee, Irina Kulikovskaya, Erica Suppa, Bipulendu Jena, Saar I. Gill, MBBS, Laurence J N Cooper, MD, PhD, Stephan A. Grupp, MD, PhD, David L Porter, MD, Carl H. June, MD
Journal: Blood
Blood (2012) 120 (21): 756.
https://doi.org/10.1182/blood.V120.21.756.756
Published: 2012
Journal Articles

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Free
Hiroki Torikai, Andreas Reik, Pei-Qi Liu, Yuanyue Zhou, Ling Zhang, Sourindra Maiti, Helen Huls, Jeffrey C. Miller, Partow Kebriaei, Brian Rabinovitch, Dean A. Lee, Richard E. Champlin, Chiara Bonini, Luigi Naldini, Edward J. Rebar, Philip D. Gregory, Michael C. Holmes, Laurence J. N. Cooper
Journal: Blood
Blood (2012) 119 (24): 5697–5705.
https://doi.org/10.1182/blood-2012-01-405365
Published: 2012
Includes: Supplemental data
Journal Articles

Engineering lymph node homing of ex vivo–expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7

Free
Srinivas S. Somanchi, Anitha Somanchi, Laurence J. N. Cooper, Dean A. Lee
Journal: Blood
Blood (2012) 119 (22): 5164–5172.
https://doi.org/10.1182/blood-2011-11-389924
Published: 2012
Includes: Supplemental data