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Journal Articles

Exposure of hiPSC-Derived Mature Megakaryocytes to Vincristine Boosts Platelet Biogenesis in Vitro

Yasuo Harada, Emiri Nakamura, Trevor Bingham, Leonard I. Zon, George Q. Daley, Andrew Frelinger, Koji Eto, Thorsten M. Schlaeger

Blood (2023) 142 (Supplement 1): 1292.

https://doi.org/10.1182/blood-2023-185254

Published: 2023

Journal Articles

Turbulence Enhances Fine-Tuning of Mitochondria Delivery in Megakaryocyte Maturation Contributing to Biogenesis of High Quality Platelets

Emiri Nakamura, Yasuo Harada, Koenraad De Wispelaere, Chantal Thys, Kathleen Freson, Koji Eto

Blood (2023) 142 (Supplement 1): 3964.

https://doi.org/10.1182/blood-2023-181330

Published: 2023

Journal Articles

iPSC-Derived Mesenchymal Stem Cells Supports the Ex Vivo expansion of Human Hematopoietic Stem and Progenitor Cells Via Sterile Inflammation Pathway

Maria Alejandra Kanashiro, Sudip Kumar Paul, Masamitsu Sone, Ikuyo Yoshino, Kyoko Tsujimura, Makoto Ikeya, Sou Nakamura, Koji Eto, Naoya Takayama

Blood (2023) 142 (Supplement 1): 2680.

https://doi.org/10.1182/blood-2023-181378

Published: 2023

Journal Articles

Ribosome dysfunction underlies SLFN14-related thrombocytopenia

Fabienne Ver Donck, Kato Ramaekers, Chantal Thys, Christine Van Laer, Kathelijne Peerlinck, Chris Van Geet, Koji Eto, Veerle Labarque, Kathleen Freson

Blood (2023) 141 (18): 2261–2274.

https://doi.org/10.1182/blood.2022017712

Published: 2023

Includes: Supplemental data

Journal Articles

iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study

Blood (2022) 140 (22): 2398–2402.

https://doi.org/10.1182/blood.2022017296

Published: 2022

Includes: Supplemental data

Journal Articles

The First-in-Human Clinical Trial of iPSC-Derived Platelets (iPLAT1): Autologous Transfusion to an Aplastic Anemia Patient with Alloimmune Platelet Transfusion Refractoriness

Naoshi Sugimoto, Junya Kanda, Sou Nakamura, Toshiyuki Kitano, Masakatsu Hishizawa, Tadakazu Kondo, Shin Shimizu, Akiko Shigemasa, Hideyo Hirai, Harue Tada, Manabu Minami, Naohide Watanabe, Masayuki Nogawa, Makoto Handa, Yoshihiko Tani, Akifumi Takaori-Kondo, Koji Eto

Blood (2021) 138 (Supplement 1): 351.

https://doi.org/10.1182/blood-2021-145814

Published: 2021

Journal Articles

The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis

Richard W. Lo, Ling Li, Fred G. Pluthero, Richard Leung, Koji Eto, Walter H. A. Kahr

Blood (2020) 136 (6): 715–725.

https://doi.org/10.1182/blood.2019004276

Published: 2020

Includes: Supplemental data

Journal Articles

Harnessing a Novel Dyrk1a-Ablim2-MKL1 Regulatory Module in Megakaryocyte Morphogenesis to Enable Scalable Platelet "Pharming"

Kamaleldin E Elagib, PhDMBBS, Ashton Brock, PhD, Goar Mosoyan, Cara Clementelli, Lorrie L Delehanty, BS, Alexandra Pacheco-Benichou, Corinne Fruit, Thierry Besson, PhD, Stephen Morris, MD, Koji Eto, MD, Camelia Iancu-Rubin, PhD, Adam N Goldfarb, MD

Blood (2019) 134 (Supplement_1): 3250.

https://doi.org/10.1182/blood-2019-129049

Published: 2019

Journal Articles

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

Sudip Kumar Paul, MSc, Masamitsu Sone, PhD, Hisaya Kato, MD PhD, Yoshiro Maezawa, MD PhD, Yasuo Ouchi, PhD, Koutaro Yokote, MD PhD, Koji Eto, MD, Naoya Takayama, MD PhD

Blood (2019) 134 (Supplement_1): 3615.

https://doi.org/10.1182/blood-2019-123919

Published: 2019

Journal Articles

Ex vivo Engineering of Platelets

Koji Eto, MD

Blood (2019) 134 (Supplement_1): SCI-6.

https://doi.org/10.1182/blood-2019-121116

Published: 2019

Journal Articles

α IIb β 3 changes gears in MKs and platelets

Naoshi Sugimoto, Koji Eto

Blood (2019) 133 (16): 1700–1701.

https://doi.org/10.1182/blood-2019-01-896092

Published: 2019

Journal Articles

Environmental Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Fate Toward Definitive Hemogenic Endothelium and Hematopoietic Progenitor Cells

Akinori Yuzuriha, Sou Nakamura, PhD, Toshie Kusunoki, Takuya Matsumoto, PhD, Naoshi Sugimoto, MD PhD, Kiyotoshi Sekiguchi, PhD, Koji Eto, MD PhD

Blood (2018) 132 (Supplement 1): 3845.

https://doi.org/10.1182/blood-2018-99-114505

Published: 2018

Journal Articles

Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells

Blood (2018) 132 (Supplement 1): 1789.

https://doi.org/10.1182/blood-2018-99-111683

Published: 2018

Journal Articles

A Novel Megakaryocyte-Based Screening System Identifies Compounds That Promote Megakaryocyte Maturation and Platelet Production in Vitro

Si Jing Chen, PhD, Hideya Seo, Akitsu Hotta, Yohei Nishi, Akira Ohta, Koji Eto

Blood (2017) 130 (Supplement 1): 2329.

https://doi.org/10.1182/blood.V130.Suppl_1.2329.2329

Published: 2017

Journal Articles

High-Vorticity with Periodic Flow Enhances in Vitro Biogenesis of Healthy Platelets from iPSC-Derived-Megakaryocytes

Yukitaka Ito, Sou Nakamura, Tomohiro Shigemori, Naoshi Sugimoto, MD PhD, Yoshikazu Kato, Kazuya Hashimoto, Naohide Watanabe, Masayuki Nogawa, Makoto Handa, Satoshi Nishimura, Koji Eto

Blood (2016) 128 (22): 2181.

https://doi.org/10.1182/blood.V128.22.2181.2181

Published: 2016

Journal Articles

Synthetic miRNA Switch Technology Elucidates Heterogeneity in Regulation of Immortalized Megakaryocyte Cell Lines, Associated with Improvement of Platelet Generation Efficiency for Clinical Use

Kazuya Hashimoto, Satoshi Matsuura, Yoshihiko Fujita, Karin Hayashi, Naoshi Sugimoto, MD PhD, Takuya Yamamoto, Hirohide Saito, Koji Eto, MD PhD

Blood (2016) 128 (22): 3867.

https://doi.org/10.1182/blood.V128.22.3867.3867

Published: 2016

Journal Articles

Natural Killer Cell Activities Against iPSCs-Derived HLA-Knockout Platelets and Megakaryocytes Reveal Perfect Rejection Profiles for Allotransfusion

Daisuke Suzuki, Naoshi Sugimoto, MD PhD, Norihide Yoshikawa, Hiroshi Endo, Sou Nakamura, Akitsu Hotta, Koji Eto, MD PhD

Blood (2016) 128 (22): 3841.

https://doi.org/10.1182/blood.V128.22.3841.3841

Published: 2016

Journal Articles

Linkage between the mechanisms of thrombocytopenia and thrombopoiesis

Koji Eto, Shinji Kunishima

Blood (2016) 127 (10): 1234–1241.

https://doi.org/10.1182/blood-2015-07-607903

Published: 2016

Includes: Supplemental data

Journal Articles

Platelet biogenesis wears silkworm cocoons

Koji Eto

Blood (2015) 125 (14): 2181–2182.

https://doi.org/10.1182/blood-2015-01-622530

Published: 2015

Journal Articles

A Novel Chemical Approach to Expand Platelets Using Immortalized Megakaryocyte Progenitor Cells Derived from Human Induced Pluripotent Stem Cells

Ayako Otani, Tomo Koike, Natsuki Abe, Takanori Nakamura, PhD, Taito Nishino, PhD, Hiromitsu Nakauchi, MD PhD, Koji Eto, MD, PhD

Blood (2014) 124 (21): 3845.

https://doi.org/10.1182/blood.V124.21.3845.3845

Published: 2014

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Exposure of hiPSC-Derived Mature Megakaryocytes to Vincristine Boosts Platelet Biogenesis in Vitro

Turbulence Enhances Fine-Tuning of Mitochondria Delivery in Megakaryocyte Maturation Contributing to Biogenesis of High Quality Platelets

iPSC-Derived Mesenchymal Stem Cells Supports the Ex Vivo expansion of Human Hematopoietic Stem and Progenitor Cells Via Sterile Inflammation Pathway

Ribosome dysfunction underlies SLFN14-related thrombocytopenia

iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study

The First-in-Human Clinical Trial of iPSC-Derived Platelets (iPLAT1): Autologous Transfusion to an Aplastic Anemia Patient with Alloimmune Platelet Transfusion Refractoriness

The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis

Harnessing a Novel Dyrk1a-Ablim2-MKL1 Regulatory Module in Megakaryocyte Morphogenesis to Enable Scalable Platelet "Pharming"

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

Ex vivo Engineering of Platelets

α IIb β 3 changes gears in MKs and platelets

Environmental Cell-Matrix Adhesion Modulates Pluripotent Stem Cell Fate Toward Definitive Hemogenic Endothelium and Hematopoietic Progenitor Cells

Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells

A Novel Megakaryocyte-Based Screening System Identifies Compounds That Promote Megakaryocyte Maturation and Platelet Production in Vitro

High-Vorticity with Periodic Flow Enhances in Vitro Biogenesis of Healthy Platelets from iPSC-Derived-Megakaryocytes

Synthetic miRNA Switch Technology Elucidates Heterogeneity in Regulation of Immortalized Megakaryocyte Cell Lines, Associated with Improvement of Platelet Generation Efficiency for Clinical Use

Natural Killer Cell Activities Against iPSCs-Derived HLA-Knockout Platelets and Megakaryocytes Reveal Perfect Rejection Profiles for Allotransfusion

Linkage between the mechanisms of thrombocytopenia and thrombopoiesis

Platelet biogenesis wears silkworm cocoons

A Novel Chemical Approach to Expand Platelets Using Immortalized Megakaryocyte Progenitor Cells Derived from Human Induced Pluripotent Stem Cells

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American Society of Hematology

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