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Journal Articles

Factor VIII–driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry

Nadia Freato, Eduard H. T. M. Ebberink, Josse van Galen, Caroline Fribourg, Mariëtte Boon-Spijker, Floris P. J. van Alphen, Alexander B. Meijer, Maartje van den Biggelaar, Koen Mertens
Journal: Blood
Blood (2020) 136 (23): 2703–2714.
https://doi.org/10.1182/blood.2020005593
Published: 2020
Includes: Supplemental data
Journal Articles

Whole Exome Sequencing and Extended Thrombophilia Testing in Patients with Venous Thromboembolism

Lauren Marsh Shevell, MD MPH, Eun-Ju Lee, MD, Rahul Dhodapkar, MBBS, Daniel Dykas, BS, MBA, Andreea Popa, MD PhD, Deqiong Ma, MD PhD, Noffar Bar, MD, Audrey Baluha, RN, Adrienne J. Burns, MMS, PA-C, Cassius Ilya Ochoa Chaar, MD, Anne Dupont, RN, Sean Gu, MD PhD, Stephanie Halene, MD, Randy Luciano, MD PhD, Rebecca Marien, RN, Natalia Neparidze, MD, Terri L Parker, MD, Xiaopan Yao, PhD, Rodney M. Camire, PhD, Eduard Ebberink, PhD, Pablo Garcia de Frutos, Kavitha Gnanasambandan, PhD, Peter P. Sayeski, PhD, James A. Huntington, PhD, Steven R. Lentz, MD PhD, Koen Mertens, PhD, Christopher Parish, PhD, Ray Rezaie, PhD, Jean M. Connors, BA, MD, Andrew Leavitt, MD, Allen Bale, MD, Alfred Ian Lee, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2506.
https://doi.org/10.1182/blood-2018-99-115529
Published: 2018
Journal Articles

Von Willebrand Factor Protects Factor VIII from Rapid Endocytosis Via LDL Receptor-Related Protein By Blocking the Initial Rate-Limiting Cell Surface Binding Step of Factor VIII

Henriet Meems, PhD, Carmen van der Zwaan, Koen Mertens, PhD, Alexander Meijer, PhD
Journal: Blood
Blood (2015) 126 (23): 214.
https://doi.org/10.1182/blood.V126.23.214.214
Published: 2015
Journal Articles

Cell-Surface Proteomics to Unravel Cytokine-Induced Endothelial Activation

Eelke Béguin, Bart van den Eshof, Koen Mertens, PhD, Alexander Meijer, PhD, Maartje van den Biggelaar
Journal: Blood
Blood (2015) 126 (23): 1039.
https://doi.org/10.1182/blood.V126.23.1039.1039
Published: 2015
Journal Articles

Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells

e-blood
Maartje van den Biggelaar, Juan Ramon Hernández-Fernaud, Bart L. van den Eshof, Lisa J. Neilson, Alexander B. Meijer, Koen Mertens, Sara Zanivan
Journal: Blood
Blood (2014) 123 (12): e22–e36.
https://doi.org/10.1182/blood-2013-12-546036
Published: 2014
Includes: Supplemental data
Journal Articles

Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease

Jiong-Wei Wang, Eveline A. M. Bouwens, Maria Carolina Pintao, Jan Voorberg, Huma Safdar, Karine M. Valentijn, Hetty C. de Boer, Koen Mertens, Pieter H. Reitsma, Jeroen Eikenboom
Journal: Blood
Blood (2013) 121 (14): 2762–2772.
https://doi.org/10.1182/blood-2012-06-434373
Published: 2013
Includes: Supplemental data
Journal Articles

Factor VIII Region 1811–1818 Is Involved in Factor IXa Binding and Factor VIIIa Stability

Esther Bloem, Msc, Henriet Meems, PhD, Maartje van den Biggelaar, PhD, Koen Mertens, PhD, Alexander B Meijer, PhD
Journal: Blood
Blood (2012) 120 (21): 3357.
https://doi.org/10.1182/blood.V120.21.3357.3357
Published: 2012
Journal Articles

Factors VIII and V swap fatty feet

Koen Mertens, Alexander B. Meijer
Journal: Blood
Blood (2012) 120 (9): 1761–1763.
https://doi.org/10.1182/blood-2012-07-434027
Published: 2012
Journal Articles

Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies

Eveline A. M. Bouwens, Marjon J. Mourik, Maartje van den Biggelaar, Jeroen C. J. Eikenboom, Jan Voorberg, Karine M. Valentijn, Koen Mertens
Journal: Blood
Blood (2011) 118 (22): 5947–5956.
https://doi.org/10.1182/blood-2011-05-355354
Published: 2011
Includes: Multimedia, Supplemental data
Journal Articles

The Role of Factor VIII C Domains in Sorting to Weibel-Palade Bodies

Eveline Bouwens, Maartje van den Biggelaar, Jan Voorberg, Koen Mertens, PhD
Journal: Blood
Blood (2011) 118 (21): 2241.
https://doi.org/10.1182/blood.V118.21.2241.2241
Published: 2011
Journal Articles

The N-Terminal Amino Acid Residues Ser764 and Lys773 of the D' Domain of Von Willebrand Factor Contribute to Factor VIII Binding

Lydia Castro-Núñez, Esther Bloem, Carmen van der Zwaan, Koen Mertens, PhD, Alexander B Meijer
Journal: Blood
Blood (2011) 118 (21): 2248.
https://doi.org/10.1182/blood.V118.21.2248.2248
Published: 2011
Journal Articles

Modification of An Interactive Surface in the C1 Domain Reduces Immune Responses to FVIII in a Mouse Model of Hemophilia A

Aleksandra Wroblewska, Simon D van Haren, Eszter Herczenik, Aleksandra Rusiecka, Paul H Kaijen, Anja ten Brinke, Koen Mertens, PhD, Jan Voorberg
Journal: Blood
Blood (2011) 118 (21): 199.
https://doi.org/10.1182/blood.V118.21.199.199
Published: 2011
Journal Articles

Co-Trafficking of Coagulation Factor VIII with Von Willebrand Factor Alters the Macromolecular Structure Inside Secretory Weibel-Palade Bodies

Eveline Bouwens, Marjon Mourik, Maartje van den Biggelaar, Jan Voorberg, Karine Valentijn, Koen Mertens, PhD
Journal: Blood
Blood (2010) 116 (21): 325.
https://doi.org/10.1182/blood.V116.21.325.325
Published: 2010
Journal Articles

Platelets Contribute to Protein S Cleavage In Vivo.

Herm Jan M Brinkman, Liane CJ te Boome, Harry R Koene, Koen Mertens
Journal: Blood
Blood (2009) 114 (22): 2124.
https://doi.org/10.1182/blood.V114.22.2124.2124
Published: 2009
Journal Articles

Factor VII Activating Protease (FSAP): Functional Implications of the “Marburg-1” Polymorphism.

Fabian Stavenuiter, Alexander B Meijer, Erica Sellink, Koen Mertens
Journal: Blood
Blood (2009) 114 (22): 2126.
https://doi.org/10.1182/blood.V114.22.2126.2126
Published: 2009
Journal Articles

Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity

Henriët Meems, Alexander B. Meijer, David B. Cullinan, Koen Mertens, Gary E. Gilbert
Journal: Blood
Blood (2009) 114 (18): 3938–3946.
https://doi.org/10.1182/blood-2009-01-197707
Published: 2009
Journal Articles

Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men

Bas de Laat, Philip G. de Groot, Ronald H. W. M. Derksen, Rolf T. Urbanus, Koen Mertens, Frits R. Rosendaal, Carine J. M. Doggen
Journal: Blood
Blood (2009) 114 (17): 3656–3661.
https://doi.org/10.1182/blood-2009-03-212910
Published: 2009
Journal Articles

Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles

Maartje van den Biggelaar, Alexander B. Meijer, Jan Voorberg, Koen Mertens
Journal: Blood
Blood (2009) 113 (13): 3102–3109.
https://doi.org/10.1182/blood-2008-05-159699
Published: 2009
Journal Articles

Differential Anticoagulant Effects of Protein S on Vascular Cells and Platelets.

Herm Jan Brinkman, Erica Sellink, Bas de Laat, Koen Mertens
Journal: Blood
Blood (2008) 112 (11): 2026.
https://doi.org/10.1182/blood.V112.11.2026.2026
Published: 2008
Journal Articles

Decreased beta2-Glycoprotein I Plasma Levels as a Risk Factor for Myocardial Infarction in Men.

Bas De Laat, PhD, Philip G. de Groot, PhD, Ronald H.W.M. Derksen, MD., Rolf T. Urbanus, Koen Mertens, PhD, Frits Rosendaal, MD, PhD, Carine J.M. Doggen, PhD
Journal: Blood
Blood (2008) 112 (11): 1813.
https://doi.org/10.1182/blood.V112.11.1813.1813
Published: 2008