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Juan Jose Lahuerta Palacios
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Journal Articles

Comprehensive DNA/RNA-based targeted sequencing for molecular karyotyping and clonality assessment in newly diagnosed multiple myeloma patients

Free
Juan Manuel Rosa-Rosa, Natalia Buenache, Iria Vazquez, Ricardo Sánchez, Cristina Jimenez, Laura Rosiñol, Norma Gutiérrez, Albert Oriol, Manuela Fernández, María-Jesús Blanchard, Rosa Ayala Diaz, Rafael Ríos, Anna Sureda, Miguel Hernandez Garcia, Javier de la Rubia, Joan Batista Blade Creixenti, María-Victoria Mateos, Juan-Jose Lahuerta Palacios, Jesus San-Miguel, Maria Calasanz, Ramon Garcia-Sanz, Joaquin Martinez-Lopez
Journal: Blood
Blood (2025) 146 (Supplement 1): 2562.
https://doi.org/10.1182/blood-2025-2562
Published: 2025
Journal Articles

Validation of the High-Risk Consensus Genomic Staging System in Newly Diagnosed Multiple Myeloma

Free
Magdalena Corona De Lapuerta, Maria Sanchez-Tabernero, Alejandro Medina, Maria Jose Larrayoz, Juan Manuel Rosa-Rosa, Veronica Gonzalez-Calle, Paula Rodriguez-Otero, Maria Calasanz, Manuela Fernández, Laura Rosiñol, Miguel Teodoro Hernández Garcia, Ana-Isabel Name, Mercedes Gironella Mesa, Albert Oriol, Javier de la Rubia, Ana Pilar Gonzalez, Joan Bargay, Marta Sonia Gonzalez Perez, Elena Garcia-Mozo, Roberto Maldonado, Anna Sureda Balarí, Enrique Ocio, Juan-Jose Lahuerta Palacios, Joan Batista Blade Creixenti, Jesus San-Miguel, María-Victoria Mateos, Norma Gutiérrez, Joaquin Martinez-Lopez
Journal: Blood
Blood (2025) 146 (Supplement 1): 922.
https://doi.org/10.1182/blood-2025-922
Published: 2025
Journal Articles

Minimally invasive assessment of peripheral residual disease (PRD) during maintenance or observation in patients (Pts) with multiple myeloma (MM): An update from the GEM2017FIT clinical trial

Free
Carmen Gonzalez, Marta Lasa, Cristina Agullo, Natalia Buenache, Laura Notarfranchi, Anastasiia Zherniakova, Maria Calasanz, Sergio Castro, Jose Perez, Veronica Gonzalez-Calle, Maria Teresa Cedena Romero, Alejandro Martín-Muñoz, Santiago Barrio Garcia, Albert Oriol, Enrique Ocio, Anna Sureda Balarí, Yolanda González-Montes, Angel Ramirez, Laura Rosiñol Dachs, Ana Lopez-Guia, Joan Bargay, Sunil Lakhwani, Luis Felipe Casado Montero, Joan Batista Blade Creixenti, Juan-Jose Lahuerta Palacios, Jesus San-Miguel, María-Victoria Mateos, Joaquin Martinez-Lopez, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2025) 146 (Supplement 1): 919.
https://doi.org/10.1182/blood-2025-919
Published: 2025
Journal Articles

Ending the undetermined significance of monoclonal gammopathies (MGUS): First results of the nomoremgus study

Free
Marta Lasa, Esperanza Martin-Sanchez, Aintzane Zabaleta, Diego Alignani, Carmen Gonzalez, Noemi Puig, Elena Alejo, Jorge Labrador, Maria Casanova Espinosa, Laura Rosiñol Dachs, Sebastián Garzón, Enrique Ocio, Albert Pérez-Montaña, Irene Romera, Carmen Couto, Sunil Lakhwani, Felipe Prosper, Adrian Alegre, Elena Cabezudo, Itziar Carro, Cristina Motlló, Montserrat Cortes, Isabel Maria Garcia Cabrera, Marta Romera, Javier de la Rubia, Andrea Manubens, Alexia Suarez Cabrera, Fernando Escalante Barrigón, Carlos Aguilar-Franco, Raquel Del Campo, Maria Esther Clavero Sanchez, Joaquin Martinez-Lopez, Valentin Cabanas Perianes, María-Jesús Blanchard, Ana Lopez-Guia, Diana Sanchez Arguello, Albert Oriol, Marta Reinoso -Segura, María Lourdes Amador Barciela, Celina Benavente Cuesta, Jose Maria Arguiñano PEREZ, Beatriz Ordoñez, Francisco Taboada, Joan Batista Blade Creixenti, María-Victoria Mateos, Juan-Jose Lahuerta Palacios, Jesus San-Miguel, Bruno Paiva
Journal: Blood
Blood (2025) 146 (Supplement 1): 578.
https://doi.org/10.1182/blood-2025-578
Published: 2025
Journal Articles

Transcriptional stratification reveals distinct molecular subtypes with treatment-specific outcomes in multiple myeloma patients from the GEM2017FIT trial

Free
Antonio Porlan, Beñat Ariceta, Paula Aguirre-Ruiz, Joana De Las Heras, Alejandro Medina, Alicia Gimenez, Patxi San Martin-Uriz, Maria Jose Larrayoz, Joaquin Martinez-Lopez, Veronica Gonzalez-Calle, Noemí Puig, Maria Calasanz, Norma Gutierrez, Anna Sureda Balarí, Maria Teresa Cedena Romero, Albert Oriol, Enrique Ocio, Laura Rosiñol Dachs, Joan Bargay, María-Jesús Blanchard, Valentin Cabanas Perianes, Juan-Jose Lahuerta Palacios, Joan Batista Blade Creixenti, Jesus San-Miguel, Paula Rodriguez-Otero, María-Victoria Mateos, Felipe Prosper
Journal: Blood
Blood (2025) 146 (Supplement 1): 496.
https://doi.org/10.1182/blood-2025-496
Published: 2025
Journal Articles

Combined assessment of circulating tumor cells (CTCs) and measurable residual disease (MRD) for dynamic risk assessment of patients (Pts) with multiple myeloma (MM)

Free
Bruno Paiva, Esperanza Martin-Sanchez, Mattia D'Agostino, Ioannis Kostopoulos, Luca Bertamini, David Žihala, Noemi Puig, Maria Teresa Cedena Romero, Hector Gracia, Pellegrino Musto, Delia Rota-Scalabrini, Angelo Belotti, Monica Galli, Elena Zamagni, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Ourania Tsitsilonis, Maria Gavriatopoulou, Sonja Zweegman, Tom Cupedo, Philippe Moreau, Jill Corre, Juan-Jose Lahuerta Palacios, Joan Batista Blade Creixenti, María-Victoria Mateos, Ondrej Venglar, Roman Hajek, Tomas Jelinek, Meletios Dimopoulos, Pieter Sonneveld, Annemiek Broijl, Marico Boccadoro, Francesca Gay, Jesus San-Miguel, Evangelos Terpos
Journal: Blood
Blood (2025) 146 (Supplement 1): 494.
https://doi.org/10.1182/blood-2025-494
Published: 2025
Journal Articles

Head-to-head longitudinal comparison of two mass spectrometry-based methods for monitoring monoclonal proteins in multiple myeloma: Analytical and clinical insights from the GEM-CESAR trial

Free
Noemi Puig, Matthew Nichols, Cristina Agullo, Sergio Castro, Joaquin Martinez-Lopez, Marta Sonia Gonzalez Perez, Albert Oriol, Rafael Rios Tamayo, Laura Rosiñol, Joan Bargay, Ana Pilar Gonzalez, Chai Phua, Adrian Alegre, María Belen Iñigo, Javier de la Rubia, Anabel Teruel, Miguel Paricio, Felipe de Arriba, Sunil Lakhwani, Javier Lopez Jimenez, Marta Reinoso -Segura, Joan Batista Blade Creixenti, Juan-Jose Lahuerta Palacios, María Teresa Cedena, Bruno Paiva, Jesus San-Miguel, Martha Louzada, María-Victoria Mateos
Journal: Blood
Blood (2025) 146 (Supplement 1): 2238.
https://doi.org/10.1182/blood-2025-2238
Published: 2025
Journal Articles

Early rescue intervention with daratumumab, pomalidomide and dexamethasone (DPd) in high-risk smoldering myeloma (HR-SMM) patients included in the GEM-CESAR treated with carfilzomib, lenalidomide and dexamethasone (KRd)- autologous stem cell transplantation (ASCT)-krd-rd

Free
María-Victoria Mateos, Joaquin Martinez-Lopez, Verónica González-Calle, Marta Sonia Gonzalez Perez, Albert Oriol, Javier Lopez Jimenez, Marta Reinoso -Segura, Rafael Rios Tamayo, Paula Rodriguez-Otero, Laura Rosiñol Dachs, Javier de la Rubia, Felipe de Arriba, Sunil Lakhwani, Joan Bargay, Ana Pilar Gonzalez, Noemí Puig, Maria Teresa Cedena Romero, Bruno Paiva, Adrian Alegre, Fernando Escalante Barrigón, Maria Belen Inigo-Rodriguez, Anabel Teruel, Luis Palomera, Aránzazu García-Mateo, Miguel Alvarez-Rivas, Enrique Ocio, Joan Batista Blade Creixenti, Juan-Jose Lahuerta Palacios, Jesus San-Miguel
Journal: Blood
Blood (2025) 146 (Supplement 1): 371.
https://doi.org/10.1182/blood-2025-371
Published: 2025
Journal Articles

Absence of circulating tumor cells (CTCs) defines a subtype of multiple myeloma (MM) patients (Pts) with unique clinical and biological features

Free
Esperanza Martin-Sanchez, Marta Lasa, Juan-Jose Garces, Luca Bertamini, Ioannis Kostopoulos, Mattia D'Agostino, David Žihala, Niels Weinhold, Aldo Roccaro, Jill Corre, Hector Gracia, Rosalinda Termini, Irene Manrique, Carmen Vicente, Maddalen Jimenez, Anna Sureda Balarí, Felipe Prosper, Enrique Ocio, Sebastián Garzón, Esther González García, Elena Cabezudo, Albert Oriol, Sunil Lakhwani, Albert Pérez-Montaña, Maria Casanova Espinosa, Pieter Sonneveld, Evangelos Terpos, Francesca Gay, Tomas Jelinek, Marta Larrayoz, Jose A. Martinez-Climent, Laura Rosiñol Dachs, Joan Batista Blade Creixenti, María-Victoria Mateos, Joaquin Martinez-Lopez, Juan-Jose Lahuerta Palacios, Jesus San-Miguel, Maria Teresa Cedena Romero, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2025) 146 (Supplement 1): 366.
https://doi.org/10.1182/blood-2025-366
Published: 2025
Journal Articles

Immune biomarkers of increased risk of infection in multiple myeloma (MM)

Free
Aintzane Zabaleta, Luis-Esteban Tamariz-Amador, Ioannis V. Kostopoulos, Romanos Sklavenitis-Pistofidis, Febe Smits, Carmen Roncal, Michelle Aranha, David Zihala, Michaela Machu, Nikolaos Tsakirakis, Panagiotis Bakouros, Ourania Tsitsilonis, Eirini Solia, Cristina Moreno, Catarina Maia, Esperanza Martin-Sanchez, José J. Perez, Cristina Encinas, Rafael Rios Tamayo, Albert Oriol, María-Jesús Blanchard, Felipe de Arriba, Esther González García, Sunil Lakhwani, Anna Sureda Balarí, Valentin Cabanas Perianes, Fernando Escalante Barrigón, Estrella Carrillo-Cruz, Albert Pérez-Montaña, Enrique Ocio, Joan Bargay, Alberto Orfao, Tomas Jelinek, Irene Ghobrial, Tuna Mutis, Sonja Zweegman, Evangelos Terpos, Efstathios Kastritis, Joaquin Martinez-Lopez, Juan-Jose Lahuerta Palacios, Carlos Fernandez de Larrea, Laura Rosiñol, Joan Batista Blade Creixenti, Paula Rodriguez-Otero, María-Victoria Mateos, Jesus San-Miguel, Maria Teresa Cedena Romero, Noemí Puig, Bruno Paiva
Journal: Blood
Blood (2025) 146 (Supplement 1): 365.
https://doi.org/10.1182/blood-2025-365
Published: 2025
Journal Articles

Integrative omics analysis of TP53 in multiple myeloma patients

Free
Cristina De Ramón Sánchez, Elizabeta A Rojas, Irena Misieweicz, Maria García-Alvarez, Myriam Cuadrado, Sara Cristobal, Ignacio J Cardona-Benavides, Isabel M Isidro, Maria Calasanz, Miguel Alcoceba, Ramon Garcia-Sanz, Laura Rosiñol Dachs, Joaquin Martinez-Lopez, Joan Batista Blade Creixenti, Juan-Jose Lahuerta Palacios, Jesus San-Miguel, María-Victoria Mateos, Luis Antonio Corchete Sanchez, Norma Gutiérrez
Journal: Blood
Blood (2025) 146 (Supplement 1): 2162.
https://doi.org/10.1182/blood-2025-2162
Published: 2025
Journal Articles

Development and Validation of Novel Machine Learning-Based Risk Scores for Multiple Myeloma: Insights from the Harmony Alliance Big Data Platform

Free
Adrian Mosquera Orgueira, Marta Sonia Gonzalez Perez, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, Carlos Pérez Míguez, Niels W.C.J. Van De Donk, Graham Jackson, Davide Crucitti, Hans Salwender, Daniele Dall'Olio, Gastone Castellani, Manuel Piñeiro Fiel, Sara Bringhen, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Pieter Sonneveld, Jesús F. San-Miguel, Mario Boccadoro, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 2226.
https://doi.org/10.1182/blood-2024-201448
Published: 2024
Journal Articles

GEM2017Fit Phase 3 Trial in Fit Elderly Patients (Aged 65-80) with Newly Diagnosed Myeloma: Impact of Daratumumab at Induction and/or Consolidation

Free
Maria- Victoria Mateos, Bruno Paiva, Maria Teresa Cedena Romero, Noemi Puig, Anna Sureda Balari, Albert Oriol, Enrique M Ocio, Laura Rosiñol, Yolanda González-Montes, Joan Bargay, Esther Gonzalez Garcia, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado, Valentin Cabanas Perianes, Jaime Perez de Oteyza, Mercedes Gironella, Joaquin Martínez-López, Ana-Isabel -Teruel, Pilar Delgado, Elena Prieto, Juan-Jose Lahuerta Palacios, Joan Bladé, Jesús F. San-Miguel
Journal: Blood
Blood (2024) 144 (Supplement 1): 678.
https://doi.org/10.1182/blood-2024-203170
Published: 2024
Journal Articles

Reevaluating the IMWG Multiple Myeloma Complete Response Criterion in the Era of Mass Spectrometry: A Critical Analysis

Free
Noemi Puig, Cristina Agullo, Bruno Paiva, María T Cedena, Laura Rosiñol Dachs, Teresa Contreras, Joaquín Martínez-Lopez, Albert Oriol, María-Jesús Blanchard, Rafael Rios Tamayo, Ana Maria Sureda Balari, Miguel Teodoro Hernández Garcia, Javier de la Rubia, Valentin Cabanas Perianes, Felipe De Arriba, Luis Palomera, Maria Belen Inigo Rodriguez, Veronica Gonzalez-Calle, Enrique M Ocio, Sergio Castro, Joan Bargay, Joan Bladé, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 489.
https://doi.org/10.1182/blood-2024-210198
Published: 2024
Journal Articles

Early Relapse in Patients with Newly-Diagnosed Multiple Myeloma: A European Myeloma Network/Harmony Alliance Analysis Including 10843 Patients

Free
Elias K. Mai, Andrea Manubens, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, María-Victoria Mateos, Daniele Dall'Olio, Niels W.C.J. van de Donk, Graham Jackson, Serena Rocchi, Hans Salwender, Joan Bladé, Bronno van der Holt, Gastone Castellani, Katja C. Weisel, Francesca Gay, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Mario Boccadoro, Jesús F. San-Miguel, Pieter Sonneveld
Journal: Blood
Blood (2024) 144 (Supplement 1): 898.
https://doi.org/10.1182/blood-2024-193310
Published: 2024
Journal Articles

Unraveling Long-Term Survival of Multiple Myeloma Patients, the GEM2000 Experience

Free
Rafael Alonso Fernandez, Andrés Arroyo Barea, Maria Teresa Cedena Romero, Laura Rosiñol Dachs, Javier de la Rubia, Sara Miqueleiz, Veronica Gonzalez-Calle, Felipe De Arriba, Luis Felipe Casado Montero, Miguel Teodoro Hernandez, Maria Mas Esteve, Pascual Fernandez, Paula Rodríguez-Otero, Carmen Calle Primo, Eugenia Abella, Paz Ribas, Adrian Alegre, Juan Miguel Bergua, Irene Gomez-Catalan, Jose Maria Arguiñano Perez, Luis Palomera, Enrique M Ocio, Maria Jose Busto Medina, Nieves Somolinos, Jose Maria Alonso Alonso, Aránzazu García Mateo, Joan Bargay, Pilar Delgado, Dunia De Miguel Llorente, Javier de la Cruz, Maria Victoria Mateos, Jesús F. San-Miguel, Joan Bladé, Juan-Jose Lahuerta Palacios, Joaquin Martinez Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2024-211383
Published: 2024
Journal Articles

Multiomic Characterization of Clonotypic B Cells in Patients with Monoclonal Gammopathies

Free
Carmen Gonzalez, Camila Guerrero, Juan-José Garcés, Alejandro Medina, Noemi Puig, Maria Teresa Cedena Romero, Diego Alignani, Sarai Sarvide, Paula Aguirre-Ruiz, Jose Maria Lamo-Espinosa, Felipe Prosper, Paula Rodríguez-Otero, Jose A. Martinez-Climent, Aldo Roccaro, Antonio Sacco, Mario Nuvolone, Giovanni O. Palladini, Laura Rosiñol Dachs, Ramon García-Sanz, Joaquín Martínez-Lopez, Juan-Jose Lahuerta Palacios, Maria-Victoria Mateos, Joan Bladé, Jesús F. San-Miguel, Bruno Paiva
Journal: Blood
Blood (2024) 144 (Supplement 1): 1879.
https://doi.org/10.1182/blood-2024-201435
Published: 2024
Journal Articles

Clinical Value of Peripheral Residual Disease (PRD) and Measurable Residual Disease (MRD) in Newly Diagnosed Elderly Patients in the GEM2017FIT Trial

Free
Noemi Puig, Bruno Paiva, María T Cedena, Cristina Agullo, Teresa Contreras, Sergio Castro, Ana Maria Sureda Balari, Veronica Gonzalez-Calle, Albert Oriol, Enrique M Ocio, Laura Rosiñol Dachs, Yolanda González-Montes, Joan Bargay, Esther González García, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado Montero, Valentin Cabanas Perianes, Jaime Perez de Oteyza, Mercedes Gironella, Joaquín Martínez-Lopez, Pilar Delgado, Elena Prieto, Juan-Jose Lahuerta Palacios, Joan Bladé, Jesús F. San-Miguel, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 365.
https://doi.org/10.1182/blood-2024-209748
Published: 2024
Journal Articles

Survival Improvement of Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma in Two Consecutive Randomized Phase III Trials: Long-Term Follow up of GEM05 and GEM12 Trials

Free
Laura Rosiñol Dachs, Albert Oriol, María-Jesús Blanchard, Javier de la Rubia, Rafael Ríos, Joan Bargay, Miguel Teodoro Hernández Garcia, Valentín Cabanas Perianes, Ana López de la Guía, Estrella Carrillo-Cruz, Anna Sureda Balari, Joaquin Martínez-López, Jose Maria Arguiñano, Esther González García, Luis Felipe Casado, Josep Maria Marti Tutusaus, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Jordi López-Pardo, Maialen Sirvent, Maria Belen Inigo Rodriguez, Bruno Paiva, Noemi Puig, Maria Teresa Cedena Romero, Norma C. Gutierrez, Javier De la Cruz, Maria-Victoria Mateos, Jesús F. San-Miguel, Juan-Jose Lahuerta Palacios, Joan Bladé
Journal: Blood
Blood (2024) 144 (Supplement 1): 3374.
https://doi.org/10.1182/blood-2024-205453
Published: 2024
Journal Articles

Minimally Invasive Assessment of Measurable Residual Disease (MRD) in Multiple Myeloma (MM)

Free
Carmen Gonzalez, Marta Lasa, Laura Notarfranchi, Cristina Agullo, Natalia Buenache Cuenda, Anastasiia Zherniakova, Sergio Castro, José Juan Pérez, Veronica Gonzalez-Calle, Maria Teresa Cedena Romero, Santiago Barrio, Alejandro Martín-Muñoz, Leire Burgos, Diego Alignani, Maria Jose Calasanz, Paula Rodriguez Otero, Laura Rosiñol, Felipe De Arriba, Enrique M Ocio, Albert Oriol Rocafiguera, Luis Palomera, Yolanda González-Montes, Anna Maria Sureda Balari, Miguel Teodoro Hernandez Garcia, Maria Esther Clavero Sanchez, Angela Ibanez Garcia, Clara Gomez, Alberto Orfao, Maria Victoria Mateos, Juan Jose Lahuerta Palacios, Joan Bladé, Jesus San-Miguel, Joaquin Martinez-Lopez, Noemi Puig, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 339.
https://doi.org/10.1182/blood-2023-186916
Published: 2023