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Journal Articles

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thomas Gentinetta, PhD, Gregory M. Vercellotti, MD, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, PhD, Gregory J Kato, MD, Nathan Brinkman, PhD, Adrian Zuercher, PhD, John D Belcher, PhD

Blood (2020) 136 (Supplement 1): 9.

https://doi.org/10.1182/blood-2020-140236

Published: 2020

Journal Articles

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

John D Belcher, PhD, Fuad Abdulla, Chunsheng Chen, Ping Zhang, PhD, Dormarie Rivera-Rodriguez, Rachel Kirchner, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Kristine Nachbor, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 3555.

https://doi.org/10.1182/blood-2019-127114

Published: 2019

Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 983.

https://doi.org/10.1182/blood-2019-127300

Published: 2019

Journal Articles

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Ping Zhang, PhD, John D Belcher, PhD, Julia Nguyen, Fuad Abdulla, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 208.

https://doi.org/10.1182/blood-2019-122912

Published: 2019

Journal Articles

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

John D Belcher, PhD, Ping Zhang, PhD, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, John O Trent, PhD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 209.

https://doi.org/10.1182/blood-2019-123788

Published: 2019

Journal Articles

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Erica Sparkenbaugh, PhD BS, Chunsheng Chen, MD, Julia Nguyen, BS, Shaobin Wang, PhD, Gregory M. Vercellotti, MD, John D Belcher, PhD, Rafal Pawlinski, PhD

Blood (2018) 132 (Supplement 1): 266.

https://doi.org/10.1182/blood-2018-99-116238

Published: 2018

Journal Articles

Decreased Erythrocyte Binding Capability for Neutrophil Siglec-9 Is a Source of Oxidative Stress in Sickle Cell Disease

Zachary Monroe Kiser, BS, PhD, Greta L Becker, Julia Nguyen, BS, Anel Lizcano, PhD, John D Belcher, PhD, Ajit P. Varki, MBBS, Gregory M. Vercellotti, MD

Blood (2018) 132 (Supplement 1): 3650.

https://doi.org/10.1182/blood-2018-99-113579

Published: 2018

Journal Articles

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

John D Belcher, PhD, Edward Gomperts, MD, Julia Nguyen, BS, Chunsheng Chen, MD, Fuad Abdulla, Hao Nguyen, Tran Vo, Karina Bursch, Zachary M Kiser, PhD, Howard Levy, MDPhD, Leo E Otterbein, PhD, Gregory M Vercellotti, MD FACP

Blood (2017) 130 (Supplement 1): 2232.

https://doi.org/10.1182/blood.V130.Suppl_1.2232.2232

Published: 2017

Journal Articles

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

Francesca Vinchi, PhD, Gregory M Vercellotti, MD, John D. Belcher, PhD, Eitan Fibach, PhD, Hala Zreid, MD, Rushdy Rasras, Hussam Ghoti, MD, Martina U. Muckenthaler, PhD, Eliezer A. Rachmilewitz, MD

Blood (2016) 128 (22): 2469.

https://doi.org/10.1182/blood.V128.22.2469.2469

Published: 2016

Journal Articles

Haptoglobin and Hemopexin Infusion Efficiently Activates the Nrf2/HO-1 Axis and Inhibits Inflammation and Vaso-Occlusion in Murine Sickle Cell Disease

John D Belcher, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Hao Nguyen, Ping Zhang, PhD, Nathan Brinkman, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 2477.

https://doi.org/10.1182/blood.V128.22.2477.2477

Published: 2016

Journal Articles

Hemoglobin S Oxidation Promotes Plasma-Derived Microparticle Membrane Alterations and Toxicity

Sirsendu Jana, PhD, Michael B Strader, PhD, Tigist Kassa, PhD, Fantao Meng, PhD, Wayne Hicks, PhD, Ivan Tarandovskiy, PhD, Silvia De Paoli, PhD, Jan Simak, PhD, Jeffery L Miller, MD, Laurel Mendelsohn, BSc., Jim Nichols, RSN, Swee Lay Thein, MD, John D. Belcher, PhD, Gregory M Vercellotti, MD, Abdu Alayash, PhD

Blood (2016) 128 (22): 856.

https://doi.org/10.1182/blood.V128.22.856.856

Published: 2016

Journal Articles

Serum Haptoglobin and Hemopexin Levels in Pediatric SS and SC Disease Patients: Biomarker of Hemolysis and Inflammation

Rayra Pereira Santiago, MSc, Caroline Conceição Guarda, MSc, Camylla Vilas Boas Figueiredo, Graduated, Luciana Magalhaes Fiuza, Graduation student, Corynne Stephanie Ahouefa Adanho, MSc, Milena Magalhães Aleluia, MSc, Dalila Luciola Zanette, PhD, Magda Oliveira Seixas Carvalho, PhD, Isa Menezes Lyra, MD PhD, Valma Maria Lopes, MD, Julia Nguyen, BS, Trevor Killeen, Hao Nguyen, Gregory M. Vercellotti, MD, John D. Belcher, PhD, Marilda Souza Goncalves, PhD

Blood (2016) 128 (22): 3649.

https://doi.org/10.1182/blood.V128.22.3649.3649

Published: 2016

Journal Articles

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

Terry Robert Schaid, Jr., BA, Julia Nguyen, BS, Chunsheng Chen, PhD, Fuad Abdulla, DVM, Trevor Killeen, Hao Nguyen, Joseph Edmund, MBBS, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD, Agustin P Dalmasso, MD, John D Belcher, PhD, Gregory M Vercellotti, MD

Blood (2016) 128 (22): 158.

https://doi.org/10.1182/blood.V128.22.158.158

Published: 2016

Journal Articles

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

James G McArthur, PhD, Thiago Maciel, PhD, Chunsheng Chen, PhD, Aurelie Fricot, Dione Kobayashi, PhD, Julia Nguyen, BS, Phong Nguyen, Anna Parachova, PhD, Fuad Abdulla, Gregory M. Vercellotti, MD, Niels Svenstrup, PhD, John D Belcher, PhD

Blood (2016) 128 (22): 268.

https://doi.org/10.1182/blood.V128.22.268.268

Published: 2016

Journal Articles

Three Months of Human Haptoglobin Treatment Decreases Iron Deposition in the Kidneys of Townes Sickle Mice

Patricia A Shi, MD, Erika Choi, BA, Julia Nguyen, BS, Xinhua Guo, BS, Narla Mohandas, DSc, Abdu Alayash, PhD, Elizabeth Manci, MD, John D. Belcher, PhD, Gregory M Vercellotti

Blood (2015) 126 (23): 2163.

https://doi.org/10.1182/blood.V126.23.2163.2163

Published: 2015

Journal Articles

Targeting Putative Mu Opioid/Chemokine Receptor Type 5 Heteromers Potently Attenuates Nociception in a Murine Model of Sickle Cell Disease

Giuseppe Cataldo, PhD, Mary M. Lunzer, MA, Donald A. Simone, PhD, Eyup Akgün, PhD, John D. Belcher, PhD, Gregory M Vercellotti, Philip S. Portoghese, PhD

Blood (2015) 126 (23): 277.

https://doi.org/10.1182/blood.V126.23.277.277

Published: 2015

Journal Articles

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Gregory M Vercellotti, Ping Zhang, PhD, Chunsheng Chen, PhD, Julia Nguyen, BS, Fuad Abdulla, DVM, Phong Nguyen, BS, Carlos Nowotny, Aman Irfanullah, Ann Smith, PhD, Clifford J. Steer, MD, John D. Belcher, PhD

Blood (2015) 126 (23): 412.

https://doi.org/10.1182/blood.V126.23.412.412

Published: 2015

Journal Articles

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

John D. Belcher, PhD, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Phong Nguyen, Minh Nguyen, Ping Zhang, PhD, Pauline Xu, Nicholas J. Slipek, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 219.

https://doi.org/10.1182/blood.V124.21.219.219

Published: 2014

Journal Articles

Phenotypic Characterization the Townes Sickle Mice

Julia Nguyen, BS, Fuad Abdulla, Chunsheng Chen, Phong Nguyen, Minh Nguyen, Benjamin Tittle, Gerard O'Sullivan, MVB, MSc, PhD MACVSc, John D. Belcher, PhD, Gregory M. Vercellotti, MD

Blood (2014) 124 (21): 4916.

https://doi.org/10.1182/blood.V124.21.4916.4916

Published: 2014

Journal Articles

H-Ferritin Ferroxidase Activity Induces Cytoprotective Pathways and Inhibits Microvascular Stasis in Transgenic Sickle Mice

Gregory M Vercellotti, MD, Chunsheng Chen, PhD, Carol M Bruzzone, MS, Heather A. Bechtel, MD, Julia Ngyuen, BS, Robert P Hebbel, MD, Clifford J Steer, MD, John D Belcher, PhD

Blood (2012) 120 (21): 378.

https://doi.org/10.1182/blood.V120.21.378.378

Published: 2012

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Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Deletion of TLR4 in Townes SS Mice Prevents Microvascular Stasis in Response to Hemin, LPS and Hypoxia/Reoxygenation: Role of Inflammation

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Thrombin-Mediated Activation of PAR-1 Contributes to Microvascular Stasis in Mouse Models of Sickle Cell Disease Via Increased Endothelial Expression of P-Selectin and VWF

Decreased Erythrocyte Binding Capability for Neutrophil Siglec-9 Is a Source of Oxidative Stress in Sickle Cell Disease

Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia

Systemic Heme and Iron Overload Results in Depletion of Serum Hemopexin, Haptoglobin and Transferrin and Correlates with Markers of Endothelial Activation and Lipid Oxidation in Beta Thalassemia Major and Intermedia

Haptoglobin and Hemopexin Infusion Efficiently Activates the Nrf2/HO-1 Axis and Inhibits Inflammation and Vaso-Occlusion in Murine Sickle Cell Disease

Hemoglobin S Oxidation Promotes Plasma-Derived Microparticle Membrane Alterations and Toxicity

Serum Haptoglobin and Hemopexin Levels in Pediatric SS and SC Disease Patients: Biomarker of Hemolysis and Inflammation

Complement Activation in a Murine Model of Sickle Cell Disease: Inhibition of Vaso-Occlusion By Blocking C5 Activation

A Novel, Highly Potent and Selective PDE9 Inhibitor for the Treatment of Sickle Cell Disease

Three Months of Human Haptoglobin Treatment Decreases Iron Deposition in the Kidneys of Townes Sickle Mice

Targeting Putative Mu Opioid/Chemokine Receptor Type 5 Heteromers Potently Attenuates Nociception in a Murine Model of Sickle Cell Disease

Hemopexin Gene Therapy Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Cell Mice

Dimethyl Fumarate Induces Cytoprotection and Inhibits Inflammation and Vaso-Occlusion in Transgenic Sickle Mice

Phenotypic Characterization the Townes Sickle Mice

H-Ferritin Ferroxidase Activity Induces Cytoprotective Pathways and Inhibits Microvascular Stasis in Transgenic Sickle Mice

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