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Journal Articles

Oral Administration of Nitrous Oxide Reduces Acute Vaso-Occlusive Pain in Mice with Sickle Cell Disease

Ana Alves, Fuad Abdulla, Kaje Allen, Iryna A. Khasabova, Sergey G. Khasabov, Mark Young, Andrew Gomperts, Edward Gomperts, John D. Belcher, Gregory M. Vercellotti, Donald A. Simone

Blood (2024) 144 (Supplement 1): 3866.

https://doi.org/10.1182/blood-2024-203365

Published: 2024

Journal Articles

Bruton Tyrosine Kinase Inhibitor Rilzabrutinib Reduces Vaso-Occlusion and Markers of Inflammation and Adhesion in Transgenic Mice with Sickle Cell Disease

Ahmed Daak, David R. Light, Fuad Abdulla, Chunsheng Chen, Julia Nguyen, Conglin Ruan, Michael Storek, Dimitry Ofengeim, Alexandra Hicks, Michelle Lee, Vincent Mikol, Gregory M. Vercellotti, John D. Belcher

Blood (2024) 144 (Supplement 1): 2482.

https://doi.org/10.1182/blood-2024-200182

Published: 2024

Journal Articles

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Zalaya K. Ivy, John D. Belcher, Iryna A. Khasabova, Chunsheng Chen, Joseph P. Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M. Rogness, Joan D. Beckman, Sergey G. Khasabov, Kalpna Gupta, Ronald P. Taylor, Donald A. Simone, Gregory M. Vercellotti

Blood (2023) 142 (22): 1918–1927.

https://doi.org/10.1182/blood.2022019282

Published: 2023

Includes: Supplemental data

Journal Articles

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Blood (2023) 141 (15): 1871–1883.

https://doi.org/10.1182/blood.2022017074

Published: 2023

Includes: Multimedia, Supplemental data

Journal Articles

Phase II Study of Myeloablative 8/8- or 7/8-Matched Allotransplantation with Post-Transplant Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil: Marked Reduction in Gvhd Risk without Increased Relapse Risk Compared to Historical Cyclosporine/Methotrexate

Blood (2022) 140 (Supplement 1): 282–283.

https://doi.org/10.1182/blood-2022-165782

Published: 2022

Journal Articles

Radiation Sparing Reduced Intensity Conditioning for Allogeneic Cell Transplantation in Patients with Dyskeratosis Congenita Comparable to Standard of Care: A Phase III Single Institution Trial

Marketa Dimitrov, Svatava Merkle, Gregory M. Vercellotti, Shernan G Holtan, Jakub Tolar, Christen L. Ebens

Blood (2022) 140 (Supplement 1): 7611–7612.

https://doi.org/10.1182/blood-2022-165290

Published: 2022

Journal Articles

Extracellular Vesicles from Sickle Red Blood Cells Activate Endothelial Cells and Trigger Von Willebrand Factor-Mediated Sickle Red Cell Adhesion

Ran An, Yuncheng Man, Kevin Cheng, Tianyi Zhang, Chunsheng Chen, Erdem Kucukal, William Wulftange, Utku Goreke, Allison Bode, Lalitha Nayak, Gregory M. Vercellotti, John D Belcher, Jane Alison Little, Umut A. Gurkan

Blood (2022) 140 (Supplement 1): 8223–8225.

https://doi.org/10.1182/blood-2022-170438

Published: 2022

Journal Articles

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Zalaya K Ivy, John D Belcher, Iryna A Khasabova, Chunsheng Chen, Joseph P Juliette, Fuad Abdulla, Conglin Ruan, Kaje Allen, Julia Nguyen, Victoria M Rogness, Sergey Khasabov, Kalpna Gupta, Donald Simone, Gregory M. Vercellotti

Blood (2022) 140 (Supplement 1): 443–444.

https://doi.org/10.1182/blood-2022-157597

Published: 2022

Journal Articles

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

Aithanh Nguyen, Joseph P Juliette, Alison Wong, Elena Aronovich, Maya Abdullah, Julia Nguyen, Fuad Abdulla, Chunsheng Chen, Iryna A Khasabova, John D Belcher, Gregory M. Vercellotti, Donald Simone, Joan D Beckman

Blood (2022) 140 (Supplement 1): 2500–2501.

https://doi.org/10.1182/blood-2022-163508

Published: 2022

Journal Articles

A model of painful vaso-occlusive crisis in mice with sickle cell disease

Iryna I. Khasabova, Joseph Juliette, Victoria M. Rogness, Sergey G. Khasabov, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, John D. Belcher, Gregory M. Vercellotti, Virginia S. Seybold, Donald A. Simone

Blood (2022) 140 (16): 1826–1830.

https://doi.org/10.1182/blood.2022017309

Published: 2022

Journal Articles

Phase 2 Results of Urinary-Derived Human Chorionic Gonadotropin/Epidermal Growth Factor As Treatment for Life-Threatening Acute Gvhd

Blood (2021) 138 (Supplement 1): 261.

https://doi.org/10.1182/blood-2021-145008

Published: 2021

Journal Articles

Low Incidence of Chronic Graft-Versus-Host Disease in Myeloablative Allogeneic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide Using Matched Related or Unrelated Donors: Phase II Study Interim Analysis

Blood (2021) 138 (Supplement 1): 1811.

https://doi.org/10.1182/blood-2021-147569

Published: 2021

Journal Articles

Updated Results of a Phase 1/2 Clinical Study of Zinc Finger Nuclease-Mediated Editing of BCL11A in Autologous Hematopoietic Stem Cells for Transfusion-Dependent Beta Thalassemia

Mark C. Walters, Angela R. Smith, Gary J. Schiller, Erica B. Esrick, David A. Williams, Tatiana Gogoleva, Didier Rouy, Bettina M. Cockroft, Gregory M. Vercellotti

Blood (2021) 138 (Supplement 1): 3974.

https://doi.org/10.1182/blood-2021-147907

Published: 2021

Journal Articles

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Selva Nataraja, Maneet Singh, Shilpa Demes, Lyndsay Olson, Jeff Stanwix, Margaret Biddle, Emer Clarke, Yongzhao Huang, Julia Nguyen, Chunsheng Chen, Ping Zhang, Fuad Abdulla, Gregory M. Vercellotti, John D Belcher

Blood (2021) 138 (Supplement 1): 854.

https://doi.org/10.1182/blood-2021-151606

Published: 2021

Journal Articles

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

Christina M Abrams, Erica Sparkenbaugh, Yongmei Xu, Chunsheng Chen, Kasemsiri Chandarajoti, Lantarima Bhoopat, John D Belcher, Gregory M. Vercellotti, Jian Liu, Rafal Pawlinski

Blood (2021) 138 (Supplement 1): 857.

https://doi.org/10.1182/blood-2021-148486

Published: 2021

Journal Articles

High Incidence of Venous Thromboembolism in Patients with Chronic Graft-Versus-Host Disease

Blood (2020) 136 (Supplement 1): 44–46.

https://doi.org/10.1182/blood-2020-136337

Published: 2020

Journal Articles

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Thomas Gentinetta, PhD, Gregory M. Vercellotti, MD, Chunsheng Chen, Julia Nguyen, Fuad Abdulla, Ping Zhang, PhD, Gregory J Kato, MD, Nathan Brinkman, PhD, Adrian Zuercher, PhD, John D Belcher, PhD

Blood (2020) 136 (Supplement 1): 9.

https://doi.org/10.1182/blood-2020-140236

Published: 2020

Journal Articles

Ruxolitinib Reduces Endothelial Pro-Adhesive Interactions: Implications for JAK2 V617+ MPN Thrombosis

Angelica DaSilva, BS, Elena Aronovich, PhD, Aithanh Nguyen, Julia Nguyen, David Reynolds, Geneva D. Doak, B.S., PhD, Gregory M. Vercellotti, MD, David K. Wood, PhD, Joan D. Beckman, MDPhD

Blood (2020) 136 (Supplement 1): 1.

https://doi.org/10.1182/blood-2020-140116

Published: 2020

Journal Articles

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Erica M. Sparkenbaugh, Chunsheng Chen, Tomasz Brzoska, Julia Nguyen, Shaobin Wang, Gregory M. Vercellotti, Nigel S. Key, Prithu Sundd, John D. Belcher, Rafal Pawlinski

Blood (2020) 135 (20): 1783–1787.

https://doi.org/10.1182/blood.2019003543

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

John D Belcher, PhD, Margaret Biddle, PhD, Domi Stickens, PhD, Lyndsay Olson, Eric Bell, Chunsheng Chen, Fuad Abdulla, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, Jacob Lloyd, MD, Gregory M Vercellotti, MD

Blood (2019) 134 (Supplement_1): 983.

https://doi.org/10.1182/blood-2019-127300

Published: 2019

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Oral Administration of Nitrous Oxide Reduces Acute Vaso-Occlusive Pain in Mice with Sickle Cell Disease

Bruton Tyrosine Kinase Inhibitor Rilzabrutinib Reduces Vaso-Occlusion and Markers of Inflammation and Adhesion in Transgenic Mice with Sickle Cell Disease

Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Phase II Study of Myeloablative 8/8- or 7/8-Matched Allotransplantation with Post-Transplant Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil: Marked Reduction in Gvhd Risk without Increased Relapse Risk Compared to Historical Cyclosporine/Methotrexate

Radiation Sparing Reduced Intensity Conditioning for Allogeneic Cell Transplantation in Patients with Dyskeratosis Congenita Comparable to Standard of Care: A Phase III Single Institution Trial

Extracellular Vesicles from Sickle Red Blood Cells Activate Endothelial Cells and Trigger Von Willebrand Factor-Mediated Sickle Red Cell Adhesion

Cold Exposure Induces Vaso-Occlusion and Hyperalgesia in Mice with Sickle Cell Disease That Is Dependent on Complement Activation

Histone Deacetylase 6 Inhibition Prevents Vaso-Occlusion and Pain in Sickle Cell Mice

A model of painful vaso-occlusive crisis in mice with sickle cell disease

Phase 2 Results of Urinary-Derived Human Chorionic Gonadotropin/Epidermal Growth Factor As Treatment for Life-Threatening Acute Gvhd

Low Incidence of Chronic Graft-Versus-Host Disease in Myeloablative Allogeneic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide Using Matched Related or Unrelated Donors: Phase II Study Interim Analysis

Updated Results of a Phase 1/2 Clinical Study of Zinc Finger Nuclease-Mediated Editing of BCL11A in Autologous Hematopoietic Stem Cells for Transfusion-Dependent Beta Thalassemia

ML-0207/ASP8731: A Novel BACH1 Inhibitor That Induces Fetal Hemoglobin in Treatment of Sickle Cell Disease

Synthetic Heparan Sulfate Compounds Attenuate Vascular Complications Associated with Sickle Cell Disease

High Incidence of Venous Thromboembolism in Patients with Chronic Graft-Versus-Host Disease

Microvascular Stasis Inhibition By Hemopexin in the Townes Mouse Model of Sickle Cell Disease

Ruxolitinib Reduces Endothelial Pro-Adhesive Interactions: Implications for JAK2 V617+ MPN Thrombosis

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Bach1 Inhibitors Reduce Stasis in Townes Sickle Cell Mouse Model

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