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Jeffrey R Shearstone
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Journal Articles

Chromatin Accessibility Mapping of Primary Erythroid Cell Populations Leads to Identification and Validation of Nuclear Factor I X (NFIX) As a Novel Fetal Hemoglobin (HbF) Repressor

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Mudit Chaand, PhD, Chris Fiore, PhD, Brian T Johnston, MS, Diane H Moon, PhD, John P Carulli, PhD, Jeffrey R Shearstone, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 812.
https://doi.org/10.1182/blood-2019-124337
Published: 2019
Journal Articles

The Histone Deacetylase 1 and 2 (HDAC1/2) Inhibitor ACY-957: Impact of Dosing Schedule on Pharmacokinetics (PK), Pharmacodynamics (PD), Hematopoietic Toxicity, and Gamma Globin (HBG, ɣ) Expression in Monkey

Free
Apurva Chonkar, MS, Matthew Jarpe, PhD, Kailash Bhol, PhD, Simon S Jones, PhD, Jeffrey R Shearstone, PhD
Journal: Blood
Blood (2016) 128 (22): 323.
https://doi.org/10.1182/blood.V128.22.323.323
Published: 2016
Journal Articles

The Histone Deacetylase 1 and 2 (HDAC1/2) Inhibitor ACY-957 Increases Epsilon (HbE) and Gamma (HbG) Globin mRNA in the Peripheral Blood of Non-Anemic Rats and Monkeys

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Jeffrey R Shearstone, PhD, Apurva Chonkar, MS, Kailash Bhol, PhD, Simon S Jones, PhD, Matt Jarpe, PhD
Journal: Blood
Blood (2015) 126 (23): 3378.
https://doi.org/10.1182/blood.V126.23.3378.3378
Published: 2015
Journal Articles

Pharmacological Inhibition of Histone Deacetylases 1 and 2 (HDAC1/2) Induces Fetal Hemoglobin (HbF) through Activation of Gata2

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Jeffrey R Shearstone, PhD, Olga Golonzhka, PhD, Apurva Chonkar, Matthew Jarpe, PhD
Journal: Blood
Blood (2014) 124 (21): 335.
https://doi.org/10.1182/blood.V124.21.335.335
Published: 2014
Journal Articles

Pharmacological Inhibition Of Histone Deacetylase (HDAC) 1, 2 Or 3 Have Distinct Effects On Cellular Viability, Erythroid Differentiation, and Fetal Globin (HbG) Induction

Free
Jeffrey R Shearstone, PhD, John H van Duzer, PhD, Simon S Jones, PhD, Matthew Jarpe, PhD
Journal: Blood
Blood (2013) 122 (21): 564.
https://doi.org/10.1182/blood.V122.21.564.564
Published: 2013
Journal Articles

Mechanistic Insights Into Fetal Hemoglobin (HbF) Induction Through Chemical Inhibition Of Histone Deacetylase 1 and 2 (HDAC1/2)

Free
Jeffrey R Shearstone, PhD, John H van Duzer, PhD, Simon S Jones, PhD, Matthew Jarpe, PhD
Journal: Blood
Blood (2013) 122 (21): 2253.
https://doi.org/10.1182/blood.V122.21.2253.2253
Published: 2013
Journal Articles

Induction of Human Fetal Hemoglobin Expression by Selective Inhibitors of Histone Deacetylase 1 and 2 (HDAC1/2)

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Jeffrey R Shearstone, PhD, John H van Duzer, PhD, James E Bradner, MD, Ralph Mazitschek, PhD, Simon S Jones, Matthew Jarpe, PhD
Journal: Blood
Blood (2012) 120 (21): 3259.
https://doi.org/10.1182/blood.V120.21.3259.3259
Published: 2012
Journal Articles

A Key Commitment Step In Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition Between PU.1 and S-Phase Progression

Free
Ramona Pop, Jeffrey R Shearstone, Qichang Shen, Ying Liu, Kelly Hallstrom, Miro Koulnis, Joost Gribnau, Merav Socolovsky
Journal: Blood
Blood (2010) 116 (21): 839.
https://doi.org/10.1182/blood.V116.21.839.839
Published: 2010
Journal Articles

Global DNA Demethylation During Physiological Erythropoiesis In Vivo

Free
Jeffrey R Shearstone, Ramona Pop, Merav Socolovsky
Journal: Blood
Blood (2010) 116 (21): 2083.
https://doi.org/10.1182/blood.V116.21.2083.2083
Published: 2010