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Journal Articles

Terminal Erythroid Differentiation Is Regulated By Mitochondrial Translation Via Maintenance of Iron Homeostasis

Tatsuya Morishima, Md Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A.C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa

Blood (2022) 140 (Supplement 1): 2203–2204.

https://doi.org/10.1182/blood-2022-162991

Published: 2022

Journal Articles

Oncometabolite-Independent Anti-Apoptotic Feature Via Phospholipid Metabolic Adaptation in IDH2 Mutant AML Cells

Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa

Blood (2022) 140 (Supplement 1): 3012–3013.

https://doi.org/10.1182/blood-2022-162976

Published: 2022

Journal Articles

Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

Blood (2022) 139 (23): 3387–3401.

https://doi.org/10.1182/blood.2021013450

Published: 2022

Includes: Supplemental data

Journal Articles

IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice

Larisa V. Kovtonyuk, Francisco Caiado, Santiago Garcia-Martin, Eva-Maria Manz, Patrick Helbling, Hitoshi Takizawa, Steffen Boettcher, Fatima Al-Shahrour, Cesar Nombela-Arrieta, Emma Slack, Markus G. Manz

Blood (2022) 139 (1): 44–58.

https://doi.org/10.1182/blood.2021011570

Published: 2022

Includes: Supplemental data

Journal Articles

Inflammageing of Hematopoietic Stem Cells Is Driven By IL-1

Larisa V. Kovtonyuk, PhD, Francisco Caiado, PhD, Emma Marie Caroline Slack, Prof. Dr., Hitoshi Takizawa, PhD, Markus G. Manz, Prof.Dr.MD

Blood (2019) 134 (Supplement_1): 819.

https://doi.org/10.1182/blood-2019-130361

Published: 2019

Journal Articles

Innate Immune Signal-Regulated Hematopoiesis

Hitoshi Takizawa, PhD

Blood (2019) 134 (Supplement_1): SCI-1.

https://doi.org/10.1182/blood-2019-121288

Published: 2019

Journal Articles

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

Philipp J. Rauch, Jana M. Ellegast, Corinne C. Widmer, Kristin Fritsch, Jeroen S. Goede, Peter J. M. Valk, Bob Löwenberg, Hitoshi Takizawa, Markus G. Manz

Blood (2016) 128 (18): 2253–2257.

https://doi.org/10.1182/blood-2016-04-711986

Published: 2016

Includes: Supplemental data

Journal Articles

Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo

Larisa V. Kovtonyuk, Markus G. Manz, Hitoshi Takizawa

Blood (2016) 127 (25): 3175–3179.

https://doi.org/10.1182/blood-2015-09-669929

Published: 2016

Includes: Supplemental data

Journal Articles

Mpl Expression on AML Blasts Predicts Cytopenia

Philipp J Rauch, MD, Corinne Widmer, MD, Kristin Fritsch, MS, Jana M Ellegast, MD, Jeroen S Goede, MD, Peter J M Valk, PhD, Hitoshi Takizawa, PhD, Markus G Manz, MD

Blood (2015) 126 (23): 1387.

https://doi.org/10.1182/blood.V126.23.1387.1387

Published: 2015

Journal Articles

Direct Sensing of Lipopolysaccharide Limits Hematopoietic Stem Cell Selfrenewal Via TLR4-TRIF-ROS-p38 Pathway

Hitoshi Takizawa, PhD, Yasuyuki Saito, MD PhD, Larisa V. Kovtonyuk, Kristin Frisch, Markus G. Manz, MD

Blood (2014) 124 (21): 604.

https://doi.org/10.1182/blood.V124.21.604.604

Published: 2014

Journal Articles

Hematopoietic Stem Cells and Circulating Myelomonocytic Precursors With BRAF-V600E Are Identified In High-Risk Patients and Define LCH As a Myeloid Neoplasia

Karen Phaik-Har Lim, MS, Tricia L Peters, MD, MS, Marie-Luise Berres, MD, Jeremy Price, Hitoshi Takizawa, PhD, Philip Lupo, PhD, M. John Hicks, MD, PhD, DDS, Albert Shih, Stephen James Simko, III, MD, Kenneth Matthew Heym, MD, Venetia Bigley, MD, PhD, Matthew P. Collin, MD, PhD, Markus G. Manz, MD, Kenneth McClain, MD, PhD, Miriam Merad, MD, PhD, Carl E. Allen, MD, PhD

Blood (2013) 122 (21): 103.

https://doi.org/10.1182/blood.V122.21.103.103

Published: 2013

Journal Articles

Thrombopoietin-Receptor Signalling Induces Proliferation of Dormant HSC.

Larisa V. Kovtonyuk, Markus G. Manz, MD, Hitoshi Takizawa, PhD

Blood (2012) 120 (21): 2343.

https://doi.org/10.1182/blood.V120.21.2343.2343

Published: 2012

Journal Articles

Demand-adapted regulation of early hematopoiesis in infection and inflammation

Hitoshi Takizawa, Steffen Boettcher, Markus G. Manz

Blood (2012) 119 (13): 2991–3002.

https://doi.org/10.1182/blood-2011-12-380113

Published: 2012

Includes: Supplemental data

Journal Articles

JAK2-V617F Expressing Stem Cells Display a Competitive Advantage At Low Limiting Dilution and Are Capable of Initiating MPN Phenotype

Pontus Lundberg, PhD, Lucia Kubovcakova, PhD, Hitoshi Takizawa, PhD, Hui Hao-Shen, Markus G Manz, MD, Radek C. Skoda, MD

Blood (2011) 118 (21): 615.

https://doi.org/10.1182/blood.V118.21.615.615

Published: 2011

Journal Articles

Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes

Michael A. Schmid, Hitoshi Takizawa, Dior R. Baumjohann, Yasuyuki Saito, Markus G. Manz

Blood (2011) 118 (18): 4829–4840.

https://doi.org/10.1182/blood-2011-03-344960

Published: 2011

Includes: Supplemental data

Journal Articles

Non-Hematopoietic Stromal Cells Sense Toll-Like Receptor 4 Agonists and Consequently Enhance Myelopoiesis.

Steffen Boettcher, Patrick Ziegler, PhD, Michael A Schmid, PhD, Guido Garavaglia, MD, Hitoshi Takizawa, PhD, Markus G Manz, MD

Blood (2010) 116 (21): 2583.

https://doi.org/10.1182/blood.V116.21.2583.2583

Published: 2010

Journal Articles

Hematopoietic Stem Cell Cycling Dynamics In Steady State and Upon Hematopoietic Challenge

Hitoshi Takizawa, PhD, Chandra S Boddupalli, Roland R Regoes, PhD, Sebastian Bonhoeffer, PhD, Markus G Manz, MD

Blood (2010) 116 (21): 572.

https://doi.org/10.1182/blood.V116.21.572.572

Published: 2010

Journal Articles

Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung.

Tim Willinger, MD, PhD, Anthony Rongvaux, PhD, Hitoshi Takizawa, PhD, Elizabeth E. Eynon, PhD, Sean Stevens, PhD, Markus G Manz, MD, Richard A. Flavell, PhD

Blood (2010) 116 (21): 3789.

https://doi.org/10.1182/blood.V116.21.3789.3789

Published: 2010

Journal Articles

Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo

Anthony Rongvaux, Tim Willinger, Hitoshi Takizawa, PhD, Chozhavendan Rathinam, Elizabeth E. Eynon, PhD, Sean Stevens, PhD, Markus G Manz, MD, Richard A. Flavell, PhD

Blood (2010) 116 (21): 403.

https://doi.org/10.1182/blood.V116.21.403.403

Published: 2010

Journal Articles

In Vivo divisional Tracking System Reveals Cycling Heterogeneity in Long-Term Hematopoietic Stem Cells.

Hitoshi Takizawa, PhD, Markus G Manz, MD

Blood (2009) 114 (22): 814.

https://doi.org/10.1182/blood.V114.22.814.814

Published: 2009

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Terminal Erythroid Differentiation Is Regulated By Mitochondrial Translation Via Maintenance of Iron Homeostasis

Oncometabolite-Independent Anti-Apoptotic Feature Via Phospholipid Metabolic Adaptation in IDH2 Mutant AML Cells

Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice

Inflammageing of Hematopoietic Stem Cells Is Driven By IL-1

Innate Immune Signal-Regulated Hematopoiesis

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo

Mpl Expression on AML Blasts Predicts Cytopenia

Direct Sensing of Lipopolysaccharide Limits Hematopoietic Stem Cell Selfrenewal Via TLR4-TRIF-ROS-p38 Pathway

Hematopoietic Stem Cells and Circulating Myelomonocytic Precursors With BRAF-V600E Are Identified In High-Risk Patients and Define LCH As a Myeloid Neoplasia

Thrombopoietin-Receptor Signalling Induces Proliferation of Dormant HSC.

Demand-adapted regulation of early hematopoiesis in infection and inflammation

JAK2-V617F Expressing Stem Cells Display a Competitive Advantage At Low Limiting Dilution and Are Capable of Initiating MPN Phenotype

Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes

Non-Hematopoietic Stromal Cells Sense Toll-Like Receptor 4 Agonists and Consequently Enhance Myelopoiesis.

Hematopoietic Stem Cell Cycling Dynamics In Steady State and Upon Hematopoietic Challenge

Human Interleukin-3/Granulocyte Macrophage-Colony Stimulating Factor Knock-In Mice Support Human Myeloid Cell Reconstitution and Human Immune Responses In the Lung.

Human Thrombopoietin Knockin Mice Efficiently Support Human Hematopoiesis In Vivo

In Vivo divisional Tracking System Reveals Cycling Heterogeneity in Long-Term Hematopoietic Stem Cells.

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