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Journal Articles

Distinct Bone Marrow Microenvironment Abnormalities in MDS and MPN with Fibrosis

Cao Sy Luan, MS, Yoshiaki Takahoko, MS, Hidekazu Nishikii, MD PhD, Naoshi Obara, MD PhD, Tatsuhiro Sakamoto, MD PhD, Takayasu Kato, MD PhD, Keiichiro Hattori, MD PhD, Ryota Matsuoka, MD PhD, Shingo Sakashita, MD PhD, Yasuhito Nannya, MD PhD, Hideki Makishima, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Seishi Ogawa, MD PhD, Shigeru Chiba, MD PhD

Blood (2019) 134 (Supplement_1): 2976.

https://doi.org/10.1182/blood-2019-129423

Published: 2019

Journal Articles

Liquid Biopsy for the Identification of Intravascular Large B-Cell Lymphoma

Blood (2017) 130 (Supplement 1): 378.

https://doi.org/10.1182/blood.V130.Suppl_1.378.378

Published: 2017

Journal Articles

Foxp3 + regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells

Hidekazu Nishikii, MD PhD, Antonio Pierini, MD, Yasuhisa Yokoyama, MD,PhD, Takaharu Kimura, MD PhD, Hye-Sook Kwon, PhD, Maite Alvarez, PhD, Jeanette Baker, PhD, Judith Shizuru, MD PhD, Joy Wu, MD PhD, Shigeru Chiba, MD, PhD, Robert S. Negrin, MD

Blood (2016) 128 (22): 431.

https://doi.org/10.1182/blood.V128.22.431.431

Published: 2016

Journal Articles

Notch Signaling in Bone Marrow Nestin-Expressing Cells Controls Balance of Erythropoiesis at the Bone Marrow and Spleen

Tatsuhiro Sakamoto, MD, Naoshi Obara, MDPhD, Takayasu Kato, MD PhD, Luan Cao Sy, Hidekazu Nishikii, MD PhD, Mamiko Sakata-Yanagimoto, MD PhD, Satoru Takahashi, MDPhD, Shigeru Chiba, MD, PhD

Blood (2016) 128 (22): 432.

https://doi.org/10.1182/blood.V128.22.432.432

Published: 2016

Journal Articles

DR3 Signaling Modulates the Function of Foxp3 + regulatory T Cells and the Severity of Acute Graft and Host Disease

Hidekazu Nishikii, MD PhD, Kim Byung-Su, Yan Chen, MD, Jeanette Baker, PhD, Antonio Pierini, MD, Maite Alvarez, PhD, Melissa Mavers, MD, Kristina Maas-Bauer, MD, Robert S. Negrin, MD

Blood (2016) 128 (22): 2148.

https://doi.org/10.1182/blood.V128.22.2148.2148

Published: 2016

Journal Articles

Abnormal Increase in a Distinct Subset of Nestin-Expressing Cells in the Bone Marrow of Myelodysplastic Syndromes

Luan Cao-Sy, MS, Naoshi Obara, MD PhD, Tatsuhiro Sakamoto, MD, Takayasu Kato, MD PhD, Hidekazu Nishikii, MD, PhD, Mamiko Sakata-Yanagimoto, MD PhD, Shigeru Chiba, MD, PhD

Blood (2016) 128 (22): 3887.

https://doi.org/10.1182/blood.V128.22.3887.3887

Published: 2016

Journal Articles

Expanded CD4+Foxp3+ Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation

Hidekazu Nishikii, MD, PhD, Byung-Su Kim, MD, Yasuhisa Yokoyama, MD,PhD, Jeanette Baker, PhD, Antonio Pierini, MD, Maite Alvarez, PhD, Yuqiong Pan, MD, PhD, Yan Chen, MD, Dominik Schneidawind, MD, Shigeru Chiba, MD, PhD, Robert Negrin, MD

Blood (2015) 126 (23): 1876.

https://doi.org/10.1182/blood.V126.23.1876.1876

Published: 2015

Journal Articles

TNF-Alpha Priming Enhances CD4 + FoxP3 + Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment

Antonio Pierini, MD, Caitlin Moffett, Dominik Schneidawind, MD, Jeanette Baker, PhD, Hidekazu Nishikii, MD PhD, Yuqiong Pan, MD, PhD, Maite Alvarez, PhD, Everett Meyer, MD PhD, Robert Negrin, MD

Blood (2015) 126 (23): 1885.

https://doi.org/10.1182/blood.V126.23.1885.1885

Published: 2015

Journal Articles

CD4+FoxP3+ Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts

Antonio Pierini, MD, Hidekazu Nishikii, MD PhD, Yuqiong Pan, MD, Jeanette Baker, PhD, Dennis B Leveson-Gower, PhD, Mareike Florek, MD, Robert Negrin, MD

Blood (2014) 124 (21): 4322.

https://doi.org/10.1182/blood.V124.21.4322.4322

Published: 2014

Journal Articles

Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells

Hidekazu Nishikii, MD PhD, Byung Su Kim, MD, Antonio Pierini, MD, Jeanette Baker, PhD, Dominik Schneidawind, MD, Yuqiong Pan, MD, Maite Alvarez, PhD, Robert S. Negrin, MD

Blood (2014) 124 (21): 1087.

https://doi.org/10.1182/blood.V124.21.1087.1087

Published: 2014

Journal Articles

Host CD4+CD25+FoxP3+ Regulatory T Cells Facilitate Donor Engraftment Without Impacting Graft Versus Host Disease Onset After Major-Mismatched Hematopoietic Stem Cell Transplantation

Antonio Pierini, MD, Hidekazu Nishikii, MD, PhD, Mareike Florek, MD, Dennis B Leveson-Gower, PhD, Yuqiong Pan, MD, Byung-Su Kim, MD, Jeanette Baker, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 1996.

https://doi.org/10.1182/blood.V122.21.1996.1996

Published: 2013

Journal Articles

Hes1 Is Responsible For Notch Signaling-Mediated Suppression Of Acute Myeloid Leukemia Development Via Suppression Of FLT3 Expression

Takayasu Kato, MD, PhD, Mamiko Sakata-Yanagimoto, MD, PhD, Hidekazu Nishikii, MD, PhD, Yasuyuki Miyake, Yasuhisa Yokoyama, MD, Yukitugu Asabe, Naoshi Obara, MD, PhD, Kazumi Suzukawa, MD, PhD, Ryoichiro Kageyama, MD, PhD, Shigeru Chiba, MD, PhD

Blood (2013) 122 (21): 3800.

https://doi.org/10.1182/blood.V122.21.3800.3800

Published: 2013

Journal Articles

Agonistic Anti-DR3 Antibody Expands Treg and Reduces Experimental Acute Graft-Versus-Host Disease

Byung-Su Kim, MD, Antonio Pierini, MD, Dominik Schneidawind, MD, Jeanette Baker, PhD, Hidekazu Nishikii, MD, PhD, Yuqiong Pan, MD, Maite Alvarez, PhD, Robert Negrin, MD

Blood (2013) 122 (21): 135.

https://doi.org/10.1182/blood.V122.21.135.135

Published: 2013

Journal Articles

Reduced Tet2 Function Contributes to Development of Peripheral T-Cell Lymphoma with Follicular Helper T-Cell-Like Features in Mice

Hideharu Muto, MD, Mamiko Sakata-Yanagimoto, MD, PhD, Yasuyuki Miyake, Terukazu Enami, MD, Yuhei Kamada, MD, Takayasu Kato, MD, PhD, Hidekazu Nishikii, MD, PhD, Kazumi Suzukawa, MD, PhD, Naoya Nakamura, MD, PhD, Seishi Ogawa, MD, PhD, Shigeru Chiba, MD, PhD

Blood (2012) 120 (21): 1299.

https://doi.org/10.1182/blood.V120.21.1299.1299

Published: 2012

Journal Articles

Transcription Factor Hes1 Functions As a Tumor Suppressor in MLL-Associated Acute Leukemia

Takayasu Kato, MD, PhD, Mamiko Sakata-Yanagimoto, MD, PhD, Yasuyuki Miyake, Hidekazu Nishikii, MD, PhD, Yasuhisa Yokoyama, MD, PhD, Shigeru Chiba, MD, PhD

Blood (2012) 120 (21): 118.

https://doi.org/10.1182/blood.V120.21.118.118

Published: 2012

Journal Articles

Implication of the Distinct Differentiation Pathway of Megakaryocytes From Hematopoietic Stem Cells in the Mouse Bone Marrow

Hidekazu Nishikii, MD, PhD, Kenji Matsushita, Yosuke Kanazawa, Yasuhisa Yokoyama, MD, PhD, Takayasu Kato, MD, PhD, Naoshi Obara, MD, PhD, Mamiko Sakata-Yanagimoto, MD, PhD, Shigeru Chiba, MD, PhD

Blood (2012) 120 (21): 1204.

https://doi.org/10.1182/blood.V120.21.1204.1204

Published: 2012

Journal Articles

Soluble Recombinant Thrombomodulin Is a Potentially Promising Agent without Causing Severe Hemorrhagic Events for Hematological Malignancy-Induced Disseminated Intravascular Coagulation

Naoki Kurita, MD, PhD, Hidekazu Nishikii, MD, PhD, Yasuhisa Yokoyama, MD, PhD, Mamiko Sakata-Yanagimoto, MD, PhD, Naoshi Obara, MD, PhD, Yasushi Okoshi, MD, PhD, Kazumi Suzukawa, MD, PhD, Yuichi Hasegawa, MD, PhD, Shigeru Chiba, MD, PhD

Blood (2012) 120 (21): 3413.

https://doi.org/10.1182/blood.V120.21.3413.3413

Published: 2012

Journal Articles

Human Embryonic Stem Cell-Derived “NET-Like” Structure Serves as a Hematopoietic Progenitor Niche and Favors Generation of Mature Megakaryocytes and Functional Platelets.

Naoya Takayama, MD, Hidekazu Nishikii, MD, Takashi Hiroyama, PhD, Yukio Nakamura, MD, PhD, Hiroko Tsukui, Koji Eto, MD, Hiromitsu Nakauchi, MD, PhD

Blood (2006) 108 (11): 1665.

https://doi.org/10.1182/blood.V108.11.1665.1665

Published: 2006

Journal Articles

Metalloproteinase Regulation Determines Integrin αIIbβ3 Function and Enhances the Capacity of ES Cell-Derived Platelets.

Hidekazu Nishikii, MD, Koji Eto, MD, Taisuke Kanaji, MD, Jerry Ware, PhD, Hiromitsu Nakauchi, MD, PhD

Blood (2006) 108 (11): 140.

https://doi.org/10.1182/blood.V108.11.140.140

Published: 2006

Journal Articles

Negative Hematopoietic Scaffold Lnk Upregulates Integrin Outside-In Signaling in Platelets.

Koji Eto, MD, Hitoshi Takizawa, Hidekazu Nishikii, MD, Jun Seita, MD, Atsushi Oda, MD, Noriko Tamura, PhD, Shinya Goto, MD, Kiyoshi Takatsu, PhD, Satoshi Takaki, MD, Hiromitsu Nakauchi, MD

Blood (2005) 106 (11): 382.

https://doi.org/10.1182/blood.V106.11.382.382

Published: 2005

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Distinct Bone Marrow Microenvironment Abnormalities in MDS and MPN with Fibrosis

Liquid Biopsy for the Identification of Intravascular Large B-Cell Lymphoma

Foxp3 + regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation from Hematopoietic Stem Cells

Notch Signaling in Bone Marrow Nestin-Expressing Cells Controls Balance of Erythropoiesis at the Bone Marrow and Spleen

DR3 Signaling Modulates the Function of Foxp3 + regulatory T Cells and the Severity of Acute Graft and Host Disease

Abnormal Increase in a Distinct Subset of Nestin-Expressing Cells in the Bone Marrow of Myelodysplastic Syndromes

Expanded CD4+Foxp3+ Regulatory T Cells through DR3 Signaling Have a Distinct Immunophenotype and Abrogate the Lethal Acute-Graft and Host Disease after Allogeneic Transplantation

TNF-Alpha Priming Enhances CD4 + FoxP3 + Regulatory T Cell Suppressive Function in GvHD Prevention and Treatment

CD4+FoxP3+ Regulatory T Cells Regulate B Cell Differentiation and Induce Tolerance to Bone Marrow Grafts

Activation of DR3 Signaling Expands Recipient Derived Regulatory T Cells and Enhances Donor Immune Reconstitution Derived from Allogeneic Hematopoietic Stem Cells

Host CD4+CD25+FoxP3+ Regulatory T Cells Facilitate Donor Engraftment Without Impacting Graft Versus Host Disease Onset After Major-Mismatched Hematopoietic Stem Cell Transplantation

Hes1 Is Responsible For Notch Signaling-Mediated Suppression Of Acute Myeloid Leukemia Development Via Suppression Of FLT3 Expression

Agonistic Anti-DR3 Antibody Expands Treg and Reduces Experimental Acute Graft-Versus-Host Disease

Reduced Tet2 Function Contributes to Development of Peripheral T-Cell Lymphoma with Follicular Helper T-Cell-Like Features in Mice

Transcription Factor Hes1 Functions As a Tumor Suppressor in MLL-Associated Acute Leukemia

Implication of the Distinct Differentiation Pathway of Megakaryocytes From Hematopoietic Stem Cells in the Mouse Bone Marrow

Soluble Recombinant Thrombomodulin Is a Potentially Promising Agent without Causing Severe Hemorrhagic Events for Hematological Malignancy-Induced Disseminated Intravascular Coagulation

Human Embryonic Stem Cell-Derived “NET-Like” Structure Serves as a Hematopoietic Progenitor Niche and Favors Generation of Mature Megakaryocytes and Functional Platelets.

Metalloproteinase Regulation Determines Integrin αIIbβ3 Function and Enhances the Capacity of ES Cell-Derived Platelets.

Negative Hematopoietic Scaffold Lnk Upregulates Integrin Outside-In Signaling in Platelets.

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