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Journal Articles

The menin-MLL1 interaction is a molecular dependency in NUP98 -rearranged AML

Emily B. Heikamp, Jill A. Henrich, Florian Perner, Eric M. Wong, Charles Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah J. Uckelmann, Sumiko Takao, Yaniv Kazansky, Yana Pikman, Gerard M. McGeehan, Edward A. Kolb, Alex Kentsis, Scott A. Armstrong
Journal: Blood
Blood (2022) 139 (6): 894–906.
https://doi.org/10.1182/blood.2021012806
Published: 2022
Includes: Supplemental data
Journal Articles

Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines

Sara Canovas Nunes, Haiming Xu, Serena De Vita, Andrew Anighoro, Francois Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad E. Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei David Chen, Monika Ermann, David A. Williams
Journal: Blood
Blood (2021) 138 (Supplement 1): 1199.
https://doi.org/10.1182/blood-2021-147009
Published: 2021
Journal Articles

Deletion of Murine Rhoh induces More Aggressive Diffuse Large B Cell Lymphoma (DLBCL) Via Interaction with Kaiso and Regulation of BCL-6 Expression

Hiroto Horiguchi, MDPhD, Marioara Felicia Ciuculescu, MD, Anja Troeger, MD, Haiming Xu, PhD, Christian Brendel, PhD, David A. Williams, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1574.
https://doi.org/10.1182/blood-2018-99-115238
Published: 2018
Journal Articles

Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice

Daria G. Valerio, Haiming Xu, Meghan E. Eisold, Carolien M. Woolthuis, Tej K. Pandita, Scott A. Armstrong
Journal: Blood
Blood (2017) 129 (1): 48–59.
https://doi.org/10.1182/blood-2016-05-714568
Published: 2017
Includes: Supplemental data
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Differential role of Id1 in MLL-AF9–driven leukemia based on cell of origin

Brief Report
Na Man, Xiao-Jian Sun, Yurong Tan, Marta García-Cao, Fan Liu, Guoyan Cheng, Megan Hatlen, Haiming Xu, Ronit Shah, Nolan Chastain, Na Liu, Gang Huang, Yuan Zhou, Mengyao Sheng, Junhong Song, Feng-Chun Yang, Robert Benezra, Stephen D. Nimer, Lan Wang
Journal: Blood
Blood (2016) 127 (19): 2322–2326.
https://doi.org/10.1182/blood-2015-11-677708
Published: 2016
Includes: Supplemental data
Journal Articles

MSI2 Is Required for Maintaining the Activated Myelodysplastic Syndrome Stem Cell

Tzu-Chieh Ho, PhD, James Taggart, BS, Elianna Amin, PhD, Haiming Xu, PhD, Trevor Barlowe, BA, Alexander R Perez, BS, Patrick Tivnan, BS, Rachel Okabe, BS, Christopher Lengner, PhD, Amit Verma, MD, Gail J Roboz, MD, Monica L. Guzman, PhD, Christina S Leslie, PhD, Stephen D. Nimer, MD, Michael G. Kharas, PhD
Journal: Blood
Blood (2015) 126 (23): 714.
https://doi.org/10.1182/blood.V126.23.714.714
Published: 2015
Journal Articles

Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression

Lan Wang, Na Man, Xiao-Jian Sun, Yurong Tan, Marta García-Cao, Fan Liu, Megan Hatlen, Haiming Xu, Gang Huang, Meredith Mattlin, Arpit Mehta, Evadnie Rampersaud, Robert Benezra, Stephen D. Nimer
Journal: Blood
Blood (2015) 126 (5): 640–650.
https://doi.org/10.1182/blood-2015-03-635532
Published: 2015
Includes: Supplemental data
Journal Articles

Role of p21 in a Mouse Model of NUP98-HOXD13 Fusion Driven Myelodysplastic Syndromes (MDS)

Haiming Xu, PhD, Tony R Deblassio, MS, Scott A. Armstrong, MD PhD, Stephen Nimer, MD
Journal: Blood
Blood (2014) 124 (21): 4616.
https://doi.org/10.1182/blood.V124.21.4616.4616
Published: 2014
Journal Articles

Loss of p53 accelerates the complications of myelodysplastic syndrome in a NUP98-HOXD13 –driven mouse model

Haiming Xu, Silvia Menendez, Brigitte Schlegelberger, Narae Bae, Peter D. Aplan, Gudrun Göhring, Tony R. Deblasio, Stephen D. Nimer
Journal: Blood
Blood (2012) 120 (15): 3089–3097.
https://doi.org/10.1182/blood-2012-01-405332
Published: 2012
Includes: Supplemental data
Journal Articles

Loss of p53 Accelerates the Complications of Myelodysplastic Syndromes (MDS) In the NUP98-HOXD13 Transgenic Mouse Model

Haiming Xu, PhD, Silvia Menendez, Tony R Deblasio, Peter Aplan, MD, Stephen Nimer, M.D.
Journal: Blood
Blood (2011) 118 (21): 2804.
https://doi.org/10.1182/blood.V118.21.2804.2804
Published: 2011
Journal Articles

Rho GTPase Activating Protein p190-B Regulates Hematopoietic Stem Cell Fate Decision

Juying Xu, Kathleen Szczur, Haiming Xu, Hartmut Geiger, Yi Zheng, Edward Srour, PhD, David A. Williams, MD, Marie-Dominique Filippi, PhD
Journal: Blood
Blood (2010) 116 (21): 575.
https://doi.org/10.1182/blood.V116.21.575.575
Published: 2010
Journal Articles

The Acetylation of AML1-ETO Is Required for Leukemogenesis.

Lan Wang, PhD, Alexander Gural, MD, Fabiana Perna, MD, Xiaojian Sun, PhD, Xinyang Zhao, PhD, Haiming Xu, PhD, Megan A Hatlen, Gang Huang, Ph.D., Fan Liu, PhD, Hao Xu, MD, Tony Deblasio, Silvia Menendez, Francesca Voza, Robert Roeder, PhD, Stephen Nimer, MD
Journal: Blood
Blood (2010) 116 (21): 1588.
https://doi.org/10.1182/blood.V116.21.1588.1588
Published: 2010
Journal Articles

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential

Haiming Xu, Satyam Eleswarapu, Hartmut Geiger, Kathleen Szczur, Deidre Daria, Yi Zheng, Jeffrey Settleman, Edward F. Srour, David A. Williams, Marie-Dominique Filippi
Journal: Blood
Blood (2009) 114 (17): 3557–3566.
https://doi.org/10.1182/blood-2009-02-205815
Published: 2009
Includes: Supplemental data
Journal Articles

The Ski oncoprotein regulates Hematopoietic Stem Cell Fitness and Functions as a Corepressor for Gfi1.

Chinavenmeni S. Velu, PhD, Michael Berk, Haiming Xu, Tristan Bourdeau, MS, Avedis Kazanjian, David A. Williams, MD, Clemencia Colmenares, Ph.D., H. Leighton Grimes, PhD
Journal: Blood
Blood (2008) 112 (11): 1403.
https://doi.org/10.1182/blood.V112.11.1403.1403
Published: 2008
Journal Articles

Absence of the Rho GTPase Activating Protein p190-B Enhances Long Term Hematopoietic Stem Cell Engraftment

Haiming Xu, Hartmut Geiger, Kathleen Szczur, Deidra Deira, Yi Zheng, Jeffrey Settleman, Edward Srour, David A Williams, Marie-Dominique Filippi
Journal: Blood
Blood (2008) 112 (11): 614.
https://doi.org/10.1182/blood.V112.11.614.614
Published: 2008
Journal Articles

Gfi1 as a Regulator of Hematopoietic Differentiation.

H. Leighton Grimes, PhD, Chinavenmeni S. Velu, PhD, Shane Horman, PhD, Aditya Chaubey, PhD, Tristan Bourdeau, MS, Haiming Xu, Jinfang Zhu, PhD, William Paul, MD, Clemencia Colmenares, PhD, David A. Williams, MD, Brian Gebelein, PhD
Journal: Blood
Blood (2008) 112 (11): sci-16.
https://doi.org/10.1182/blood.V112.11.sci-16.sci-16
Published: 2008
Journal Articles

microRNA Control of Hematopoietic Stem Cell Fitness and Myelopoiesis.

Chinavenmeni S. Velu, PhD, Sarah Porteous, PhD, Haiming Xu, Avinash M. Baktula, Philip Roehrs, MD, Tristan Bourdeau, Ed Stavnezer, PhD, David Williams, MD, Clemencia Colmenares, PhD, H. Leighton Grimes, PhD
Journal: Blood
Blood (2007) 110 (11): 373.
https://doi.org/10.1182/blood.V110.11.373.373
Published: 2007
Journal Articles

Loss of the Rho GTPase Activating Protein p190-B Enhances Hematopoietic Stem Cell Engraftment Potential.

Haiming Xu, Harmut Geiger, PhD, Kathleen Szczur, BS, Deidra Deira, MS, Yi Zheng, PhD, Jeffrey Settleman, PhD, David Williams, MD, Marie-Dominique Filippi, PhD
Journal: Blood
Blood (2007) 110 (11): 508.
https://doi.org/10.1182/blood.V110.11.508.508
Published: 2007
Journal Articles

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils

Kathleen Szczur, Haiming Xu, Simon Atkinson, Yi Zheng, Marie-Dominique Filippi
Journal: Blood
Blood (2006) 108 (13): 4205–4213.
https://doi.org/10.1182/blood-2006-03-013789
Published: 2006
Includes: Multimedia, Supplemental data