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Journal Articles

Treatment with a Novel Small Molecule Dual Factor IIa/Xa Inhibitor Protects Against Coagulopathy and Organ Dysfunction in a Baboon Model of Staphylococcus Aureus Sepsis

Robert Silasi, Ravi Shankar Keshari, Tomohiro Abe, Girija Regmi, Cristina Lupu, Joe Simmons, Nils Pfaff, Stefan Heitmeier, Florea Lupu

Blood (2024) 144 (Supplement 1): 3988.

https://doi.org/10.1182/blood-2024-203669

Published: 2024

Journal Articles

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Cristina Puy, Samantha A. Moellmer, Jiaqing Pang, Helen H. Vu, Alexander R. Melrose, Christina U. Lorentz, Erik I. Tucker, Joseph J. Shatzel, Ravi S. Keshari, Florea Lupu, David Gailani, Owen J. T. McCarty

Blood (2024) 144 (17): 1821–1833.

https://doi.org/10.1182/blood.2023022257

Published: 2024

Includes: Supplemental data

Journal Articles

Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice

Huiping Shi, Liang Gao, Nicole Kirby, Bojing Shao, Xindi Shan, Mariko Kudo, Robert Silasi, John Michael McDaniel, Meixiang Zhou, Samuel McGee, Wei Jing, Florea Lupu, Audrey Cleuren, James N. George, Lijun Xia

Blood (2024) 143 (13): 1293–1309.

https://doi.org/10.1182/blood.2023021583

Published: 2024

Includes: Supplemental data

Journal Articles

Disseminated intravascular coagulation and its immune mechanisms

Narcis I. Popescu, Cristina Lupu, Florea Lupu

Blood (2022) 139 (13): 1973–1986.

https://doi.org/10.1182/blood.2020007208

Published: 2022

Journal Articles

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Robert Silasi, Ravi S. Keshari, Girija Regmi, Cristina Lupu, Constantin Georgescu, Joe H. Simmons, Michael Wallisch, Tia C. L. Kohs, Joseph J. Shatzel, Sven R. Olson, Christina U. Lorentz, Cristina Puy, Erik I. Tucker, David Gailani, Sidney Strickland, András Gruber, Owen J. T. McCarty, Florea Lupu

Blood (2021) 138 (2): 178–189.

https://doi.org/10.1182/blood.2020009345

Published: 2021

Includes: Supplemental data

Journal Articles

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Narcis I. Popescu, Robert Silasi, Ravi S. Keshari, Alanson Girton, Tarea Burgett, Sacha S. Zeerleder, David Gailani, Andras Gruber, Florea Lupu, K. Mark Coggeshall

Blood (2018) 132 (8): 849–860.

https://doi.org/10.1182/blood-2017-10-813618

Published: 2018

Includes: Supplemental data

Journal Articles

In vivo–generated thrombin and plasmin do not activate the complement system in baboons

Ravi S. Keshari, Robert Silasi, Cristina Lupu, Fletcher B. Taylor, Jr, Florea Lupu

Blood (2017) 130 (24): 2678–2681.

https://doi.org/10.1182/blood-2017-06-788216

Published: 2017

Includes: Supplemental data

Journal Articles

Synthetic Pentasaccharide Fondaparinux (Arixtra ® ) Reduces Sepsis Induced Coagulopathy and Promotes Survival in the Baboon Model of E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi, PhD, Narcis Ioan Popescu, PhD, Cristina Lupu, PhD, Charles Esmon, PhD, Florea Lupu, PhD

Blood (2017) 130 (Supplement 1): 2375.

https://doi.org/10.1182/blood.V130.Suppl_1.2375.2375

Published: 2017

Journal Articles

Role of Androgen Dependent TFPI-Regulating Protein (ADTRP) in Vascular Development and Function

Maulin Mukeshchandra Patel, Robert Silasi-Mansat, PhD, Ravi Shankar Keshari, PhD, Christopher L. Sansam, PhD, David A. Jones, PhD, Cristina Lupu, PhD, Florea Lupu, PhD

Blood (2016) 128 (22): 556.

https://doi.org/10.1182/blood.V128.22.556.556

Published: 2016

Journal Articles

Bacteremia, Not Coagulation Proteases Contribute to In Vivo Complement Activation in Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Cristina Lupu, PhD, Fletcher B. Taylor, Jr., MD, Florea Lupu, PhD

Blood (2016) 128 (22): 275.

https://doi.org/10.1182/blood.V128.22.275.275

Published: 2016

Journal Articles

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Ravi Shankar Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Marybeth Langer, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Mark K. Coggeshall, Steven DeMarco, PhD, Florea Lupu, PhD

Blood (2015) 126 (23): 765.

https://doi.org/10.1182/blood.V126.23.765.765

Published: 2015

Journal Articles

Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

Hala Chaaban, Ravi S. Keshari, Robert Silasi-Mansat, Narcis I. Popescu, Padmaja Mehta-D’Souza, Yow-Pin Lim, Florea Lupu

Blood (2015) 125 (14): 2286–2296.

https://doi.org/10.1182/blood-2014-06-582759

Published: 2015

Includes: Supplemental data

Journal Articles

A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis

Ravi Keshari, PhD, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Hala Chaaban, MD, Cristina Lupu, PhD, Steven J DeMarco, PhD, Florea Lupu, PhD

Blood (2014) 124 (21): 112.

https://doi.org/10.1182/blood.V124.21.112.112

Published: 2014

Journal Articles

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Daniel Ricklin, Yijun Huang, Edimara S. Reis, Hui Chen, Patrizia Ricci, Zhuoer Lin, Caterina Pascariello, Maddalena Raia, Michela Sica, Luigi Del Vecchio, Fabrizio Pane, Florea Lupu, Rosario Notaro, Ranillo R. G. Resuello, Robert A. DeAngelis, John D. Lambris

Blood (2014) 123 (13): 2094–2101.

https://doi.org/10.1182/blood-2013-11-536573

Published: 2014

Includes: Supplemental data

Journal Articles

Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice

Longbiao Yao, Tadayuki Yago, Bojing Shao, Zhenghui Liu, Robert Silasi-Mansat, Hendra Setiadi, Florea Lupu, Rodger P. McEver

Blood (2013) 122 (23): 3832–3842.

https://doi.org/10.1182/blood-2012-12-473835

Published: 2013

Includes: Multimedia, Supplemental data

Journal Articles

Protective Mechanisms Of Inter-Alpha Inhibitor Protein On Extracellular Histone Toxicity

Hala Chaaban, MD, Ravi Keshari, PhD, Padmaja Mehta-D'Souza, Robert Silasi-Mansat, PhD, Narcis I. Popescu, PhD, Florea Lupu, PhD

Blood (2013) 122 (21): 19.

https://doi.org/10.1182/blood.V122.21.19.19

Published: 2013

Journal Articles

Bacillus anthracis peptidoglycan activates human platelets through FcγRII and complement

Dawei Sun, Narcis I. Popescu, Brent Raisley, Ravi S. Keshari, George L. Dale, Florea Lupu, K. Mark Coggeshall

Blood (2013) 122 (4): 571–579.

https://doi.org/10.1182/blood-2013-02-486613

Published: 2013

Includes: Supplemental data

Journal Articles

Inhibitory Autoantibodies to Protein Disulfide Isomerase From Systemic Lupus Erythematosus Patients Are Prothrombotic

Narcis I. Popescu, PhD, Joan T. Merrill, MD, Florea Lupu, PhD

Blood (2012) 120 (21): 392.

https://doi.org/10.1182/blood.V120.21.392.392

Published: 2012

Journal Articles

Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen

Cristina Lupu, Hua Zhu, Narcis I. Popescu, Jonathan D. Wren, Florea Lupu

Blood (2011) 118 (16): 4463–4471.

https://doi.org/10.1182/blood-2011-05-355370

Published: 2011

Includes: Supplemental data

Journal Articles

Crosstalk Between Inflammation and Thrombosis: The Surprising Role of Extracellular Histones

Jun Xu, PhD, Florea Lupu, PhD, Charles T. Esmon, PhD

Blood (2010) 116 (21): MRG-1.

https://doi.org/10.1182/blood.V116.21.MRG-1.MRG-1

Published: 2010

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Treatment with a Novel Small Molecule Dual Factor IIa/Xa Inhibitor Protects Against Coagulopathy and Organ Dysfunction in a Baboon Model of Staphylococcus Aureus Sepsis

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice

Disseminated intravascular coagulation and its immune mechanisms

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

In vivo–generated thrombin and plasmin do not activate the complement system in baboons

Synthetic Pentasaccharide Fondaparinux (Arixtra ® ) Reduces Sepsis Induced Coagulopathy and Promotes Survival in the Baboon Model of E. coli Sepsis

Role of Androgen Dependent TFPI-Regulating Protein (ADTRP) in Vascular Development and Function

Bacteremia, Not Coagulation Proteases Contribute to In Vivo Complement Activation in Sepsis

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Inter-α inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

A Novel C5 Complement Inhibitor Protects Against Sepsis-Induced Activation of Complement, Coagulation and Inflammation and Provides Survival Benefit in E. coli Sepsis

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice

Protective Mechanisms Of Inter-Alpha Inhibitor Protein On Extracellular Histone Toxicity

Bacillus anthracis peptidoglycan activates human platelets through FcγRII and complement

Inhibitory Autoantibodies to Protein Disulfide Isomerase From Systemic Lupus Erythematosus Patients Are Prothrombotic

Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen

Crosstalk Between Inflammation and Thrombosis: The Surprising Role of Extracellular Histones

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American Society of Hematology

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