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Journal Articles

Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study

Parinda A. Mehta, Stella M. Davies, Thomas Leemhuis, Kasiani Myers, Nancy A. Kernan, Susan E. Prockop, Andromachi Scaradavou, Richard J. O’Reilly, David A. Williams, Leslie Lehmann, Eva Guinan, David Margolis, K. Scott Baker, Adam Lane, Farid Boulad

Blood (2017) 129 (16): 2308–2315.

https://doi.org/10.1182/blood-2016-09-743112

Published: 2017

Journal Articles

Mutations in the Poly(A)-Specific Ribonuclease ( PARN ) Impair Telomerase RNA 3' End Maturation in Dyskeratosis Congenita Patients

Diane H. Moon, PhD, Matthew Segal, Baris Boyraz, Eva Guinan, MD, Inga Hofmann, MD, Patrick Cahan, PhD, Albert K Tai, PhD, Suneet Agarwal, MD PhD

Blood (2015) 126 (23): 669.

https://doi.org/10.1182/blood.V126.23.669.669

Published: 2015

Journal Articles

Defibrotide (DF) in the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) Following Stem Cell Transplantation (SCT): Results of a Phase 3 Study Utilizing a Historical Control.

Paul Richardson, M.D., Marcie Tomblyn, MD, MS, Nancy Kernan, M.D., Joel A. Brochstein, MD, Shin Mineishi, MD, Amanda Termuhlen, MD, Sally Arai, MD, Stephan A. Grupp, MD, PhD, Eva Guinan, M.D., Paul L. Martin, MD, PhD, Selim Corbacioglu, MD, Ernst Holler, M.D., Ralph D'Agostino, Ph.D., Joseph Massaro, Ph.D., Alison L. Hannah, MD, Massimo Iacobelli, M.D., Robert J Soiffer, MD

Blood (2009) 114 (22): 654.

https://doi.org/10.1182/blood.V114.22.654.654

Published: 2009

Journal Articles

Phase 1 Clinical Study of Adoptive Immunotherapy with Delayed Infusion of Alloanergized Donor T Cells to Improve Immune Reconstution after Haploidentical Stem Cell Transplantation.

Jeff Davies, Marcos De Lima, Laurence Cooper, Thomas Spitzer, Neena Kapoor, Lisa Brennan, Peter Thall, John McMannis, Richard Champlin, Lee Nadler, Eva Guinan

Blood (2008) 112 (11): 1156.

https://doi.org/10.1182/blood.V112.11.1156.1156

Published: 2008

Journal Articles

Alloanergization of HLA-Mismatched Human Donor T Cells Results in the Generation of Allosuppressive CD4 + T Regulatory Cells Both in Vitro and in Vivo

Jeff Davies, Dongin Yuk, Lee Nadler, Eva Guinan

Blood (2008) 112 (11): 207.

https://doi.org/10.1182/blood.V112.11.207.207

Published: 2008

Journal Articles

Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) Is Accompanied by Endotoxemia, Activation of Endotoxin-Directed Innate Immunity, and Deficiency of Endogenous Proteins That Limit Endotoxin- Induced TNF Production

Ofer Levy, MD, PhD, Eugenie E. Suter, MA, Leslie A. Kalish, PhD, Leighanne C. Gallington, SB, Athmane Teghanemt, MA, Suganya Viriyakosol, PhD, Robert J. Soiffer, MD, Jerrold Weiss, PhD, Patrick Scannon, MD, PhD, Hoi M. Leung, PHD, Gregory Priebe, MD, Janice Russell, BS, Paul Walker, MD, Michael R. Wessels, MD, Eva Guinan, MD

Blood (2008) 112 (11): 800.

https://doi.org/10.1182/blood.V112.11.800.800

Published: 2008

Journal Articles

Costimulatory Blockade (CSB) during Mixed Lymphocyte Reaction (MLR) Prevents IL27 Upregulation and Signalling.

Gullu Gorgun, PhD, Patrick Philpot, Kamila Naxerova, Isaac Kohane, MD, PhD, Lee Nadler, MD, Eva Guinan, MD

Blood (2007) 110 (11): 4878.

https://doi.org/10.1182/blood.V110.11.4878.4878

Published: 2007

Journal Articles

In Vivo Expansion of CD4+ FOXP3+ Regulatory T Cells May Contribute To Control of Acute GvHD after HLA-Mismatched Alloanergized HSCT.

Jeff Davies, Dongin Yuk, Lisa Brennan, Lee Nadler, Eva Guinan

Blood (2007) 110 (11): 2978.

https://doi.org/10.1182/blood.V110.11.2978.2978

Published: 2007

Journal Articles

Donor-Derived T Cells Can Be Rendered Hyporesponsive to Alloantigen without Loss of Pathogen or Tumor Immune Responses.

Jeff Davies, Dongin Yuk, Lee Nadler, Eva Guinan

Blood (2007) 110 (11): 771.

https://doi.org/10.1182/blood.V110.11.771.771

Published: 2007

Journal Articles

A Phase 3 Randomized, Historically-Controlled Clinical Trial Investigating the Use of Defibrotide in the Treatment of Severe Veno-Occlusive Disease Post-SCT: A Novel Approach to the Validation of a Promising New Drug for the Treatment of a Life Threatening Disease.

Paul Richardson, Nancy Kernan, Marcie Tomblyn, Paul Martin, Sally Arai, Joel Brochstein, Eva Guinan, Gideon Steinbach, Elizabeth Nemecek, Ralph D’Agostino, Carolyn Revta, Alison Hannah, Massimo Iacobelli, Robert Soiffer

Blood (2007) 110 (11): 614.

https://doi.org/10.1182/blood.V110.11.614.614

Published: 2007

Journal Articles

Induction of Alloantigen Specific CD4 T Cell Anergy by B7: CD28 Mediated Costimulatory Blockade Significantly Alters the Functional Program of Bystander CD8, Monocytes, NK and B Cells.

Gullu Gorgun, PhD, Fenglong Liu, PhD, Eleanor Howe, PhD, Patrick Philpot, Eva Guinan, MD, Lee Nadler, MD

Blood (2006) 108 (11): 3656.

https://doi.org/10.1182/blood.V108.11.3656.3656

Published: 2006

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Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study

Mutations in the Poly(A)-Specific Ribonuclease ( PARN ) Impair Telomerase RNA 3' End Maturation in Dyskeratosis Congenita Patients

Defibrotide (DF) in the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF) Following Stem Cell Transplantation (SCT): Results of a Phase 3 Study Utilizing a Historical Control.

Phase 1 Clinical Study of Adoptive Immunotherapy with Delayed Infusion of Alloanergized Donor T Cells to Improve Immune Reconstution after Haploidentical Stem Cell Transplantation.

Alloanergization of HLA-Mismatched Human Donor T Cells Results in the Generation of Allosuppressive CD4 + T Regulatory Cells Both in Vitro and in Vivo

Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) Is Accompanied by Endotoxemia, Activation of Endotoxin-Directed Innate Immunity, and Deficiency of Endogenous Proteins That Limit Endotoxin- Induced TNF Production

Costimulatory Blockade (CSB) during Mixed Lymphocyte Reaction (MLR) Prevents IL27 Upregulation and Signalling.

In Vivo Expansion of CD4+ FOXP3+ Regulatory T Cells May Contribute To Control of Acute GvHD after HLA-Mismatched Alloanergized HSCT.

Donor-Derived T Cells Can Be Rendered Hyporesponsive to Alloantigen without Loss of Pathogen or Tumor Immune Responses.

A Phase 3 Randomized, Historically-Controlled Clinical Trial Investigating the Use of Defibrotide in the Treatment of Severe Veno-Occlusive Disease Post-SCT: A Novel Approach to the Validation of a Promising New Drug for the Treatment of a Life Threatening Disease.

Induction of Alloantigen Specific CD4 T Cell Anergy by B7: CD28 Mediated Costimulatory Blockade Significantly Alters the Functional Program of Bystander CD8, Monocytes, NK and B Cells.

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