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Journal Articles

Updated Efficacy and Safety of Tabelecleucel in Patients with Epstein-Barr Virus-Positive (EBV + ) Leiomyosarcomas (LMS)

Lauren S Jiménez-Kurlander, Gerald Behr, Nancy J Bunin, Ekaterina Doubrovina, Rajani Dinavahi, Laurence Gamelin, Armin Ghobadi, Leo Mascarenhas, Sarah Nikiforow, Richard J O'Reilly, Anita Price, Barry Shulkin, Ashok Srinivasan, Stephanie Suser, Justin Wahlstrom, Baodong Xing, Susan Prockop

Blood (2022) 140 (Supplement 1): 7524–7526.

https://doi.org/10.1182/blood-2022-157765

Published: 2022

Journal Articles

Epigenetic reprogramming sensitizes immunologically silent EBV + lymphomas to virus-directed immunotherapy

Tanner Dalton, Ekaterina Doubrovina, Dmitry Pankov, Raymond Reynolds, Hanna Scholze, Annamalai Selvakumar, Teresa Vizconde, Bhumesh Savalia, Vadim Dyomin, Christoph Weigel, Christopher C. Oakes, Alicia Alonso, Olivier Elemento, Heng Pan, Jude M. Phillip, Richard J. O’Reilly, Benjamin E. Gewurz, Ethel Cesarman, Lisa Giulino-Roth

Blood (2020) 135 (21): 1870–1881.

https://doi.org/10.1182/blood.2019004126

Published: 2020

Includes: Supplemental data

Journal Articles

Adoptive Therapy with EBV-Specific T Cells for Treatment of CNS EBV Post-Transplant Lymphoproliferative Disease Arising after Hematopoietic Stem Cell Transplant or Solid Organ Transplant

Susan Prockop, MD, Stephanie Suser, Ekaterina Doubrovina, MD PhD, Hugo R. Castro-Malaspina, MD, Esperanza B. Papadopoulos, MD, Craig S. Sauter, MD, James W. Young, MD, Victoria Szenes, PNP, Alison Slocum, MA, Karim Baroudy, MS, Richard J. O'Reilly, MD

Blood (2018) 132 (Supplement 1): 4590.

https://doi.org/10.1182/blood-2018-99-120133

Published: 2018

Journal Articles

Dual-Sensitized T-Cells Responding to EBV Blcl and Either CMVpp65 or WT-1 Peptide Pools Have Distinct or Shared HLA Restrictions That May Depend on the Presenting HLA Alleles

Ekaterina Doubrovina, MD PhD, Aisha N. Hasan, MD, Susan Prockop, MD, Karim Baroudy, MS, Richard O'Reilly, MD

Blood (2018) 132 (Supplement 1): 4596.

https://doi.org/10.1182/blood-2018-99-119001

Published: 2018

Journal Articles

Adoptive T-Cell Therapy with 3 rd Party CMV-pp65-Specific CTLs for CMV Viremia and Disease Arising after Allogeneic Hematopoietic Stem Cell Transplant

Susan Prockop, MD, Ekaterina Doubrovina, MD PhD, Irene Rodriguez-Sanchez, Aisha N. Hasan, MD, Juliet Barker, MBBS, H.R. Castro-Malaspina, MD, Parastoo B. Dahi, MD, Sergio A. Giralt, MD, Boglarka Gyurkocza, MD, Nancy A. Kernan, MD, Guenther Koehne, MDPhD, Esperanza B. Papadopoulos, MD, Doris Ponce, MD, Craig S. Sauter, MD, Virginia Escobedo, RN, Victoria Szenes, PNP, Karim Baroudy, BS, Alison Slocum, MA, Richard J. O'Reilly, MD

Blood (2017) 130 (Supplement 1): 747.

https://doi.org/10.1182/blood.V130.Suppl_1.747.747

Published: 2017

Journal Articles

Third Party CMV-Specific Cytotoxic T Cells for Treatment of Antiviral Resistant CMV Infection after Hematopoietic Stem Cell Transplant

Susan Prockop, MD, Ekaterina Doubrovina, MD PhD, Aisha N Hasan, MD, Parastoo B Dahi, MD, Sergio Giralt, MD, Guenther Koehne, MD PhD, Nancy A. Kernan, MD, Esperanza B Papadopoulos, MD, Rachel Lehrman, Irene Rodriguez-Sanchez, Richard J. O'Reilly, MD

Blood (2016) 128 (22): 61.

https://doi.org/10.1182/blood.V128.22.61.61

Published: 2016

Journal Articles

Successful Treatment of Refractory CMV Chorioretinitis and Meningoencephalitis with Adoptive Transfer of Third Party CMVpp65 Specific T-Cell Lines

Susan Prockop, MD, Aisha Hasan, MD, Ekaterina Doubrovina, MD PhD, H.R. Castro-Malaspina, MD, Juliet N. Barker, MBBS(Hons), FRACP, Parastoo B Dahi, MD, Farid Boulad, MD, Nancy A. Kernan, MD, Guenther Koehne, MD PhD, Craig S. Sauter, MD, Szilard Kiss, MD, Mrinali Patel, MD, Stephanie Suser, BA, Richard J O'Reilly, MD

Blood (2015) 126 (23): 3157.

https://doi.org/10.1182/blood.V126.23.3157.3157

Published: 2015

Journal Articles

Wilms´Tumor 1 Protein Is Highly Expressed on Malignant Plasma Cells and Provides a Novel Target for Immunotherapeutic Approaches

Guenther Koehne, MDPhD, Satyajit Kosuri, MD, Ekaterina Doubrovina, MD PhD, Tao Dao, PhD, Andrew Scott, Achim A Jungbluth, MD, Richard J O'Reilly, MD

Blood (2015) 126 (23): 98.

https://doi.org/10.1182/blood.V126.23.98.98

Published: 2015

Journal Articles

Third Party Donor Derived CMV Specific T Cells for the Treatment of Refractory CMV Viremia and Disease after Hematopoietic Stem Cell Transplant

Susan E. Prockop, MD, Aisha Hasan, MD, Guenther Koehne, MD PhD, Ekaterina Doubrovina, MD PhD, Craig S. Sauter, MD, Juliet N, Barker, MBBS, Karim Baroudy, Farid Boulad, MD, Sergio Giralt, MD, Ramzi Khalaf, Nancy A. Kernan, MD, Esperanza B Papadopoulos, MD, Doris M. Ponce, MD, Andromachi Scaradavou, MD, Stephanie Suser, Gloria Wasilewski, RN, Richard J. O'Reilly, MD

Blood (2014) 124 (21): 184.

https://doi.org/10.1182/blood.V124.21.184.184

Published: 2014

Journal Articles

Targeted Therapy of B Cell Lymphoma with a Direct Inhibitor of the NF-κB Subunit c-Rel

Yusuke Shono, MD PhD, Andrea Z. Tuckett, PhD, Hsiou-Chi Liou, PhD, Samedy Ouk, PhD, Ekaterina Doubrovina, MD PhD, Mikhail Doubrovin, MD PhD, Enrico Derenzini, MD, Mary I. Scallion, BS, Jennifer J. Tsai, MD, Odette M. Smith, Anas Younes, MD PhD, Richard J. O'Reilly, MD PhD, Marcel R.M. van den Brink, MD PhD, Johannes L. Zakrzewski, MD

Blood (2014) 124 (21): 507.

https://doi.org/10.1182/blood.V124.21.507.507

Published: 2014

Journal Articles

Banked, GMP Grade Third Party T-Cell Lines Specific for CMVpp65 Epitopes Presented By Certain Prevalent HLA Alleles More Consistently Clear CMV Infections in a Genetically Heterogeneous Population of HSCT Recipients

Aisha N. Hasan, MD, Susan E. Prockop, MD, Guenther Koehne, MD PhD, Ekaterina Doubrovina, MD PhD, Richard J. O'Reilly, MD

Blood (2014) 124 (21): 309.

https://doi.org/10.1182/blood.V124.21.309.309

Published: 2014

Journal Articles

Adoptive Transfer Of WT-1 Specific HLA Class 2 Restricted Donor-Derived T-cells Induces Sustained Remission Of AML Relapse Post Transplant Presenting As Leukemia Cutis

Susan E. Prockop, MD, Ekaterina Doubrovina, MD, PhD, Roberta Adams, MD, Farid Boulad, MD, Nancy A. Kernan, MD, Richard J. O'Reilly, MD

Blood (2013) 122 (21): 2085.

https://doi.org/10.1182/blood.V122.21.2085.2085

Published: 2013

Journal Articles

Generation and Characterization Of a Third Party GMP Grade Bank Of CMV Specific T-Cells For Adoptive Immunotherapy Of CMV Infections In Recipients Of HSCT From Cord Blood Or Seronegative Donors

Aisha N. Hasan, MD, Ekaterina Doubrovina, MD, PhD, Guenther Koehne, MD, PhD, Susan E. Prockop, MD, Richard J. O'Reilly, MD

Blood (2013) 122 (21): 2021.

https://doi.org/10.1182/blood.V122.21.2021.2021

Published: 2013

Journal Articles

A Bi-Specific T Cell Engaging Monoclonal Antibody (mAb) Derived From a TCR-Like Mab Specific For WT1/HLA-A0201 (ESK-BiTE) Shows a Potent Activity Against Human AML and Ph+ ALL In Mouse Models

Dmitry Pankov, MD, Tao Dao, MD, PhD, Yiyang Wang, Andrew Scott, Tatyana Korontsvit, MD, Victoria Zakhaleva, Nicholas Veomett, Michael Curcio, Ekaterina Doubrovina, MD, PhD, Richard J. O'Reilly, MD, Cheng Liu, PhD, David A. Scheinberg, MD, PhD

Blood (2013) 122 (21): 2521.

https://doi.org/10.1182/blood.V122.21.2521.2521

Published: 2013

Journal Articles

Adoptive Treatment Of EBV-Associated Leiomyosarcoma In Immunodeficient Patients With EBV Specific Cytotoxic T Cells

Susan E. Prockop, MD, Ekaterina Doubrovina, MD, PhD, Farid Boulad, MD, Nancy A. Kernan, MD, Rachel Kobos, MD, Andromachi Scaradavou, MD, Sara J. Abramson, MD, Michael Laquaglia, MD, Anita Price, MD, Richard J. O’Reilly, MD

Blood (2013) 122 (21): 3267.

https://doi.org/10.1182/blood.V122.21.3267.3267

Published: 2013

Journal Articles

Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants

Blood (2012) 120 (21): 351.

https://doi.org/10.1182/blood.V120.21.351.351

Published: 2012

Journal Articles

CD19 Targeted Allogeneic EBV-Specific T Cells for the Treatment of Relapsed ALL in Pediatric Patients Post HSCT

Kevin J. Curran, MD, Nancy A. Kernan, MD, Xiuyan Wang, PhD, Clare Taylor, MSc, Ekaterina Doubrovina, MD, PhD, Shirley Bartido, PhD, Michel Sadelain, MD, PhD, Richard J. O'Reilly, MD, Renier J Brentjens, MD, PhD, Isabelle Rivière, PhD

Blood (2012) 120 (21): 353.

https://doi.org/10.1182/blood.V120.21.353.353

Published: 2012

Journal Articles

Third Party Donor Derived EBV Specific T Cells for the Treatment of Refractory EBV-Related Malignancies in Immunodeficient Recipients

Susan E. Prockop, MD, Ekaterina Doubrovina, MD, PhD, Juliet N Barker, MBBS, Karim Baroudy, Farid Boulad, MD, Ramzi Khalaf, Nancy A. Kernan, MD, Rachel Kobos, MD, Esperanza B. Papadopoulos, MD, Andromachi Scaradavou, MD, Trudy N Small, MD, Gloria Wasilewski, RN, Richard J. O'Reilly, MD

Blood (2012) 120 (21): 577.

https://doi.org/10.1182/blood.V120.21.577.577

Published: 2012

Journal Articles

Engineered Antigen- Presenting Cells Expressing Human HLA Class-II DR Alleles Support Efficient Enrichment and Expansion of Antigen Specific T h 1 CD4[+] T-Cells Which Are Functionally Augmented by IL-15Rα/IL-15 Complexes

Aisha N. Hasan, MD, Rosanna J. Ricafort, MD, Annamalai Selvakumar, PhD, Ekaterina Doubrovina, MD, PhD, Isabelle Riviere, Michel Sadelain, MD, PhD, Richard J. O'Reilly, MD

Blood (2012) 120 (21): 1905.

https://doi.org/10.1182/blood.V120.21.1905.1905

Published: 2012

Journal Articles

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1 + leukemias

Ekaterina Doubrovina, Taissia Carpenter, Dmitry Pankov, Annamalai Selvakumar, Aisha Hasan, Richard J. O'Reilly

Blood (2012) 120 (8): 1633–1646.

https://doi.org/10.1182/blood-2011-11-394619

Published: 2012

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Updated Efficacy and Safety of Tabelecleucel in Patients with Epstein-Barr Virus-Positive (EBV + ) Leiomyosarcomas (LMS)

Epigenetic reprogramming sensitizes immunologically silent EBV + lymphomas to virus-directed immunotherapy

Adoptive Therapy with EBV-Specific T Cells for Treatment of CNS EBV Post-Transplant Lymphoproliferative Disease Arising after Hematopoietic Stem Cell Transplant or Solid Organ Transplant

Dual-Sensitized T-Cells Responding to EBV Blcl and Either CMVpp65 or WT-1 Peptide Pools Have Distinct or Shared HLA Restrictions That May Depend on the Presenting HLA Alleles

Adoptive T-Cell Therapy with 3 rd Party CMV-pp65-Specific CTLs for CMV Viremia and Disease Arising after Allogeneic Hematopoietic Stem Cell Transplant

Third Party CMV-Specific Cytotoxic T Cells for Treatment of Antiviral Resistant CMV Infection after Hematopoietic Stem Cell Transplant

Successful Treatment of Refractory CMV Chorioretinitis and Meningoencephalitis with Adoptive Transfer of Third Party CMVpp65 Specific T-Cell Lines

Wilms´Tumor 1 Protein Is Highly Expressed on Malignant Plasma Cells and Provides a Novel Target for Immunotherapeutic Approaches

Third Party Donor Derived CMV Specific T Cells for the Treatment of Refractory CMV Viremia and Disease after Hematopoietic Stem Cell Transplant

Targeted Therapy of B Cell Lymphoma with a Direct Inhibitor of the NF-κB Subunit c-Rel

Banked, GMP Grade Third Party T-Cell Lines Specific for CMVpp65 Epitopes Presented By Certain Prevalent HLA Alleles More Consistently Clear CMV Infections in a Genetically Heterogeneous Population of HSCT Recipients

Adoptive Transfer Of WT-1 Specific HLA Class 2 Restricted Donor-Derived T-cells Induces Sustained Remission Of AML Relapse Post Transplant Presenting As Leukemia Cutis

Generation and Characterization Of a Third Party GMP Grade Bank Of CMV Specific T-Cells For Adoptive Immunotherapy Of CMV Infections In Recipients Of HSCT From Cord Blood Or Seronegative Donors

A Bi-Specific T Cell Engaging Monoclonal Antibody (mAb) Derived From a TCR-Like Mab Specific For WT1/HLA-A0201 (ESK-BiTE) Shows a Potent Activity Against Human AML and Ph+ ALL In Mouse Models

Adoptive Treatment Of EBV-Associated Leiomyosarcoma In Immunodeficient Patients With EBV Specific Cytotoxic T Cells

Adoptive Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides of the CMV-pp65 Protein for the Treatment of Persistent CMV Antigenemia Following Allogeneic Hematopoietic Stem Cell Transplants

CD19 Targeted Allogeneic EBV-Specific T Cells for the Treatment of Relapsed ALL in Pediatric Patients Post HSCT

Third Party Donor Derived EBV Specific T Cells for the Treatment of Refractory EBV-Related Malignancies in Immunodeficient Recipients

Engineered Antigen- Presenting Cells Expressing Human HLA Class-II DR Alleles Support Efficient Enrichment and Expansion of Antigen Specific T h 1 CD4[+] T-Cells Which Are Functionally Augmented by IL-15Rα/IL-15 Complexes

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1 + leukemias

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