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Journal Articles

Sepsis induces platelet‑activating anti‑PF4 antibodies with potential protective role against secondary bacterial infection

Tao Liu, Daniel Villalobos, Shiqi Cai, Archana Mollangiri, Pawjai Khampang, Kenneth Brockman,, Demin Wang, Renren Wen

Blood (2025) 146 (Supplement 1): 4875.

https://doi.org/10.1182/blood-2025-4875

Published: 2025

Journal Articles

JMJD1C-mediated epigenetic control of HIT antibody production

Mei Yu, Yongguang Zhang, Yuhong Chen, Lu Zhou, Yongwei Zheng, David W Wang, Nan Zhu, Renren Wen, Demin Wang

Blood (2025) 146 (Supplement 1): 3110.

https://doi.org/10.1182/blood-2025-3110

Published: 2025

Journal Articles

HIT antibodies activate platelets by interacting with a negatively charged epitope on human PF4

Guoping Fu, Daniel Villalobos, Demin Wang, Renren Wen

Blood (2025) 146 (Supplement 1): 3100.

https://doi.org/10.1182/blood-2025-3100

Published: 2025

Journal Articles

Novel PF4/heparin complexes drive platelet activation in heparin-induced thrombocytopenia

Daniel Villalobos, Renren Wen, Demin Wang, Nathan Witman

Blood (2025) 146 (Supplement 1): 3097.

https://doi.org/10.1182/blood-2025-3097

Published: 2025

Journal Articles

Extrafollicular B cell expansion in COVID-19 patients with prothrombotic antibodies linked to inflammatory and Th1 signatures

Nathan Witman, Mei Yu, Yuqi Zhang, Kexin Gai, Yuhong Chen, Lu Zhou, Christine Nguyen, Wen Zhu, Yongwei Zheng, Shawn Jobe, Mary Beth Graham, Weiguo Cui, Demin Wang, Renren Wen

Blood (2025) 146 (Supplement 1): 1232.

https://doi.org/10.1182/blood-2025-1232

Published: 2025

Journal Articles

Prothrombotic antibodies targeting the spike protein's receptor-binding domain in severe COVID-19

Blood (2025) 145 (6): 635–647.

https://doi.org/10.1182/blood.2024025010

Published: 2025

Includes: Supplemental data

Journal Articles

A Subset of Antibodies to the Spike Protein's Receptor-Binding Domain in Severe COVID-19 Activate Platelets

Wen Zhu, Yongwei Zheng, Mei Yu, Nathan Witman, Anand Pabmanabhan, Lisa Baumann Kreuziger, Gilbert C. White, Tongjun Gu, Alexander Fields, Lucy Kornblith, Richard H. Aster, Weiguo Cui, Shawn M. Jobe, Mary Beth Graham, Demin Wang, Renren Wen

Blood (2024) 144 (Supplement 1): 1229.

https://doi.org/10.1182/blood-2024-211524

Published: 2024

Journal Articles

Identification of Platelet-Activating Antibodies That Do Not Bind to PF4/Heparin Complexes in Heparin-Induced Thrombocytopenia

Lu Zhou, Daniel Villalobos, Richard H. Aster, Anand Pabmanabhan, Demin Wang, Renren Wen

Blood (2024) 144 (Supplement 1): 5588.

https://doi.org/10.1182/blood-2024-210295

Published: 2024

Journal Articles

Epigenetic Control of B Cell Autoimmunity By Jmjd1c

Yongguang Zhang, Mei Yu, Yongwei Zheng, Yuhong Chen, Jesus Izaguirre-Carbonell, Nan Zhu, Renren Wen, Demin Wang

Blood (2023) 142 (Supplement 1): 155.

https://doi.org/10.1182/blood-2023-182034

Published: 2023

Journal Articles

Arid1b Loss Impairs Hematopoietic Stem Cell Function in Normal Hematopoiesis

Olivia Arnold, Theresa Bluemn, Cary Stelloh, Yongwei Zheng, Demin Wang, Sridhar Rao, Nan Zhu

Blood (2023) 142 (Supplement 1): 5588.

https://doi.org/10.1182/blood-2023-186386

Published: 2023

Journal Articles

MiR-9-1 Controls Osteoblastic Regulation of Lymphopoiesis

Yongguang Zhang, Yongwei Zheng, Yuhong Chen, Mei Yu, Karen-Sue Carlson, Renren Wen, Demin Wang

Blood (2023) 142 (Supplement 1): 1333.

https://doi.org/10.1182/blood-2023-181128

Published: 2023

Journal Articles

Monoclonal gammopathy of thrombotic/thrombocytopenic significance

Adam J. Kanack, Jordan K. Schaefer, Meera Sridharan, Noah P. Splinter, Mindy C. Kohlhagen, Bandana Singh, Silvana B. De Lorenzo, Emily E. Mauch, Maen A. Hussein, Marwan Shaikh, Shaji Kumar, Renren Wen, Demin Wang, David Murray, Anand Padmanabhan

Blood (2023) 141 (14): 1772–1776.

https://doi.org/10.1182/blood.2022018797

Published: 2023

Includes: Supplemental data

Journal Articles

Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis

Wen Zhu, Yongwei Zheng, Mei Yu, Yaling Wu, Jianhui Wei, Lu Zhou, Guoping Fu, Nicholas Schneider, Curtis Jones, Mehraboon Irani, Anand Padmanabhan, Richard Aster, Demin Wang, Renren Wen

Blood (2023) 141 (9): 1060–1069.

https://doi.org/10.1182/blood.2022017612

Published: 2023

Includes: Supplemental data

Journal Articles

Genomic and Transcriptional Profiling Stratifies Vq Myeloma Lines into Two Clusters with Distinct Risk Signatures and Drug Responses

Evan Flietner, Mei Yu, Adhithi Rajagopalan, Yun Zhou, Yubin Feng, Anthony Veltri, Terra Lasho, Zhi Wen, Yuqian Sun, Robert Burns, Mrinal M. Patnaik, Natalie Callander, Fotis Asimakopoulos, Demin Wang, Jing Zhang

Blood (2022) 140 (Supplement 1): 9935–9936.

https://doi.org/10.1182/blood-2022-162827

Published: 2022

Journal Articles

CD4+ T Cells Are Required for Production of Disease-Causing Antibodies in an Alloantigen-Specific Murine Model of Fetal/Neonatal Alloimmune Thrombocytopenia

Huiying Zhi, Guoping Fu, Renren Wen, Demin Wang, Peter J. Newman, Debra K. Newman

Blood (2022) 140 (Supplement 1): 2828.

https://doi.org/10.1182/blood-2022-169883

Published: 2022

Journal Articles

MCD-DLBCL arises from germinal center B cells

Renren Wen, Demin Wang

Blood (2022) 140 (10): 1058–1059.

https://doi.org/10.1182/blood.2022017534

Published: 2022

Journal Articles

Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

Adam J. Kanack, Antonios Bayas, Gemlyn George, Mouhamed Yazan Abou-Ismail, Bandana Singh, Mindy C. Kohlhagen, Noah P. Splinter, Monika Christ, Markus Naumann, Karen A. Moser, Kristi J. Smock, Alison Grazioli, Renren Wen, Demin Wang, David L. Murray, Anand Padmanabhan

Blood (2022) 140 (1): 73–77.

https://doi.org/10.1182/blood.2021014588

Published: 2022

Includes: Supplemental data

Journal Articles

Immune cells surveil aberrantly sialylated O -glycans on megakaryocytes to regulate platelet count

Melissa M. Lee-Sundlov, Robert T. Burns, Taylor O. Kim, Renata Grozovsky, Silvia Giannini, Leonardo Rivadeneyra, Yongwei Zheng, Simon H. Glabere, Walter H. A. Kahr, Reza Abdi, Jenny M. Despotovic, Demin Wang, Karin M. Hoffmeister

Blood (2021) 138 (23): 2408–2424.

https://doi.org/10.1182/blood.2020008238

Published: 2021

Includes: Multimedia, Supplemental data

Journal Articles

STAT5B, the dominant twin, in hematopoietic stem cells

Yuhong Chen, Demin Wang

Blood (2021) 138 (23): 2303–2305.

https://doi.org/10.1182/blood.2021013532

Published: 2021

Journal Articles

CARD19, a Novel Negative Regulator of B-Cell Tolerance

Yongwei Zheng, Mei Yu, Yuhong Chen, Liquan Xue, Wen Zhu, Guoping Fu, Robert Burns, Stephan Morris, Renren Wen, Demin Wang

Blood (2021) 138 (Supplement 1): 997.

https://doi.org/10.1182/blood-2021-149732

Published: 2021

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Sepsis induces platelet‑activating anti‑PF4 antibodies with potential protective role against secondary bacterial infection

JMJD1C-mediated epigenetic control of HIT antibody production

HIT antibodies activate platelets by interacting with a negatively charged epitope on human PF4

Novel PF4/heparin complexes drive platelet activation in heparin-induced thrombocytopenia

Extrafollicular B cell expansion in COVID-19 patients with prothrombotic antibodies linked to inflammatory and Th1 signatures

Prothrombotic antibodies targeting the spike protein's receptor-binding domain in severe COVID-19

A Subset of Antibodies to the Spike Protein's Receptor-Binding Domain in Severe COVID-19 Activate Platelets

Identification of Platelet-Activating Antibodies That Do Not Bind to PF4/Heparin Complexes in Heparin-Induced Thrombocytopenia

Epigenetic Control of B Cell Autoimmunity By Jmjd1c

Arid1b Loss Impairs Hematopoietic Stem Cell Function in Normal Hematopoiesis

MiR-9-1 Controls Osteoblastic Regulation of Lymphopoiesis

Monoclonal gammopathy of thrombotic/thrombocytopenic significance

Cloned antibodies from patients with HIT provide new clues to HIT pathogenesis

Genomic and Transcriptional Profiling Stratifies Vq Myeloma Lines into Two Clusters with Distinct Risk Signatures and Drug Responses

CD4+ T Cells Are Required for Production of Disease-Causing Antibodies in an Alloantigen-Specific Murine Model of Fetal/Neonatal Alloimmune Thrombocytopenia

MCD-DLBCL arises from germinal center B cells

Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

Immune cells surveil aberrantly sialylated O -glycans on megakaryocytes to regulate platelet count

STAT5B, the dominant twin, in hematopoietic stem cells

CARD19, a Novel Negative Regulator of B-Cell Tolerance

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