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Journal Articles

Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia

Ahmed Khalaf, Lucie de Beauchamp, Eric Kalkman, Kevin Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary Scott, Karen Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, Vignir Helgason

Blood (2023) 142 (Supplement 1): 862.

https://doi.org/10.1182/blood-2023-186405

Published: 2023

Journal Articles

Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis

Martha M. Zarou, Kevin Rattigan, Daniele Sarnello, Amy Dawson, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason

Blood (2023) 142 (Supplement 1): 1369.

https://doi.org/10.1182/blood-2023-185915

Published: 2023

Journal Articles

Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells

Martha M. Zarou, Kevin Rattigan, Zuzana Brabcova, Amy Dawson, David Sumpton, Alexei Vazquez, Vignir Helgason

Blood (2021) 138 (Supplement 1): 2543.

https://doi.org/10.1182/blood-2021-149664

Published: 2021