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Journal Articles

DISC-0974, a Novel, First-in-Class, Anti-Hemojuvelin Monoclonal Antibody Decreases Hepcidin and Increases Transferrin Saturation in a Non-Human Primate Model of Cytokine (IL-6) Induced Hypoferremia

Brian MacDonald, PhDMBBChir,MRCP, Cecile Blaustein, PhD, Sophia Nguyen, MS, Christopher King, PhD MBA, Vu Hong, PhD, Will Savage, MDPhD, Srikanth Venkatraman, PhD, Maria G. Beconi, PhD MS

Blood (2020) 136 (Supplement 1): 2.

https://doi.org/10.1182/blood-2020-138720

Published: 2020

Journal Articles

DISC-0974, a Novel, First-in-Class, Anti-Hemojuvelin Monoclonal Antibody Is Predicted to be Efficacious at Low Doses in Humans As Determined By Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling in Non-Clinical Studies

Mark Hixon, PhD, Cecile Blaustein, PhD, Christopher King, PhD MBA, Sophia Nguyen, MS, Will Savage, MDPhD, Maria G. Beconi, PhD MS

Blood (2020) 136 (Supplement 1): 14–15.

https://doi.org/10.1182/blood-2020-138547

Published: 2020

Journal Articles

TRAIL/ DR5 Interactions Are Important for Thymic Damage After Allogeneic Bone Marrow Transplantation.

Blood (2009) 114 (22): 234.

https://doi.org/10.1182/blood.V114.22.234.234

Published: 2009

Journal Articles

P-Selectin in Recipients of Allogeneic Bone Marrow Transplantation Regulates Experimental Graft-Versus-Host-Disease.

Sydney X Lu, PhD, Maria Lia Palomba, MD, Il-Kang Na, MD, Theis Terwey, Onder Alpdogan, MD, Jhoanne L Bautista, Marsinay O Smith, David Suh, Christopher King, Uttam Rao, Nury Yim, Robert R. Jenq, MD, Johannes L Zakrzewski, MD, Amanda M. Holland, Olaf Penack, MD, Lindsay Dykstra, Kevin Bampoe, Marcel R.M. van den Brink, MD, PhD

Blood (2009) 114 (22): 1335.

https://doi.org/10.1182/blood.V114.22.1335.1335

Published: 2009

Journal Articles

STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease

Sydney X. Lu, Onder Alpdogan, Janine Lin, Robert Balderas, Roberto Campos-Gonzalez, Xiao Wang, Guo-Jian Gao, David Suh, Christopher King, Melanie Chow, Odette M. Smith, Vanessa M. Hubbard, Johanne L. Bautista, Javier Cabrera-Perez, Johannes L. Zakrzewski, Adam A. Kochman, Andrew Chow, Gregoire Altan-Bonnet, Marcel R. M. van den Brink

Blood (2008) 112 (13): 5254–5258.

https://doi.org/10.1182/blood-2008-03-147322

Published: 2008

Includes: Supplemental data

Journal Articles

Rapidly proliferating CD44 hi peripheral T cells undergo apoptosis and delay posttransplantation T-cell reconstitution after allogeneic bone marrow transplantation

S. Önder Alpdogan, Sydney X. Lu, Neel Patel, Suzanne McGoldrick, David Suh, Tulin Budak-Alpdogan, Odette M. Smith, Jeremy Grubin, Christopher King, Gabrielle L. Goldberg, Vanessa M. Hubbard, Adam A. Kochman, Marcel R. M. van den Brink

Blood (2008) 112 (12): 4755–4764.

https://doi.org/10.1182/blood-2008-02-142737

Published: 2008

Includes: Supplemental data

Journal Articles

Depletion of Vascular Endothelial Progenitor Cells Inhibits Inflammation

Olaf Penack, Erik Henke, David Suh, Christopher King, Marsinay O Smith, Il-Kang Na, MD, Amanda Holland, Arnab Ghosh, Sydney X Lu, Robert Jenq, Chen Liu, George F Murphy, Theresa Lu, Chad May, David A. Scheinberg, MD, PhD, Ding Cheng Gao, Vivek Mittal, Robert Benezra, Marcel Van Den Brink, MD, PhD

Blood (2008) 112 (11): 694.

https://doi.org/10.1182/blood.V112.11.694.694

Published: 2008

Journal Articles

Targeted ‘Off-the-Shelf’ Tumor Immunotherapy Using Allogeneic T-Cell Precursors.

Johannes L. Zakrzewski, MD, David Suh, Odette M. Smith, Christopher King, Gabrielle L. Goldberg, PhD, Robert Jenq, MD, Amanda M. Holland, Jeremy Grubin, Sydney X. Lu, Javier Cabrera-Perez, Gabrielle Rizzuto, Derek B. Sant’Angelo, PhD, Marcel R.M. van den Brink, MD, PhD, John C. Markley, Isabelle Riviere, PhD, Michel Sadelain, MD, PhD, Juan Carlos Zuniga-Pflucker, PhD

Blood (2007) 110 (11): 579.

https://doi.org/10.1182/blood.V110.11.579.579

Published: 2007

Journal Articles

Discovery and Validation of STAT-3 and ERK1/2 Phosphorylation as Critical for the Function of Alloactivated T Cells in Acute Graft-Versus-Host-Disease Via a Novel Technique for Drug Discovery.

Sydney X. Lu, Onder Alpdogan, Roberto Campos, Xiao Wang, Guo-Jian Gao, Melanie Chow, Janine Lin, David Suh, Christopher King, Vanessa M. Hubbard, Johanne L. Bautista, Adam A. Kochman, Johannes L. Zakrzewski, O. Marsinay Smith, Jeremy Grubin, Andrew Chow, Neel Patel, Marcel R.M. van den Brink

Blood (2007) 110 (11): 3236.

https://doi.org/10.1182/blood.V110.11.3236.3236

Published: 2007

Journal Articles

CEACAM-1 Is Involved in Graft-Versus-Host-Disease in Murine Allogeneic Bone Marrow Transplantation Models.

Sydney X. Lu, Lucy Willis, Marsinay Smith, David Suh, Christopher King, Johanne Bautista, Melanie Chow, Javier Cabrera-Perez, Vanessa Hubbard, Jimmy Rotolo, Chen Liu, George Murphy, Onder Alpdogan, Richard Blumberg, Kathryn Holmes, Claire Turbide, Nicole Beauchemin, Marcel R.M. van den Brink

Blood (2007) 110 (11): 67.

https://doi.org/10.1182/blood.V110.11.67.67

Published: 2007

Journal Articles

Peripheral T Cell Apoptosis Is Associated with Homeostatic T Cell Proliferation and Plays a Significant Role in Post-Transplant Immune Deficiency.

Onder Alpdogan, MD, Neel Patel, BS, David Suh, BS, Jeremy Grubin, BS, Suzanne McGoldrick, MD, Odette M. Smith, BA, Sydney Lu, BS, Christopher King, BS, Adam Kochman, BS, Vanessa Hubbard, BS, Marcel R.M. van den Brink, MD, PhD

Blood (2006) 108 (11): 71.

https://doi.org/10.1182/blood.V108.11.71.71

Published: 2006

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DISC-0974, a Novel, First-in-Class, Anti-Hemojuvelin Monoclonal Antibody Decreases Hepcidin and Increases Transferrin Saturation in a Non-Human Primate Model of Cytokine (IL-6) Induced Hypoferremia

DISC-0974, a Novel, First-in-Class, Anti-Hemojuvelin Monoclonal Antibody Is Predicted to be Efficacious at Low Doses in Humans As Determined By Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling in Non-Clinical Studies

TRAIL/ DR5 Interactions Are Important for Thymic Damage After Allogeneic Bone Marrow Transplantation.

P-Selectin in Recipients of Allogeneic Bone Marrow Transplantation Regulates Experimental Graft-Versus-Host-Disease.

STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease

Rapidly proliferating CD44 hi peripheral T cells undergo apoptosis and delay posttransplantation T-cell reconstitution after allogeneic bone marrow transplantation

Depletion of Vascular Endothelial Progenitor Cells Inhibits Inflammation

Targeted ‘Off-the-Shelf’ Tumor Immunotherapy Using Allogeneic T-Cell Precursors.

Discovery and Validation of STAT-3 and ERK1/2 Phosphorylation as Critical for the Function of Alloactivated T Cells in Acute Graft-Versus-Host-Disease Via a Novel Technique for Drug Discovery.

CEACAM-1 Is Involved in Graft-Versus-Host-Disease in Murine Allogeneic Bone Marrow Transplantation Models.

Peripheral T Cell Apoptosis Is Associated with Homeostatic T Cell Proliferation and Plays a Significant Role in Post-Transplant Immune Deficiency.

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American Society of Hematology

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