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Carsten Müller
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Journal Articles

Disrupting tRNA modifications to target mitochondrial vulnerabilities in drug-resistant leukemia cells

Open Access
Cornelius Pauli, Michael Kienhöfer, Maximilian Felix Blank, Oguzhan Begik, Christian Rohde, Sarah MN Zimmermann, Laura Werner, Daniel Heid, Fu Xu, Katharina Weidenauer, Sylvain Delaunay, Nadja Krall, Katrin Trunk, Duoduo Zhao, Fengbiao Zhou, Laia Llovera, Ollivier Alexane, Anke Heit-Mondrzyk, Uwe Platzbecker, Claudia D. Baldus, Hubert Serve, Martin Bornhäuser, Cathrine B Vågbø, Salvador Aznar Benitah, Jeroen Krijgsveld, Eva Maria Novoa, Carsten Müller-Tidow, Michaela Frye
Journal: Blood
Blood blood.2024027822.
https://doi.org/10.1182/blood.2024027822
Published: 2025
Includes: Supplemental data
Journal Articles

Inflammation conjoins differentiation and resistance in AML

Free
Maike Janssen, Carsten Müller-Tidow
Journal: Blood
Blood (2025) 145 (21): 2405–2407.
https://doi.org/10.1182/blood.2025028651
Published: 2025
Journal Articles

Salvage autologous transplant in relapsed multiple myeloma: long-term follow-up of the phase 3 GMMG ReLApsE trial

Open Access
Clinical Trials & Observations Brief Report
Marc-Andrea Baertsch, Jana Schlenzka, Thomas Hielscher, Marc S. Raab, Sandra Sauer, Maximilian Merz, Elias Karl Mai, Carsten Müller-Tidow, Steffen Luntz, Anna Jauch, Peter Brossart, Martin Goerner, Stefan Klein, Bertram Glass, Peter Reimer, Ullrich Graeven, Roland Fenk, Mathias Haenel, Ivana von Metzler, Hans W. Lindemann, Christof Scheid, Igor-Wolfgang Blau, Hans J. Salwender, Richard Noppeney, Britta Besemer, Katja C. Weisel, Hartmut Goldschmidt
Journal: Blood
Blood (2025) 145 (16): 1780–1787.
https://doi.org/10.1182/blood.2024027342
Published: 2025
Includes: Supplemental data
Journal Articles

Single Vs. Tandem Autologous Stem Cell Transplantation in Newly Diagnosed Multiple Myeloma: A Real-World Multi-Center Study from the German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy (DRST)

Free
Nora Grieb, Alexander Oeser, Maximilian Ferle, Franziska Hanke, Sarah Flossdorf, Sandra Sauer, Hartmut Goldschmidt, Carsten Müller-Tidow, Hans Salwender, Roland Fenk, Monika Engelhardt, Robert Zeiser, Vladan Vucinic, Georg-Nikolaus Franke, Igor Wolfgang Blau, Daniel Teschner, Hermann Einsele, Christoph Richard Kimmich, Miriam Kull, Britta Besemer, Nico Gagelmann, Nicolaus Kröger, Thomas Neumuth, Uwe Platzbecker, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 708.
https://doi.org/10.1182/blood-2024-198638
Published: 2024
Journal Articles

Trial in Progress: A Randomized-Controlled Phase 2 Study Evaluating Venetoclax Plus Azacitidine Versus Intensive Chemotherapy in Adult Patients with Newly Diagnosed, NPM1 -Mutated AML - the SAL/AMLCG Vincent Trial

Free
Lydia Kretschmer, Leo Ruhnke, Christoph Schliemann, Lars Fransecky, Björn Steffen, Martin Kaufmann, Andreas Burchert, Christoph Schmid, Maher Hanoun, Tim Sauer, Klaus H Metzeler, Kerstin Schäfer-Eckart, Mathias Hänel, Martina Crysandt, Paul Jäger, Stefan W. Krause, Christine Dierks, Stefan Klein, Nadia Maguire, Lukas Peter Frenzel, Veit L. Buecklein, Frank Fiebig, Anna Harig, Christian Thiede, Moritz Middeke, Richard Dillon, Claudia D Baldus, Hubert Serve, Uwe Platzbecker, Karsten Spiekermann, Wolfgang Hiddemann, Martin Bornhäuser, Richard F. Schlenk, Carsten Müller-Tidow, Christoph Röllig
Journal: Blood
Blood (2024) 144 (Supplement 1): 1527.1.
https://doi.org/10.1182/blood-2024-198164
Published: 2024
Journal Articles

Age-Stratified Game-Theory-Informed Machine Learning of Molecular Alterations Unveils Prognostic Divergence in 3062 Pediatric and Adult Acute Myeloid Leukemia Patients

Free
Jan-Niklas Eckardt, Waldemar Hahn, Rhonda E. Ries, Szymon Dariusz Chrost, Susann Winter, Sebastian Stasik, Christoph Röllig, Uwe Platzbecker, Carsten Müller-Tidow, Hubert Serve, Claudia D Baldus, Christoph Schliemann, Kerstin Schäfer-Eckart, Maher Hanoun, Martin Kaufmann, Andreas Burchert, Johannes Schetelig, Martin Bornhäuser, Markus Wolfien, Soheil Meshinchi, Christian Thiede, Jan Moritz Middeke
Journal: Blood
Blood (2024) 144 (Supplement 1): 2211.
https://doi.org/10.1182/blood-2024-198861
Published: 2024
Journal Articles

Tumor Reactive T Cells Drive Clinical Responses to Multiple Myeloma

Free
Tim Robin Wagner, Niklas Kehl, Simon Steiger, Tamara Boschert, Michael Kilian, Kane A Foster, Hartmut Goldschmidt, Niels Weinhold, Steven A. Carr, Kwee Yong, Carsten Müller-Tidow, Karsten Rippe, Marc S. Raab, Michael Platten, Stefan B Eichmüller, Mirco Julian Friedrich
Journal: Blood
Blood (2024) 144 (Supplement 1): 1890.
https://doi.org/10.1182/blood-2024-210272
Published: 2024
Journal Articles

The CAR-Hematotox As a Risk Model to Predict Early Complications and Outcome after Bispecific T-Cell Engager Therapy in Relapsed/Refractory Multiple Myeloma

Free
Jan H. Frenking, Christine Riedhammer, David N. Sedloev, Valentine Landrin, Mirco Julian Friedrich, Niels Weinhold, Martin K. Kortüm, Carsten Müller-Tidow, Hermann Einsele, Sandra Sauer, Leo Rasche, Marc S. Raab
Journal: Blood
Blood (2024) 144 (Supplement 1): 1952.
https://doi.org/10.1182/blood-2024-210021
Published: 2024
Journal Articles

Endothelial Dysfunction in Hematological Patients: Sublingual Microscopy, Hyperspectral Imaging, and Serum Endothelial Markers

Free
Laura Simons, Muath Qadoura, Jule Buhl, Franziska Sunderer, Felix Korell, Ignatios Ikonomidis, Maximilian Dietrich, Silvia Seidlitz, Hans Vink, Lena Maier-Hein, Richard F. Schlenk, Carsten Müller-Tidow, Peter Dreger, Thomas Luft
Journal: Blood
Blood (2024) 144 (Supplement 1): 5519.
https://doi.org/10.1182/blood-2024-205216
Published: 2024
Journal Articles

A Venetoclax/Azacytidine Single-Cell RNA-Seq Resistance Signature (VARS) Predicts Response and Relapse in AML Patients

Free
Anne Kathrin Merbach, Christian Rohde, Sergi Beneyto-Calabuig, Patrick Stelmach, Aino-Maija Leppä, Alexander Waclawiczek, Simon Renders, Michelle Lotze, Lars Velten, Andreas Trumpp, Tim Sauer, Rabia Shahswar, Michael Heuser, Carsten Müller-Tidow, Maike Janssen
Journal: Blood
Blood (2024) 144 (Supplement 1): 5744.
https://doi.org/10.1182/blood-2024-209706
Published: 2024
Journal Articles

Clonal Dynamics of Leukemic and Clonal Hematopoiesis Mutations Predict Relapse in Single Cell MRD Analysis of AML in First Complete Remission

Free
Enise Ceran, Anne Kathrin Merbach, Christian Rohde, Robert Durruthy-Durruthy, Adam Sciambi, Michelle Lotze, Gema Fuerte, Matteo Cattaneo, Ivan Lukic, Maxi Wass, Judith Schaffrath, Christoph Röllig, Richard F. Schlenk, Marina Scheller, Simone Kowoll, Jörg Steighardt, Bayram Edemir, Beatrice Ludwig-Kraus, Lutz P. Mueller, Sabine Edemir, Abi Vainstein-Haras, Ella Sorani, Irit Gliko Kabir, Shaul Kadosh, Cora Gromann, Andreas Wienke, Claudia Wickenhauser, Claudia D Baldus, Uwe Platzbecker, Hubert Serve, Martin Bornhäuser, Carsten Müller-Tidow
Journal: Blood
Blood (2024) 144 (Supplement 1): 4337.
https://doi.org/10.1182/blood-2024-209953
Published: 2024
Journal Articles

Structurally Optimized, IL-2-Armored CLL1 CAR-NK Cells Are Highly Potent Effectors Against AML without Hpsc Toxicity

Free
David N. Sedloev, Qian Chen, Julia M. Unglaub, Anita Schmitt, Carsten Müller-Tidow, Michael Schmitt, Tim Sauer
Journal: Blood
Blood (2024) 144 (Supplement 1): 3440.
https://doi.org/10.1182/blood-2024-210286
Published: 2024
Journal Articles

Specific U6 Small Nucleolar RNAs Are Present on the Surface of Primary AML Specimens and Are Accompanied By Short Fragments of Longer RNAs

Free
Josephine Jagd Brysting, Christian Rohde, Laura Villacorta, Vladimir Benes, Simon Renders, Judith Zaugg, Carsten Müller-Tidow
Journal: Blood
Blood (2024) 144 (Supplement 1): 1339.
https://doi.org/10.1182/blood-2024-208198
Published: 2024
Journal Articles

Mapping Genotype to Phenotype in Clonal Hematopoiesis Uncovers Downregulated MHC-II Molecules in DNMT3A R882 - Mutant Hematopoietic Stem Cells

Free
Patrick Stelmach, Dominik Vonficht, Anne Kathrin Merbach, Dawn S Lin, Sergi Beneyto-Calabuig, Marina Scheller, Aino-Maija Leppä, Florian Grünschläger, George S Vassiliou, Simon Haas, Lars Velten, Carsten Müller-Tidow, Andreas Trumpp
Journal: Blood
Blood (2024) 144 (Supplement 1): 1292.
https://doi.org/10.1182/blood-2024-203041
Published: 2024
Journal Articles

Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia

Free
Eloísa Felipe Fumero, Carolin Walter, Joris Maximillian Frenz, Franca Seifert, Vijay Alla, Thorben Hennig, Linus Angenendt, Wolfgang Hartmann, Sebastian Wolf, Hubert Serve, Thomas Oellerich, Georg Lenz, Carsten Müller-Tidow, Christoph Schliemann, Otmar Huber, Martin Dugas, Matthias Mann, Ashok Kumar Jayavelu, Jan-Henrik Mikesch, Maria Francisca Arteaga
Journal: Blood
Blood (2024) 143 (22): 2284–2299.
https://doi.org/10.1182/blood.2023021640
Published: 2024
Includes: Supplemental data
Journal Articles

The remission status of AML patients after allo-HCT is associated with a distinct single-cell bone marrow T-cell signature

Free
Anna Mathioudaki, Xizhe Wang, David Sedloev, Richard Huth, Aryan Kamal, Michael Hundemer, Yi Liu, Spyridoula Vasileiou, Premal Lulla, Carsten Müller-Tidow, Peter Dreger, Thomas Luft, Tim Sauer, Michael Schmitt, Judith B. Zaugg, Caroline Pabst
Journal: Blood
Blood (2024) 143 (13): 1269–1281.
https://doi.org/10.1182/blood.2023021815
Published: 2024
Includes: Supplemental data
Journal Articles

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis

Free
Alexandra M. Poos, Nina Prokoph, Moritz J. Przybilla, Jan-Philipp Mallm, Simon Steiger, Isabelle Seufert, Lukas John, Stephan M. Tirier, Katharina Bauer, Anja Baumann, Jennifer Rohleder, Umair Munawar, Leo Rasche, K. Martin Kortüm, Nicola Giesen, Philipp Reichert, Stefanie Huhn, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Marc S. Raab, Karsten Rippe, Niels Weinhold
Journal: Blood
Blood (2023) 142 (19): 1633–1646.
https://doi.org/10.1182/blood.2023019758
Published: 2023
Includes: Supplemental data
Journal Articles

Impact of KMT2A -PTD Mutational Subgroups on Outcome of AML Patients after Induction Therapy and Allogeneic Hematopoietic Cell Transplantation

Free
Desiree Kunadt, Sven Zukunft, Klaus H Metzeler, Christoph Röllig, Christoph Schliemann, Jan Braess, Carsten Müller-Tidow, Alwin Kraemer, Sebastian Scholl, Inken Hilgendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Thomas Schroeder, Martin Kaufmann, Jan Moritz Middeke, Katja Sockel, Leo Ruhnke, Uwe Platzbecker, Hubert Serve, Matthias Stelljes, Claudia D Baldus, Andreas Neubauer, Johannes Schetelig, David Poitz, Christian Thiede, Martin Bornhäuser, Friedrich Stölzel
Journal: Blood
Blood (2023) 142 (Supplement 1): 2236.
https://doi.org/10.1182/blood-2023-187273
Published: 2023
Journal Articles

Risk Stratification of Patients with RUNX1- mutated Acute Myeloid Leukemia

Free
Christian Rausch, Roman Hornung, Aarif M. N. Batcha, Maja Rothenberg-Thurley, Stefanos A. Bamopoulos, Vindi Jurinovic, Bianka Ksienzyk, Stephanie Schneider, Annika Maria Dufour, Michaela Neusser, Maria Cristina Sauerland, Dennis Görlich, Utz Krug, Wolfgang E. Berdel, Bernhard J. Woermann, Jan Braess, Wolfgang Hiddemann, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Johannes Schetelig, Moritz Middeke, Sebastian Stasik, Katharina Egger-Heidrich, Christoph Röllig, Martin Bornhäuser, Christian Thiede, Claudia D Baldus, Carsten Müller-Tidow, Uwe Platzbecker, Hubert Serve, Wendy Stock, Geoffrey L Uy, John C. Byrd, Deedra Nicolet, Ann-Kathrin Eisfeld, Ulrich Mansmann, Karsten Spiekermann, Klaus H Metzeler, Tobias Herold
Journal: Blood
Blood (2023) 142 (Supplement 1): 2934.
https://doi.org/10.1182/blood-2023-174059
Published: 2023
Journal Articles

Tumor Reactive T Cells Reside in the Bone Marrow and Are Associated with Clinical Response to Hematological Malignancies

Free
Tim Robin Wagner, Niklas Kehl, Simon Steiger, Michael Kilian, Kane Foster, Tamara Boschert, Gabrielle M. Hernandez, Jennifer Abelin, Katharina Lindner, Lilli Sophie Sester, Jan Frenking, Bruno Schönfelder, Daria Galas-Filipowicz, Evie Fitzsimons, Edward W. Green, Patrick Schmidt, Sebastian Uhrig, Lukas Bunse, Benny Chain, Hartmut Goldschmidt, Niels Weinhold, Stefan Fröhling, Carsten Müller-Tidow, Steven A. Carr, Kwee Yong, Karsten Rippe, Marc S. Raab, Michael Platten, Stefan B Eichmüller, Mirco Julian Friedrich
Journal: Blood
Blood (2023) 142 (Supplement 1): 4074.
https://doi.org/10.1182/blood-2023-189779
Published: 2023