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Journal Articles

Efficacy, molecular and translational analysis of TP53-mutated HR-MDS with bexmarilimab and azacitidine: Updated results from the bexmab Phase 1/2 study

Free
Amer Zeidan, Anthony Selwyn Stein, Johanna Rimpiläinen, Marja Pyörälä, Timo Siitonen, Brian Ball, Mikko Myllymäki, Joshua Zeidner, Dr. Emma Searle, Ruth Witherall, Petri Bono, Aneel Nimba, Joab Williamson, Sofia Aakko, Maija Hollmén, Mika Kontro, Naval Daver
Journal: Blood
Blood (2025) 146 (Supplement 1): 236.
https://doi.org/10.1182/blood-2025-236
Published: 2025
Journal Articles

Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality

Free
Anthony Selwyn Stein, Joycelynne Palmer, Yan Wang, Monzr M. Al Malki, Ibrahim Aldoss, Haris Ali, Ahmed Aribi, Andrew Artz, Brian Ball, Savita Dandapani, Leonardo Farol, Chunhui Han, An Liu, Vinod Pullarkat, Eric Radany, Firoozeh Sahebi, James Sanchez, Karamjeet Sandhu, Amandeep Salhotra, Eileen Smith, Ricardo Spielberger, Susanta Hui, Guido Marcucci, Ryotaro Nakamura, Stephen Forman, Jeffrey Wong
Journal: Blood
Blood (2025) 146 (Supplement 1): 2441.
https://doi.org/10.1182/blood-2025-2441
Published: 2025
Journal Articles

The addition of venetoclax to FLAG IDA or FCE in relapsed or refractory (R/R) acute myeloid leukemia (AML)

Free
Jose Tinajero, Dat Ngo, Brian Lee, ryan jackson, Michelle Afkhami, Haoyue Shan, Jianying Zhang, Dongyun Yang, Joycelynne Palmer, Idoroenyi Amanam, Sunmin Park, Ahmed Aribi, Shukaib Arslan, Vaibhav Agrawal, Hoda Pourhassan, Brian Ball, Paul Koller, Amandeep Salhotra, Salman Otoukesh, Monzr M. Al Malki, Pamela Becker, Ibrahim Aldoss, Andrew Artz, Eileen Smith, Vinod Pullarkat, Ryotaro Nakamura, Anthony Selwyn Stein, Stephen Forman, Guido Marcucci, Amanda Blackmon, Karamjeet Sandhu
Journal: Blood
Blood (2025) 146 (Supplement 1): 1684.
https://doi.org/10.1182/blood-2025-1684
Published: 2025
Journal Articles

A phase 1/1b open-label, dose escalation, first-in-human study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-leukemic activity of the orally available clk inhibitor, BH-30236, in adults with R/R AML or HR-MDS

Free
Eytan Stein, Alice Mims, Zhuoer Xie, Gabriel Mannis, Justin Watts, Farhad Ravandi, Gary Schiller, Brian Ball, Hongtao Liu, Jessica Altman, Eunice Wang, J. Jean Cui, Jihao Zhou, Zachary Zimmerman, Stephen Strickland
Journal: Blood
Blood (2025) 146 (Supplement 1): 1655.
https://doi.org/10.1182/blood-2025-1655
Published: 2025
Journal Articles

The outcomes of patients who are relapsed or refractory to menin inhibitors is poor with a limited overall survival

Free
Kuo-Kai Chin, Brian Ball, Yasmin Abaza, Jessica Altman, Rahul Thakur, Moiez Ali, Andriy Derkach, Mark Geyer, Aaron Goldberg, Tamanna Haque, Meghan Thompson, Jae Park, Martin Tallman, Sheng Cai, Eunice Wang, Ibrahim Aldoss, Eytan Stein
Journal: Blood
Blood (2025) 146 (Supplement 1): 39.
https://doi.org/10.1182/blood-2025-39
Published: 2025
Journal Articles

Transfusion independence, hematological improvement and associated safety outcomes with bexmarilimab and azacitidine in HR-MDS: Results of the bexmab Phase 1/2 study

Free
Mika Kontro, Anthony Selwyn Stein, Johanna Rimpiläinen, Marja Pyörälä, Timo Siitonen, Brian Ball, Mikko Myllymäki, Joshua Zeidner, Dr. Emma Searle, Ruth Witherall, Petri Bono, Aneel Nimba, Joab Williamson, Sofia Aakko, Maija Hollmén, Amer Zeidan, Naval Daver
Journal: Blood
Blood (2025) 146 (Supplement 1): 5627.
https://doi.org/10.1182/blood-2025-5627
Published: 2025
Journal Articles

Prevalence and impact of somatic mutations in patients with aplastic anemia (AA) undergoing allogeneic hematopoietic cell transplantation (HCT): A single center retrospective analysis

Free
Salman Otoukesh, Brian Ball, Dongyun Yang, Ketevan Gendzekhadze, Karamjeet Sandhu, Shukaib Arslan, Amanda Blackmon, Pamela Becker, Firoozeh Sahebi, Anna Pawlowska, Monzr M. Al Malki, Michelle Afkhami, Stephen Forman, Guido Marcucci, Vinod Pullarkat, Raju Pillai, Ryotaro Nakamura
Journal: Blood
Blood (2025) 146 (Supplement 1): 1431.
https://doi.org/10.1182/blood-2025-1431
Published: 2025
Journal Articles

High efficacy of blinatumomab combined with pembrolizumab in patients with relapsed/refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL): primary analysis of a Phase 1/2 study

Free
Karamjeet Sandhu, Marissa Del Real, Alan Macias, Jianying Zhang, Kenneth Ng, Young Kim, Mojtaba Akhtari, Colt Egelston, Manjyot Nanhwan, Joycelynne Palmer, Marjorie Robbins, Ahmed Aribi, Matthew Mei, Amandeep Salhotra, Idoroenyi Amanam, Vaibhav Agrawal, Shukaib Arslan, Brian Ball, Salman Otoukesh, Paul Koller, Hoda Pourhassan, Haris Ali, Pamela Becker, Vinod Pullarkat, Stephen Forman, Ibrahim Aldoss, Anthony Selwyn Stein, Guido Marcucci, Elizabeth Budde
Journal: Blood
Blood (2025) 146 (Supplement 1): 3352.
https://doi.org/10.1182/blood-2025-3352
Published: 2025
Journal Articles

The transition from myelodysplastic neoplasm to secondary acute myeloid leukemia is revealed by molecular analysis, while functional drug screening demonstrates novel sensitivity patterns with clinical implication

Free
Jieya Wu, Guangrong Qin, Brian Ball, Michelle Afkhami, Khyati Joshi, Elaine Jiang, Mika Tsubota, Yueming Tang, Tim Monahan, Lucy Ghoda, Timothy Martins, Holly Yin, Jacob Appelbaum, Stanley Lee, Sergei Doulatov, Melinda Biernacki, Derek Stirewalt, Guido Marcucci, Marie Bleakley, Pamela Becker
Journal: Blood
Blood (2025) 146 (Supplement 1): 4328.
https://doi.org/10.1182/blood-2025-4328
Published: 2025
Journal Articles

Clearance of RAS pathway mutations prior to allogeneic transplant in Acute Myeloid Leukemia are associated with favorable overall and leukemia free survival

Free
Claire Carlson, Jose Tinajero, Dat Ngo, Huiyan Ma, Sunmin Park, Shukaib Arslan, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Salman Otoukesh, Idoroenyi Amanam, Paul Koller, Karamjeet Sandhu, Ahmed Aribi, Ibrahim Aldoss, Andrew Artz, Monzr M. Al Malki, Vinod Pullarkat, Haris Ali, Eileen Smith, Anthony Selwyn Stein, Guido Marcucci, Stephen Forman, Ryotaro Nakamura, Pamela Becker, Michelle Afkhami, Brian Ball, Amandeep Salhotra
Journal: Blood
Blood (2025) 146 (Supplement 1): 4305.
https://doi.org/10.1182/blood-2025-4305
Published: 2025
Journal Articles

Genomic and phenotypic impact of FHD-286–induced inhibition of SMARCA4/2 in patients with relapsed/refractory myeloid malignancies

Free
Mike Collins, David Lahr, Eytan Stein, Courtney DiNardo, Ashwin Kishtagari, Brian Ball, Kim Horrigan, Alexis Khalil, Katie D'Aco, Mia Bosinger, Salih Topal, Nicholas Spidale, Alfonso Quintas-Cardama, Gromoslaw Smolen
Journal: Blood
Blood (2025) 146 (Supplement 1): 655.
https://doi.org/10.1182/blood-2025-655
Published: 2025
Journal Articles

Day 7 mount sinai acute GVHD international consortium (MAGIC) algorithm probability predicts GVHD and non-GVHD-related non-relapse mortality in a contemporary cohort of allogeneic transplant patients

Free
Sunmin Park, NI-Chun Tsai, Amanda Blackmon, Vaibhav Agrawal, Brian Ball, Hoda Pourhassan, Salman Otoukesh, Shukaib Arslan, Idoroenyi Amanam, Paul Koller, Ahmed Aribi, Peter Curtin, Ibrahim Aldoss, Andrew Artz, Vinod Pullarkat, Haris Ali, Amandeep Salhotra, Pamela Becker, Ji-Lian Cai, Firoozeh Sahebi, Anna Pawlowska, Yunzu Wang, F. Marc Stewart, Eileen Smith, Anthony Selwyn Stein, Guido Marcucci, Stephen Forman, Dongyun Yang, Monzr M. Al Malki, Ryotaro Nakamura, Karamjeet Sandhu
Journal: Blood
Blood (2025) 146 (Supplement 1): 2464.
https://doi.org/10.1182/blood-2025-2464
Published: 2025
Journal Articles

Itacitinib in combination with post-transplant cyclophosphamide and tacrolimus (ICT) as GVHD prophylaxis for reduced intensity matched donor peripheral blood stem cell hematopoietic cell transplantation: Interim analysis

Free
Monzr M. Al Malki, Dongyun Yang, Sally Mokhtari, Anissa Bailey, Pooja Rajeevan, Rhiannon Imbeah, Salman Otoukesh, Brian Ball, Paul Koller, Vaibhav Agrawal, Yazeed Samara, Firoozeh Sahebi, Ibrahim Aldoss, Andrew Artz, Guido Marcucci, Stephen Forman, Ryotaro Nakamura, Haris Ali
Journal: Blood
Blood (2025) 146 (Supplement 1): 2455.
https://doi.org/10.1182/blood-2025-2455
Published: 2025
Journal Articles

Total marrow and lymphoid irradiation (TMLI) with fludarabine-melphalan (FM) conditioning for matched donor hematopoietic cell transplant (HCT) in older patients with Relapsed/Refractory (R/R) disease

Free
Monzr M. Al Malki, Susanta Hui, Dongyun Yang, Sally Mokhtari, Hoda Pourhassan, Matthew Mei, Amanda Blackmon, Firoozeh Sahebi, Amandeep Salhotra, Brian Ball, Shukaib Arslan, Salman Otoukesh, Haris Ali, Guido Marcucci, Ryotaro Nakamura, Stephen Forman, Anthony Selwyn Stein, Jeffrey Wong
Journal: Blood
Blood (2025) 146 (Supplement 1): 376.
https://doi.org/10.1182/blood-2025-376
Published: 2025
Journal Articles

Trial in progress: A phase I study evaluating the safety of cirtuvivint (CIRT) as monotherapy and in combination with ASTX727 in patients with myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML)

Free
Evan Chen, Yiwen Liu, Eytan Stein, Brian Ball, Ivana Gojo, Olatoyosi Odenike, Neil Palmisiano, Vu Duong, Zimu Gong, Michael Hochman, Carine Bossard, John Hill, Mirta Grifman, Daniel Deangelo, Richard Stone, Ilene Galinsky, Rebecca Leonard, Richard Little, Steven Gore, Jan Philipp Bewersdorf, Lourdes Mendez, Nikolai Podoltsev, Amer Zeidan, Omar Abdel-Wahab, Maximilian Stahl
Journal: Blood
Blood (2025) 146 (Supplement 1): 3431.
https://doi.org/10.1182/blood-2025-3431
Published: 2025
Journal Articles

A first-in-human phase 1 Study of cbx-250, a TCR-mimetic bispecific T cell engager targeting CG1/ HLA-a*02:01 in patients with relapsed or refractory AML, HR-MDS, or CMML (CROSSCHECK-001) (Trial in Progress)

Free
Brian Ball, Stephen Strickland, Briggs Morrison, John DiPersio, Shaliny Kushwaha, Benjamin Lee, Rachel Ghiraldi, Kevin Cho, John Goll, David Sallman, Ghayas Issa
Journal: Blood
Blood (2025) 146 (Supplement 1): 3430.
https://doi.org/10.1182/blood-2025-3430
Published: 2025
Journal Articles

A phase 1 dose escalation and dose optimization study to evaluate the preliminary safety, tolerability, pharmacokinetic, pharmacodynamic, and clinical activity profile of AUTX703 in participants with relapsed/refractory acute myeloid leukemia and myelodysplastic syndromes

Free
Stephen Strickland, Eunice Wang, Brian Ball, Alice Mims, Joshua Zeidner, Xin Wang, Rory Shallis, Catherine Lai, Katharine Yen, David Millan, Joseph DeBartolo, James Neef, Laura Antipov, Erika Manyak, Rachael Kendrick, Guangbin Peng, Kimberly Straley, Caroline Almon, Carrie Brownstein, Courtney DiNardo
Journal: Blood
Blood (2025) 146 (Supplement 1): 6952.
https://doi.org/10.1182/blood-2025-6952
Published: 2025
Journal Articles

A multicenter phase 1 trial evaluating the safety and preliminary efficacy of revumenib as post-transplant maintenance after allogeneic hematopoietic cell transplant in patients with KMT2A-rearranged or NPM1-mutated acute leukemia

Free
Brian Ball, Mahasweta Gooptu, Ling Li, Christopher Hourigan, Sally Mokhtari, Dongyun Yang, Leonardo Farol, Yazeed Samara, Anthony Selwyn Stein, Guido Marcucci, Monzr M. Al Malki, Corey Cutler, Ryotaro Nakamura, Ibrahim Aldoss
Journal: Blood
Blood (2025) 146 (Supplement 1): 5207.
https://doi.org/10.1182/blood-2025-5207
Published: 2025
Journal Articles

Outcomes of allogeneic hematopoietic cell transplant (HCT) in patients with TP53-altered acute leukemia or myelodysplastic syndrome: A retrospective single center analysis

Free
Salman Otoukesh, Amrita Desai, Dongyun Yang, Sally Mokhtari, Brian Ball, Paul Koller, Amanda Blackmon, Shukaib Arslan, Idoroenyi Amanam, Amandeep Salhotra, Karamjeet Sandhu, Ahmed Aribi, Ibrahim Aldoss, Andrew Artz, Haris Ali, Anthony Selwyn Stein, Guido Marcucci, Stephen Forman, Ryotaro Nakamura, Michelle Afkhami, Monzr M. Al Malki
Journal: Blood
Blood (2025) 146 (Supplement 1): 2516.
https://doi.org/10.1182/blood-2025-2516
Published: 2025
Journal Articles

Allogeneic hematopoietic stem cell transplantation for acute leukemias of mixed or ambiguous lineage

Free
Sunmin Park, Fei Fei, NI-Chun Tsai, Hui Pan, Dongyun Yang, Shukaib Arslan, Amanda Blackmon, Vaibhav Agrawal, Hoda Pourhassan, Salman Otoukesh, Idoroenyi Amanam, Brian Ball, Paul Koller, Karamjeet Sandhu, Amandeep Salhotra, Ahmed Aribi, Ibrahim Aldoss, Andrew Artz, Monzr M. Al Malki, Vinod Pullarkat, Haris Ali, F. Marc Stewart, Eileen Smith, Anthony Selwyn Stein, Guido Marcucci, Stephen Forman, Ryotaro Nakamura, Michelle Afkhami, Pamela Becker
Journal: Blood
Blood (2025) 146 (Supplement 1): 4282.
https://doi.org/10.1182/blood-2025-4282
Published: 2025