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Amrita Sarkar
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Journal Articles

Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Lubica Rauova, Khalil Bdeir, Ann H Rux, Manu Thomas Kalathottukaren, Jenna Oberg, Chanel C. La, David Thiam En Lim, Vincent M Hayes, Gavin T. Koma, Amrita Sarkar, Mortimer Poncz, Jayachandran N Kizhakkedathu, Douglas B. Cines
Journal: Blood
Blood blood.2024025653.
https://doi.org/10.1182/blood.2024025653
Published: 2025
Includes: Supplemental data
Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz
Journal: Blood
Blood (2024) 144 (Supplement 1): 185.
https://doi.org/10.1182/blood-2024-201682
Published: 2024
Journal Articles

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Amrita Sarkar, Conroy O Field, Keith R. McCrae, Thomas L. Ortel, Gow Arepally, Roxanne Cofiell, Sung-Kwon Kim, Lubica Rauova, Mortimer Poncz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2606.
https://doi.org/10.1182/blood-2024-198182
Published: 2024
Journal Articles

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Anh T.P. Ngo, Veronica Bochenek, Hyunjun Kim, Nate Levine, Samir Maarouf, Jenna Oberg, Manuela Roggiani, Amrita Sarkar, Lubica Rauova, Caroline Diorio, Zachary Martinez, Mark Goulian, Mortimer Poncz, Victor Nizet, Kandace Gollomp
Journal: Blood
Blood (2024) 144 (Supplement 1): 1231.
https://doi.org/10.1182/blood-2024-211717
Published: 2024
Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2611.
https://doi.org/10.1182/blood-2024-200849
Published: 2024
Journal Articles

Platelet Factor 4 Enhances Antimicrobial Function of the Endothelium and Improves Outcome in a Murine Model of Sepsis

Anh T.P. Ngo, Nate Levine, Abigail E Skidmore, Amrita Sarkar, Veronica Bochenek, Manuela Roggiani, Mark Goulian, Mortimer Poncz, Kandace Gollomp
Journal: Blood
Blood (2023) 142 (Supplement 1): 1198.
https://doi.org/10.1182/blood-2023-186989
Published: 2023
Journal Articles

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Anh T.P. Ngo, Amrita Sarkar, Nathan Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M. Anna Kowalska, Kaitlyn Eckart, Nilam S. Mangalmurti, Ann Rux, Douglas B. Cines, Mortimer Poncz, Kandace Gollomp
Journal: Blood
Blood (2022) 140 (Supplement 1): 5529–5530.
https://doi.org/10.1182/blood-2022-169709
Published: 2022
Journal Articles

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Sanjay Khandelwal, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge V. Yarovoi, S. Sergei Zaitsev, John D. Lambris, Sooho S. Myoung, Alexandra Johnson, Grace M. Lee, Madelaine Duarte, Mortimer Poncz, Gowthami M. Arepally, Douglas B. Cines
Journal: Blood
Blood (2021) 138 (21): 2106–2116.
https://doi.org/10.1182/blood.2020009487
Published: 2021
Includes: Supplemental data
Journal Articles

Fc-Modified Kko: A Novel Therapeutic for Heparin-Induced Thrombocytopenia (HIT), Reversing Both the Thrombocytopenia and Thrombosis

Amrita Sarkar, Sanjay Khandelwal, Serge Yarovoi, Gowthami M. Arepally, Douglas B. Cines, Mortimer Poncz, Lubica Rauova
Journal: Blood
Blood (2021) 138 (Supplement 1): 581.
https://doi.org/10.1182/blood-2021-146233
Published: 2021
Journal Articles

Platelet Factor 4 (PF4) Modulates the Prothrombotic Nature of Neutrophil-Extracellular Traps (NETs): Therapeutic Implications of a NET-Stabilization Strategy

Anh T.P. Ngo, Irene Yarovoi, Guohua Zhao, Amrita Sarkar, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz, Kandace Gollomp
Journal: Blood
Blood (2021) 138 (Supplement 1): 2096.
https://doi.org/10.1182/blood-2021-153352
Published: 2021
Journal Articles

FcRn augments induction of tissue factor activity by IgG-containing immune complexes

Douglas B. Cines, Sergei Zaitsev, Lubica Rauova, Ann H. Rux, Victoria Stepanova, Sriram Krishnaswamy, Amrita Sarkar, M. Anna Kowalska, Guohua Zhao, Alan E. Mast, Laurence J. Blumberg, Keith R. McCrae, Mortimer Poncz, Jonathan J. Hubbard, Michal Pyzik, Richard S. Blumberg
Journal: Blood
Blood (2020) 135 (23): 2085–2093.
https://doi.org/10.1182/blood.2019001133
Published: 2020
Includes: Supplemental data
Journal Articles

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Ian Johnston, Amrita Sarkar, Vincent Hayes, Gavin T. Koma, Gowthami M. Arepally, Junmei Chen, Dominic W. Chung, José A. López, Douglas B. Cines, Lubica Rauova, Mortimer Poncz
Journal: Blood
Blood (2020) 135 (15): 1270–1280.
https://doi.org/10.1182/blood.2018881607
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis

Kandace Gollomp, Amrita Sarkar, Sanjiv Harikumar, Steven H. Seeholzer, Gowthami M. Arepally, Kristin Hudock, Lubica Rauova, M. Anna Kowalska, Mortimer Poncz
Journal: Blood
Blood (2020) 135 (10): 743–754.
https://doi.org/10.1182/blood.2019002329
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Understanding How Fc-Modification Transforms a Pathogenic Heparin-Induced Thrombocytopenia (HIT)-like Monoclonal Antibody into a Novel Treatment for Sepsis

Kandace Gollomp, MD, Amrita Sarkar, PhD, Gowthami Arepally, MD, Douglas B. Cines, MD, M. Anna Kowalska, PhD, Lubica Rauova, MD PhD, Mortimer Poncz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 10.
https://doi.org/10.1182/blood-2019-123132
Published: 2019
Journal Articles

Antibody Stabilization of Neutrophil Extracellular Trap-Platelet Factor 4 Complexes Is Therapeutic in a Murine Model of Endotoxemia

Amrita Sarkar, PhD, Gowthami Arepally, MD, M. Anna Kowalska, PhD, Douglas B. Cines, MD, Lubica Rauova, MD PhD, Mortimer Poncz, MD, Kandace Gollomp, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 271.
https://doi.org/10.1182/blood-2018-99-111381
Published: 2018