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Volume 99, Issue 9

May 1 2002

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
HOW I TREAT
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Photodynamic purging of immunoreactive T cells: the magic bullet?

Claudio Anasetti

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Moyamoya and stroke in sickle cell anemia: bad news and good news

Ronald L. Nagel

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PLENARY PAPERS

Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process

Benny J. Chen,Xiuyu Cui,Congxiao Liu,Nelson J. Chao

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REVIEW ARTICLES

Differentiation plasticity of hematopoietic cells

Thomas Graf

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HOW I TREAT

How we diagnose and treat deep vein thrombosis

Jack Hirsh,Agnes Y. Y. Lee

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CHEMOKINES

Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration

Michel Ticchioni,Céline Charvet,Nelly Noraz,Laurence Lamy,Marcos Steinberg,Alain Bernard,Marcel Deckert

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Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-γ in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome

Todd A. Reinhart,Beth A. Fallert,Melanie E. Pfeifer,Sonali Sanghavi,Saverio Capuano, III,Premeela Rajakumar,Michael Murphey-Corb,Richard Day,Craig L. Fuller,Todd M Schaefer

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia
Clinical Trials & Observations

Jaroslaw P. Maciejewski,Antonio Risitano,Elaine M. Sloand,Olga Nunez,Neal S. Young

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Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report
Clinical Trials & Observations

Dao-Pei Lu,Jing-Ying Qiu,Bin Jiang,Qin Wang,Kai-Yan Liu,Yan-Rong Liu,Shan-Shan Chen

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Moyamoya syndrome in childhood sickle cell disease: a predictive factor for recurrent cerebrovascular events
Clinical Trials & Observations

Scott R. Dobson,Kenton R. Holden,Paul J. Nietert,Joel K. Cure,Joseph H. Laver,Deborah Disco,Miguel R. Abboud

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Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remission
Clinical Trials & Observations

Nancy Bunin,Michael Carston,Donna Wall,Roberta Adams,James Casper,Naynesh Kamani,Roberta King,the National Marrow Donor Program Working Group

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High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma
Clinical Trials & Observations

Ajay K. Gopal,Joseph G. Rajendran,Stephen H. Petersdorf,David G. Maloney,Janet F. Eary,Brent L. Wood,Theodore A. Gooley,Sharon A. Bush,Lawrence D. Durack,Paul J. Martin,Dana C. Matthews,Frederick R. Appelbaum,Irwin D. Bernstein,Oliver W. Press

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Maintenance therapy with alternate-day prednisone improves survival in multiple myeloma patients
Clinical Trials & Observations

James R. Berenson,John J. Crowley,Thomas M. Grogan,Jeffrey Zangmeister,Adrienne D. Briggs,Glenn M. Mills,Bart Barlogie,Sydney E. Salmon

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GENE THERAPY

Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells

Thasia Leimig,Linda Mann,Maria del Pilar Martin,Erik Bonten,Derek Persons,James Knowles,James A. Allay,John Cunningham,Arthur W. Nienhuis,Richard Smeyne,Alessandra d'Azzo

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Adapting a transforming growth factor β–related tumor protection strategy to enhance antitumor immunity

Catherine M. Bollard,Claudia Rössig,M. Julia Calonge,M. Helen Huls,Hans-Joachim Wagner,Joan Massague,Malcolm K. Brenner,Helen E. Heslop,Cliona M. Rooney

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HEMATOPOIESIS

Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity

Kay Grobe,Leland D. Powell

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Modulation of p210^BCR-ABL activity in transduced primary human hematopoietic cells controls lineage programming

Yves Chalandon,Xiaoyan Jiang,Glen Hazlewood,Slade Loutet,Eibhlin Conneally,Allen Eaves,Connie Eaves

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Vitamin C inhibits granulocyte macrophage–colony-stimulating factor–induced signaling pathways

Juan M. Cárcamo,Oriana Bórquez-Ojeda,David W. Golde

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Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein–deficient bone marrow–derived macrophages

Axel Kallies,Frank Rosenbauer,Marina Scheller,Klaus-Peter Knobeloch,Ivan Horak

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A functional role of Stat3 in in vivo megakaryopoiesis

Keita Kirito,Masatake Osawa,Haruhiko Morita,Ritsuko Shimizu,Masayuki Yamamoto,Atsushi Oda,Hiroyoshi Fujita,Masaru Tanaka,Koichi Nakajima,Yasusada Miura,Keiya Ozawa,Norio Komatsu

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Glycoprotein VI–mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP

Todd M. Quinton,Fatih Ozdener,Carol Dangelmaier,James L. Daniel,Satya P. Kunapuli

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Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model

Inderjit Singh,Alberto Smith,Beatrijs Vanzieleghem,Désiré Collen,Kevin Burnand,Jean-Marie Saint-Remy,Marc Jacquemin

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A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis

Hiroki Miyashita,Tohru Yamazaki,Tetsuya Akada,Osamu Niizeki,Minetaro Ogawa,Shin-ichi Nishikawa,Yasufumi Sato

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Constitutive and functional association of the platelet collagen receptor glycoprotein VI–Fc receptor γ-chain complex with membrane rafts

Yasuharu Ezumi,Kumi Kodama,Takashi Uchiyama,Hiroshi Takayama

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IMMUNOBIOLOGY

Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure

Maria J. Polyak,Julie P. Deans

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Type I interferons produced by dendritic cells promote their phenotypic and functional activation

Maria Montoya,Giovanna Schiavoni,Fabrizio Mattei,Ion Gresser,Filippo Belardelli,Persephone Borrow,David F. Tough

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Humoral immune responses against Wilms tumor gene WT1product in patients with hematopoietic malignancies

Olga A. Elisseeva,Yoshihiro Oka,Akihiro Tsuboi,Kiyoyuki Ogata,Fei Wu,Eui Ho Kim,Toshihiro Soma,Hiroya Tamaki,Manabu Kawakami,Yusuke Oji,Naoki Hosen,Takeshi Kubota,Masashi Nakagawa,Tamotsu Yamagami,Akira Hiraoka,Machiko Tsukaguchi,Keiko Udaka,Hiroyasu Ogawa,Tadamitsu Kishimoto,Taisei Nomura,Haruo Sugiyama

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Tumor lysate–specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy

Yue-Jin Wen,Rui Min,Guido Tricot,Bart Barlogie,Qing Yi

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HLA-B7 β-pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses

Anja Freese,Nicholas Zavazava

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Human Immune Associated Nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells

Marie Cambot,Sandra Aresta,Brigitte Kahn-Perlès,Jean de Gunzburg,Paul-Henri Roméo

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Cytokine production and cytolytic mechanism of CD4⁺cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus–specific T-cell cultures

Qi Sun,Robert L. Burton,Kenneth G. Lucas

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Interleukin-7–treated naive T cells can be productively infected by T-cell–adapted and primary isolates of human immunodeficiency virus 1

Carolyn M. Steffens,Elizabeth Z. Managlia,Alan Landay,Lena Al-Harthi

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Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application

Michael S. von Bergwelt-Baildon,Robert H. Vonderheide,Britta Maecker,Naoto Hirano,Karen S. Anderson,Marcus O. Butler,Zhinan Xia,Wan Y. Zeng,Kai W. Wucherpfennig,Lee M. Nadler,Joachim L. Schultze

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Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells

Christian P. Gray,Paolo Arosio,Peter Hersey

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High frequencies of Th1-type CD4⁺ T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis

Peter K. C. Goon,Emmanuel Hanon,Tadahiko Igakura,Yuetsu Tanaka,Jonathan N. Weber,Graham P. Taylor,Charles R. M. Bangham

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Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor–induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration

Shuji Ueda,Masao Mizuki,Hirokazu Ikeda,Tohru Tsujimura,Itaru Matsumura,Kazushi Nakano,Hanako Daino,Zen-ichiro Honda,Junko Sonoyama,Hirohiko Shibayama,Hiroyuki Sugahara,Takashi Machii,Yuzuru Kanakura

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Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1

Peter I. Chuang,Samantha Morefield,Chien-Ying Liu,Stephen Chen,John M. Harlan,Dennis M. Willerford

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Identification of an HLA A*0201–restricted CD8⁺T-cell epitope for the glycoprotein B homolog of human herpesvirus 8

Qiong J. Wang,Xiao-Li Huang,Giovanna Rappocciolo,Frank J. Jenkins,William H. Hildebrand,Zheng Fan,Elaine K. Thomas,Charles R. Rinaldo, Jr

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NEOPLASIA

MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia

Lubing Gu,Harry W. Findley,Muxiang Zhou

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In situ localization of follicular lymphoma: description and analysis by laser capture microdissection

Peijie Cong,Mark Raffeld,Julie Teruya-Feldstein,Lynn Sorbara,Stefania Pittaluga,Elaine S. Jaffe

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Human T-cell lymphotropic virus type 1–transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells

Marwan E. El-Sabban,Raghida Abou Merhi,Hounaida Abi Haidar,Bertrand Arnulf,Hilda Khoury,Jihane Basbous,Julie Nijmeh,Hugues de Thé,Olivier Hermine,Ali Bazarbachi

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Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21^WAF1/CIP1 proteins in human acute lymphoblastic leukemia cells

Ryosuke Ogawa,Michael B. Streiff,Artem Bugayenko,Gregory J. Kato

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Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

Franziska Jundt,Ioannis Anagnostopoulos,Reinhold Förster,Stephan Mathas,Harald Stein,Bernd Dörken

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Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF–retinoic acid receptor alpha oncoprotein

Shinobu Tsuzuki,Tariq Enver

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Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells

Anita Challa,Aristides G. Eliopoulos,Michelle J. Holder,Alondra Schweizer Burguete,John D. Pound,Anita Chamba,Gillian Grafton,Richard J. Armitage,Christopher D. Gregory,Hector Martinez-Valdez,Lawrence Young,John Gordon

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Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis

Fei Guo,Ramadevi Nimmanapalli,Shanthi Paranawithana,Sylvie Wittman,David Griffin,Purva Bali,Erica O'Bryan,Carlos Fumero,Hong Gang Wang,Kapil Bhalla

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PHAGOCYTES

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide

Daniela Bosisio,Nadia Polentarutti,Marina Sironi,Sergio Bernasconi,Kensuke Miyake,Ginette R. Webb,Michael U. Martin,Alberto Mantovani,Marta Muzio

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Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis

Patricia M. De Souza,Hannu Kankaanranta,Ashour Michael,Peter J. Barnes,Mark A. Giembycz,Mark A. Lindsay

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RED CELLS

Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X_L

Melanie Walsh,Robert J. Lutz,Thomas G. Cotter,Rosemary O'Connor

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TRANSPLANTATION

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events

Mette D. Hazenberg,Sigrid A. Otto,Elmar S. de Pauw,Helene Roelofs,Willem E. Fibbe,Dörte Hamann,Frank Miedema

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BRIEF REPORTS

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor–1 enhances their ability to engraft NOD/SCID mice
Brief Report

Hanno Glimm,Patrick Tang,Ian Clark-Lewis,Christof von Kalle,Connie Eaves

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HLA-haploidentical blood progenitor cell transplantation in osteopetrosis
Clinical Trials & Observations Brief Report

Ansgar S. Schulz,Carl Friedrich Classen,Walther A. Mihatsch,Michael Sigl-Kraetzig,Markus Wiesneth,Klaus-Michael Debatin,Wilhelm Friedrich,Susanna M. Müller

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
Brief Report

Michele Milella,Zeev Estrov,Steven M. Kornblau,Bing Z. Carter,Marina Konopleva,Ana Tari,Wendy D. Schober,David Harris,Clinton E. Leysath,Gabriel Lopez-Berestein,Ziwei Huang,Michael Andreeff

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Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation
Clinical Trials & Observations Brief Report

Stephen G. O'Brien,Sara A. D. Vieira,Samantha Connors,Nick Bown,James Chang,Renaud Capdeville,Junia V. Melo

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Significance of the detection of antineutrophil antibodies in children with chronic neutropenia
Clinical Trials & Observations Brief Report

Masao Kobayashi,Kazuhiro Nakamura,Hiroshi Kawaguchi,Takashi Sato,Hirotaka Kihara,Asako Hiraoka,Misae Tanihiro,Kikuyo Taniguchi,Noboru Takata,Kazuhiro Ueda

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High frequency of point mutations clustered within the adenosine triphosphate–binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
Brief Report

Susan Branford,Zbigniew Rudzki,Sonya Walsh,Andrew Grigg,Chris Arthur,Kerry Taylor,Richard Herrmann,Kevin P. Lynch,Timothy P. Hughes

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CORRESPONDENCE

Elevated lipoprotein(a) concentration is an independent risk factor of venous thromboembolism

Ulrike Nowak-Göttl,Rosemarie Schobess,Karin Kurnik,Dirk Schwabe,Gudrun Fleischhack,Ralf Junker

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Mixed warm and cold autoimmune hemolytic anemia: complete recovery after 2 courses of rituximab treatment

Monica Morselli,Mario Luppi,Leonardo Potenza,Luca Facchini,Stefania Tonelli,Daniele Dini,Giovanna Leonardi,Amedea Donelli,Franco Narni,Giuseppe Torelli

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Sperm protein 17 is not expressed on normal leukocytes

Fabio Grizzi,Seah H. Lim,Maurizio Chiriva-Internati,Barbara Franceschini,Zhiqing Wang,David Lawrence,Nicola Dioguardi

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Severe neurotoxicity following arsenic therapy for acute promyelocytic leukemia: potentiation by thiamine deficiency

Sze-Fai Yip,Yiu-Ming Yeung,Edmond-Yik-Kong Tsui

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Successful double bone marrow and renal transplantation in a patient with Fanconi anemia

Maurizio Miano,Fabrizio Ginevri,Arcangelo Nocera,Sandro Dallorso,Iris Fontana,Francesco Perfumo,Giorgio Dini,Carlo Dufour

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Cytomegalovirus infections in cancer patients receiving granulocyte transfusions

W. Garrett Nichols,Thomas Price,Michael Boeckh

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Expression of survival receptors in Hodgkin disease cell lines

Herbert Bosshart

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Safety of early immunization against measles/mumps/rubella after bone marrow transplantation

Peter J. Shaw,Marie Bleakley,Margaret Burgess

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Erythrocyte mean cell volume and genetic polymorphism of aldehyde dehydrogenase 2 in alcohol drinkers

Yoshiaki Hashimoto,Toshifumi Nakayama,Azusa Futamura,Miho Omura,Kazuhiko Nakahara

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The role of interleukin-7 and interleukin-15 in cutaneous T-cell lymphoma

Dorothea Zucker-Franklin

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The “academic cartel”: another pernicious weed in the field of academic medicine

Muttuswamy Sivakumaran

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Issue Archive

Table of Contents

INSIDE BLOOD

Photodynamic purging of immunoreactive T cells: the magic bullet? Free

Moyamoya and stroke in sickle cell anemia: bad news and good news Free

PLENARY PAPERS

Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process Free

REVIEW ARTICLES

Differentiation plasticity of hematopoietic cells Free

HOW I TREAT

How we diagnose and treat deep vein thrombosis Free

CHEMOKINES

Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration Free

Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-γ in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome Free

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia Free Clinical Trials & Observations

Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report Free Clinical Trials & Observations

Moyamoya syndrome in childhood sickle cell disease: a predictive factor for recurrent cerebrovascular events Free Clinical Trials & Observations

Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remission Free Clinical Trials & Observations

High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma Free Clinical Trials & Observations

Maintenance therapy with alternate-day prednisone improves survival in multiple myeloma patients Free Clinical Trials & Observations

GENE THERAPY

Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells Free

Adapting a transforming growth factor β–related tumor protection strategy to enhance antitumor immunity Free

HEMATOPOIESIS

Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity Free

Modulation of p210BCR-ABL activity in transduced primary human hematopoietic cells controls lineage programming Free

Vitamin C inhibits granulocyte macrophage–colony-stimulating factor–induced signaling pathways Free

Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein–deficient bone marrow–derived macrophages Free

A functional role of Stat3 in in vivo megakaryopoiesis Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Glycoprotein VI–mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP Free

Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model Free

A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis Free

Constitutive and functional association of the platelet collagen receptor glycoprotein VI–Fc receptor γ-chain complex with membrane rafts Free

IMMUNOBIOLOGY

Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure Free

Type I interferons produced by dendritic cells promote their phenotypic and functional activation Free

Humoral immune responses against Wilms tumor gene WT1product in patients with hematopoietic malignancies Free

Tumor lysate–specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy Free

HLA-B7 β-pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses Free

Human Immune Associated Nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells Free

Cytokine production and cytolytic mechanism of CD4+cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus–specific T-cell cultures Free

Interleukin-7–treated naive T cells can be productively infected by T-cell–adapted and primary isolates of human immunodeficiency virus 1 Free

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application Free

Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells Free

High frequencies of Th1-type CD4+ T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis Free

Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor–induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration Free

Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1 Free

Identification of an HLA A*0201–restricted CD8+T-cell epitope for the glycoprotein B homolog of human herpesvirus 8 Free

NEOPLASIA

MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia Free

In situ localization of follicular lymphoma: description and analysis by laser capture microdissection Free

Human T-cell lymphotropic virus type 1–transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells Free

Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21WAF1/CIP1 proteins in human acute lymphoblastic leukemia cells Free

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma Free

Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF–retinoic acid receptor alpha oncoprotein Free

Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells Free

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis Free

PHAGOCYTES

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide Free

Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis Free

RED CELLS

Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-XL Free

TRANSPLANTATION

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events Free

BRIEF REPORTS

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor–1 enhances their ability to engraft NOD/SCID mice Free Brief Report

HLA-haploidentical blood progenitor cell transplantation in osteopetrosis Free Clinical Trials & Observations Brief Report

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia Free Brief Report

Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation Free Clinical Trials & Observations Brief Report

Significance of the detection of antineutrophil antibodies in children with chronic neutropenia Free Clinical Trials & Observations Brief Report

High frequency of point mutations clustered within the adenosine triphosphate–binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance Free Brief Report

CORRESPONDENCE

Elevated lipoprotein(a) concentration is an independent risk factor of venous thromboembolism Free

Mixed warm and cold autoimmune hemolytic anemia: complete recovery after 2 courses of rituximab treatment Free

Sperm protein 17 is not expressed on normal leukocytes Free

Severe neurotoxicity following arsenic therapy for acute promyelocytic leukemia: potentiation by thiamine deficiency Free

Successful double bone marrow and renal transplantation in a patient with Fanconi anemia Free

Cytomegalovirus infections in cancer patients receiving granulocyte transfusions Free

Photodynamic purging of immunoreactive T cells: the magic bullet?

Moyamoya and stroke in sickle cell anemia: bad news and good news

Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process

Differentiation plasticity of hematopoietic cells

How we diagnose and treat deep vein thrombosis

Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration

Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-γ in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome

Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia
Clinical Trials & Observations

Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report
Clinical Trials & Observations

Moyamoya syndrome in childhood sickle cell disease: a predictive factor for recurrent cerebrovascular events
Clinical Trials & Observations

Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remission
Clinical Trials & Observations

High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma
Clinical Trials & Observations

Maintenance therapy with alternate-day prednisone improves survival in multiple myeloma patients
Clinical Trials & Observations

Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells

Adapting a transforming growth factor β–related tumor protection strategy to enhance antitumor immunity

Role of protein kinase C in the phosphorylation of CD33 (Siglec-3) and its effect on lectin activity

Modulation of p210^BCR-ABL activity in transduced primary human hematopoietic cells controls lineage programming

Vitamin C inhibits granulocyte macrophage–colony-stimulating factor–induced signaling pathways

Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein–deficient bone marrow–derived macrophages

A functional role of Stat3 in in vivo megakaryopoiesis

Glycoprotein VI–mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP

Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model

A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis

Constitutive and functional association of the platelet collagen receptor glycoprotein VI–Fc receptor γ-chain complex with membrane rafts

Alanine-170 and proline-172 are critical determinants for extracellular CD20 epitopes; heterogeneity in the fine specificity of CD20 monoclonal antibodies is defined by additional requirements imposed by both amino acid sequence and quaternary structure

Type I interferons produced by dendritic cells promote their phenotypic and functional activation

Humoral immune responses against Wilms tumor gene WT1product in patients with hematopoietic malignancies

Tumor lysate–specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy

HLA-B7 β-pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses

Human Immune Associated Nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells

Cytokine production and cytolytic mechanism of CD4⁺cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus–specific T-cell cultures

Interleukin-7–treated naive T cells can be productively infected by T-cell–adapted and primary isolates of human immunodeficiency virus 1

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application

Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells

High frequencies of Th1-type CD4⁺ T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis

Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor–induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration

Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1

Identification of an HLA A*0201–restricted CD8⁺T-cell epitope for the glycoprotein B homolog of human herpesvirus 8

MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia

In situ localization of follicular lymphoma: description and analysis by laser capture microdissection

Human T-cell lymphotropic virus type 1–transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells

Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21^WAF1/CIP1 proteins in human acute lymphoblastic leukemia cells

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma

Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF–retinoic acid receptor alpha oncoprotein

Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis

Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide

Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis

Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X_L

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor–1 enhances their ability to engraft NOD/SCID mice
Brief Report

HLA-haploidentical blood progenitor cell transplantation in osteopetrosis
Clinical Trials & Observations Brief Report

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
Brief Report

Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation
Clinical Trials & Observations Brief Report

Significance of the detection of antineutrophil antibodies in children with chronic neutropenia
Clinical Trials & Observations Brief Report

High frequency of point mutations clustered within the adenosine triphosphate–binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
Brief Report

Elevated lipoprotein(a) concentration is an independent risk factor of venous thromboembolism

Mixed warm and cold autoimmune hemolytic anemia: complete recovery after 2 courses of rituximab treatment

Sperm protein 17 is not expressed on normal leukocytes

Severe neurotoxicity following arsenic therapy for acute promyelocytic leukemia: potentiation by thiamine deficiency

Successful double bone marrow and renal transplantation in a patient with Fanconi anemia

Cytomegalovirus infections in cancer patients receiving granulocyte transfusions

Expression of survival receptors in Hodgkin disease cell lines

Safety of early immunization against measles/mumps/rubella after bone marrow transplantation

Erythrocyte mean cell volume and genetic polymorphism of aldehyde dehydrogenase 2 in alcohol drinkers

The role of interleukin-7 and interleukin-15 in cutaneous T-cell lymphoma

The “academic cartel”: another pernicious weed in the field of academic medicine