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Volume 93, Issue 5

March 1 1999

In this Issue

EDITORIAL
INTRODUCTION: FOCUS ON HEMATOLOGY
FOCUS ON HEMATOLOGY
REVIEW ARTICLES
RAPID COMMUNICATIONS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
CORRESPONDENCE
ERRATA

EDITORIAL

Evolution in BLOOD

Kenneth Kaushansky, MD

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INTRODUCTION: FOCUS ON HEMATOLOGY

Resolving Conflicting Signals: Cross Inhibition of Cytokine Signaling Pathways

C.G. Begley,N.A. Nicola

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FOCUS ON HEMATOLOGY

Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells by Transforming Growth Factor-β: Relationship With IL-12 Signaling

Cécile Pardoux,Xiaojing Ma,Stéphanie Gobert,Sandra Pellegrini,Patrick Mayeux,Françoise Gay,Giorgio Trinchieri,Salem Chouaib

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Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1

Satoshi Ito,Parswa Ansari,Minoru Sakatsume,Harold Dickensheets,Nancy Vazquez,Raymond P. Donnelly,Andrew C. Larner,David S. Finbloom

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REVIEW ARTICLES

NADPH Oxidase: An Update

Bernard M. Babior

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RAPID COMMUNICATIONS

Constitutive Degradation of PML/RAR Through the Proteasome Pathway Mediates Retinoic Acid Resistance

Mirco Fanelli,Saverio Minucci,Vania Gelmetti,Clara Nervi,Carlo Gambacorti-Passerini,Pier Giuseppe Pelicci

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Detection of Kaposi’s Sarcoma Herpesvirus DNA Sequences in Multiple Myeloma Bone Marrow Stromal Cells

Dharminder Chauhan,Ajit Bharti,Noopur Raje,Eric Gustafson,Geraldine S. Pinkus,Jack L. Pinkus,Gerrard Teoh,Teru Hideshima,Steve P. Treon,Joyce D. Fingeroth,Kenneth C. Anderson

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Bone Marrow and Peripheral Blood Dendritic Cells From Patients With Multiple Myeloma Are Phenotypically and Functionally Normal Despite the Detection of Kaposi’s Sarcoma Herpesvirus Gene Sequences

Noopur Raje,Jianlin Gong,Dharminder Chauhan,Gerrard Teoh,David Avigan,Zekui Wu,Dongshu Chen,Steven P. Treon,Iain J. Webb,Donald W. Kufe,Kenneth C. Anderson

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Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms

Maja Krajinovic,Damian Labuda,Chantal Richer,Sepideh Karimi,Daniel Sinnett

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A Prospective Study on TT Virus Infection in Transfusion-Dependent Patients With β-Thalassemia

Daniele Prati,Yu-Huei Lin,Claudia De Mattei,Jen-Kuei Liu,Elena Farma,Latha Ramaswamy,Alberto Zanella,Helen Lee,Paolo Rebulla,Jean-Pierre Allain,Girolamo Sirchia,Benjamin Chen,for the Cooleycare Cooperative Group

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Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome

Rusung Tan,Xiaoning Xu,Graham S. Ogg,Pokrath Hansasuta,Tao Dong,Tim Rostron,Graz Luzzi,Christopher P. Conlon,Gavin R. Screaton,Andrew J. McMichael,Sarah Rowland-Jones

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CHEMOKINES

Phenotypic and Functional Evidence for the Expression of CXCR4 Receptor During Megakaryocytopoiesis

Christel Rivière,Frédéric Subra,Karine Cohen-Solal,Véronique Cordette-Lagarde,Remi Letestu,Christian Auclair,William Vainchenker,Fawzia Louache

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Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2

Suzanna Reid,Alec Ritchie,Landin Boring,Jennifa Gosling,Scott Cooper,Giao Hangoc,Israel F. Charo,Hal E. Broxmeyer

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Autografting With Philadelphia Chromosome–Negative Mobilized Hematopoietic Progenitor Cells in Chronic Myelogenous Leukemia

Angelo M. Carella,Enrica Lerma,Maria T. Corsetti,Anna Dejana,Palmina Basta,Franca Vassallo,Monica Abate,Monica Soracco,Federica Benvenuto,Osvaldo Figari,Marina Podestà,Giovanna Piaggio,Raimondo Ferrara,Mario Sessarego,Caterina Parodi,Michele Pizzuti,Alessandra Rubagotti,Domenico Occhini,Francesco Frassoni

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HEMATOPOIESIS

H-Ras Is Involved in the Inside-out Signaling Pathway of Interleukin-3–Induced Integrin Activation

Hirohiko Shibayama,Naoyuki Anzai,Stephen E. Braun,Seiji Fukuda,Charlie Mantel,Hal E. Broxmeyer

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In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region

Isao Hamaguchi,Xu-Ling Huang,Nobuyuki Takakura,Jun-ichi Tada,Yuji Yamaguchi,Hiroaki Kodama,Toshio Suda

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Organ-Selective Homing Defines Engraftment Kinetics of Murine Hematopoietic Stem Cells and Is Compromised by Ex Vivo Expansion

Stephen J. Szilvassy,Michael J. Bass,Gary Van Zant,Barry Grimes

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Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression

Dai Chida,Osamu Miura,Akihiko Yoshimura,Atsushi Miyajima

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Receptor Clearance Obscures the Magnitude of Granulocyte-Macrophage Colony-Stimulating Factor Responses in Mice to Endotoxin or Local Infections

Donald Metcalf,Nicos A. Nicola,Sandra Mifsud,Ladina Di Rago

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Structural and Functional Abnormalities in the Spleen of anmFtz-F1 Gene–Disrupted Mouse

Ken-ichirou Morohashi,Hisae Tsuboi-Asai,Sumie Matsushita,Masahiro Suda,Manabu Nakashima,Hironobu Sasano,Yoshiaki Hataba,Chun-Lin Li,Junichi Fukata,Junji Irie,Takeshi Watanabe,Hiroshi Nagura,En Li

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Prospective Evaluation of the Thrombotic Risk in Children With Acute Lymphoblastic Leukemia Carrying the MTHFR TT 677 Genotype, the Prothrombin G20210A Variant, and Further Prothrombotic Risk Factors

Ulrike Nowak-Göttl,Cornelia Wermes,Ralf Junker,Hans-Georg Koch,Rosmarie Schobess,Gudrun Fleischhack,Dirk Schwabe,Silke Ehrenforth

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The Megakaryocyte/Platelet-Specific Enhancer of the ₂β₁ Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade

Mary M. Zutter,Audrey D. Painter,Xun Yang

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Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12

Lei Yao,Cecilia Sgadari,Keizo Furuke,Eda T. Bloom,Julie Teruya-Feldstein,Giovanna Tosato

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Labeling of the Internal Pool of GP IIb-IIIa in Platelets by c7E3 Fab Fragments (abciximab): Flow and Endocytic Mechanisms Contribute to the Transport

Paquita Nurden,Christel Poujol,Catherine Durrieu-Jais,Joëlle Winckler,Robert Combrié,Laurent Macchi,Claude Bihour,Carrie Wagner,Robert Jordan,Alan T. Nurden

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IMMUNOBIOLOGY

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8⁺ T Cells Resulting in a Failure to Lyse Tumor Cells

Kerstin Steinbrink,Helmut Jonuleit,Gabriele Müller,Gerold Schuler,Jürgen Knop,Alexander H. Enk

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NEOPLASIA

Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation

Vladimir M. Belkov,Eugene Y. Krynetski,John D. Schuetz,Yuri Yanishevski,Eric Masson,Susan Mathew,Susana Raimondi,Ching-Hon Pui,Mary V. Relling,William E. Evans

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Clonality of Isolated Eosinophils in the Hypereosinophilic Syndrome

Hsiao-Wen Chang,Kah-Hoo Leong,Dow-Rhoon Koh,Szu-Hee Lee

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Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

Jason S. Damiano,Anne E. Cress,Lori A. Hazlehurst,Alexander A. Shtil,William S. Dalton

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Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities

Marina Konopleva,Adel Mikhail,Zeev Estrov,Shourong Zhao,David Harris,Gisela Sanchez-Williams,Steven M. Kornblau,Joan Dong,Kay-Oliver Kliche,Shuwei Jiang,H. Ralph Snodgrass,Elihu H. Estey,Michael Andreeff

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Role of Folylpolyglutamate Synthetase and Folylpolyglutamate Hydrolase in Methotrexate Accumulation and Polyglutamylation in Childhood Leukemia

Marianne G. Rots,Rob Pieters,Godefridus J. Peters,Paul Noordhuis,Christina H. van Zantwijk,Gertjan J.L. Kaspers,Karel Hählen,Ursula Creutzig,Anjo J.P. Veerman,Gerrit Jansen

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Overexpression of the Receptor for Hyaluronan-Mediated Motility (RHAMM) Characterizes the Malignant Clone in Multiple Myeloma: Identification of Three Distinct RHAMM Variants

Mary Crainie,Andrew R. Belch,Michael J. Mant,Linda M. Pilarski

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Ibandronate Reduces Osteolytic Lesions but not Tumor Burden in a Murine Model of Myeloma Bone Disease

Sarah L. Dallas,I. Ross Garrett,Babatunde O. Oyajobi,Mark R. Dallas,Brendan F. Boyce,Frieder Bauss,Jiri Radl,Gregory R. Mundy

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TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor

Michael H. Tomasson,Ifor R. Williams,Robert Hasserjian,Chirayu Udomsakdi,Shannon M. McGrath,Juerg Schwaller,Brian Druker,D. Gary Gilliland

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Heparin-Binding Epidermal Growth Factor–Like Growth Factor/Diphtheria Toxin Receptor Expression by Acute Myeloid Leukemia Cells

Fabrizio Vinante,Antonella Rigo,Emanuele Papini,Marco A. Cassatella,Giovanni Pizzolo

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The Somatostatin Analog Octreotide Inhibits Growth of Interleukin-6 (IL-6)–Dependent and IL-6–Independent Human Multiple Myeloma Cell Lines

Patrik Georgii-Hemming,Thomas Strömberg,Eva Tiensuu Janson,Mats Stridsberg,Helena Jernberg Wiklund,Kenneth Nilsson

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Elevated Serum Thymidine Kinase Levels Identify a Subgroup at High Risk of Disease Progression in Early, Nonsmoldering Chronic Lymphocytic Leukemia

Michael Hallek,Irmgard Langenmayer,Christoph Nerl,Wolfgang Knauf,Hermann Dietzfelbinger,Dagmar Adorf,Marianne Ostwald,Raymonde Busch,Ingrid Kuhn-Hallek,Eckhard Thiel,Bertold Emmerich

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PHAGOCYTES

Cell-Specific Peptide Binding by Human Neutrophils

Luca Mazzucchelli,James B. Burritt,Algirdas J. Jesaitis,Asma Nusrat,Tony W. Liang,Andrew T. Gewirtz,Frederick J. Schnell,Charles A. Parkos

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RED CELLS

Resistance of Paroxysmal Nocturnal Hemoglobinuria Cells to the Glycosylphosphatidylinositol-Binding Toxin Aerolysin

Robert A. Brodsky,Galina L. Mukhina,Kim L. Nelson,Tracy S. Lawrence,Richard J. Jones,J. Thomas Buckley

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Four New Mutations in the Erythroid-Specific 5-Aminolevulinate Synthase (ALAS2) Gene Causing X-Linked Sideroblastic Anemia: Increased Pyridoxine Responsiveness After Removal of Iron Overload by Phlebotomy and Coinheritance of Hereditary Hemochromatosis

Philip D. Cotter,Alison May,Liping Li,A.I. Al-Sabah,Edward J. Fitzsimons,Mario Cazzola,David F. Bishop

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TRANSFUSION MEDICINE

Soluble HLA Class I, HLA Class II, and Fas Ligand in Blood Components: A Possible Key to Explain the Immunomodulatory Effects of Allogeneic Blood Transfusions

M. Ghio,P. Contini,C. Mazzei,S. Brenci,G. Barberis,G. Filaci,F. Indiveri,F. Puppo

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CORRESPONDENCE

Hepatitis C Virus Infection in Patients With Overt B-Cell Non-Hodgkin’s Lymphoma in a French Center

Georgios Germanidis,Corinne Haioun,Jérôme Pourquier,Philippe Gaulard,Jean-Michel Pawlotsky,Daniel Dhumeaux,Félix Reyes

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The Adverse Influence of Pretransplant Interferon- (IFN-) on Transplant Outcome After Marrow Transplantation for Chronic Phase Chronic Myelogenous Leukemia Increases With the Duration of IFN- Exposure

Dietrich W. Beelen,Ahmet H. Elmaagacli,Prof. Ulrich W. Schaefer

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Successful Modification of a pp65 Antigenemia-Based Early Treatment Strategy for Prevention of Cytomegalovirus Disease in Allogeneic Marrow Transplant Recipients

Michael Boeckh,Raleigh A. Bowden,Ted Gooley,David Myerson,Lawrence Corey

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Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity

Hiroyasu Ishikura,Hisanori Fukui,Naoshi Takeyama,Takaya Tanaka

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ERRATA

Erratum for vol. 92, p. 3309

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Erratum for vol. 91, p. 1152

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Issue Archive

Table of Contents

EDITORIAL

Evolution in BLOOD Free

INTRODUCTION: FOCUS ON HEMATOLOGY

Resolving Conflicting Signals: Cross Inhibition of Cytokine Signaling Pathways Free

FOCUS ON HEMATOLOGY

Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells by Transforming Growth Factor-β: Relationship With IL-12 Signaling Free

Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1 Free

REVIEW ARTICLES

NADPH Oxidase: An Update Free

RAPID COMMUNICATIONS

Constitutive Degradation of PML/RAR Through the Proteasome Pathway Mediates Retinoic Acid Resistance Free

Detection of Kaposi’s Sarcoma Herpesvirus DNA Sequences in Multiple Myeloma Bone Marrow Stromal Cells Free

Bone Marrow and Peripheral Blood Dendritic Cells From Patients With Multiple Myeloma Are Phenotypically and Functionally Normal Despite the Detection of Kaposi’s Sarcoma Herpesvirus Gene Sequences Free

Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms Free

A Prospective Study on TT Virus Infection in Transfusion-Dependent Patients With β-Thalassemia Free

Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome Free

CHEMOKINES

Phenotypic and Functional Evidence for the Expression of CXCR4 Receptor During Megakaryocytopoiesis Free

Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2 Free

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Autografting With Philadelphia Chromosome–Negative Mobilized Hematopoietic Progenitor Cells in Chronic Myelogenous Leukemia Free

HEMATOPOIESIS

H-Ras Is Involved in the Inside-out Signaling Pathway of Interleukin-3–Induced Integrin Activation Free

In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region Free

Organ-Selective Homing Defines Engraftment Kinetics of Murine Hematopoietic Stem Cells and Is Compromised by Ex Vivo Expansion Free

Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression Free

Receptor Clearance Obscures the Magnitude of Granulocyte-Macrophage Colony-Stimulating Factor Responses in Mice to Endotoxin or Local Infections Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Structural and Functional Abnormalities in the Spleen of anmFtz-F1 Gene–Disrupted Mouse Free

Prospective Evaluation of the Thrombotic Risk in Children With Acute Lymphoblastic Leukemia Carrying the MTHFR TT 677 Genotype, the Prothrombin G20210A Variant, and Further Prothrombotic Risk Factors Free

The Megakaryocyte/Platelet-Specific Enhancer of the 2β1 Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade Free

Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12 Free

Labeling of the Internal Pool of GP IIb-IIIa in Platelets by c7E3 Fab Fragments (abciximab): Flow and Endocytic Mechanisms Contribute to the Transport Free

IMMUNOBIOLOGY

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells Free

NEOPLASIA

Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation Free

Clonality of Isolated Eosinophils in the Hypereosinophilic Syndrome Free

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines Free

Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities Free

Role of Folylpolyglutamate Synthetase and Folylpolyglutamate Hydrolase in Methotrexate Accumulation and Polyglutamylation in Childhood Leukemia Free

Overexpression of the Receptor for Hyaluronan-Mediated Motility (RHAMM) Characterizes the Malignant Clone in Multiple Myeloma: Identification of Three Distinct RHAMM Variants Free

Ibandronate Reduces Osteolytic Lesions but not Tumor Burden in a Murine Model of Myeloma Bone Disease Free

TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor Free

Heparin-Binding Epidermal Growth Factor–Like Growth Factor/Diphtheria Toxin Receptor Expression by Acute Myeloid Leukemia Cells Free

The Somatostatin Analog Octreotide Inhibits Growth of Interleukin-6 (IL-6)–Dependent and IL-6–Independent Human Multiple Myeloma Cell Lines Free

Elevated Serum Thymidine Kinase Levels Identify a Subgroup at High Risk of Disease Progression in Early, Nonsmoldering Chronic Lymphocytic Leukemia Free

PHAGOCYTES

Cell-Specific Peptide Binding by Human Neutrophils Free

RED CELLS

Resistance of Paroxysmal Nocturnal Hemoglobinuria Cells to the Glycosylphosphatidylinositol-Binding Toxin Aerolysin Free

Four New Mutations in the Erythroid-Specific 5-Aminolevulinate Synthase (ALAS2) Gene Causing X-Linked Sideroblastic Anemia: Increased Pyridoxine Responsiveness After Removal of Iron Overload by Phlebotomy and Coinheritance of Hereditary Hemochromatosis Free

TRANSFUSION MEDICINE

Soluble HLA Class I, HLA Class II, and Fas Ligand in Blood Components: A Possible Key to Explain the Immunomodulatory Effects of Allogeneic Blood Transfusions Free

CORRESPONDENCE

Hepatitis C Virus Infection in Patients With Overt B-Cell Non-Hodgkin’s Lymphoma in a French Center Free

The Adverse Influence of Pretransplant Interferon- (IFN-) on Transplant Outcome After Marrow Transplantation for Chronic Phase Chronic Myelogenous Leukemia Increases With the Duration of IFN- Exposure Free

Successful Modification of a pp65 Antigenemia-Based Early Treatment Strategy for Prevention of Cytomegalovirus Disease in Allogeneic Marrow Transplant Recipients Free

Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity Free

ERRATA

Erratum for vol. 92, p. 3309 Free

Erratum for vol. 91, p. 1152 Free

Email alerts

ASH Publications

American Society of Hematology

Evolution in BLOOD

Resolving Conflicting Signals: Cross Inhibition of Cytokine Signaling Pathways

Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells by Transforming Growth Factor-β: Relationship With IL-12 Signaling

Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1

NADPH Oxidase: An Update

Constitutive Degradation of PML/RAR Through the Proteasome Pathway Mediates Retinoic Acid Resistance

Detection of Kaposi’s Sarcoma Herpesvirus DNA Sequences in Multiple Myeloma Bone Marrow Stromal Cells

Bone Marrow and Peripheral Blood Dendritic Cells From Patients With Multiple Myeloma Are Phenotypically and Functionally Normal Despite the Detection of Kaposi’s Sarcoma Herpesvirus Gene Sequences

Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms

A Prospective Study on TT Virus Infection in Transfusion-Dependent Patients With β-Thalassemia

Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome

Phenotypic and Functional Evidence for the Expression of CXCR4 Receptor During Megakaryocytopoiesis

Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2

Autografting With Philadelphia Chromosome–Negative Mobilized Hematopoietic Progenitor Cells in Chronic Myelogenous Leukemia

H-Ras Is Involved in the Inside-out Signaling Pathway of Interleukin-3–Induced Integrin Activation

In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region

Organ-Selective Homing Defines Engraftment Kinetics of Murine Hematopoietic Stem Cells and Is Compromised by Ex Vivo Expansion

Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression

Receptor Clearance Obscures the Magnitude of Granulocyte-Macrophage Colony-Stimulating Factor Responses in Mice to Endotoxin or Local Infections

Structural and Functional Abnormalities in the Spleen of anmFtz-F1 Gene–Disrupted Mouse

Prospective Evaluation of the Thrombotic Risk in Children With Acute Lymphoblastic Leukemia Carrying the MTHFR TT 677 Genotype, the Prothrombin G20210A Variant, and Further Prothrombotic Risk Factors

The Megakaryocyte/Platelet-Specific Enhancer of the ₂β₁ Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade

Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12

Labeling of the Internal Pool of GP IIb-IIIa in Platelets by c7E3 Fab Fragments (abciximab): Flow and Endocytic Mechanisms Contribute to the Transport

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8⁺ T Cells Resulting in a Failure to Lyse Tumor Cells

Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation

Clonality of Isolated Eosinophils in the Hypereosinophilic Syndrome

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities

Role of Folylpolyglutamate Synthetase and Folylpolyglutamate Hydrolase in Methotrexate Accumulation and Polyglutamylation in Childhood Leukemia

Overexpression of the Receptor for Hyaluronan-Mediated Motility (RHAMM) Characterizes the Malignant Clone in Multiple Myeloma: Identification of Three Distinct RHAMM Variants

Ibandronate Reduces Osteolytic Lesions but not Tumor Burden in a Murine Model of Myeloma Bone Disease

TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor

Heparin-Binding Epidermal Growth Factor–Like Growth Factor/Diphtheria Toxin Receptor Expression by Acute Myeloid Leukemia Cells

The Somatostatin Analog Octreotide Inhibits Growth of Interleukin-6 (IL-6)–Dependent and IL-6–Independent Human Multiple Myeloma Cell Lines

Elevated Serum Thymidine Kinase Levels Identify a Subgroup at High Risk of Disease Progression in Early, Nonsmoldering Chronic Lymphocytic Leukemia

Cell-Specific Peptide Binding by Human Neutrophils

Resistance of Paroxysmal Nocturnal Hemoglobinuria Cells to the Glycosylphosphatidylinositol-Binding Toxin Aerolysin

Four New Mutations in the Erythroid-Specific 5-Aminolevulinate Synthase (ALAS2) Gene Causing X-Linked Sideroblastic Anemia: Increased Pyridoxine Responsiveness After Removal of Iron Overload by Phlebotomy and Coinheritance of Hereditary Hemochromatosis

Soluble HLA Class I, HLA Class II, and Fas Ligand in Blood Components: A Possible Key to Explain the Immunomodulatory Effects of Allogeneic Blood Transfusions

Hepatitis C Virus Infection in Patients With Overt B-Cell Non-Hodgkin’s Lymphoma in a French Center

The Adverse Influence of Pretransplant Interferon- (IFN-) on Transplant Outcome After Marrow Transplantation for Chronic Phase Chronic Myelogenous Leukemia Increases With the Duration of IFN- Exposure

Successful Modification of a pp65 Antigenemia-Based Early Treatment Strategy for Prevention of Cytomegalovirus Disease in Allogeneic Marrow Transplant Recipients

Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity

Erratum for vol. 92, p. 3309

Erratum for vol. 91, p. 1152