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Volume 93, Issue 2

January 15 1999

In this Issue

INTRODUCTION: FOCUS ON HEMATOLOGY
FOCUS ON HEMATOLOGY
REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

INTRODUCTION: FOCUS ON HEMATOLOGY

Essential Thrombocythemia: Another “Heterogeneous Disease” Better Understood?

Stephen D. Nimer

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FOCUS ON HEMATOLOGY

A Large Proportion of Patients With a Diagnosis of Essential Thrombocythemia Do Not Have a Clonal Disorder and May Be at Lower Risk of Thrombotic Complications

Claire N. Harrison,Rosemary E. Gale,Samuel J. Machin,David C. Linch

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REVIEW ARTICLES

Granulocyte Colony-Stimulating Factor to Prevent the Progression of Systemic Nonresponsiveness in Systemic Inflammatory Response Syndrome and Sepsis

Manfred Weiss,Lyle L. Moldawer,E. Marion Schneider

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RAPID COMMUNICATIONS

Deletion of a Critical Internalization Domain in the G-CSFR in Acute Myelogenous Leukemia Preceded by Severe Congenital Neutropenia

Melissa G. Hunter,Belinda R. Avalos

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Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia

Alister C. Ward,Yvette M. van Aesch,Anita M. Schelen,Ivo P. Touw

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Myelodysplastic and Myeloproliferative Disorders of Childhood: A Study of 167 Patients

Sandra Luna-Fineman,Kevin M. Shannon,Susan K. Atwater,Jeffrey Davis,Margaret Masterson,Jorge Ortega,Jean Sanders,Peter Steinherz,Vivian Weinberg,Beverly J. Lange

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Comparison of Immune Reconstitution After Unrelated and Related T-Cell–Depleted Bone Marrow Transplantation: Effect of Patient Age and Donor Leukocyte Infusions

T.N. Small,E.B. Papadopoulos,F. Boulad,P. Black,H. Castro-Malaspina,B.H. Childs,N. Collins,A. Gillio,D. George,A. Jakubowski,G. Heller,M. Fazzari,N. Kernan,S. MacKinnon,P. Szabolcs,J.W. Young,R.J. O’Reilly

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HEMATOPOIESIS

Human Growth Factor–Enhanced Regeneration of Transplantable Human Hematopoietic Stem Cells in Nonobese Diabetic/Severe Combined Immunodeficient Mice

Johanne D. Cashman,Connie J. Eaves

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Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis

Derek A. Persons,James A. Allay,Esther R. Allay,Richard A. Ashmun,Donald Orlic,Stephen M. Jane,John M. Cunningham,Arthur W. Nienhuis

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Positive and Negative Cis-Acting Elements Are Required for Hematopoietic Expression of Zebrafish GATA-1

Anming Meng,Hong Tang,Baozheng Yuan,Bruce A. Ong,Qiaoming Long,Shuo Lin

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Neutrophilic Cell Production by Combination of Stem Cell Factor and Thrombopoietin From CD34⁺ Cord Blood Cells in Long-Term Serum-Deprived Liquid Culture

Nobukuni Sawai,Kenichi Koike,Susumu Ito,Hadija Hemed Mwamtemi,Yumi Kurokawa,Tatsuya Kinoshita,Kazuo Sakashita,Tsukasa Higuchi,Kouichi Takeuchi,Masaaki Shiohara,Hiroshi Miyazaki,Takashi Kato,Atsushi Komiyama

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The Activity of the CCAAT-box Binding Factor NF-Y Is Modulated Through the Regulated Expression of Its A Subunit During Monocyte to Macrophage Differentiation: Regulation of Tissue-Specific Genes Through a Ubiquitous Transcription Factor

Giovanna Marziali,Edvige Perrotti,Ramona Ilari,Eliana M. Coccia,Roberto Mantovani,Ugo Testa,Angela Battistini

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D3: A Gene Induced During Myeloid Cell Differentiation of Lin^lo c-Kit⁺ Sca-1⁺ Progenitor Cells

Sarah R. Weiler,John M. Gooya,Mariaestela Ortiz,Schickwann Tsai,Steven J. Collins,Jonathan R. Keller

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Synergistic Activation of Mitogen-Activated Protein Kinase by Cyclic AMP and Myeloid Growth Factors Opposes Cyclic AMP’s Growth-Inhibitory Effects

Angel Wai-mun Lee

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Downregulation of c-kit (Stem Cell Factor Receptor) in Transformed Hematopoietic Precursor Cells by Stroma Cells

Christoph Heberlein,Jutta Friel,Christine Laker,Dorothee von Laer,Ulla Bergholz,Martina Bögel,Leonie K. Ashman,Karl Klingler,Wolfram Ostertag

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Fibrin-Dependent Platelet Procoagulant Activity Requires GPIb Receptors and von Willebrand Factor

S. Béguin,R. Kumar,I. Keularts,U. Seligsohn,B.S. Coller,H.C. Hemker

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Identification of a Cellubrevin/Vesicle Associated Membrane Protein 3 Homologue in Human Platelets

Audrey M. Bernstein,Sidney W. Whiteheart

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IMMUNOBIOLOGY

Selective Requirements for Leukocyte Adhesion Molecules in Models of Acute and Chronic Cutaneous Inflammation: Participation of E- and P- But Not L-Selectin

Michelle D. Catalina,Pila Estess,Mark H. Siegelman

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Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

Fabienne Anjuère,Pilar Martı́n,Isabel Ferrero,Marta López Fraga,Gloria Martı́nez del Hoyo,Natalia Wright,Carlos Ardavı́n

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P-Glycoprotein Expression on Normal and Abnormally Expanded Natural Killer Cells and Inhibition of P-Glycoprotein Function by Cyclosporin A and Its Analogue, PSC833

Motoki Egashira,Norihiko Kawamata,Koichi Sugimoto,Takako Kaneko,Kazuo Oshimi

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Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency

Satoru Kumaki,Naoto Ishii,Masayoshi Minegishi,Shigeru Tsuchiya,David Cosman,Kazuo Sugamura,Tasuke Konno

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NEOPLASIA

Detailed Deletion Mapping of the Long Arm of Chromosome 6 in Adult T-Cell Leukemia

Yoshihiro Hatta,Yasuaki Yamada,Masao Tomonaga,Isao Miyoshi,Jonathan W. Said,H. Phillip Koeffler

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Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid Cells

Horst Dürkop,Hans-Dieter Foss,Gudrun Demel,Heike Klotzbach,Corinna Hahn,Harald Stein

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Reduced Expression of Adhesion Molecules and Cell Signaling Receptors by Chronic Lymphocytic Leukemia Cells With 11q Deletion

Sabine Sembries,Heike Pahl,Stephan Stilgenbauer,Hartmut Döhner,Folke Schriever

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Detection of Normal and Chimeric Nucleophosmin in Human Cells

Jacqueline L. Cordell,Karen A.F. Pulford,Barbara Bigerna,Giovanna Roncador,Alison Banham,Emanuela Colombo,Pier-Giuseppe Pelicci,David Y. Mason,Brunangelo Falini

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Eradication of Pre-Established Lymphoma Using Herpes Simplex Virus Amplicon Vectors

Mahmood Kutubuddin,Howard J. Federoff,Pia M. Challita-Eid,Marc Halterman,Brian Day,Meredith Atkinson,Vicente Planelles,Joseph D. Rosenblatt

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PHAGOCYTES

Selective Expansion of Alveolar Macrophages In Vivo by Adenovirus-Mediated Transfer of the Murine Granulocyte-Macrophage Colony-Stimulating Factor cDNA

Stefan Worgall,Ravi Singh,Philip L. Leopold,Robert J. Kaner,Neil R. Hackett,Norbert Topf,Malcolm A.S. Moore,Ronald G. Crystal

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Augmented Proliferation of Human Alveolar Macrophages After Allogeneic Bone Marrow Transplantation

Koh Nakata,Hajime Gotoh,Junichi Watanabe,Takeshi Uetake,Iwao Komuro,Kazumi Yuasa,Shinya Watanabe,Ryuji Ieki,Hisashi Sakamaki,Hideki Akiyama,Shohji Kudoh,Makoto Naitoh,Hitoshi Satoh,Kaoru Shimada

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Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production

Kouhei Yamashita,Atsushi Takahashi,Susumu Kobayashi,Hirokazu Hirata,Peter W. Mesner, Jr,Scott H. Kaufmann,Shin Yonehara,Kokichi Yamamoto,Takashi Uchiyama,Masataka Sasada

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Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation

Evelin M.B. Raeder,Pamela J. Mansfield,Vania Hinkovska-Galcheva,Lars Kjeldsen,James A. Shayman,Laurence A. Boxer

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The Biologic Role of Interleukin-8: Functional Analysis and Expression of CXCR1 and CXCR2 on Human Eosinophils

Holger Petering,Otto Götze,Daniela Kimmig,Regina Smolarski,Alexander Kapp,Jörn Elsner

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RED CELLS

Correct Function of the Locus Control Region May Require Passage Through a Nonerythroid Cellular Environment

George Vassilopoulos,Patrick A. Navas,Evangelia Skarpidi,Kenneth R. Peterson,Chris H. Lowrey,Thalia Papayannopoulou,George Stamatoyannopoulos

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TRANSFUSION MEDICINE

Extreme Leukoreduction of Major Histocompatibility Complex Class II Positive B Cells Enhances Allogeneic Platelet Immunity

John W. Semple,Edwin R. Speck,Donna Cosgrave,Alan H. Lazarus,Victor S. Blanchette,John Freedman

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Persistence and Clinical Outcome of Hepatitis G Virus Infection in Pediatric Bone Marrow Transplant Recipients and Children Treated for Hematological Malignancy

Maki Yamada-Osaki,Ryo Sumazaki,Masahiro Tsuchida,Kazutoshi Koike,Takashi Fukushima,Akira Matsui

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TRANSPLANTATION

Monitoring Human Blood Dendritic Cell Numbers in Normal Individuals and in Stem Cell Transplantation

D.B. Fearnley,L.F. Whyte,S.A. Carnoutsos,A.H. Cook,D.N.J. Hart

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Marrow Ablative and Immunosuppressive Effects of¹³¹I-Anti-CD45 Antibody in Congenic and H2-Mismatched Murine Transplant Models

Dana C. Matthews,Paul J. Martin,Cynthia Nourigat,Frederick R. Appelbaum,Darrell R. Fisher,Irwin D. Bernstein

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Proliferation and Survival of Mammary Carcinoma Cells Are Influenced by Culture Conditions Used for Ex Vivo Expansion of CD34⁺Blood Progenitor Cells

A. Spyridonidis,W. Bernhardt,D. Behringer,G. Köhler,M. Azemar,A. Pflug,R. Henschler

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CORRESPONDENCE

Flow Cytometric Analysis of Wiskott-Aldrich Syndrome (WAS) Protein in Lymphocytes From WAS Patients and Their Familial Carriers

Masafumi Yamada,Makoto Ohtsu,Ichiro Kobayashi,Nobuaki Kawamura,Kunihiko Kobayashi,Tadashi Ariga,Yukio Sakiyama,David L. Nelson,Satoshi Tsuruta,Michiya Anakura,Nobuyoshi Ishikawa

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What Is Burkitt’s Lymphoma and When Is It Endemic?

D.H. Wright

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Founder Effect in Protein S-Deficient Families Sharing a Hot Spot Mutation in PROS1

Bente Damm Andersen,Marie Luise Bisgaard,Stefan Mustafa,Christine Mannhalter

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Issue Archive

Table of Contents

INTRODUCTION: FOCUS ON HEMATOLOGY

Essential Thrombocythemia: Another “Heterogeneous Disease” Better Understood? Free

FOCUS ON HEMATOLOGY

A Large Proportion of Patients With a Diagnosis of Essential Thrombocythemia Do Not Have a Clonal Disorder and May Be at Lower Risk of Thrombotic Complications Free

REVIEW ARTICLES

Granulocyte Colony-Stimulating Factor to Prevent the Progression of Systemic Nonresponsiveness in Systemic Inflammatory Response Syndrome and Sepsis Free

RAPID COMMUNICATIONS

Deletion of a Critical Internalization Domain in the G-CSFR in Acute Myelogenous Leukemia Preceded by Severe Congenital Neutropenia Free

Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia Free

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Myelodysplastic and Myeloproliferative Disorders of Childhood: A Study of 167 Patients Free

Comparison of Immune Reconstitution After Unrelated and Related T-Cell–Depleted Bone Marrow Transplantation: Effect of Patient Age and Donor Leukocyte Infusions Free

HEMATOPOIESIS

Human Growth Factor–Enhanced Regeneration of Transplantable Human Hematopoietic Stem Cells in Nonobese Diabetic/Severe Combined Immunodeficient Mice Free

Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis Free

Positive and Negative Cis-Acting Elements Are Required for Hematopoietic Expression of Zebrafish GATA-1 Free

Neutrophilic Cell Production by Combination of Stem Cell Factor and Thrombopoietin From CD34+ Cord Blood Cells in Long-Term Serum-Deprived Liquid Culture Free

The Activity of the CCAAT-box Binding Factor NF-Y Is Modulated Through the Regulated Expression of Its A Subunit During Monocyte to Macrophage Differentiation: Regulation of Tissue-Specific Genes Through a Ubiquitous Transcription Factor Free

D3: A Gene Induced During Myeloid Cell Differentiation of Linlo c-Kit+ Sca-1+ Progenitor Cells Free

Synergistic Activation of Mitogen-Activated Protein Kinase by Cyclic AMP and Myeloid Growth Factors Opposes Cyclic AMP’s Growth-Inhibitory Effects Free

Downregulation of c-kit (Stem Cell Factor Receptor) in Transformed Hematopoietic Precursor Cells by Stroma Cells Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Fibrin-Dependent Platelet Procoagulant Activity Requires GPIb Receptors and von Willebrand Factor Free

Identification of a Cellubrevin/Vesicle Associated Membrane Protein 3 Homologue in Human Platelets Free

IMMUNOBIOLOGY

Selective Requirements for Leukocyte Adhesion Molecules in Models of Acute and Chronic Cutaneous Inflammation: Participation of E- and P- But Not L-Selectin Free

Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse Free

P-Glycoprotein Expression on Normal and Abnormally Expanded Natural Killer Cells and Inhibition of P-Glycoprotein Function by Cyclosporin A and Its Analogue, PSC833 Free

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency Free

NEOPLASIA

Detailed Deletion Mapping of the Long Arm of Chromosome 6 in Adult T-Cell Leukemia Free

Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid Cells Free

Reduced Expression of Adhesion Molecules and Cell Signaling Receptors by Chronic Lymphocytic Leukemia Cells With 11q Deletion Free

Detection of Normal and Chimeric Nucleophosmin in Human Cells Free

Eradication of Pre-Established Lymphoma Using Herpes Simplex Virus Amplicon Vectors Free

PHAGOCYTES

Selective Expansion of Alveolar Macrophages In Vivo by Adenovirus-Mediated Transfer of the Murine Granulocyte-Macrophage Colony-Stimulating Factor cDNA Free

Augmented Proliferation of Human Alveolar Macrophages After Allogeneic Bone Marrow Transplantation Free

Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production Free

Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation Free

The Biologic Role of Interleukin-8: Functional Analysis and Expression of CXCR1 and CXCR2 on Human Eosinophils Free

RED CELLS

Correct Function of the Locus Control Region May Require Passage Through a Nonerythroid Cellular Environment Free

TRANSFUSION MEDICINE

Extreme Leukoreduction of Major Histocompatibility Complex Class II Positive B Cells Enhances Allogeneic Platelet Immunity Free

Persistence and Clinical Outcome of Hepatitis G Virus Infection in Pediatric Bone Marrow Transplant Recipients and Children Treated for Hematological Malignancy Free

TRANSPLANTATION

Monitoring Human Blood Dendritic Cell Numbers in Normal Individuals and in Stem Cell Transplantation Free

Marrow Ablative and Immunosuppressive Effects of131I-Anti-CD45 Antibody in Congenic and H2-Mismatched Murine Transplant Models Free

Proliferation and Survival of Mammary Carcinoma Cells Are Influenced by Culture Conditions Used for Ex Vivo Expansion of CD34+Blood Progenitor Cells Free

CORRESPONDENCE

Flow Cytometric Analysis of Wiskott-Aldrich Syndrome (WAS) Protein in Lymphocytes From WAS Patients and Their Familial Carriers Free

What Is Burkitt’s Lymphoma and When Is It Endemic? Free

Founder Effect in Protein S-Deficient Families Sharing a Hot Spot Mutation in PROS1 Free

Email alerts

ASH Publications

American Society of Hematology

Essential Thrombocythemia: Another “Heterogeneous Disease” Better Understood?

A Large Proportion of Patients With a Diagnosis of Essential Thrombocythemia Do Not Have a Clonal Disorder and May Be at Lower Risk of Thrombotic Complications

Granulocyte Colony-Stimulating Factor to Prevent the Progression of Systemic Nonresponsiveness in Systemic Inflammatory Response Syndrome and Sepsis

Deletion of a Critical Internalization Domain in the G-CSFR in Acute Myelogenous Leukemia Preceded by Severe Congenital Neutropenia

Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia

Myelodysplastic and Myeloproliferative Disorders of Childhood: A Study of 167 Patients

Comparison of Immune Reconstitution After Unrelated and Related T-Cell–Depleted Bone Marrow Transplantation: Effect of Patient Age and Donor Leukocyte Infusions

Human Growth Factor–Enhanced Regeneration of Transplantable Human Hematopoietic Stem Cells in Nonobese Diabetic/Severe Combined Immunodeficient Mice

Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis

Positive and Negative Cis-Acting Elements Are Required for Hematopoietic Expression of Zebrafish GATA-1

Neutrophilic Cell Production by Combination of Stem Cell Factor and Thrombopoietin From CD34⁺ Cord Blood Cells in Long-Term Serum-Deprived Liquid Culture

The Activity of the CCAAT-box Binding Factor NF-Y Is Modulated Through the Regulated Expression of Its A Subunit During Monocyte to Macrophage Differentiation: Regulation of Tissue-Specific Genes Through a Ubiquitous Transcription Factor

D3: A Gene Induced During Myeloid Cell Differentiation of Lin^lo c-Kit⁺ Sca-1⁺ Progenitor Cells

Synergistic Activation of Mitogen-Activated Protein Kinase by Cyclic AMP and Myeloid Growth Factors Opposes Cyclic AMP’s Growth-Inhibitory Effects

Downregulation of c-kit (Stem Cell Factor Receptor) in Transformed Hematopoietic Precursor Cells by Stroma Cells

Fibrin-Dependent Platelet Procoagulant Activity Requires GPIb Receptors and von Willebrand Factor

Identification of a Cellubrevin/Vesicle Associated Membrane Protein 3 Homologue in Human Platelets

Selective Requirements for Leukocyte Adhesion Molecules in Models of Acute and Chronic Cutaneous Inflammation: Participation of E- and P- But Not L-Selectin

Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

P-Glycoprotein Expression on Normal and Abnormally Expanded Natural Killer Cells and Inhibition of P-Glycoprotein Function by Cyclosporin A and Its Analogue, PSC833

Functional Role of Interleukin-4 (IL-4) and IL-7 in the Development of X-Linked Severe Combined Immunodeficiency

Detailed Deletion Mapping of the Long Arm of Chromosome 6 in Adult T-Cell Leukemia

Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin’s Disease and Epstein-Barr Virus-Transformed Lymphoid Cells

Reduced Expression of Adhesion Molecules and Cell Signaling Receptors by Chronic Lymphocytic Leukemia Cells With 11q Deletion

Detection of Normal and Chimeric Nucleophosmin in Human Cells

Eradication of Pre-Established Lymphoma Using Herpes Simplex Virus Amplicon Vectors

Selective Expansion of Alveolar Macrophages In Vivo by Adenovirus-Mediated Transfer of the Murine Granulocyte-Macrophage Colony-Stimulating Factor cDNA

Augmented Proliferation of Human Alveolar Macrophages After Allogeneic Bone Marrow Transplantation

Caspases Mediate Tumor Necrosis Factor-–Induced Neutrophil Apoptosis and Downregulation of Reactive Oxygen Production

Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation

The Biologic Role of Interleukin-8: Functional Analysis and Expression of CXCR1 and CXCR2 on Human Eosinophils

Correct Function of the Locus Control Region May Require Passage Through a Nonerythroid Cellular Environment

Extreme Leukoreduction of Major Histocompatibility Complex Class II Positive B Cells Enhances Allogeneic Platelet Immunity

Persistence and Clinical Outcome of Hepatitis G Virus Infection in Pediatric Bone Marrow Transplant Recipients and Children Treated for Hematological Malignancy

Monitoring Human Blood Dendritic Cell Numbers in Normal Individuals and in Stem Cell Transplantation

Marrow Ablative and Immunosuppressive Effects of¹³¹I-Anti-CD45 Antibody in Congenic and H2-Mismatched Murine Transplant Models

Proliferation and Survival of Mammary Carcinoma Cells Are Influenced by Culture Conditions Used for Ex Vivo Expansion of CD34⁺Blood Progenitor Cells

Flow Cytometric Analysis of Wiskott-Aldrich Syndrome (WAS) Protein in Lymphocytes From WAS Patients and Their Familial Carriers

What Is Burkitt’s Lymphoma and When Is It Endemic?

Founder Effect in Protein S-Deficient Families Sharing a Hot Spot Mutation in PROS1