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Volume 130, Issue 2

July 13 2017

Blood Cover Image for Volume 130, Issue 2

In this Issue

INSIDE BLOOD COMMENTARIES
PLENARY PAPER
PERSPECTIVE
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
TRANSFUSION MEDICINE
TRANSPLANTATION
BLOOD WORK
ERRATA

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY

The challenge of hospital-related thrombosis

Kenneth A. Bauer

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INSIDE BLOOD COMMENTARY

A molecular roadmap for midostaurin in mastocytosis
Clinical Trials & Observations

Jason Gotlib

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INSIDE BLOOD COMMENTARY

Targeting deubiquitinases in CLL

Deepa Sampath

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INSIDE BLOOD COMMENTARY

Soluble P-selectin is the smoke, not the fire

Peter L. Gross

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INSIDE BLOOD COMMENTARY

Factor V marks platelet-primed megakaryocytes

Alessandra Bertoni

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INSIDE BLOOD COMMENTARY

Myocardial fibrosis: the heart of diastole?

Jon A. Detterich

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INSIDE BLOOD COMMENTARY

Bruised platelet transfusions work

Thomas S. Kickler

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INSIDE BLOOD COMMENTARY

Checking up on checkpoint inhibitors

Richard F. Little,Howard Streicher

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PLENARY PAPER

THROMBOSIS AND HEMOSTASIS

Effect of a near-universal hospitalization-based prophylaxis regimen on annual number of venous thromboembolism events in the US
Clinical Trials & Observations

John A. Heit,Daniel J. Crusan,Aneel A. Ashrani,Tanya M. Petterson,Kent R. Bailey

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Supplemental data

PERSPECTIVE

JAK2 inhibitors for myeloproliferative neoplasms: what is next?
Clinical Trials & Observations

Prithviraj Bose,Srdan Verstovsek

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HOW I TREAT

How I treat chronic myelomonocytic leukemia
Clinical Trials & Observations

Eric Solary,Raphael Itzykson

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CLINICAL TRIALS AND OBSERVATIONS

Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers
Clinical Trials & Observations

Mohamad Jawhar,Juliana Schwaab,Nicole Naumann,Hans-Peter Horny,Karl Sotlar,Torsten Haferlach,Georgia Metzgeroth,Alice Fabarius,Peter Valent,Wolf-Karsten Hofmann,Nicholas C. P. Cross,Manja Meggendorfer,Andreas Reiter

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IMMUNOBIOLOGY

T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

David M. Woods,Karrune V. Woan,Fengdong Cheng,Andressa L. Sodré,Dapeng Wang,Yongxia Wu,Zi Wang,Jie Chen,John Powers,Javier Pinilla-Ibarz,Yu Yu,Ya Zhang,Xuefeng Wu,Xiaoyan Zheng,Jeffrey Weber,Wayne W. Hancock,Edward Seto,Alejandro Villagra,Xue-Zhong Yu,Eduardo M. Sotomayor

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Supplemental data

LYMPHOID NEOPLASIA

USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status

Angelo Agathanggelou,Edward Smith,Nicholas J. Davies,Marwan Kwok,Anastasia Zlatanou,Ceri E. Oldreive,Jingwen Mao,David Da Costa,Sina Yadollahi,Tracey Perry,Pamela Kearns,Anna Skowronska,Elliot Yates,Helen Parry,Peter Hillmen,Celine Reverdy,Remi Delansorne,Shankara Paneesha,Guy Pratt,Paul Moss,A. Malcolm R. Taylor,Grant S. Stewart,Tatjana Stankovic

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Supplemental data

MYELOID NEOPLASIA

Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults

Paul Milne,Venetia Bigley,Chris M. Bacon,Antoine Néel,Naomi McGovern,Simon Bomken,Muzlifah Haniffa,Eli L. Diamond,Benjamin H. Durham,Johannes Visser,David Hunt,Harsha Gunawardena,Mac Macheta,Kenneth L. McClain,Carl Allen,Omar Abdel-Wahab,Matthew Collin

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Supplemental data

Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells
Brief Report

Benjamin H. Durham,Damien Roos-Weil,Claude Baillou,Fleur Cohen-Aubart,Akihide Yoshimi,Makoto Miyara,Matthias Papo,Zofia Hélias-Rodzewicz,Nathalie Terrones,Neval Ozkaya,Ahmet Dogan,Raajit Rampal,Fanny Urbain,Lucie Le Fèvre,Eli L. Diamond,Christopher Y. Park,Thomas Papo,Frédéric Charlotte,Guy Gorochov,Valérie Taly,Olivier A. Bernard,Zahir Amoura,Omar Abdel-Wahab,François M. Lemoine,Julien Haroche,Jean-François Emile

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Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice

Sumith R. Panicker,Padmaja Mehta-D’souza,Nan Zhang,Arkadiusz G. Klopocki,Bojing Shao,Rodger P. McEver

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Supplemental data

PLATELETS AND THROMBOPOIESIS

Identifying and enriching platelet-producing human stem cell–derived megakaryocytes using factor V uptake

Xiuli Sim,Danuta Jarocha,Vincent Hayes,Hayley A. Hanby,Michael S. Marks,Rodney M. Camire,Deborah L. French,Mortimer Poncz,Paul Gadue

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Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia
Clinical Trials & Observations

Omar Niss,Robert Fleck,Fowe Makue,Tarek Alsaied,Payal Desai,Jeffrey A. Towbin,Punam Malik,Michael D. Taylor,Charles T. Quinn

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Supplemental data

TRANSFUSION MEDICINE

The effect of variation in donor platelet function on transfusion outcome: a semirandomized controlled trial
Clinical Trials & Observations

Anne M. Kelly,Stephen F. Garner,Theodora Foukaneli,Thomas R. Godec,Nina Herbert,Brennan C. Kahan,Alison Deary,Lekha Bakrania,Charlotte Llewelyn,Willem H. Ouwehand,Lorna M. Williamson,Rebecca A. Cardigan

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Supplemental data

TRANSPLANTATION

PD-1 blockade for relapsed lymphoma post–allogeneic hematopoietic cell transplant: high response rate but frequent GVHD
Clinical Trials & Observations

Bradley M. Haverkos,Diana Abbott,Mehdi Hamadani,Philippe Armand,Mary E. Flowers,Reid Merryman,Manali Kamdar,Abraham Sebastian Kanate,Ayman Saad,Amitkumar Mehta,Siddhartha Ganguly,Timothy S. Fenske,Parameswaran Hari,Robert Lowsky,Leslie Andritsos,Madan Jagasia,Asad Bashey,Stacey Brown,Veronika Bachanova,Deborah Stephens,Shin Mineishi,Ryotaro Nakamura,Yi-Bin Chen,Bruce R. Blazar,Jonathan Gutman,Steven M. Devine

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Supplemental data

BLOOD WORK

CART attack

Vinodh Pillai,Shannon L. Maude

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Myeloid leukemia associated with Down syndrome

Caroline E. Talsma,Daniel F. Boyer

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Diagnosing therapy-related acute myeloid leukemia with 8% blasts in bone marrow with concomitant plasma cell myeloma

Beenu Thakral,Tariq Muzzafar

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ERRATA

Straus SE, Jaffe ES, Puck JM, et al. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. Blood. 2001;98(1):194-200.

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Fischer K, Al-Sawaf O, Fink A-M, et al. Venetoclax and obinutuzumab in chronic lymphocytic leukemia. Blood. 2017;129(19):2702-2705.

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Cannavò A, Valsecchi C, Garagiola I, et al. Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A. Blood. 2017;129(10):1245-1250.

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Cover Image

Cover Image

Human megakaryocyte with factor V loaded into its α-granules in green. Staining is as follows: magenta, CD42b (megakaryocyte marker); red, von Willebrand factor (α-granule marker); blue, DAPI (4′,6-diamidino-2-phenylindole) nuclear staining. See the article by Sim et al on page 192.
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