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Volume 126, Issue 4

July 23 2015

Blood Cover Image for Volume 126, Issue 4

In this Issue

EDITORIAL
INSIDE BLOOD COMMENTARIES
PLENARY PAPER
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
REVIEW SERIES
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY
LYMPHOID NEOPLASIA
PLATELETS AND THROMBOPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
BLOOD WORK
CORRESPONDENCE

Table of Contents

EDITORIAL

Introduction to a series of reviews on chronic lymphocytic leukemia
Clinical Trials & Observations

John C. Byrd

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INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY

TWEAKing for a fight with GVHD

David J. MacEwan

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INSIDE BLOOD COMMENTARY

The wacky hypercoagulable state of malignancy
Clinical Trials & Observations

Alok A. Khorana

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INSIDE BLOOD COMMENTARY

Balancing bleeding in brain metastases
Clinical Trials & Observations

Lisa Baumann Kreuziger

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INSIDE BLOOD COMMENTARY

Platelet secretion paves the way

Yunjie Huang,Sidney W. Whiteheart

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INSIDE BLOOD COMMENTARY

Warfarin pharmacogenomics and African ancestry

Elvin T. Price

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PLENARY PAPER

TRANSPLANTATION

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD

Martin Chopra,Andreas Brandl,Daniela Siegmund,Anja Mottok,Viktoria Schäfer,Marlene Biehl,Sabrina Kraus,Carina A. Bäuerlein,Miriam Ritz,Katharina Mattenheimer,Stefanie Schwinn,Axel Seher,Thomas Grabinger,Hermann Einsele,Andreas Rosenwald,Thomas Brunner,Andreas Beilhack,Harald Wajant

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Supplemental data

REVIEW SERIES

Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia
Clinical Trials & Observations

Romain Guièze,Catherine J. Wu

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REVIEW SERIES

Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification
Clinical Trials & Observations

Paolo Strati,Tait D. Shanafelt

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REVIEW SERIES

Initial treatment of CLL: integrating biology and functional status
Clinical Trials & Observations

Nitin Jain,Susan O’Brien

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REVIEW SERIES

Targeted therapies in CLL: mechanisms of resistance and strategies for management
Clinical Trials & Observations

Jennifer A. Woyach,Amy J. Johnson

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REVIEW SERIES

A drive through cellular therapy for CLL in 2015: allogeneic cell transplantation and CARs
Clinical Trials & Observations

Anthony Mato,David L. Porter

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CLINICAL TRIALS AND OBSERVATIONS

Warfarin-induced venous limb ischemia/gangrene complicating cancer: a novel and clinically distinct syndrome
Clinical Trials & Observations

Theodore E. Warkentin,Richard J. Cook,Ravi Sarode,Debi A. Sloane,Mark A. Crowther

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Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study
Clinical Trials & Observations

Jessica Donato,Federico Campigotto,Erik J. Uhlmann,Erika Coletti,Donna Neuberg,Griffin M. Weber,Jeffrey I. Zwicker

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A novel triple therapy for ITP using high-dose dexamethasone, low-dose rituximab, and cyclosporine (TT4)
Clinical Trials & Observations Brief Report

Philip Young-Ill Choi,Fernando Roncolato,Xavier Badoux,Sundra Ramanathan,Shir-Jing Ho,Beng H. Chong

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Supplemental data

IMMUNOBIOLOGY

New role for the (pro)renin receptor in T-cell development
Brief Report

Sabrina Geisberger,Ulrike Maschke,Matthias Gebhardt,Markus Kleinewietfeld,Arndt Manzel,Ralf A. Linker,Ann Chidgey,Ralf Dechend,Genevieve Nguyen,Oliver Daumke,Dominik N. Muller,Mark D. Wright,Katrina J. Binger

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Supplemental data

LYMPHOID NEOPLASIA

Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides

Laura Y. McGirt,Peilin Jia,Devin A. Baerenwald,Robert J. Duszynski,Kimberly B. Dahlman,John A. Zic,Jeffrey P. Zwerner,Donald Hucks,Utpal Dave,Zhongming Zhao,Christine M. Eischen

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Supplemental data

PLATELETS AND THROMBOPOIESIS

Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis

Zhenhua Sui,Roberta B. Nowak,Chad Sanada,Stephanie Halene,Diane S. Krause,Velia M. Fowler

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Supplemental data

Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition

Yumiko Sakurai,Jennifer L. Fitch-Tewfik,Yongzhi Qiu,Byungwook Ahn,David R. Myers,Reginald Tran,Meredith E. Fay,Lingmei Ding,Paul W. Spearman,Alan D. Michelson,Robert Flaumenhaft,Wilbur A. Lam

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Supplemental data

THROMBOSIS AND HEMOSTASIS

Race influences warfarin dose changes associated with genetic factors
Clinical Trials & Observations

Nita A. Limdi,Todd M. Brown,Qi Yan,Jonathan L. Thigpen,Aditi Shendre,Nianjun Liu,Charles E. Hill,Donna K. Arnett,T. Mark Beasley

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TRANSPLANTATION

Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease

Byung-Su Kim,Hidekazu Nishikii,Jeanette Baker,Antonio Pierini,Dominik Schneidawind,Yuqiong Pan,Andreas Beilhack,Chung-Gyu Park,Robert S. Negrin

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Supplemental data

BLOOD WORK

Disseminated blastic plasmacytoid dendritic cell neoplasm

Sanam Loghavi,Joseph D. Khoury

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Pseudoplatelets in acute myeloid leukemia

Randall Y. Chan,Maria Vergara-Lluri

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CORRESPONDENCE

White blood cell counts and thrombosis in polycythemia vera: a subanalysis of the CYTO-PV study
Clinical Trials & Observations

Tiziano Barbui,Arianna Masciulli,Maria Rosa Marfisi,Giovanni Tognoni,Guido Finazzi,Alessandro Rambaldi,Alessandro Vannucchi

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Improved outcomes associated with hematopoietic stem cell transplantation for patients with juvenile myelomonocytic leukemia

Quan Zhao,Kris Michael Mahadeo,Neena Kapoor,Hisham Abdel-Azim

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Cover Image

Cover Image

Mitochondria and F-actin localization during megakaryocyte morphogenesis. Shown is a collage of 3 different immunostained fetal liver megakaryocytes at various stages of differentiation stained for mitochondria (red), F-actin (green), and DNA (blue). Images were acquired on a Zeiss LSM780 laser scanning confocal microscope (×100 objective, zoom 2). See the article by Sui et al on page 520.
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